{"id":"https://openalex.org/W4387651804","doi":"https://doi.org/10.36401/jipo-23-20","title":"Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma","display_name":"Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma","publication_year":2023,"publication_date":"2023-10-15","ids":{"openalex":"https://openalex.org/W4387651804","doi":"https://doi.org/10.36401/jipo-23-20","pmid":"https://pubmed.ncbi.nlm.nih.gov/38327758","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10846635"},"language":"en","primary_location":{"id":"doi:10.36401/jipo-23-20","doi":"https://doi.org/10.36401/jipo-23-20","is_oa":true,"landing_page_url":"https://doi.org/10.36401/jipo-23-20","pdf_url":"https://meridian.allenpress.com/innovationsjournals-JIPO/article-pdf/doi/10.36401/JIPO-23-20/3273803/10.36401_jipo-23-20.pdf","source":{"id":"https://openalex.org/S4210228385","display_name":"Journal of Immunotherapy and Precision Oncology","issn_l":"2590-017X","issn":["2590-017X","2666-2345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy and Precision Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://meridian.allenpress.com/innovationsjournals-JIPO/article-pdf/doi/10.36401/JIPO-23-20/3273803/10.36401_jipo-23-20.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013859670","display_name":"Ugur T. Sener","orcid":"https://orcid.org/0000-0002-3919-7408","observed_orcids":["https://orcid.org/0000-0002-3919-7408"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ugur Sener","raw_affiliation_strings":["1 Department of Neurology, Mayo Clinic, Rochester, MN, USA","2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-3919-7408","affiliations":[{"raw_affiliation_string":"1 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102957519","display_name":"Mason Webb","orcid":"https://orcid.org/0000-0003-4775-9164","observed_orcids":["https://orcid.org/0000-0003-4775-9164"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason Webb","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0003-4775-9164","affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083513023","display_name":"William G. Breen","orcid":"https://orcid.org/0000-0001-8039-2398","observed_orcids":["https://orcid.org/0000-0001-8039-2398"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Breen","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007147060","display_name":"Bryan J. Neth","orcid":"https://orcid.org/0000-0003-2342-0000","observed_orcids":["https://orcid.org/0000-0003-2342-0000"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan J. Neth","raw_affiliation_strings":["1 Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071466700","display_name":"Nadia N. Laack","orcid":"https://orcid.org/0000-0002-4385-6349","observed_orcids":["https://orcid.org/0000-0002-4385-6349"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadia N. Laack","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044706598","display_name":"David M. Routman","orcid":"https://orcid.org/0000-0002-2768-003X","observed_orcids":["https://orcid.org/0000-0002-2768-003X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Routman","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067520533","display_name":"Paul D. Brown","orcid":"https://orcid.org/0000-0003-0022-4533","observed_orcids":["https://orcid.org/0000-0003-0022-4533"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Brown","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060593662","display_name":"Anita Mahajan","orcid":"https://orcid.org/0000-0001-7609-4451","observed_orcids":["https://orcid.org/0000-0001-7609-4451"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Mahajan","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045791621","display_name":"Kelsey  M. Frechette","orcid":"https://orcid.org/0009-0006-5035-3420","observed_orcids":["https://orcid.org/0009-0006-5035-3420"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey Frechette","raw_affiliation_strings":["3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090069473","display_name":"Arkadiusz Zbigniew Dudek","orcid":"https://orcid.org/0000-0002-9114-8945","observed_orcids":["https://orcid.org/0000-0002-9114-8945"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arkadiusz Z. Dudek","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082719040","display_name":"Svetomir N. Markovic","orcid":"https://orcid.org/0000-0002-9238-4325","observed_orcids":["https://orcid.org/0000-0002-9238-4325"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svetomir N. Markovic","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000164383","display_name":"Matthew Stephen Block","orcid":"https://orcid.org/0000-0001-5692-4219","observed_orcids":["https://orcid.org/0000-0001-5692-4219"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Block","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006194799","display_name":"Robert R. McWilliams","orcid":"https://orcid.org/0000-0002-8199-5040","observed_orcids":["https://orcid.org/0000-0002-8199-5040"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. McWilliams","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073550585","display_name":"Anastasios Dimou","orcid":"https://orcid.org/0000-0002-3950-3305","observed_orcids":["https://orcid.org/0000-0002-3950-3305"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasios Dimou","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067707171","display_name":"Lisa A. Kottschade","orcid":"https://orcid.org/0000-0001-8922-2619","observed_orcids":["https://orcid.org/0000-0001-8922-2619"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Kottschade","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016700077","display_name":"Heather N. Montane","orcid":"https://orcid.org/0000-0001-7488-4767","observed_orcids":["https://orcid.org/0000-0001-7488-4767"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather N. Montane","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031473630","display_name":"Sani Haider Kizilbash","orcid":"https://orcid.org/0000-0001-8568-1519","observed_orcids":["https://orcid.org/0000-0001-8568-1519"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sani H. Kizilbash","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034837880","display_name":"Jian Li Campian","orcid":"https://orcid.org/0000-0002-5317-8481","observed_orcids":["https://orcid.org/0000-0002-5317-8481","https://orcid.org/0009-0001-0355-0337"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian L. Campian","raw_affiliation_strings":["2 Department of Oncology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Department of Oncology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013859670"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":1.4158,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82487671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-craniospinal-irradiation","display_name":"proton craniospinal irradiation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9760000109672546},{"id":"https://openalex.org/keywords/relatlimab","display_name":"relatlimab","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":1.0},{"id":"https://openalex.org/keywords/braf-wild-type-melanoma","display_name":"BRAF wild-type melanoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/braf-targeted-therapy","display_name":"BRAF-targeted therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/central-nervous-system-progression","display_name":"central nervous system progression","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.724770188331604},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7237289547920227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6714293360710144},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.625401496887207},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5190044641494751},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4935530424118042},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42712903022766113},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4263661503791809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38401278853416443},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29097381234169006},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13497033715248108}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.36401/jipo-23-20","doi":"https://doi.org/10.36401/jipo-23-20","is_oa":true,"landing_page_url":"https://doi.org/10.36401/jipo-23-20","pdf_url":"https://meridian.allenpress.com/innovationsjournals-JIPO/article-pdf/doi/10.36401/JIPO-23-20/3273803/10.36401_jipo-23-20.pdf","source":{"id":"https://openalex.org/S4210228385","display_name":"Journal of Immunotherapy and Precision Oncology","issn_l":"2590-017X","issn":["2590-017X","2666-2345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy and Precision Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10846635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10846635","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10846635/pdf/i2590-017X-7-1-1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Precis Oncol","raw_type":"Text"},{"id":"pmid:38327758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38327758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunotherapy and precision oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e46cf582bd95407aa5330e020924b4ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e46cf582bd95407aa5330e020924b4ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.36401/jipo-23-20","doi":"https://doi.org/10.36401/jipo-23-20","is_oa":true,"landing_page_url":"https://doi.org/10.36401/jipo-23-20","pdf_url":"https://meridian.allenpress.com/innovationsjournals-JIPO/article-pdf/doi/10.36401/JIPO-23-20/3273803/10.36401_jipo-23-20.pdf","source":{"id":"https://openalex.org/S4210228385","display_name":"Journal of Immunotherapy and Precision Oncology","issn_l":"2590-017X","issn":["2590-017X","2666-2345"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunotherapy and Precision Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G1275906799","display_name":null,"funder_award_id":"TR002377","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G7665511017","display_name":null,"funder_award_id":"R01 FD-R-07288","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G9000868933","display_name":"Mayo Clinic Center for Clinical and Translational Science (CCaTS)","funder_award_id":"UL1TR002377","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387651804.pdf","grobid_xml":"https://content.openalex.org/works/W4387651804.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W2059140616","https://openalex.org/W2102814382","https://openalex.org/W2170895976","https://openalex.org/W2753065806","https://openalex.org/W2788208686","https://openalex.org/W2797301174","https://openalex.org/W2888298425","https://openalex.org/W2944589699","https://openalex.org/W2982795271","https://openalex.org/W2994208520","https://openalex.org/W3036320843","https://openalex.org/W3037884130","https://openalex.org/W3044423036","https://openalex.org/W3045946240","https://openalex.org/W3105137750","https://openalex.org/W3155097581","https://openalex.org/W3159719186","https://openalex.org/W3164336527","https://openalex.org/W3217266879","https://openalex.org/W4284975686","https://openalex.org/W4321489398","https://openalex.org/W4361301317","https://openalex.org/W4385263749"],"related_works":["https://openalex.org/W4388588516","https://openalex.org/W4387206579","https://openalex.org/W4409654032","https://openalex.org/W4385263749","https://openalex.org/W4394599165","https://openalex.org/W3037884130","https://openalex.org/W4414003088","https://openalex.org/W4404237698","https://openalex.org/W3211307894","https://openalex.org/W4284975686"],"abstract_inverted_index":{"ABSTRACT":[0],"Introduction":[1],"Proton":[2],"craniospinal":[3],"irradiation":[4],"(pCSI)":[5],"is":[6,155,170],"a":[7,163],"treatment":[8,18,48],"option":[9],"for":[10,137,157],"leptomeningeal":[11],"disease":[12],"(LMD),":[13],"which":[14],"permits":[15],"whole":[16],"neuroaxis":[17],"while":[19],"minimizing":[20],"toxicity.":[21],"Despite":[22],"this,":[23],"patients":[24,63,158],"inevitably":[25],"experience":[26],"progression.":[27,109],"Adding":[28,150],"systemic":[29],"therapy":[30,134],"to":[31,75,116,153],"pCSI":[32,50,86,124,154,173],"may":[33,176],"improve":[34],"outcomes.":[35],"Methods":[36],"In":[37],"this":[38],"single-institution":[39],"retrospective":[40],"case":[41],"series,":[42],"we":[43],"present":[44],"the":[45,90,140],"feasibility":[46],"of":[47,92],"with":[49,64,87,125,159,174],"(30Gy,":[51],"10":[52],"fractions)":[53],"and":[54,82,94,128,161],"an":[55,151],"immune":[56],"checkpoint":[57],"inhibitor":[58],"(ICI)":[59],"in":[60],"two":[61],"sequential":[62],"LMD":[65,73,103,114,147,160],"from":[66],"melanoma.":[67],"Results":[68],"The":[69,110],"first":[70],"patient":[71,112,141],"developed":[72,113],"related":[74,115],"BRAF":[76],"V600E-mutant":[77],"melanoma":[78,118],"after":[79,102,119,146,181],"prior":[80,182],"ICI":[81,138,152,175],"BRAF-targeted":[83,95],"therapy.":[84],"After":[85],"concurrent":[88,126],"nivolumab,":[89,129],"addition":[91],"relatlimab,":[93],"therapy,":[96],"he":[97],"remained":[98,142],"alive":[99],"7":[100],"months":[101,145],"diagnosis":[104],"despite":[105],"central":[106],"nervous":[107],"system":[108],"second":[111],"BRAF-wildtype":[117],"up-front":[120],"ICI.":[121,183],"He":[122],"received":[123],"ipilimumab":[127],"then":[130],"nivolumab":[131],"maintenance.":[132],"Though":[133],"was":[135],"held":[136],"hepatitis,":[139],"progression-free":[143],"5":[144],"diagnosis.":[148],"Conclusion":[149],"feasible":[156],"demonstrates":[162],"tolerable":[164],"toxicity":[165],"profile.":[166],"While":[167],"prospective":[168],"evaluation":[169],"ultimately":[171],"warranted,":[172],"confer":[177],"survival":[178],"benefits,":[179],"even":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-16T00:00:00"}