{"id":"https://openalex.org/W4387643241","doi":"https://doi.org/10.1016/j.jds.2023.10.005","title":"Combining microfluidic chip and low-attachment culture devices to isolate oral cancer stem cells","display_name":"Combining microfluidic chip and low-attachment culture devices to isolate oral cancer stem cells","publication_year":2023,"publication_date":"2023-10-14","ids":{"openalex":"https://openalex.org/W4387643241","doi":"https://doi.org/10.1016/j.jds.2023.10.005","pmid":"https://pubmed.ncbi.nlm.nih.gov/38303836","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10829749"},"language":"en","primary_location":{"id":"doi:10.1016/j.jds.2023.10.005","doi":"https://doi.org/10.1016/j.jds.2023.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jds.2023.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S173463841","display_name":"Journal of Dental Sciences","issn_l":"1991-7902","issn":["1991-7902","2213-8862"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jds.2023.10.005","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044822620","display_name":"Hsin-Hu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Hu Chen","raw_affiliation_strings":["School of Dentistry, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035120034","display_name":"Thanh-Hien Vu Nguyen","orcid":"https://orcid.org/0009-0002-7280-0616","observed_orcids":["https://orcid.org/0009-0002-7280-0616"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Thanh-Hien Vu Nguyen","raw_affiliation_strings":["School of Dentistry, China Medical University, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0009-0002-7280-0616","affiliations":[{"raw_affiliation_string":"School of Dentistry, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070134456","display_name":"Yin-Hwa Shih","orcid":"https://orcid.org/0000-0003-0893-4185","observed_orcids":["https://orcid.org/0000-0003-0893-4185"]},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yin-Hwa Shih","raw_affiliation_strings":["Department of Healthcare Administration, Asia University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Healthcare Administration, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041959823","display_name":"Kai\u2010Chi Chang","orcid":"https://orcid.org/0000-0002-0257-2833","observed_orcids":["https://orcid.org/0000-0002-0257-2833"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Chi Chang","raw_affiliation_strings":["School of Dentistry, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050473054","display_name":"Kuo\u2010Chou Chiu","orcid":"https://orcid.org/0000-0001-9633-3974","observed_orcids":["https://orcid.org/0000-0001-9633-3974"]},"institutions":[{"id":"https://openalex.org/I4210158931","display_name":"Taichung Armed Forces General Hospital","ror":"https://ror.org/04nx04y60","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158931"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Chou Chiu","raw_affiliation_strings":["Division of General Dentistry, Taichung Armed Forces General Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Dentistry, Taichung Armed Forces General Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210158931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075181713","display_name":"Shih\u2010Min Hsia","orcid":"https://orcid.org/0000-0003-2888-2618","observed_orcids":["https://orcid.org/0000-0003-2888-2618"]},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Min Hsia","raw_affiliation_strings":["Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan","School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802331550"]},{"raw_affiliation_string":"School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012735559","display_name":"Lih\u2010Jyh Fuh","orcid":"https://orcid.org/0000-0003-3008-8165","observed_orcids":["https://orcid.org/0000-0003-3008-8165"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Lih-Jyh Fuh","raw_affiliation_strings":["Department of Dentistry, China Medical University Hospital, Taichung, Taiwan","School of Dentistry, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dentistry, China Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210126829"]},{"raw_affiliation_string":"School of Dentistry, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060746010","display_name":"Tzong\u2010Ming Shieh","orcid":"https://orcid.org/0000-0003-1759-9120","observed_orcids":["https://orcid.org/0000-0003-1759-9120","https://orcid.org/0000-0001-5197-644X"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tzong-Ming Shieh","raw_affiliation_strings":["School of Dentistry, China Medical University, Taichung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-1759-9120","affiliations":[{"raw_affiliation_string":"School of Dentistry, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012735559","https://openalex.org/A5060746010"],"corresponding_institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210126829"],"apc_list":{"value":1200,"currency":"USD","value_usd":1200},"apc_paid":{"value":1200,"currency":"USD","value_usd":1200},"fwci":0.6016,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63531483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"560","last_page":"567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.75},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":1.0},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-isolation","display_name":"cell isolation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/sphere-formation","display_name":"sphere formation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/aldh1a1","display_name":"ALDH1A1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":1.0},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":1.0},{"id":"https://openalex.org/keywords/stem-like-phenotype","display_name":"stem cell-like phenotype","score":0.8510000109672546},{"id":"https://openalex.org/keywords/sas-cell-line","display_name":"SAS cell line","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.8935853242874146},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7110005617141724},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5692650675773621},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.5673221945762634},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5567580461502075},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5458455681800842},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5409587025642395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4642959535121918},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4608243703842163},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.4550701975822449},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4521307647228241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38207322359085083},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2707379460334778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2605277895927429},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1759289801120758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09043601155281067}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jds.2023.10.005","doi":"https://doi.org/10.1016/j.jds.2023.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jds.2023.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S173463841","display_name":"Journal of Dental Sciences","issn_l":"1991-7902","issn":["1991-7902","2213-8862"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10829749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10829749","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10829749/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Dent Sci","raw_type":"Text"},{"id":"pmid:38303836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38303836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of dental sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jds.2023.10.005","doi":"https://doi.org/10.1016/j.jds.2023.10.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jds.2023.10.005","pdf_url":null,"source":{"id":"https://openalex.org/S173463841","display_name":"Journal of Dental Sciences","issn_l":"1991-7902","issn":["1991-7902","2213-8862"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6297676029","display_name":null,"funder_award_id":"CMU111-S-36","funder_id":"https://openalex.org/F4320324301","funder_display_name":"China Medical University"},{"id":"https://openalex.org/G8447334547","display_name":"Study on the Application of Electroacupuncture and Hinokitiol in the Treatment of Xerostomia and Oral Mucositis Induced by Chemoradiotherapy","funder_award_id":"MOST111-2314-B039-027-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G8483981990","display_name":null,"funder_award_id":"CMU112-MF-41","funder_id":"https://openalex.org/F4320324301","funder_display_name":"China Medical University"}],"funders":[{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"},{"id":"https://openalex.org/F4320337244","display_name":"Office of Research and Development, Taipei Medical University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387643241.pdf","grobid_xml":"https://content.openalex.org/works/W4387643241.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1703367660","https://openalex.org/W1861961197","https://openalex.org/W2001258296","https://openalex.org/W2007062957","https://openalex.org/W2014691022","https://openalex.org/W2060551076","https://openalex.org/W2065934262","https://openalex.org/W2070160283","https://openalex.org/W2101336111","https://openalex.org/W2111276564","https://openalex.org/W2151592927","https://openalex.org/W2172727158","https://openalex.org/W2405339666","https://openalex.org/W2486182939","https://openalex.org/W2591862276","https://openalex.org/W2607045925","https://openalex.org/W2783756649","https://openalex.org/W2889629830","https://openalex.org/W2889646458","https://openalex.org/W2895926103","https://openalex.org/W2985794029","https://openalex.org/W3136370467","https://openalex.org/W3160409340","https://openalex.org/W3202871496","https://openalex.org/W4214908473","https://openalex.org/W4283360415","https://openalex.org/W4285585604","https://openalex.org/W4285820952","https://openalex.org/W4287510527","https://openalex.org/W4299287609","https://openalex.org/W4321374031","https://openalex.org/W4321786059","https://openalex.org/W4379794345","https://openalex.org/W6639222132","https://openalex.org/W6795209330"],"related_works":["https://openalex.org/W3044699223","https://openalex.org/W2809299733","https://openalex.org/W2950870703","https://openalex.org/W2939736930","https://openalex.org/W3007159321","https://openalex.org/W4415996396","https://openalex.org/W4415616649","https://openalex.org/W4398135823","https://openalex.org/W2024065857","https://openalex.org/W3032525608"],"abstract_inverted_index":{"Background/purpose:":[0],"Cancer":[1],"stem":[2],"cells":[3,43,105],"(CSCs)":[4],"are":[5],"widely":[6],"recognized":[7],"as":[8,224,226],"key":[9],"drivers":[10],"of":[11,35,66,122,148,165,192,216],"cancer":[12,46,91,200,222],"initiation,":[13],"progression,":[14,223],"and":[15,28,63,75,83,88,125,151,170,218],"therapeutic":[16],"resistance.":[17],"Microfluidic":[18],"chip":[19],"technology":[20],"offers":[21,209],"a":[22,36,99,182,210],"promising":[23],"approach":[24,196],"for":[25,40,213,230],"CSC":[26,67,166],"isolation":[27,97,141],"study.":[29],"This":[30,187,207],"study":[31,56,188],"investigated":[32],"the":[33,55,60,64,118,128,145,162,175,190,193],"efficacy":[34],"microfluidic":[37,100,139,176,194],"chip-based":[38,195],"method":[39,142,208],"isolating":[41,198],"single":[42,104],"from":[44,81],"oral":[45,199,231],"cell":[47,79,85,92,130,153,159,179,201],"lines":[48,93],"characterized":[49],"by":[50],"high":[51],"stem-like":[52,184,205],"phenotypes.":[53],"Specifically,":[54],"focused":[57],"on":[58],"examining":[59],"sphere-forming":[61,111,146],"capability":[62,147],"expression":[65,120,163],"markers,":[68],"including":[69],"aldehyde":[70],"dehydrogenase":[71],"1A1":[72],"(ALDH1A1),":[73],"CD44,":[74,124,169],"CD133,":[76],"in":[77,113,127,174,197,221],"isolated":[78,129,178],"clones":[80,131,154,202],"OECM-1":[82,150],"SAS":[84,152],"lines.":[86,160],"Materials":[87],"methods:":[89],"Oral":[90],"were":[94,106,132,172],"subjected":[95],"to":[96,108,156],"using":[98,134],"chip.":[101],"The":[102,138],"captured":[103],"cultured":[107],"assess":[109],"their":[110,157,219],"capacity":[112],"ultra-low":[114],"binding":[115],"culture.":[116],"Furthermore,":[117],"protein":[119],"levels":[121,164],"ALDH1A1,":[123,168],"CD133":[126,171],"analyzed":[133],"western":[135],"blotting.":[136],"Results:":[137],"chip-assisted":[140,177],"significantly":[143],"enhanced":[144],"both":[149],"compared":[155],"parent":[158],"Moreover,":[161],"markers":[167],"upregulated":[173],"clones,":[180],"indicating":[181],"higher":[183],"phenotype.":[185],"Conclusion:":[186],"demonstrates":[189],"effectiveness":[191],"with":[203],"elevated":[204],"characteristics.":[206],"valuable":[211],"tool":[212],"further":[214],"investigation":[215],"CSCs":[217],"role":[220],"well":[225],"future":[227],"therapy":[228],"development":[229],"cancers.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-15T00:00:00"}