{"id":"https://openalex.org/W4387633112","doi":"https://doi.org/10.1161/res.133.suppl_1.p1132","title":"Abstract P1132: Mettl3 Induced Fibronectin M6a Mrna Methylation Facilitates Cardiac Fibrosis Following Myocardial Ischemia","display_name":"Abstract P1132: Mettl3 Induced Fibronectin M6a Mrna Methylation Facilitates Cardiac Fibrosis Following Myocardial Ischemia","publication_year":2023,"publication_date":"2023-08-04","ids":{"openalex":"https://openalex.org/W4387633112","doi":"https://doi.org/10.1161/res.133.suppl_1.p1132"},"language":"en","primary_location":{"id":"doi:10.1161/res.133.suppl_1.p1132","doi":"https://doi.org/10.1161/res.133.suppl_1.p1132","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/res.133.suppl_1.p1132","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058679717","display_name":"Roshan Kumar Dutta","orcid":"https://orcid.org/0000-0001-8146-1041","observed_orcids":["https://orcid.org/0000-0001-8146-1041"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roshan K Dutta","raw_affiliation_strings":["UAB, Birmingham, AL","Roshan K Dutta UAB, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UAB, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Roshan K Dutta UAB, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032227273","display_name":"Prabhat Ranjan","orcid":"https://orcid.org/0000-0003-0576-8599","observed_orcids":["https://orcid.org/0000-0003-0576-8599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prabhat Ranjan","raw_affiliation_strings":["Prabhat Ranjan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prabhat Ranjan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066085163","display_name":"Karen Colin","orcid":"https://orcid.org/0000-0002-6157-3473","observed_orcids":["https://orcid.org/0000-0002-6157-3473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Colin","raw_affiliation_strings":["Karen Colin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karen Colin","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vasundhara Pathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasundhara Pathak","raw_affiliation_strings":["UAB, Birmingham, AL","Vasundhara Pathak UAB, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UAB, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Vasundhara Pathak UAB, Birmingham, AL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059427088","display_name":"Qinkun Zhang","orcid":"https://orcid.org/0000-0002-0876-609X","observed_orcids":["https://orcid.org/0000-0002-0876-609X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"qinkun zhang","raw_affiliation_strings":["Univ of Alabama at Birmingham, Birmingham, AL","qinkun zhang Univ of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"qinkun zhang Univ of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004233469","display_name":"Hind Lal","orcid":"https://orcid.org/0000-0001-8980-9874","observed_orcids":["https://orcid.org/0000-0001-8980-9874"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hind Lal","raw_affiliation_strings":["UAB, Birmiham, AL","Hind Lal UAB, Birmiham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UAB, Birmiham, AL","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Hind Lal UAB, Birmiham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057917635","display_name":"Suresh Kumar Verma","orcid":"https://orcid.org/0000-0002-0739-1302","observed_orcids":["https://orcid.org/0000-0002-0739-1302"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh K Verma","raw_affiliation_strings":["UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL","Suresh K Verma UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Suresh K Verma UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mettl3","display_name":"METTL3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mrna-methylation","display_name":"mRNA methylation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stm2457","display_name":"STM2457","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.9279999732971191},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.5460000038146973},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.695929229259491},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6477768421173096},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.5979153513908386},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5911886096000671},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5507987141609192},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5164754390716553},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.4497157037258148},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.44961848855018616},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4243262708187103},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.42108750343322754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4163975119590759},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.374672532081604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35900062322616577},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34356796741485596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3059605360031128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23803818225860596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22323104739189148},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16018739342689514},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13997569680213928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07040593028068542},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.06616589426994324}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.133.suppl_1.p1132","doi":"https://doi.org/10.1161/res.133.suppl_1.p1132","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/res.133.suppl_1.p1132","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220934152","https://openalex.org/W4414936699","https://openalex.org/W4414032092","https://openalex.org/W4395466899","https://openalex.org/W4403246928","https://openalex.org/W4319461909","https://openalex.org/W3097534263","https://openalex.org/W4386252208","https://openalex.org/W4322504014","https://openalex.org/W4382047255"],"abstract_inverted_index":{"Objective:":[0],"Cardiac":[1],"fibrosis":[2,62,207,276],"is":[3,19,30,66],"one":[4],"of":[5,46,56,133,157,230,280],"the":[6,43,47,54,79,84,130,134,155,233],"most":[7],"warranted":[8],"cardiac":[9,61,110,140,248,263,275,316],"impairments":[10],"which":[11,222,296],"ultimately":[12,261],"leads":[13,223],"to":[14,128,153,180,224,313],"heart":[15],"failure.":[16],"N6-methyladenosine":[17],"(m6A)":[18,272],"an":[20,143,149],"abundant":[21],"and":[22,29,69,89,114,164,192,202,208,228,257,260,287,294],"conserved":[23],"chemical":[24],"modification":[25],"in":[26,60,72,87,97,102,125,138,212,217,285,308],"eukaryotic":[27],"mRNA":[28,33,40,58,161,199,210,220,226,255,271,281],"associated":[31],"with":[32,310],"metabolism.":[34],"Recently,":[35],"we":[36,77,93,108],"showed":[37,205],"that":[38,268],"m6A":[39,57,209],"methylation":[41,59,95,101,158,195,211,256,273,282],"regulates":[42],"angiogenic":[44],"potential":[45,302],"endothelial":[48],"cells":[49],"following":[50,63,277],"ischemic":[51,64,144],"injury.":[52],"However,":[53],"role":[55,156],"injury":[65],"still":[67],"elusive":[68],"needs":[70],"improvement":[71],"treatment":[73],"strategy.":[74],"Methods:":[75],"First":[76],"analyzed":[78],"available":[80],"data":[81],"set":[82],"for":[83,118],"fibrosis-regulating":[85],"targets":[86],"Sham":[88],"MI":[90,103],"hearts.":[91],"Further,":[92],"studied":[94,169],"patterns":[96],"vivo":[98],"by":[99,236],"inhibiting":[100],"mice":[104,213],"using":[105,112,170,243,283],"STM2457.":[106],"Then":[107],"assessed":[109],"function":[111],"echocardiography":[113],"harvested":[115],"tissue":[116],"samples":[117],"further":[119],"biochemical":[120,203],"analysis.":[121],"We":[122,146,185,266],"also":[123,147,193],"performed":[124,148],"vitro":[126],"experiment":[127],"investigate":[129],"expression":[131,190],"pattern":[132],"screened":[135],"gene":[136],"(Fibronectin)":[137],"hypoxic":[139],"fibroblast":[141,218],"as":[142],"model.":[145],"Actinomycin":[150],"D":[151],"assay":[152],"check":[154],"on":[159,197],"FN":[160,189,198,225,231,254,258,270,292],"stability.":[162],"Fibrosis":[163],"other":[165],"phenotypic":[166],"statuses":[167],"were":[168],"several":[171,194],"molecular":[172],"techniques":[173],"including":[174],"ICC/IHC.":[175],"Finally,":[176],"siMETTL3":[177],"was":[178],"used":[179],"study":[181],"rescue":[182],"experiments.":[183],"Results:":[184],"have":[186],"shown":[187],"upregulated":[188],"post-MI,":[191],"sites":[196],"in-silico.":[200],"Histological":[201],"analysis":[204],"increased":[206,269],"post-MI.":[214],"Hypoxic":[215],"stress":[216],"induces":[219],"methylation,":[221],"stabilization":[227],"deposition":[229,293],"at":[232],"scar":[234],"site":[235],"activated":[237],"fibroblast.":[238],"In":[239],"contrast,":[240],"METTL3":[241,250],"inhibition":[242,251],"STM":[244],"2457":[245],"significantly":[246,252],"improved":[247],"function.":[249],"reduced":[253,262,290],"expression,":[259],"fibrosis.":[264,317],"Conclusion:":[265],"observed":[267],"enhanced":[274],"MI.":[278],"Inhibition":[279],"STM2457":[284,298],"in-vivo,":[286],"siRNA":[288],"in-vitro":[289],"hypoxia-induced":[291],"fibrosis,":[295],"suggests":[297],"could":[299],"be":[300],"a":[301],"therapeutic":[303],"molecule":[304],"either":[305],"alone":[306],"or":[307],"combination":[309],"current":[311],"regimens":[312],"curb":[314],"methylation-induced":[315]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-10-14T00:00:00"}
