{"id":"https://openalex.org/W4387620910","doi":"https://doi.org/10.1161/res.133.suppl_1.p3090","title":"Abstract P3090: The Role Of Circular Cdr1as In Macrophage Cardiac Inflammation And Fibrosis","display_name":"Abstract P3090: The Role Of Circular Cdr1as In Macrophage Cardiac Inflammation And Fibrosis","publication_year":2023,"publication_date":"2023-08-04","ids":{"openalex":"https://openalex.org/W4387620910","doi":"https://doi.org/10.1161/res.133.suppl_1.p3090"},"language":"en","primary_location":{"id":"doi:10.1161/res.133.suppl_1.p3090","doi":"https://doi.org/10.1161/res.133.suppl_1.p3090","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/res.133.suppl_1.p3090","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Carolina Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolina Gonzalez","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Carolina Gonzalez Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Carolina Gonzalez Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059275940","display_name":"Maria Cimini","orcid":"https://orcid.org/0000-0001-5414-6257","observed_orcids":["https://orcid.org/0000-0001-5414-6257"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Cimini","raw_affiliation_strings":["Temple Univ,Lewis Katz Sch, Philadelphia, PA","Maria Cimini Temple Univ,Lewis Katz Sch, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ,Lewis Katz Sch, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Maria Cimini Temple Univ,Lewis Katz Sch, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060437129","display_name":"Cindy Benedict","orcid":"https://orcid.org/0000-0001-8380-161X","observed_orcids":["https://orcid.org/0000-0001-8380-161X"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Benedict","raw_affiliation_strings":["TEMPLE UNIVERSITY, Philadelphia, PA","Cindy Benedict TEMPLE UNIVERSITY, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEMPLE UNIVERSITY, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Cindy Benedict TEMPLE UNIVERSITY, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010003697","display_name":"Vandana Mallaredy","orcid":"https://orcid.org/0000-0002-1891-9758","observed_orcids":["https://orcid.org/0000-0002-1891-9758"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vandana Mallaredy","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","Vandana Mallaredy Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Vandana Mallaredy Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090449188","display_name":"May Trungcao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May Trungcao","raw_affiliation_strings":["Temple Univ, Philadelphia, PA","May Trungcao Temple Univ, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"May Trungcao Temple Univ, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047939416","display_name":"Sudarsan Rajan","orcid":"https://orcid.org/0000-0003-4096-0586","observed_orcids":["https://orcid.org/0000-0003-4096-0586"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudarsan Rajan","raw_affiliation_strings":["TEMPLE UNIVERISTY SCHOOL OF ME, Philadelphia, PA","Sudarsan Rajan TEMPLE UNIVERISTY SCHOOL OF ME, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEMPLE UNIVERISTY SCHOOL OF ME, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Sudarsan Rajan TEMPLE UNIVERISTY SCHOOL OF ME, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071738730","display_name":"Venkata Naga Srikanth Garikipati","orcid":"https://orcid.org/0009-0006-7811-9302","observed_orcids":["https://orcid.org/0009-0006-7811-9302","https://orcid.org/0000-0001-5803-5335"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata N Garikipati","raw_affiliation_strings":["Ohio State Univ Wexner MC, Columbus, OH","Venkata N Garikipati Ohio State Univ Wexner MC, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State Univ Wexner MC, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]},{"raw_affiliation_string":"Venkata N Garikipati Ohio State Univ Wexner MC, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024396516","display_name":"Raj Kishore","orcid":"https://orcid.org/0000-0002-8168-3004","observed_orcids":["https://orcid.org/0000-0002-8168-3004"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Kishore","raw_affiliation_strings":["TEMPLE UNIVERSITY SCHOOL OF MED, Philadelphia, PA","Raj Kishore TEMPLE UNIVERSITY SCHOOL OF MED, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TEMPLE UNIVERSITY SCHOOL OF MED, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Raj Kishore TEMPLE UNIVERSITY SCHOOL OF MED, Philadelphia, PA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.9829999804496765},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.9319999814033508},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8790000081062317},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cardiac-inflammation","display_name":"cardiac inflammation","score":0.890999972820282},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5609999895095825},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.5490000247955322},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6231831312179565},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.6120107769966125},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5915160775184631},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5820807218551636},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.5710014700889587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5488111972808838},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5100072622299194},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4891093373298645},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.48590222001075745},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.46477749943733215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4214504361152649},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37640151381492615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3682616949081421},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3465162515640259},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3461684584617615},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31154876947402954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28080835938453674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17710146307945251},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11251932382583618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.133.suppl_1.p3090","doi":"https://doi.org/10.1161/res.133.suppl_1.p3090","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/res.133.suppl_1.p3090","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407868890","https://openalex.org/W4414249091","https://openalex.org/W4313397345","https://openalex.org/W7033817379","https://openalex.org/W4398166515","https://openalex.org/W4297984387","https://openalex.org/W7128637591","https://openalex.org/W7213305219","https://openalex.org/W7168375341","https://openalex.org/W3180195743"],"abstract_inverted_index":{"In":[0],"response":[1],"to":[2,11,25,82,106,121,285],"cardiac":[3,78,315],"injury,":[4],"macrophages":[5,118,204,219,228],"are":[6,44,63,229],"recruited":[7],"in":[8,21,27,55,72,89,133,151,202,207,216,235,254,262,278],"high":[9],"numbers":[10],"the":[12,22,28,33,39,56,68,84,266,310],"infarcted":[13],"myocardium":[14],"and":[15,36,75,93,137,157,173,187,193,205,218,240,244,290],"undergo":[16],"phenotypic":[17],"switching":[18,92],"from":[19,50,114],"pro-inflammatory":[20,227],"early":[23],"stage":[24],"anti-inflammatory":[26,283],"later":[29],"stage.":[30],"Thereby,":[31],"controlling":[32],"initiation,":[34],"maintenance,":[35],"resolution":[37,311],"of":[38,58,70,87,170,214,232,294,312],"inflammatory":[40],"response.":[41],"Circular":[42],"RNAs":[43],"newly":[45],"discovered":[46],"non-coding":[47],"RNA":[48,103,112],"generated":[49,143,161],"protein-coding":[51],"genes":[52],"that":[53,273],"implicated":[54],"regulation":[57],"immune":[59],"cells.":[60],"However,":[61],"there":[62,258],"currently":[64],"no":[65],"reports":[66],"on":[67],"role":[69,86,277],"circRNAs":[71],"macrophage":[73,90,279],"biology":[74,280],"function":[76,97,180,299],"during":[77,225],"ischemia.":[79],"We":[80,100,127,142,160],"aim":[81],"determine":[83],"specific":[85,139],"circ-CDR1as":[88,95,162],"class":[91],"how":[94],"modulates":[96],"post-cardiac":[98],"injury.":[99,316],"performed":[101],"circular":[102],"microarray":[104],"analyses":[105],"assess":[107],"circRNA":[108,129],"transcriptome":[109],"changes":[110,150],"using":[111],"isolated":[113],"bone":[115],"marrow":[116],"derived":[117],"(BMDM)":[119],"polarized":[120],"a":[122,212,276,307],"M1":[123,203],"or":[124],"M2":[125,208,288],"phenotype.":[126],"validated":[128],"expression":[130],"by":[131,155,175,183,191,195,281],"RT-qPCR":[132,158],"3D":[134],"post-MI":[135],"hearts":[136],"within":[138],"cell":[140],"types.":[141],"circCdr1as":[144],"overexpression":[145,163],"plasmid":[146,167],"transfected":[147],"into":[148],"BMDM,":[149],"phenotype":[152,186,289],"were":[153],"determined":[154,182,190],"FACS":[156],"analysis.":[159],"associated":[164],"adenoviral":[165],"vector":[166],"under":[168],"control":[169],"CMV":[171],"promoter":[172],"administered":[174],"tail":[176],"vein":[177],"injection.":[178],"LV":[179,298],"was":[181,189],"echocardiography.":[184],"Macrophage":[185],"CD31":[188],"immunohistochemistry":[192],"fibrosis":[194],"masson":[196],"trichrome":[197,249],"staining.":[198],"Circ-CDR1as":[199],"is":[200,211,259],"downregulated":[201],"upregulated":[206],"macrophages.":[209],"There":[210],"downregulation":[213],"cdr1as":[215],"cardiomyocytes":[217],"(F4/80+)":[220],"3":[221],"days":[222,246],"post":[223],"MI,":[224],"which":[226],"dominant.":[230],"Administration":[231],"AAV9":[233],"circCDR1as":[234,295],"vivo":[236],"significantly":[237],"improved":[238],"%EF":[239],"%FS":[241],"at":[242,265],"21":[243],"28D":[245],"post-MI.":[247],"Masson":[248],"staining":[250],"showed":[251],"significant":[252],"decrease":[253],"fibrotic":[255],"area.":[256,269],"Additionally,":[257],"an":[260,287],"increase":[261],"CD206+":[263],"cells":[264],"border":[267],"zone/infarcted":[268],"This":[270],"study":[271],"suggests":[272],"circ-Cdr1as":[274,303],"plays":[275],"upregulating":[282],"markers":[284],"promote":[286],"exogenous":[291],"gene":[292],"delivery":[293],"may":[296,304],"improve":[297],"over":[300],"time.":[301],"Therefore,":[302],"potentially":[305],"be":[306],"therapeutic":[308],"for":[309],"inflammation":[313],"after":[314]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-10-14T00:00:00"}