{"id":"https://openalex.org/W4387618583","doi":"https://doi.org/10.1002/jex2.118","title":"Crosstalk between tumour and stroma modifies CLIC4 cargo in extracellular vesicles","display_name":"Crosstalk between tumour and stroma modifies CLIC4 cargo in extracellular vesicles","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387618583","doi":"https://doi.org/10.1002/jex2.118","pmid":"https://pubmed.ncbi.nlm.nih.gov/38264628","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10803055"},"language":"en","primary_location":{"id":"doi:10.1002/jex2.118","doi":"https://doi.org/10.1002/jex2.118","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jex2.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jex2.118","source":{"id":"https://openalex.org/S4210205960","display_name":"Journal of Extracellular Biology","issn_l":"2768-2811","issn":["2768-2811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Extracellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jex2.118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039864098","display_name":"Vanesa C. Sanchez","orcid":"https://orcid.org/0000-0002-8580-3480","observed_orcids":["https://orcid.org/0000-0002-8580-3480"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanesa C. Sanchez","raw_affiliation_strings":["Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080963931","display_name":"Alayna B. Craig-Lucas","orcid":"https://orcid.org/0000-0002-0936-6231","observed_orcids":["https://orcid.org/0000-0002-0936-6231"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210094360","display_name":"Lehigh Valley Health Network","ror":"https://ror.org/00sf92s91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094360"]},{"id":"https://openalex.org/I4210133885","display_name":"Lehigh Valley Hospital","ror":"https://ror.org/03h4fx826","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094360","https://openalex.org/I4210133885"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alayna Craig\u2010Lucas","raw_affiliation_strings":["Department of Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA","Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Lehigh Valley Health Network, Allentown, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210094360","https://openalex.org/I4210133885"]},{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060478731","display_name":"Christophe Cataisson","orcid":"https://orcid.org/0000-0003-2600-1573","observed_orcids":["https://orcid.org/0000-0003-2600-1573"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe Cataisson","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066080402","display_name":"Brandi L. Carofino","orcid":"https://orcid.org/0000-0003-0717-6917","observed_orcids":["https://orcid.org/0000-0003-0717-6917"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi L. Carofino","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart H. Yuspa","raw_affiliation_strings":["Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0003-4785-337X","affiliations":[{"raw_affiliation_string":"Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045531616"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":{"value":3100,"currency":"USD","value_usd":3100},"fwci":0.2662,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44513089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clic4","display_name":"CLIC4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9470000267028809},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-stroma-interactions","display_name":"tumor-stroma interactions","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6520000100135803},{"id":"https://openalex.org/keywords/circulating-vesicles","display_name":"circulating vesicles","score":0.5529999732971191},{"id":"https://openalex.org/keywords/plasma-derived-vesicles","display_name":"plasma-derived vesicles","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5371931195259094},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5249533653259277},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.489510178565979},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.4721543788909912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4373050332069397},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4179002642631531},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3396049737930298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31449469923973083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2962496876716614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10387647151947021},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.076682448387146},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.06199517846107483},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.05859676003456116},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/jex2.118","doi":"https://doi.org/10.1002/jex2.118","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jex2.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jex2.118","source":{"id":"https://openalex.org/S4210205960","display_name":"Journal of Extracellular Biology","issn_l":"2768-2811","issn":["2768-2811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Extracellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10803055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10803055","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10803055/pdf/JEX2-2-e118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Extracell Biol","raw_type":"Text"},{"id":"pmid:38264628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38264628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of extracellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ff75b39973fb4ceda5f966035cbeeddc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff75b39973fb4ceda5f966035cbeeddc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Extracellular Biology, Vol 2, Iss 10, Pp n/a-n/a (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/jex2.118","doi":"https://doi.org/10.1002/jex2.118","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jex2.118","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jex2.118","source":{"id":"https://openalex.org/S4210205960","display_name":"Journal of Extracellular Biology","issn_l":"2768-2811","issn":["2768-2811"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Extracellular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2226336016","display_name":"Pathways that Suppress or Accelerate Premalignant Progression of Squamous      Cancer","funder_award_id":"ZIABC005445","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6713892807","display_name":"Pathways that Suppress or Accelerate Premalignant Progression of Squamous Cancer","funder_award_id":"Z01BC005445","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387618583.pdf","grobid_xml":"https://content.openalex.org/works/W4387618583.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1877686344","https://openalex.org/W1950118853","https://openalex.org/W1964616722","https://openalex.org/W1968440214","https://openalex.org/W1973441562","https://openalex.org/W1985596675","https://openalex.org/W1987312485","https://openalex.org/W1991918456","https://openalex.org/W1993523174","https://openalex.org/W2003409252","https://openalex.org/W2020048154","https://openalex.org/W2025436502","https://openalex.org/W2029289451","https://openalex.org/W2057441939","https://openalex.org/W2061377366","https://openalex.org/W2064837843","https://openalex.org/W2087555663","https://openalex.org/W2104669682","https://openalex.org/W2112151002","https://openalex.org/W2132738790","https://openalex.org/W2172030715","https://openalex.org/W2181940340","https://openalex.org/W2550362349","https://openalex.org/W2567639438","https://openalex.org/W2588209192","https://openalex.org/W2588530307","https://openalex.org/W2603630537","https://openalex.org/W2606793345","https://openalex.org/W2657602602","https://openalex.org/W2755019485","https://openalex.org/W2761458899","https://openalex.org/W2795923478","https://openalex.org/W2893973924","https://openalex.org/W2900756811","https://openalex.org/W2998022240","https://openalex.org/W3105404443","https://openalex.org/W3211633208","https://openalex.org/W4200449605","https://openalex.org/W4225289862","https://openalex.org/W4283275244","https://openalex.org/W4285807805","https://openalex.org/W4387618583"],"related_works":["https://openalex.org/W2741355619","https://openalex.org/W4283275244","https://openalex.org/W7147566142","https://openalex.org/W4287838091","https://openalex.org/W4211044993","https://openalex.org/W4386778408","https://openalex.org/W4379054263","https://openalex.org/W4385161776","https://openalex.org/W4402369203","https://openalex.org/W4206573550"],"abstract_inverted_index":{"Mouse":[0],"models":[1],"of":[2,22,53,84,99,114],"breast":[3,39,58,148],"cancer":[4,40,59,149],"have":[5],"revealed":[6],"that":[7,44,78,88],"tumor-bearing":[8,55],"hosts":[9,66],"must":[10],"express":[11],"the":[12,20,29,79,82,85,112,130],"oxidoreductase":[13],"CLIC4":[14,46,90,100,108,115,139],"to":[15],"develop":[16],"lung":[17,30],"metastases.":[18],"In":[19],"absence":[21],"host":[23],"CLIC4,":[24,76],"primary":[25,103],"tumors":[26,63,104,125],"grow":[27],"but":[28,72],"premetastatic":[31],"niche":[32],"is":[33,81,140],"defective":[34],"for":[35],"metastatic":[36],"seeding.":[37],"Primary":[38],"cells":[41,60],"release":[42,68],"EVs":[43,69,74,87,95,145],"incorporate":[45],"as":[47,91,120],"cargo":[48,122],"and":[49,67],"circulate":[50],"in":[51,64,70,107,143],"plasma":[52],"wildtype":[54,65],"hosts.":[56,110],"CLIC4-deficient":[57],"also":[61,97,141],"form":[62],"plasma,":[71],"these":[73],"lack":[75],"suggesting":[77],"tumor":[80],"source":[83],"plasma-derived":[86],"carry":[89],"cargo.":[92],"Paradoxically,":[93],"circulating":[94,144],"are":[96,105],"devoid":[98],"when":[101],"CLIC4-expressing":[102],"grown":[106],"knockout":[109],"Thus,":[111],"incorporation":[113],"(and":[116],"perhaps":[117],"other":[118],"factors)":[119],"EV":[121],"released":[123],"from":[124,129,146],"involves":[126],"specific":[127],"signals":[128],"surrounding":[131],"stroma":[132],"determined":[133],"by":[134],"its":[135,155],"genetic":[136],"composition.":[137],"Since":[138],"detected":[142],"human":[147],"patients,":[150],"future":[151],"studies":[152],"will":[153],"address":[154],"association":[156],"with":[157],"disease.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-14T00:00:00"}
