{"id":"https://openalex.org/W4387616449","doi":"https://doi.org/10.3390/pharmaceutics15102459","title":"Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells","display_name":"Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells","publication_year":2023,"publication_date":"2023-10-13","ids":{"openalex":"https://openalex.org/W4387616449","doi":"https://doi.org/10.3390/pharmaceutics15102459","pmid":"https://pubmed.ncbi.nlm.nih.gov/37896219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10610421"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics15102459","doi":"https://doi.org/10.3390/pharmaceutics15102459","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15102459","pdf_url":"https://www.mdpi.com/1999-4923/15/10/2459/pdf?version=1697189030","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/15/10/2459/pdf?version=1697189030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052407744","display_name":"Andoni G\u00f3mez-Moreno","orcid":"https://orcid.org/0000-0003-3417-9099","observed_orcids":["https://orcid.org/0000-0003-3417-9099"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Andoni G\u00f3mez-Moreno","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3417-9099","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113920562","display_name":"Enara San Sebastian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enara San Sebastian","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075779318","display_name":"Jennifer Moya","orcid":"https://orcid.org/0000-0003-4569-4678","observed_orcids":["https://orcid.org/0000-0003-4569-4678"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jennifer Moya","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038218653","display_name":"Pilar Gomoll\u00f3n-Zueco","orcid":"https://orcid.org/0000-0002-3699-7442","observed_orcids":["https://orcid.org/0000-0002-3699-7442"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Gomoll\u00f3n-Zueco","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3699-7442","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108870374","display_name":"Sergio Isola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Isola","raw_affiliation_strings":["DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069905573","display_name":"\u00c1frica Vales","orcid":"https://orcid.org/0009-0000-4507-8117","observed_orcids":["https://orcid.org/0009-0000-4507-8117"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1frica Vales","raw_affiliation_strings":["DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain"],"raw_orcid":"https://orcid.org/0009-0000-4507-8117","affiliations":[{"raw_affiliation_string":"DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011904150","display_name":"Gloria Gonz\u00e1lez\u2010Aseguinolaza","orcid":"https://orcid.org/0000-0002-1600-4562","observed_orcids":["https://orcid.org/0000-0002-1600-4562"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gloria Gonz\u00e1lez-Aseguinolaza","raw_affiliation_strings":["DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1600-4562","affiliations":[{"raw_affiliation_string":"DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068822180","display_name":"Carmen Unzu","orcid":"https://orcid.org/0000-0002-1582-7196","observed_orcids":["https://orcid.org/0000-0002-1582-7196"]},"institutions":[{"id":"https://openalex.org/I4392738196","display_name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada","ror":"https://ror.org/01qew8q20","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Unzu","raw_affiliation_strings":["DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNA & RNA Medicine Division, CIMA, Universidad de Navarra, Avda Pio XII, 55, 31008 Pamplona, Spain","institution_ids":["https://openalex.org/I4392738196","https://openalex.org/I88155538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011327938","display_name":"Urtzi Garaigorta","orcid":"https://orcid.org/0000-0002-0683-5725","observed_orcids":["https://orcid.org/0000-0002-0683-5725"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Urtzi Garaigorta","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0683-5725","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-Consejo Superior de Investigaciones Cient\u00edficas (CNB-CSIC), Calle Darwin 3, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011327938","https://openalex.org/A5052407744"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210104776"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.159,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46782496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"15","issue":"10","first_page":"2459","last_page":"2459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-inhibitors","display_name":"topoisomerase inhibitors","score":1.0},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lentiviral-vectors","display_name":"lentiviral vectors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/viral-transduction","display_name":"viral transduction","score":0.5569999814033508},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.7739136219024658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7537034153938293},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7086835503578186},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.6603655219078064},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5399693250656128},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4966734051704407},{"id":"https://openalex.org/C2778616834","wikidata":"https://www.wikidata.org/wiki/Q281044","display_name":"Topoisomerase inhibitor","level":4,"score":0.4517310857772827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4327232241630554},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.41964519023895264},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.41323041915893555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3473896384239197},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3387185335159302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25089043378829956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15121641755104065},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.14379951357841492}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics15102459","doi":"https://doi.org/10.3390/pharmaceutics15102459","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15102459","pdf_url":"https://www.mdpi.com/1999-4923/15/10/2459/pdf?version=1697189030","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10610421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10610421","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10610421/pdf/pharmaceutics-15-02459.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:37896219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37896219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/364064","doi":null,"is_oa":true,"landing_page_url":"https://api.elsevier.com/content/abstract/scopus_id/85175070061","pdf_url":"https://digital.csic.es/bitstream/10261/364064/1/Gomez_Moreno_et_al_Topoisomerase_Inhibitors_2023.pdf","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:5e663564f87f4a8693ce1e621bd230ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e663564f87f4a8693ce1e621bd230ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 15, Iss 10, p 2459 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics15102459","doi":"https://doi.org/10.3390/pharmaceutics15102459","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15102459","pdf_url":"https://www.mdpi.com/1999-4923/15/10/2459/pdf?version=1697189030","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4469383875","display_name":null,"funder_award_id":"CNS2022_135593","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G8864025811","display_name":null,"funder_award_id":"PID2020-118970RB-100","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320321764","display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","ror":"https://ror.org/03nc27g21"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387616449.pdf","grobid_xml":"https://content.openalex.org/works/W4387616449.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1517131856","https://openalex.org/W1525365796","https://openalex.org/W1702771419","https://openalex.org/W1804821915","https://openalex.org/W1964810194","https://openalex.org/W1977115071","https://openalex.org/W1980524600","https://openalex.org/W1981167981","https://openalex.org/W1991453997","https://openalex.org/W1992479002","https://openalex.org/W1994495694","https://openalex.org/W2014265802","https://openalex.org/W2020466762","https://openalex.org/W2026560201","https://openalex.org/W2028692066","https://openalex.org/W2044296969","https://openalex.org/W2050289194","https://openalex.org/W2050870581","https://openalex.org/W2051159468","https://openalex.org/W2053576250","https://openalex.org/W2058884419","https://openalex.org/W2060420367","https://openalex.org/W2060765814","https://openalex.org/W2067904759","https://openalex.org/W2069360361","https://openalex.org/W2077023423","https://openalex.org/W2090628264","https://openalex.org/W2102345056","https://openalex.org/W2108156511","https://openalex.org/W2120064876","https://openalex.org/W2120426460","https://openalex.org/W2125235624","https://openalex.org/W2128959103","https://openalex.org/W2134812217","https://openalex.org/W2139166113","https://openalex.org/W2154853638","https://openalex.org/W2157418548","https://openalex.org/W2163740636","https://openalex.org/W2167279371","https://openalex.org/W2345720602","https://openalex.org/W2475768353","https://openalex.org/W2593029352","https://openalex.org/W2766673110","https://openalex.org/W2774819103","https://openalex.org/W2952065249","https://openalex.org/W2979824718","https://openalex.org/W2982694103","https://openalex.org/W2996114603","https://openalex.org/W3128825549","https://openalex.org/W3158125987","https://openalex.org/W3159949344","https://openalex.org/W4221027577","https://openalex.org/W4281664094","https://openalex.org/W4316494570","https://openalex.org/W4318620434"],"related_works":["https://openalex.org/W2013935240","https://openalex.org/W4403904202","https://openalex.org/W7135310822","https://openalex.org/W1977115071","https://openalex.org/W7045205420","https://openalex.org/W2118663108","https://openalex.org/W4253582654","https://openalex.org/W4205254690","https://openalex.org/W2025079315","https://openalex.org/W2075862099"],"abstract_inverted_index":{"Gene":[0],"therapy":[1],"is":[2,81,153],"a":[3,68,108,131],"promising":[4],"strategy":[5],"to":[6,32,36,58,78,83,175],"treat":[7],"and":[8,25,75,86,102,179],"cure":[9],"most":[10],"inherited":[11],"metabolic":[12],"liver":[13],"disorders.":[14],"Viral":[15],"vectors":[16],"such":[17],"as":[18,30,56],"those":[19],"based":[20],"on":[21,134],"adeno-associated":[22],"viruses":[23],"(AAVs)":[24],"lentiviruses":[26],"(LVs)":[27],"are":[28],"used":[29],"vehicles":[31],"deliver":[33],"functional":[34],"genes":[35],"affected":[37],"hepatocytes.":[38],"Adverse":[39],"events":[40],"associated":[41],"with":[42,71,107,119,130,158],"the":[43,51,60,113,135,139,162,168,173,187],"use":[44,52],"of":[45,53,182],"high":[46],"vector":[47],"doses":[48],"have":[49],"motivated":[50],"small":[54],"molecules":[55],"adjuvants":[57],"reduce":[59],"dose.":[61],"In":[62,117],"this":[63],"study,":[64],"we":[65],"showed":[66],"that":[67,141,194],"one-hour":[69],"treatment":[70],"topoisomerase":[72,121,142],"inhibitors":[73,97,122,143],"(camptothecin":[74],"etoposide)":[76],"prior":[77],"viral":[79,124,150,183,196],"transduction":[80,115],"enough":[82],"increase":[84,111,160,195],"AAV":[85],"LV":[87],"reporter":[88],"expression":[89],"in":[90,94,112,127,161],"non-dividing":[91],"hepatic":[92],"cells":[93],"culture.":[95],"Topoisomerase":[96],"increased":[98,123,144],"both":[99,128],"integration-competent":[100],"(ICLV)":[101],"integration-deficient":[103],"(IDLV)":[104],"LV-derived":[105],"expression,":[106],"much":[109],"stronger":[110],"IDLV":[114,136],"system.":[116],"agreement":[118],"that,":[120],"genome":[125,189],"integration":[126,181],"strains,":[129],"greater":[132],"impact":[133],"strain,":[137],"supporting":[138],"idea":[140],"episomal":[145,184],"DNA":[146,163,177],"integration,":[147],"especially":[148],"when":[149,190],"integrase":[151],"activity":[152],"abolished.":[154],"These":[155],"effects":[156],"correlated":[157],"an":[159],"damage":[164,178],"response":[165],"produced":[166],"by":[167],"treatments.":[169],"Our":[170],"study":[171],"highlights":[172],"need":[174],"monitor":[176],"undesired":[180],"DNAs":[185],"into":[186],"host":[188],"studying":[191],"chemical":[192],"compounds":[193],"transduction.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-14T00:00:00"}