{"id":"https://openalex.org/W4387614644","doi":"https://doi.org/10.3390/pathogens12101242","title":"Novel Baicalein-Derived Inhibitors of Plasmodium falciparum","display_name":"Novel Baicalein-Derived Inhibitors of Plasmodium falciparum","publication_year":2023,"publication_date":"2023-10-13","ids":{"openalex":"https://openalex.org/W4387614644","doi":"https://doi.org/10.3390/pathogens12101242","pmid":"https://pubmed.ncbi.nlm.nih.gov/37887758","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10610289"},"language":"en","primary_location":{"id":"doi:10.3390/pathogens12101242","doi":"https://doi.org/10.3390/pathogens12101242","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens12101242","pdf_url":"https://www.mdpi.com/2076-0817/12/10/1242/pdf?version=1697205428","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-0817/12/10/1242/pdf?version=1697205428","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092416978","display_name":"Chandra Sekhar Gudla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chandra Sekhar Gudla","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101868850","display_name":"Vignesh Selvam","orcid":"https://orcid.org/0009-0003-0187-7293","observed_orcids":["https://orcid.org/0009-0003-0187-7293"]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vignesh Selvam","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":"https://orcid.org/0009-0003-0187-7293","affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101784103","display_name":"Siva Shanmugam Selvaraj","orcid":"https://orcid.org/0000-0001-9188-8276","observed_orcids":["https://orcid.org/0000-0001-9188-8276"]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siva Shanmugam Selvaraj","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0001-9188-8276","affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066687301","display_name":"Renu Tripathi","orcid":"https://orcid.org/0000-0002-3719-8802","observed_orcids":["https://orcid.org/0000-0002-3719-8802"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Renu Tripathi","raw_affiliation_strings":["Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045891150","display_name":"Prince Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prince Joshi","raw_affiliation_strings":["Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076003599","display_name":"Salique Hassan Shaham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Salique Hassan Shaham","raw_affiliation_strings":["Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001185641","display_name":"Mayas Singh","orcid":"https://orcid.org/0000-0002-5960-9449","observed_orcids":["https://orcid.org/0000-0002-5960-9449"]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mayas Singh","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078612453","display_name":"Radha Krishan Shandil","orcid":"https://orcid.org/0000-0002-0908-1340","observed_orcids":["https://orcid.org/0000-0002-0908-1340"]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Radha Krishan Shandil","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0002-0908-1340","affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017413200","display_name":"Saman Habib","orcid":"https://orcid.org/0000-0001-9378-7786","observed_orcids":["https://orcid.org/0000-0001-9378-7786"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saman Habib","raw_affiliation_strings":["Biochemistry and Structural Biology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Structural Biology, CSIR\u2014Central Drug Research Institute, Lucknow 226301, Uttar Pradesh, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030201796","display_name":"Shridhar Narayanan","orcid":"https://orcid.org/0000-0002-7781-7399","observed_orcids":["https://orcid.org/0000-0002-7781-7399"]},"institutions":[{"id":"https://openalex.org/I4210160732","display_name":"Foundation for Neglected Disease Research","ror":"https://ror.org/05d8r3q58","country_code":"IN","type":"nonprofit","lineage":["https://openalex.org/I4210160732"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shridhar Narayanan","raw_affiliation_strings":["Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Neglected Disease Research, Bangalore 561203, Karnataka, India","institution_ids":["https://openalex.org/I4210160732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5092416978"],"corresponding_institution_ids":["https://openalex.org/I4210160732"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":1.1058,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74312499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"12","issue":"10","first_page":"1242","last_page":"1242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.8339999914169312},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.8730000257492065},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9290000200271606},{"id":"https://openalex.org/keywords/in-vivo-antimalarial-activity","display_name":"in vivo antimalarial activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/rational-drug-design","display_name":"rational drug design","score":0.6660000085830688},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8586240410804749},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.8404850363731384},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7691097259521484},{"id":"https://openalex.org/C2781466915","wikidata":"https://www.wikidata.org/wiki/Q2879363","display_name":"Baicalein","level":2,"score":0.7583544254302979},{"id":"https://openalex.org/C2776486806","wikidata":"https://www.wikidata.org/wiki/Q12065970","display_name":"Plasmodium yoelii","level":5,"score":0.6662818193435669},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6167052388191223},{"id":"https://openalex.org/C2908859342","wikidata":"https://www.wikidata.org/wiki/Q521616","display_name":"Antimalarial Agent","level":4,"score":0.5694528818130493},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5193396806716919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40307411551475525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3819054961204529},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.34371960163116455},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18090200424194336},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.08514353632926941},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07755333185195923}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pathogens12101242","doi":"https://doi.org/10.3390/pathogens12101242","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens12101242","pdf_url":"https://www.mdpi.com/2076-0817/12/10/1242/pdf?version=1697205428","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10610289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10610289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"Text"},{"id":"pmid:37887758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37887758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fcf51b0a3d2b49e2ba36375fe9318aec","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fcf51b0a3d2b49e2ba36375fe9318aec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pathogens, Vol 12, Iss 10, p 1242 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pathogens12101242","doi":"https://doi.org/10.3390/pathogens12101242","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens12101242","pdf_url":"https://www.mdpi.com/2076-0817/12/10/1242/pdf?version=1697205428","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310838","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36"},{"id":"https://openalex.org/F4320320283","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10"},{"id":"https://openalex.org/F4320322413","display_name":"Medicines for Malaria Venture","ror":"https://ror.org/00p9jf779"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387614644.pdf","grobid_xml":"https://content.openalex.org/works/W4387614644.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W114572312","https://openalex.org/W1935711444","https://openalex.org/W1973769767","https://openalex.org/W1977560610","https://openalex.org/W2034745024","https://openalex.org/W2038603712","https://openalex.org/W2061316164","https://openalex.org/W2061456055","https://openalex.org/W2104243533","https://openalex.org/W2117211902","https://openalex.org/W2126672069","https://openalex.org/W2127733438","https://openalex.org/W2134089325","https://openalex.org/W2135874703","https://openalex.org/W2139271485","https://openalex.org/W2146694756","https://openalex.org/W2289660161","https://openalex.org/W2409306670","https://openalex.org/W2565383127","https://openalex.org/W2608011451","https://openalex.org/W2801362739","https://openalex.org/W2889956192","https://openalex.org/W2913315260","https://openalex.org/W2954500169","https://openalex.org/W2969849188","https://openalex.org/W2980287330","https://openalex.org/W3005533031","https://openalex.org/W3023231197","https://openalex.org/W3024118190","https://openalex.org/W3086670596","https://openalex.org/W3174004259","https://openalex.org/W3194160511","https://openalex.org/W4284689967","https://openalex.org/W4284970243","https://openalex.org/W6716264694"],"related_works":["https://openalex.org/W7215811686","https://openalex.org/W2014289062","https://openalex.org/W2964743285","https://openalex.org/W7160633228","https://openalex.org/W3019423445","https://openalex.org/W2952839380","https://openalex.org/W2144947876","https://openalex.org/W1967517956","https://openalex.org/W2051527241","https://openalex.org/W2792008505"],"abstract_inverted_index":{"Malaria,":[0],"a":[1,12,73,80,140,176],"life-threatening":[2],"mosquito-borne":[3],"disease":[4,23],"caused":[5],"by":[6],"Plasmodium":[7,92,118],"parasites,":[8],"continues":[9],"to":[10,61],"pose":[11],"significant":[13],"global":[14],"health":[15],"burden.":[16],"Despite":[17],"notable":[18],"progress":[19],"in":[20,24,30,34,87,112,121,168],"combating":[21],"the":[22,54,115,162,169],"recent":[25],"years,":[26],"malaria":[27],"remains":[28],"prevalent":[29],"many":[31],"regions,":[32],"particularly":[33],"Southeast":[35],"Asia":[36],"and":[37,71,78,100,196],"most":[38],"of":[39,46,48,57,75,127,130,144,154,165,179],"sub-Saharan":[40],"Africa,":[41],"where":[42],"it":[43],"claims":[44],"hundreds":[45],"thousands":[47],"lives":[49],"annually.":[50],"Flavonoids,":[51],"such":[52],"as":[53],"baicalein":[55,76],"class":[56],"compounds,":[58],"are":[59],"known":[60],"have":[62],"antimalarial":[63,89,110,180],"properties.":[64],"In":[65],"this":[66],"study,":[67],"we":[68],"rationally":[69],"designed":[70],"synthesized":[72],"series":[74,178],"derivatives":[77],"identified":[79],"lead":[81],"compound,":[82],"FNDR-10132,":[83],"that":[84,182],"displayed":[85,158],"potent":[86,187],"vitro":[88],"activity":[90,111,160],"against":[91,114,161,189],"falciparum":[93,167],"(P.":[94],"falciparum),":[95],"both":[96],"chloroquine-sensitive":[97],"(60":[98],"nM)":[99,103],"chloroquine-resistant":[101,116,190],"(177":[102],"parasites.":[104],"FNDR-10132":[105,131,157],"was":[106],"evaluated":[107],"for":[108],"its":[109],"vivo":[113],"strain":[117],"yoelii":[119],"N67":[120],"Swiss":[122],"mice.":[123],"The":[124],"oral":[125],"administration":[126],"100":[128],"mg/kg":[129],"showed":[132],"44%":[133],"parasite":[134],"suppression":[135],"on":[136],"day":[137],"4,":[138],"with":[139],"mean":[141],"survival":[142],"time":[143],"13.5":[145],"\u00b1":[146,151],"2.3":[147,152],"days":[148,153],"vs.":[149],"8.4":[150],"control.":[155],"Also,":[156],"equivalent":[159],"resistant":[163],"strains":[164],"P.":[166],"200\u2013300":[170],"nM":[171],"range.":[172],"This":[173],"study":[174],"offers":[175],"novel":[177],"compounds":[181],"could":[183],"be":[184],"developed":[185],"into":[186],"drugs":[188],"malarial":[191],"parasites":[192],"through":[193],"further":[194],"chemistry":[195],"DMPK":[197],"optimization.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-14T00:00:00"}