{"id":"https://openalex.org/W4387613541","doi":"https://doi.org/10.1016/j.omtn.2023.102053","title":"Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice","display_name":"Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice","publication_year":2023,"publication_date":"2023-10-13","ids":{"openalex":"https://openalex.org/W4387613541","doi":"https://doi.org/10.1016/j.omtn.2023.102053","pmid":"https://pubmed.ncbi.nlm.nih.gov/37941832","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628790"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2023.102053","doi":"https://doi.org/10.1016/j.omtn.2023.102053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.102053","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtn.2023.102053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034161076","display_name":"Chandran Sivasankar","orcid":"https://orcid.org/0000-0002-3010-9563","observed_orcids":["https://orcid.org/0000-0002-3010-9563"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chandran Sivasankar","raw_affiliation_strings":["College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068940055","display_name":"Chamith Hewawaduge","orcid":"https://orcid.org/0000-0002-2950-4080","observed_orcids":["https://orcid.org/0000-0002-2950-4080"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chamith Hewawaduge","raw_affiliation_strings":["College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084714754","display_name":"Pandiyan Muthuramalingam","orcid":"https://orcid.org/0000-0001-7294-1625","observed_orcids":["https://orcid.org/0000-0001-7294-1625"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pandiyan Muthuramalingam","raw_affiliation_strings":["Department of GreenBio Science, Gyeongsang National University, Jinju 52725, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of GreenBio Science, Gyeongsang National University, Jinju 52725, South Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107973946","display_name":"John Hwa Lee","orcid":"https://orcid.org/0000-0002-2028-2207","observed_orcids":["https://orcid.org/0000-0002-2028-2207"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"John Hwa Lee","raw_affiliation_strings":["College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2028-2207","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Jeonbuk National University, Iksan Campus 54596, Republic of Korea","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107973946"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.2916,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75241392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"34","issue":null,"first_page":"102053","last_page":"102053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rcas1","display_name":"RCAS1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/live-attenuated-bacteria","display_name":"live attenuated bacteria","score":0.703000009059906},{"id":"https://openalex.org/keywords/tumor-targeted-delivery","display_name":"tumor-targeted delivery","score":0.8159999847412109},{"id":"https://openalex.org/keywords/4t1-breast-cancer-model","display_name":"4T1 breast cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9470000267028809},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/cancer-treatment-resistance","display_name":"cancer therapy resistance","score":0.44699999690055847},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6158295273780823},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.5230235457420349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4963582158088684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44630852341651917},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42166486382484436},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42039021849632263},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4175903797149658},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2970149517059326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25266504287719727},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.omtn.2023.102053","doi":"https://doi.org/10.1016/j.omtn.2023.102053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.102053","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10628790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628790","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10628790/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:37941832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37941832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9a85a65ab5d34eae8506d158b5a48b80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9a85a65ab5d34eae8506d158b5a48b80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102053- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2023.102053","doi":"https://doi.org/10.1016/j.omtn.2023.102053","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.102053","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1834879965","display_name":null,"funder_award_id":"2019R1A6A1A03033084","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2932468412","display_name":null,"funder_award_id":"RS-2023-00272216","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3763588226","display_name":null,"funder_award_id":"RS-2023-00272216","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G4989854467","display_name":null,"funder_award_id":"2019R1A6A1A03033084","funder_id":"https://openalex.org/F4320321408","funder_display_name":"Ministry of Education"},{"id":"https://openalex.org/G6017139087","display_name":null,"funder_award_id":"2019R1A6A1A03033084","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1964065596","https://openalex.org/W1964229335","https://openalex.org/W1968311390","https://openalex.org/W1971520866","https://openalex.org/W1974548520","https://openalex.org/W1975639558","https://openalex.org/W1981600623","https://openalex.org/W2004653083","https://openalex.org/W2006709929","https://openalex.org/W2007377499","https://openalex.org/W2009098686","https://openalex.org/W2009770467","https://openalex.org/W2015538356","https://openalex.org/W2017613003","https://openalex.org/W2018335660","https://openalex.org/W2020966115","https://openalex.org/W2025767721","https://openalex.org/W2025954620","https://openalex.org/W2046041427","https://openalex.org/W2046692348","https://openalex.org/W2048799038","https://openalex.org/W2051446833","https://openalex.org/W2060058804","https://openalex.org/W2071663634","https://openalex.org/W2080829828","https://openalex.org/W2085099489","https://openalex.org/W2097187878","https://openalex.org/W2109448914","https://openalex.org/W2110033484","https://openalex.org/W2115205513","https://openalex.org/W2115785123","https://openalex.org/W2122415351","https://openalex.org/W2126923269","https://openalex.org/W2134562563","https://openalex.org/W2144220448","https://openalex.org/W2158795833","https://openalex.org/W2161133478","https://openalex.org/W2162029970","https://openalex.org/W2163454425","https://openalex.org/W2167685929","https://openalex.org/W2170187216","https://openalex.org/W2177617302","https://openalex.org/W2215729635","https://openalex.org/W2325596649","https://openalex.org/W2329772271","https://openalex.org/W2342822806","https://openalex.org/W2409057459","https://openalex.org/W2472363039","https://openalex.org/W2513531256","https://openalex.org/W2604821592","https://openalex.org/W2796409747","https://openalex.org/W2803714085","https://openalex.org/W2804875433","https://openalex.org/W2808077597","https://openalex.org/W2887502320","https://openalex.org/W2888312739","https://openalex.org/W2892164262","https://openalex.org/W2904071444","https://openalex.org/W2909134306","https://openalex.org/W2951496808","https://openalex.org/W2982592788","https://openalex.org/W2999405370","https://openalex.org/W3008550537","https://openalex.org/W3087399825","https://openalex.org/W3098592536","https://openalex.org/W3115880421","https://openalex.org/W3135629475","https://openalex.org/W3160716708","https://openalex.org/W3171835979","https://openalex.org/W3172453970","https://openalex.org/W3179854736","https://openalex.org/W3198257688","https://openalex.org/W3198281602","https://openalex.org/W3209053043","https://openalex.org/W3217222991","https://openalex.org/W4205824800","https://openalex.org/W4280614262","https://openalex.org/W4283013891","https://openalex.org/W4293776465","https://openalex.org/W4295974752","https://openalex.org/W4298616225","https://openalex.org/W4303961795","https://openalex.org/W4304687342","https://openalex.org/W4310251760","https://openalex.org/W4313340245","https://openalex.org/W4319660598","https://openalex.org/W4366534494","https://openalex.org/W6764281268"],"related_works":["https://openalex.org/W4389802790","https://openalex.org/W4280614262","https://openalex.org/W7197048440","https://openalex.org/W2981869001","https://openalex.org/W2433496323","https://openalex.org/W4386502962","https://openalex.org/W7154958606","https://openalex.org/W1487470928","https://openalex.org/W2394850841","https://openalex.org/W6921268059"],"abstract_inverted_index":{"Emerging":[0],"chemo-":[1],"and":[2,9,78,92,138,150,167,186],"radiotherapy":[3],"resistance":[4],"exacerbated":[5],"the":[6,29,73,109,143,160,172,177,194],"cancer":[7,60],"risk":[8],"necessitated":[10],"novel":[11],"treatment":[12,155,174],"strategies.":[13],"Although":[14],"RNA":[15],"therapeutics":[16],"against":[17,89],"pro-oncogenic":[18],"genes":[19],"are":[20],"highly":[21],"effective,":[22],"tumor-specific":[23],"delivery":[24,48],"remains":[25],"a":[26,40,68,85,97],"barrier":[27],"to":[28],"implementation":[30],"of":[31,75,198],"this":[32,36],"valuable":[33],"tool.":[34],"In":[35,152],"study,":[37],"we":[38],"report":[39],"tryptophan-auxotrophic":[41,199],"Salmonella":[42,95,200],"typhimurium":[43],"strain":[44,121],"as":[45],"an":[46],"onco-therapeutic":[47,203],"system":[49],"with":[50],"tumor-targeting":[51,196],"ability":[52,197],"using":[53,96],"4T1":[54],"mice":[55],"breast-cancer":[56],"model.":[57],"The":[58],"receptor-binding":[59],"antigen":[61],"expressed":[62],"on":[63],"SiSo":[64],"cell":[65,162],"(RCAS1)":[66],"is":[67],"cancer-specific":[69],"protein":[70],"that":[71],"induces":[72],"apoptosis":[74],"peripheral":[76],"lymphocytes":[77],"confers":[79],"tumor":[80,136,144,178],"immune":[81],"evasion.":[82],"We":[83],"designed":[84],"long":[86],"non-coding":[87],"antisense-RNA":[88],"RCAS1":[90,140],"(asRCAS1)":[91],"delivered":[93],"by":[94,147,180,184],"non-antibiotic,":[98],"auxotrophic-selective,":[99],"eukaryotic":[100],"expression":[101],"plasmid,":[102],"pJHL204.":[103],"After":[104],"in":[105,125,131,142],"vivo":[106],"tumor-to-tumor":[107],"passaging,":[108],"JOL2888":[110,154,173],"(\u0394":[111],"trpA":[112],",":[113,116],"\u0394":[114,117],"trpE":[115],"asd":[118],"+":[119],"asRCAS1)":[120],"exhibited":[122],"high":[123],"sustainability":[124],"tumors,":[126],"but":[127],"did":[128],"not":[129],"last":[130],"healthy":[132],"organs,":[133],"thereby":[134],"demonstrating":[135],"specificity":[137],"safety.":[139],"inhibition":[141],"was":[145],"confirmed":[146],"western":[148],"blotting":[149],"qPCR.":[151],"mice,":[153],"reduced":[156],"tumor-associated":[157],"macrophages,":[158],"improved":[159],"T":[161],"population,":[163],"elicited":[164],"cell-mediated":[165],"immunity,":[166],"suppressed":[168],"cancer-promoting":[169],"genes.":[170],"Consequently,":[171],"significantly":[175],"decreased":[176,182],"volume":[179],"80%,":[181],"splenomegaly":[183],"30%,":[185],"completely":[187],"arrested":[188],"lung":[189],"metastasis.":[190],"These":[191],"findings":[192],"highlight":[193],"intrinsic":[195],"for":[201],"delivering":[202],"macromolecules.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-10-14T00:00:00"}
