{"id":"https://openalex.org/W4387613089","doi":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","title":"Network pharmacology and molecular docking study to reveal the potential anticancer activity of Oscillatoxin D, E, and F marine cytotoxins","display_name":"Network pharmacology and molecular docking study to reveal the potential anticancer activity of Oscillatoxin D, E, and F marine cytotoxins","publication_year":2023,"publication_date":"2023-10-12","ids":{"openalex":"https://openalex.org/W4387613089","doi":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389"},"language":"en","primary_location":{"id":"doi:10.21323/2618-9771-2023-6-3-365-389","doi":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","is_oa":true,"landing_page_url":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","pdf_url":"https://www.fsjour.com/jour/article/download/306/250","source":{"id":"https://openalex.org/S4210182703","display_name":"Food systems","issn_l":"2618-7272","issn":["2618-7272","2618-9771"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312675","host_organization_name":"The V.M. Gorbatov All-Russian Meat Research \u00a0Institute","host_organization_lineage":["https://openalex.org/P4310312675"],"host_organization_lineage_names":["The V.M. Gorbatov All-Russian Meat Research \u00a0Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food systems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.fsjour.com/jour/article/download/306/250","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060323478","display_name":"Dewi Luthfiana","orcid":"https://orcid.org/0000-0001-6109-5283","observed_orcids":["https://orcid.org/0000-0001-6109-5283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Luthfiana","raw_affiliation_strings":["Bioinformatics Research Center, Indonesian Institute of Bioinformatics (INBIO)"],"raw_orcid":"https://orcid.org/0000-0001-6109-5283","affiliations":[{"raw_affiliation_string":"Bioinformatics Research Center, Indonesian Institute of Bioinformatics (INBIO)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074851525","display_name":"Maratu Soleha","orcid":"https://orcid.org/0009-0007-3119-4951","observed_orcids":["https://orcid.org/0009-0007-3119-4951"]},"institutions":[{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"M. Soleha","raw_affiliation_strings":["National Research and Innovation Agency"],"raw_orcid":"https://orcid.org/0009-0007-3119-4951","affiliations":[{"raw_affiliation_string":"National Research and Innovation Agency","institution_ids":["https://openalex.org/I4387154144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091659337","display_name":"Andri Prasetiyo","orcid":"https://orcid.org/0000-0002-9936-6058","observed_orcids":["https://orcid.org/0000-0002-9936-6058"]},"institutions":[{"id":"https://openalex.org/I3129280579","display_name":"Pancasila University","ror":"https://ror.org/0062tve42","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129280579"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A. Prasetiyo","raw_affiliation_strings":["Department of Pharmaceutical Science, Faculty of Pharmacy, Pancasila University"],"raw_orcid":"https://orcid.org/0000-0002-9936-6058","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, Faculty of Pharmacy, Pancasila University","institution_ids":["https://openalex.org/I3129280579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075302300","display_name":"Wisnu Ananta Kusuma","orcid":"https://orcid.org/0000-0002-3682-244X","observed_orcids":["https://orcid.org/0000-0002-3682-244X"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"W. A. Kusuma","raw_affiliation_strings":["Department of Computer Science, Faculty Mathematics and Natural Sciences, IPB University; Tropical Biopharmaca Research Center, IPB University","Tropical Biopharmaca Research Center, IPB University"],"raw_orcid":"https://orcid.org/0000-0002-3682-244X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Faculty Mathematics and Natural Sciences, IPB University; Tropical Biopharmaca Research Center, IPB University","institution_ids":["https://openalex.org/I21881038"]},{"raw_affiliation_string":"Tropical Biopharmaca Research Center, IPB University","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014207237","display_name":"Rizka Fatriani","orcid":"https://orcid.org/0000-0002-1739-8698","observed_orcids":["https://orcid.org/0000-0002-1739-8698"]},"institutions":[{"id":"https://openalex.org/I21881038","display_name":"IPB University","ror":"https://ror.org/05smgpd89","country_code":"ID","type":"education","lineage":["https://openalex.org/I21881038"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"R. Fatriani","raw_affiliation_strings":["Tropical Biopharmaca Research Center, IPB University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tropical Biopharmaca Research Center, IPB University","institution_ids":["https://openalex.org/I21881038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069887124","display_name":"Lina Nurfadhila","orcid":"https://orcid.org/0000-0001-8629-6866","observed_orcids":["https://orcid.org/0000-0001-8629-6866"]},"institutions":[{"id":"https://openalex.org/I4210096913","display_name":"University of Singaperbangsa Karawang","ror":"https://ror.org/00vc1fz20","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210096913"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"L. Nurfadhila","raw_affiliation_strings":["Department of Pharmacy, Faculty of Health Sciences, Singaperbangsa Karawang University"],"raw_orcid":"https://orcid.org/0000-0001-8629-6866","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Health Sciences, Singaperbangsa Karawang University","institution_ids":["https://openalex.org/I4210096913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082577246","display_name":"Norainny Yunitasari","orcid":"https://orcid.org/0000-0002-1861-0953","observed_orcids":["https://orcid.org/0000-0002-1861-0953"]},"institutions":[{"id":"https://openalex.org/I4210092405","display_name":"Universitas Muhammadiyah Gresik","ror":"https://ror.org/00f8d9297","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210092405"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"N. Yunitasari","raw_affiliation_strings":["Faculty of Health, University of Muhammadiyah Gresik"],"raw_orcid":"https://orcid.org/0000-0002-1861-0953","affiliations":[{"raw_affiliation_string":"Faculty of Health, University of Muhammadiyah Gresik","institution_ids":["https://openalex.org/I4210092405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093058559","display_name":"Ahmad Hafidul Ahkam","orcid":"https://orcid.org/0000-0003-3107-534X","observed_orcids":["https://orcid.org/0000-0003-3107-534X"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"A. H. Ahkam","raw_affiliation_strings":["Faculty of Pharmacy, Padjadjaran University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Padjadjaran University","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055989755","display_name":"Teresa Liliana Wargasetia","orcid":"https://orcid.org/0000-0002-3433-3300","observed_orcids":["https://orcid.org/0000-0002-3433-3300","https://orcid.org/0000-0002-9990-4741"]},"institutions":[{"id":"https://openalex.org/I146087005","display_name":"Maranatha Christian University","ror":"https://ror.org/05pd2ed85","country_code":"ID","type":"education","lineage":["https://openalex.org/I146087005"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"T. L. Wargasetia","raw_affiliation_strings":["Faculty of Medicine, Maranatha Christian University"],"raw_orcid":"https://orcid.org/0000-0002-3433-3300","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Maranatha Christian University","institution_ids":["https://openalex.org/I146087005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048312899","display_name":"Rizal Irfandi","orcid":"https://orcid.org/0000-0002-4845-3397","observed_orcids":["https://orcid.org/0000-0002-4845-3397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Irfandi","raw_affiliation_strings":["Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung"],"raw_orcid":"https://orcid.org/0000-0002-4845-3397","affiliations":[{"raw_affiliation_string":"Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042650965","display_name":"Arif Nur Muhammad Ansori","orcid":"https://orcid.org/0000-0002-1279-3904","observed_orcids":["https://orcid.org/0000-0002-1279-3904"]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]},{"id":"https://openalex.org/I3132702812","display_name":"Uttaranchal University","ror":"https://ror.org/00ba6pg24","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132702812"]}],"countries":["ID","IN"],"is_corresponding":false,"raw_author_name":"A. N. M. Ansori","raw_affiliation_strings":["Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University; Postgraduate School, Universitas Airlangga","Postgraduate School, Universitas Airlangga"],"raw_orcid":"https://orcid.org/0000-0002-1279-3904","affiliations":[{"raw_affiliation_string":"Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University; Postgraduate School, Universitas Airlangga","institution_ids":["https://openalex.org/I205133468","https://openalex.org/I3132702812"]},{"raw_affiliation_string":"Postgraduate School, Universitas Airlangga","institution_ids":["https://openalex.org/I205133468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044810587","display_name":"Viol Dhea Kharisma","orcid":"https://orcid.org/0000-0001-9060-0429","observed_orcids":["https://orcid.org/0000-0001-9060-0429"]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"V. D. Kharisma","raw_affiliation_strings":["Department of Biology, Faculty of Science and Technology, Universitas Airlangga; Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation","Department of Biology, Faculty of Science and Technology, Universitas Airlangga"],"raw_orcid":"https://orcid.org/0000-0001-9060-0429","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga; Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation","institution_ids":["https://openalex.org/I205133468"]},{"raw_affiliation_string":"Department of Biology, Faculty of Science and Technology, Universitas Airlangga","institution_ids":["https://openalex.org/I205133468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103957472","display_name":"Sin War Naw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3130905595","display_name":"Myitkyina University","ror":"https://ror.org/05f92a127","country_code":"MM","type":"education","lineage":["https://openalex.org/I3130905595"]}],"countries":["MM"],"is_corresponding":false,"raw_author_name":"S. W. Naw","raw_affiliation_strings":["Department of Chemistry, Myitkyina University"],"raw_orcid":"https://orcid.org/0000-0002-5985-361X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Myitkyina University","institution_ids":["https://openalex.org/I3130905595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111001200","display_name":"Md. Emdad Ullah","orcid":"https://orcid.org/0000-0002-1683-2501","observed_orcids":["https://orcid.org/0000-0002-1683-2501"]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Ullah","raw_affiliation_strings":["Department of Chemistry, Mississippi State University"],"raw_orcid":"https://orcid.org/0000-0002-1683-2501","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Mississippi State University","institution_ids":["https://openalex.org/I99041443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025855311","display_name":"Vikash Jakhmola","orcid":"https://orcid.org/0000-0002-8108-006X","observed_orcids":["https://orcid.org/0000-0002-8108-006X"]},"institutions":[{"id":"https://openalex.org/I3132702812","display_name":"Uttaranchal University","ror":"https://ror.org/00ba6pg24","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132702812"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V. Jakhmola","raw_affiliation_strings":["Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University"],"raw_orcid":"https://orcid.org/0000-0002-8108-006X","affiliations":[{"raw_affiliation_string":"Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University","institution_ids":["https://openalex.org/I3132702812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004308749","display_name":"Rahadian Zainul","orcid":"https://orcid.org/0000-0002-3740-3597","observed_orcids":["https://orcid.org/0000-0002-3740-3597"]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"R. Zainul","raw_affiliation_strings":["Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang"],"raw_orcid":"https://orcid.org/0000-0002-3740-3597","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang","institution_ids":["https://openalex.org/I245308123"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5221,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55282341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"6","issue":"3","first_page":"365","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.972000002861023},{"id":"https://openalex.org/keywords/pd-1-pd-l1-immune-checkpoint","display_name":"PD-1/PD-L1 immune checkpoint","score":0.875},{"id":"https://openalex.org/keywords/proteoglycans-in-cancer","display_name":"proteoglycans in cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cancer-pathways","display_name":"cancer pathways","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.58030766248703},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5677552223205566},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5134297609329224},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4740821123123169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46704429388046265},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.45104503631591797},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4340442419052124},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36345934867858887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3415900468826294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2626574635505676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08215221762657166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07682502269744873},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21323/2618-9771-2023-6-3-365-389","doi":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","is_oa":true,"landing_page_url":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","pdf_url":"https://www.fsjour.com/jour/article/download/306/250","source":{"id":"https://openalex.org/S4210182703","display_name":"Food systems","issn_l":"2618-7272","issn":["2618-7272","2618-9771"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312675","host_organization_name":"The V.M. Gorbatov All-Russian Meat Research \u00a0Institute","host_organization_lineage":["https://openalex.org/P4310312675"],"host_organization_lineage_names":["The V.M. Gorbatov All-Russian Meat Research \u00a0Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food systems","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fe0a7e6e3a8a4eba94aa678428c8e2e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fe0a7e6e3a8a4eba94aa678428c8e2e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041f\u0438\u0449\u0435\u0432\u044b\u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u044b, Vol 6, Iss 3, Pp 365-389 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21323/2618-9771-2023-6-3-365-389","doi":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","is_oa":true,"landing_page_url":"https://doi.org/10.21323/2618-9771-2023-6-3-365-389","pdf_url":"https://www.fsjour.com/jour/article/download/306/250","source":{"id":"https://openalex.org/S4210182703","display_name":"Food systems","issn_l":"2618-7272","issn":["2618-7272","2618-9771"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312675","host_organization_name":"The V.M. Gorbatov All-Russian Meat Research \u00a0Institute","host_organization_lineage":["https://openalex.org/P4310312675"],"host_organization_lineage_names":["The V.M. Gorbatov All-Russian Meat Research \u00a0Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food systems","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387613089.pdf","grobid_xml":"https://content.openalex.org/works/W4387613089.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2045167826","https://openalex.org/W2074473216","https://openalex.org/W2136359059","https://openalex.org/W2154124833","https://openalex.org/W2169678694","https://openalex.org/W2171068265","https://openalex.org/W2533789013","https://openalex.org/W2594247592","https://openalex.org/W2795353688","https://openalex.org/W2805554722","https://openalex.org/W2884323962","https://openalex.org/W2901086483","https://openalex.org/W2914084793","https://openalex.org/W2973039076","https://openalex.org/W3011014170","https://openalex.org/W3028447181","https://openalex.org/W3084247016","https://openalex.org/W3104079531","https://openalex.org/W3126309680","https://openalex.org/W3154038971","https://openalex.org/W4223923864","https://openalex.org/W4285233423","https://openalex.org/W4304808822","https://openalex.org/W4306811901"],"related_works":["https://openalex.org/W3154038971","https://openalex.org/W4390665757","https://openalex.org/W7158883356","https://openalex.org/W4386084283","https://openalex.org/W4385650162","https://openalex.org/W4403253496","https://openalex.org/W4386117097","https://openalex.org/W4380204170","https://openalex.org/W4294750994","https://openalex.org/W7163074882"],"abstract_inverted_index":{"Oscillatoxins":[0],"(OTXs)":[1],"are":[2,100,116],"cytotoxins":[3],"produced":[4],"by":[5,125],"some":[6],"marine":[7],"cyanobacteria.":[8],"Their":[9],"unique":[10],"structures":[11],"show":[12],"a":[13,193],"great":[14],"potency":[15],"as":[16],"an":[17],"anticancer":[18,168],"agent.":[19],"The":[20],"limited":[21],"availability":[22],"of":[23,36,58,81,83,104,114,159],"OTX":[24,37],"derivatives":[25,158],"in":[26,42,44,47,183,186,190],"nature":[27],"provides":[28],"little":[29],"information":[30],"about":[31],"their":[32,55,139,162],"biological":[33],"activity.":[34],"Some":[35],"activities":[38],"have":[39],"been":[40],"tested":[41],"the":[43,61,70,77,105,111,126,132,135,145,151,167,197],"vitro":[45],"or":[46],"vivo":[48],"studies":[49],"toward":[50,108],"cancer":[51],"cell":[52],"lines,":[53],"but":[54],"exact":[56],"mechanism":[57,80],"action":[59,82,169],"on":[60],"target":[62,78],"is":[63],"unclear.":[64],"In":[65,154],"this":[66,155],"study,":[67,156],"we":[68],"used":[69],"network":[71],"pharmacology":[72],"analysis":[73],"method":[74],"to":[75,130],"predict":[76],"and":[79,95,110,119,138,161,179,188],"oscillatoxin":[84,89,92,96],"D":[85,90],"(OTX-D),":[86],"30":[87],"methyl":[88],"(30-methyl-OTX-D),":[91],"E":[93],"(OTX-E),":[94],"F":[97],"(OTX-F).":[98],"There":[99],"20":[101],"possible":[102],"targets":[103,113,165],"four":[106,136,146,157],"compounds":[107,137,147],"cancer,":[109,184,187,191],"main":[112],"them":[115],"PIK3CA,":[117],"CDK1,":[118],"MTOR.":[120],"This":[121],"was":[122],"also":[123],"followed":[124],"molecular":[127],"docking":[128,142],"study":[129],"understand":[131],"interaction":[133],"between":[134],"targets.":[140,153],"Molecular":[141],"showed":[143],"that":[144],"interacted":[148],"well":[149],"with":[150],"key":[152,164],"OTXs":[160],"three":[163],"for":[166,196],"were":[170],"revealed":[171],"suggesting":[172],"multiple":[173],"signaling":[174],"pathways,":[175],"including":[176],"PD-L1":[177],"expression":[178],"PD\u20111":[180],"checkpoint":[181],"pathway":[182],"proteoglycans":[185],"pathways":[189],"establishing":[192],"theoretical":[194],"framework":[195],"further":[198],"experimental":[199],"study.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-14T00:00:00"}