{"id":"https://openalex.org/W4387577413","doi":"https://doi.org/10.3389/froh.2023.1285276","title":"Aging and oral squamous cell carcinoma development: the role of cellular senescence","display_name":"Aging and oral squamous cell carcinoma development: the role of cellular senescence","publication_year":2023,"publication_date":"2023-10-12","ids":{"openalex":"https://openalex.org/W4387577413","doi":"https://doi.org/10.3389/froh.2023.1285276","pmid":"https://pubmed.ncbi.nlm.nih.gov/37904749","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10613501"},"language":"en","primary_location":{"id":"doi:10.3389/froh.2023.1285276","doi":"https://doi.org/10.3389/froh.2023.1285276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2023.1285276","pdf_url":"https://www.frontiersin.org/articles/10.3389/froh.2023.1285276/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/froh.2023.1285276/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022556328","display_name":"Sven Eric Niklander","orcid":"https://orcid.org/0000-0003-1858-3091","observed_orcids":["https://orcid.org/0000-0003-1858-3091"]},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Sven Eric Niklander","raw_affiliation_strings":["Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Vi\u00f1a del Mar, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I13897259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058182309","display_name":"Pablo Ar\u00e1nguiz","orcid":"https://orcid.org/0000-0002-4379-2429","observed_orcids":["https://orcid.org/0000-0002-4379-2429"]},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pablo Ar\u00e1nguiz","raw_affiliation_strings":["Escuela de Qu\u00edmica y Farmacia, Facultad de Medicina, Universidad Andres Bello, Vi\u00f1a del Mar, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Qu\u00edmica y Farmacia, Facultad de Medicina, Universidad Andres Bello, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I13897259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020493466","display_name":"Fernando Faunes","orcid":"https://orcid.org/0000-0003-2657-2552","observed_orcids":["https://orcid.org/0000-0003-2657-2552"]},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Fernando Faunes","raw_affiliation_strings":["Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Vi\u00f1a del Mar, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I13897259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007412397","display_name":"Rene Flores","orcid":"https://orcid.org/0000-0002-0800-8117","observed_orcids":["https://orcid.org/0000-0002-0800-8117"]},"institutions":[{"id":"https://openalex.org/I13897259","display_name":"Universidad Andr\u00e9s Bello","ror":"https://ror.org/01qq57711","country_code":"CL","type":"education","lineage":["https://openalex.org/I13897259"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ren\u00e9 Mart\u00ednez-Flores","raw_affiliation_strings":["Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Vi\u00f1a del Mar, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Oral Pathology and Oral Medicine, Faculty of Dentistry, Universidad Andres Bello, Vi\u00f1a del Mar, Chile","institution_ids":["https://openalex.org/I13897259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007412397","https://openalex.org/A5022556328"],"corresponding_institution_ids":["https://openalex.org/I13897259"],"apc_list":{"value":2125,"currency":"USD","value_usd":2125},"apc_paid":{"value":2125,"currency":"USD","value_usd":2125},"fwci":0.5029,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.48642534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"4","issue":null,"first_page":"1285276","last_page":"1285276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9599999785423279},{"id":"https://openalex.org/keywords/senotherapeutics","display_name":"senotherapeutics","score":0.7129999995231628},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/senomorphics","display_name":"senomorphics","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8330000042915344},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5609999895095825},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8528139591217041},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.684298038482666},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5952669382095337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5940826535224915},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5481085181236267},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5329082608222961},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4925747513771057},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4818590581417084},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47226133942604065},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.41322463750839233},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37250590324401855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33066093921661377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14270737767219543},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10888254642486572},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/froh.2023.1285276","doi":"https://doi.org/10.3389/froh.2023.1285276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2023.1285276","pdf_url":"https://www.frontiersin.org/articles/10.3389/froh.2023.1285276/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10613501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10613501","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10613501/pdf/froh-04-1285276.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oral Health","raw_type":"Text"},{"id":"pmid:37904749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37904749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oral health","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unab.cl:ria/57583","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unab.cl/handle/ria/57583","pdf_url":"https://repositorio.unab.cl/bitstreams/2867cc06-da8b-4448-af68-9c094122221e/download","source":{"id":"https://openalex.org/S4306400858","display_name":"Repositorio Institucional Acad\u00e9mico , Sistema de Bibliotecas Universidad Andr\u00e9s Bello (UNAB) (Universidad Andr\u00e9s Bello (UNAB))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210156962","host_organization_name":"Universidad Dr. Andr\u00e9s Bello","host_organization_lineage":["https://openalex.org/I4210156962"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Art\u00edculo"},{"id":"pmh:oai:doaj.org/article:1b924fa583c64dfa900c46836c7fe992","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b924fa583c64dfa900c46836c7fe992","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oral Health, Vol 4 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/froh.2023.1285276","doi":"https://doi.org/10.3389/froh.2023.1285276","is_oa":true,"landing_page_url":"https://doi.org/10.3389/froh.2023.1285276","pdf_url":"https://www.frontiersin.org/articles/10.3389/froh.2023.1285276/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S4210201735","display_name":"Frontiers in Oral Health","issn_l":"2673-4842","issn":["2673-4842"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oral Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387577413.pdf","grobid_xml":"https://content.openalex.org/works/W4387577413.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W239602587","https://openalex.org/W1033197108","https://openalex.org/W1520881062","https://openalex.org/W1524549603","https://openalex.org/W1583634202","https://openalex.org/W1601771278","https://openalex.org/W1631191622","https://openalex.org/W1800944583","https://openalex.org/W1882072066","https://openalex.org/W1910950086","https://openalex.org/W1970924670","https://openalex.org/W1985549756","https://openalex.org/W1989479849","https://openalex.org/W1991797115","https://openalex.org/W2000909070","https://openalex.org/W2001733842","https://openalex.org/W2007452394","https://openalex.org/W2027329764","https://openalex.org/W2028169108","https://openalex.org/W2041892424","https://openalex.org/W2062854830","https://openalex.org/W2067117191","https://openalex.org/W2080769506","https://openalex.org/W2088172593","https://openalex.org/W2091850478","https://openalex.org/W2092668553","https://openalex.org/W2095746947","https://openalex.org/W2098995242","https://openalex.org/W2108887402","https://openalex.org/W2111348546","https://openalex.org/W2112018589","https://openalex.org/W2115852450","https://openalex.org/W2135829603","https://openalex.org/W2136380412","https://openalex.org/W2139712402","https://openalex.org/W2140930678","https://openalex.org/W2145639290","https://openalex.org/W2147030667","https://openalex.org/W2159195088","https://openalex.org/W2161640397","https://openalex.org/W2161682129","https://openalex.org/W2164361361","https://openalex.org/W2171199340","https://openalex.org/W2195306450","https://openalex.org/W2210634983","https://openalex.org/W2213222087","https://openalex.org/W2217986049","https://openalex.org/W2234607726","https://openalex.org/W2397706209","https://openalex.org/W2399096846","https://openalex.org/W2415434225","https://openalex.org/W2471558537","https://openalex.org/W2530530576","https://openalex.org/W2561396377","https://openalex.org/W2561691830","https://openalex.org/W2573540928","https://openalex.org/W2611479744","https://openalex.org/W2616929080","https://openalex.org/W2742007963","https://openalex.org/W2762611634","https://openalex.org/W2788013393","https://openalex.org/W2799990159","https://openalex.org/W2805184558","https://openalex.org/W2860743873","https://openalex.org/W2884937981","https://openalex.org/W2897749150","https://openalex.org/W2906721882","https://openalex.org/W2911902696","https://openalex.org/W2937053683","https://openalex.org/W2937879402","https://openalex.org/W2951114010","https://openalex.org/W2953870751","https://openalex.org/W2954240092","https://openalex.org/W2954445592","https://openalex.org/W2955356877","https://openalex.org/W2959728234","https://openalex.org/W2965836614","https://openalex.org/W2972176863","https://openalex.org/W2973133331","https://openalex.org/W2975349219","https://openalex.org/W2994470479","https://openalex.org/W2995607278","https://openalex.org/W3009846583","https://openalex.org/W3021054303","https://openalex.org/W3041106862","https://openalex.org/W3080778385","https://openalex.org/W3081579781","https://openalex.org/W3087598675","https://openalex.org/W3088158882","https://openalex.org/W3092894005","https://openalex.org/W3093701510","https://openalex.org/W3095906787","https://openalex.org/W3100618950","https://openalex.org/W3111207111","https://openalex.org/W3116631834","https://openalex.org/W3118851201","https://openalex.org/W3127259386","https://openalex.org/W3130687534","https://openalex.org/W3130906579","https://openalex.org/W3131101747","https://openalex.org/W3146579363","https://openalex.org/W3146591907","https://openalex.org/W3156549918","https://openalex.org/W3167216271","https://openalex.org/W3177785038","https://openalex.org/W3184452038","https://openalex.org/W3186384150","https://openalex.org/W3197120522","https://openalex.org/W3202117617","https://openalex.org/W3212562966","https://openalex.org/W3216431848","https://openalex.org/W4200487776","https://openalex.org/W4205869028","https://openalex.org/W4206662285","https://openalex.org/W4220787268","https://openalex.org/W4225568633","https://openalex.org/W4281550744","https://openalex.org/W4293747103","https://openalex.org/W4302028132","https://openalex.org/W4307870433","https://openalex.org/W4309461284","https://openalex.org/W4315928863","https://openalex.org/W4322719147","https://openalex.org/W4324019000","https://openalex.org/W4360946974","https://openalex.org/W6681497794"],"related_works":["https://openalex.org/W4412034994","https://openalex.org/W2161640397","https://openalex.org/W4405075820","https://openalex.org/W7132820527","https://openalex.org/W3216431848","https://openalex.org/W4220787268","https://openalex.org/W3176292789","https://openalex.org/W2195306450","https://openalex.org/W4408750156","https://openalex.org/W7163821484"],"abstract_inverted_index":{"The":[0],"gradual":[1],"accumulation":[2],"and":[3,20,87,96,106],"inadequate":[4],"renewal":[5],"of":[6,37,45,59,72,89,119,128],"senescent":[7,51,104],"cells":[8,15,52,76,105],"over":[9],"time":[10],"drive":[11],"organismal":[12],"aging.":[13],"Senescent":[14,75],"undergo":[16],"altered":[17],"gene":[18],"expression":[19],"release":[21,81],"inflammatory":[22,109],"mediators":[23],"collectively":[24],"termed":[25],"the":[26,43,47,57,68,78,85,117,125,133,144],"senescence-associated":[27],"secretory":[28],"phenotype":[29],"(SASP),":[30],"which":[31],"significantly":[32],"contributes":[33],"to":[34,102],"a":[35],"spectrum":[36],"age-related":[38],"disorders,":[39],"including":[40,62,94],"cancer.":[41,74],"In":[42],"context":[44],"carcinogenesis,":[46],"SASP":[48],"produced":[49],"by":[50],"has":[53],"been":[54],"implicated":[55],"in":[56],"promotion":[58],"epithelial":[60],"cancers,":[61],"oral":[63,73],"squamous":[64],"cell":[65],"carcinoma":[66],"(OSCC),":[67],"most":[69],"common":[70],"form":[71],"within":[77],"tumor":[79],"microenvironment":[80],"factors":[82],"that":[83],"amplify":[84],"growth":[86],"invasiveness":[88],"neighboring":[90],"cancer":[91,120,139],"cells.":[92],"Senotherapeutics,":[93],"senolytics":[95],"senomorphics,":[97],"emerge":[98],"as":[99],"promising":[100],"modalities":[101],"target":[103],"their":[107],"associated":[108],"factors,":[110],"thereby":[111],"opening":[112],"novel":[113],"avenues":[114],"for":[115],"augmenting":[116],"efficacy":[118],"treatments.":[121],"Here,":[122],"we":[123],"review":[124],"general":[126],"aspects":[127],"cellular":[129,148],"senescence,":[130],"focusing":[131],"on":[132],"relation":[134],"between":[135],"senescence-related":[136],"inflammation":[137],"with":[138,150],"development.":[140],"We":[141],"also":[142],"analyze":[143],"available":[145],"evidence":[146],"linking":[147],"senescence":[149],"OSCC,":[151],"highlighting":[152],"possible":[153],"clinical":[154],"applications.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-13T00:00:00"}