{"id":"https://openalex.org/W4387562913","doi":"https://doi.org/10.2478/enr-2023-0025","title":"Identification of DNA methylation of CAPN10 gene changes in the patients with type 2 diabetes mellitus as a predictive biomarker instead of HbA1c, random blood sugar, lipid profile, kidney function test, and some risk factors","display_name":"Identification of DNA methylation of CAPN10 gene changes in the patients with type 2 diabetes mellitus as a predictive biomarker instead of HbA1c, random blood sugar, lipid profile, kidney function test, and some risk factors","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387562913","doi":"https://doi.org/10.2478/enr-2023-0025","pmid":"https://pubmed.ncbi.nlm.nih.gov/37823570"},"language":"en","primary_location":{"id":"doi:10.2478/enr-2023-0025","doi":"https://doi.org/10.2478/enr-2023-0025","is_oa":true,"landing_page_url":"https://doi.org/10.2478/enr-2023-0025","pdf_url":"https://sciendo.com/pdf/10.2478/enr-2023-0025","source":{"id":"https://openalex.org/S7498391","display_name":"Endocrine Regulations","issn_l":"1210-0668","issn":["1210-0668","1336-0329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Regulations","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://sciendo.com/pdf/10.2478/enr-2023-0025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042948384","display_name":"Harem Othman Smail","orcid":"https://orcid.org/0000-0001-9867-4289","observed_orcids":["https://orcid.org/0000-0001-9867-4289"]},"institutions":[{"id":"https://openalex.org/I4896460","display_name":"Koya University","ror":"https://ror.org/017pq0w72","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4896460"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Harem Othman Smail","raw_affiliation_strings":["Department of Biology, Faculty of Science and Health , Koya University , Koya KOY45, Kurdistan Region \u2013 F.R. Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science and Health , Koya University , Koya KOY45, Kurdistan Region \u2013 F.R. Iraq","institution_ids":["https://openalex.org/I4896460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024480600","display_name":"Dlnya Mohamad","orcid":"https://orcid.org/0000-0002-4201-0501","observed_orcids":["https://orcid.org/0000-0002-4201-0501"]},"institutions":[{"id":"https://openalex.org/I64952554","display_name":"University of Sulaimani","ror":"https://ror.org/00saanr69","country_code":"IQ","type":"education","lineage":["https://openalex.org/I64952554"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Dlnya Asaad Mohamad","raw_affiliation_strings":["Department of Biology, College of Science , University of Sulaimani , Sulaymanyah , Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science , University of Sulaimani , Sulaymanyah , Iraq","institution_ids":["https://openalex.org/I64952554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042948384"],"corresponding_institution_ids":["https://openalex.org/I4896460"],"apc_list":null,"apc_paid":null,"fwci":0.3708,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4490543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"57","issue":"1","first_page":"221","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8420000076293945},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.828000009059906},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.859000027179718},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8809999823570251},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.7704291939735413},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7488492727279663},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7019018530845642},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6280574798583984},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5515397787094116},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5139086246490479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5049307942390442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5036167502403259},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.49002182483673096},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4709761142730713},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4318038821220398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.397023469209671},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36841878294944763},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3633631467819214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29478147625923157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23115882277488708},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16209641098976135},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011236","descriptor_name":"Prediabetic State","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2478/enr-2023-0025","doi":"https://doi.org/10.2478/enr-2023-0025","is_oa":true,"landing_page_url":"https://doi.org/10.2478/enr-2023-0025","pdf_url":"https://sciendo.com/pdf/10.2478/enr-2023-0025","source":{"id":"https://openalex.org/S7498391","display_name":"Endocrine Regulations","issn_l":"1210-0668","issn":["1210-0668","1336-0329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Regulations","raw_type":"journal-article"},{"id":"pmid:37823570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37823570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine regulations","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f8adf1ea890942a78326a6f80c346230","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8adf1ea890942a78326a6f80c346230","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrine Regulations, Vol 57, Iss 1, Pp 221-234 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2478/enr-2023-0025","doi":"https://doi.org/10.2478/enr-2023-0025","is_oa":true,"landing_page_url":"https://doi.org/10.2478/enr-2023-0025","pdf_url":"https://sciendo.com/pdf/10.2478/enr-2023-0025","source":{"id":"https://openalex.org/S7498391","display_name":"Endocrine Regulations","issn_l":"1210-0668","issn":["1210-0668","1336-0329"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Regulations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387562913.pdf","grobid_xml":"https://content.openalex.org/works/W4387562913.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2088948992","https://openalex.org/W2103714979","https://openalex.org/W2105093768","https://openalex.org/W2158567066","https://openalex.org/W2201264930","https://openalex.org/W2486962364","https://openalex.org/W2602591558","https://openalex.org/W2768540056","https://openalex.org/W2794434809","https://openalex.org/W2902576384","https://openalex.org/W2922331630","https://openalex.org/W2939354927","https://openalex.org/W2939633281","https://openalex.org/W2984757304","https://openalex.org/W2987802490","https://openalex.org/W3011491737","https://openalex.org/W3022154971","https://openalex.org/W3038861232","https://openalex.org/W3045445851","https://openalex.org/W3080885753","https://openalex.org/W4200106583","https://openalex.org/W4205805562","https://openalex.org/W4220969504","https://openalex.org/W4224979909","https://openalex.org/W4281609546"],"related_works":["https://openalex.org/W4360981536","https://openalex.org/W4281609546","https://openalex.org/W3210452762","https://openalex.org/W6991746068","https://openalex.org/W4400681313","https://openalex.org/W4396976798","https://openalex.org/W2093571914","https://openalex.org/W2996260410","https://openalex.org/W2736331890","https://openalex.org/W4362673659"],"abstract_inverted_index":{"Abstract":[0],"Objective.":[1],"Nowadays,":[2],"type":[3],"2":[4],"diabetes":[5,73,169],"mellitus":[6],"(T2DM)":[7],"is":[8],"the":[9,28,41,51,92,102,161,165,168,175,183,199,211],"most":[10],"common":[11],"chronic":[12],"endocrine":[13],"disorder,":[14],"affecting":[15],"an":[16],"estimated":[17],"5\u201310%":[18],"of":[19,107,140,145,167,185],"adults":[20],"worldwide":[21],"and":[22,50,60,79,98,123,132,142,170,194],"this":[23,228,235],"disease":[24],"rapidly":[25],"increases":[26],"in":[27,40,48,101,160,164,191,198,210],"Kurdistan":[29,105],"region":[30,106,125,163,215],"population.":[31],"This":[32],"research":[33],"aims":[34],"to":[35,174,224,233],"identify":[36],"DNA":[37,54,111,156,186,207],"methylation":[38,55,112,208],"change":[39],"CPAN10":[42],"gene":[43,213],"as":[44,189,219],"a":[45,143,220],"predictive":[46,222],"biomarker":[47,223],"T2DM":[49],"association":[52],"between":[53,96],"status":[56],"with":[57,117],"lipid":[58],"profile":[59],"kidney":[61],"function":[62],"test.":[63],"Methods.":[64],"The":[65,83,128,151],"participants":[66],"(113)":[67],"were":[68,135],"divided":[69],"into":[70],"three":[71],"groups:":[72],"group":[74,77,81,177,193],"(47),":[75],"prediabetes":[76,171,192],"(36),":[78],"control":[80,200],"(30).":[82],"study":[84,229],"was":[85,126,147,158],"carried":[86],"out":[87],"on":[88],"patients":[89],"who":[90],"visited":[91],"private":[93],"clinical":[94],"sectors":[95],"August":[97],"December":[99],"2021":[100],"Koya":[103],"city":[104],"Iraq.":[108],"To":[109],"determine":[110],"status,":[113],"methylation-specific":[114],"PCR":[115],"(MPS)":[116],"paired":[118],"primer":[119],"for":[120,137],"each":[121],"methylated":[122],"unmethylated":[124],"used.":[127],"Mann-Whitney":[129],"U":[130],"test":[131],"Spearman\u2019s":[133],"correlation":[134],"performed":[136],"statistical":[138],"analysis":[139],"data":[141,232],"value":[144],"p<0.05":[146],"considered":[148],"significant.":[149],"Results.":[150],"obtained":[152],"results":[153,204],"show":[154],"that":[155,206],"hypermethylation":[157],"recorded":[159],"promoter":[162,214],"samples":[166],"groups":[172],"compared":[173],"healthy":[176],"(control).":[178],"Various":[179],"factors":[180],"also":[181],"affected":[182],"level":[184],"methylation,":[187],"such":[188],"HbA1c":[190],"body":[195],"mass":[196],"index":[197],"group.":[201],"Conclusion.":[202],"These":[203],"indicate":[205],"changes":[209],"CAPN10":[212],"may":[216],"be":[217],"used":[218],"potential":[221],"diagnose":[225],"T2DM;":[226],"however,":[227],"requires":[230],"further":[231],"support":[234],"evidence.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-13T00:00:00"}