{"id":"https://openalex.org/W4387516301","doi":null,"title":"Luteolin overcomes acquired resistance to osimertinib in non-small cell lung cancer cells by targeting the HGF-MET-Akt pathway.","display_name":"Luteolin overcomes acquired resistance to osimertinib in non-small cell lung cancer cells by targeting the HGF-MET-Akt pathway.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387516301","pmid":"https://pubmed.ncbi.nlm.nih.gov/37818074","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560942"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073983362","display_name":"Guodong Huang","orcid":"https://orcid.org/0000-0002-2848-7581","observed_orcids":["https://orcid.org/0000-0002-2848-7581","https://orcid.org/0009-0001-5574-6016"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guodong Huang","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020594075","display_name":"Xinning Liu","orcid":"https://orcid.org/0000-0001-9035-2189","observed_orcids":["https://orcid.org/0000-0001-9035-2189"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinning Liu","raw_affiliation_strings":["Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101937579","display_name":"Ting Jiang","orcid":"https://orcid.org/0000-0001-6431-4744","observed_orcids":["https://orcid.org/0000-0001-6431-4744"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Jiang","raw_affiliation_strings":["Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818060","display_name":"Yufeng Cao","orcid":"https://orcid.org/0000-0002-4273-4358","observed_orcids":["https://orcid.org/0000-0002-4273-4358"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufeng Cao","raw_affiliation_strings":["Cancer Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingyu Sang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyu Sang","raw_affiliation_strings":["Preventive Treatment Department, Shouguang Hospital of Traditional Chinese Medicine Weifang 262799, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Preventive Treatment Department, Shouguang Hospital of Traditional Chinese Medicine Weifang 262799, Shandong, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109659057","display_name":"Xiaomeng Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaomeng Song","raw_affiliation_strings":["Department of Pharmacology, School of Basic Medical Sciences, Shandong University Jinan 250012, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Basic Medical Sciences, Shandong University Jinan 250012, Shandong, PR China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111137422","display_name":"Baochen Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baochen Zhou","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024189714","display_name":"Honglin Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honglin Qu","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054110227","display_name":"Houhao Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Houhao Cai","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113020422","display_name":"Daijun Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daijun Xing","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102549274","display_name":"Yuecheng Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuecheng Mao","raw_affiliation_strings":["School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine Jinan 250355, Shandong, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057277301","display_name":"Gaoyang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoyang Lin","raw_affiliation_strings":["Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034228710","display_name":"Xiantao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210159257","display_name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/052q26725","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159257"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiantao Liu","raw_affiliation_strings":["Department of Respiratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, PR China","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210159257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050958919","display_name":"Xin Zheng","orcid":"https://orcid.org/0000-0003-1414-1755","observed_orcids":["https://orcid.org/0000-0003-1414-1755"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zheng","raw_affiliation_strings":["Cancer Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China","institution_ids":["https://openalex.org/I108688024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2201,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.93060918,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"4145","last_page":"4162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9639999866485596},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.968999981880188},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.843999981880188},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.5910000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/met-phosphorylation","display_name":"MET phosphorylation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.640999972820282},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.9409091472625732},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.7594120502471924},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.6287133097648621},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6255044341087341},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6240237355232239},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.49253353476524353},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.46143198013305664},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4423925280570984},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41655001044273376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4047780930995941},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.38676345348358154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30021780729293823},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.15499722957611084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14346659183502197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1368831992149353},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.12642627954483032},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.057267993688583374},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10560942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37818074","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37818074","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1462606079","https://openalex.org/W1518930887","https://openalex.org/W1925720400","https://openalex.org/W1998971866","https://openalex.org/W2042331042","https://openalex.org/W2062110561","https://openalex.org/W2069213289","https://openalex.org/W2102748761","https://openalex.org/W2111662961","https://openalex.org/W2114953089","https://openalex.org/W2131487381","https://openalex.org/W2140584796","https://openalex.org/W2154149901","https://openalex.org/W2166084034","https://openalex.org/W2171139285","https://openalex.org/W2184779060","https://openalex.org/W2240638205","https://openalex.org/W2265160193","https://openalex.org/W2413097448","https://openalex.org/W2416111151","https://openalex.org/W2560717039","https://openalex.org/W2563499062","https://openalex.org/W2564838688","https://openalex.org/W2605556058","https://openalex.org/W2618442076","https://openalex.org/W2739786760","https://openalex.org/W2770828094","https://openalex.org/W2790922923","https://openalex.org/W2792821195","https://openalex.org/W2795708883","https://openalex.org/W2804636211","https://openalex.org/W2890599782","https://openalex.org/W2891909134","https://openalex.org/W2899325153","https://openalex.org/W2911642225","https://openalex.org/W2917968580","https://openalex.org/W2973691417","https://openalex.org/W2976334328","https://openalex.org/W2994352857","https://openalex.org/W3013637791","https://openalex.org/W3038129235","https://openalex.org/W3096869785","https://openalex.org/W3118321568","https://openalex.org/W3124270040","https://openalex.org/W3128646645","https://openalex.org/W3132131035","https://openalex.org/W3148970978","https://openalex.org/W3159143889","https://openalex.org/W3165164686","https://openalex.org/W4211193262","https://openalex.org/W4212946897","https://openalex.org/W4221009599","https://openalex.org/W4296354708","https://openalex.org/W4297459500"],"related_works":["https://openalex.org/W3138966469","https://openalex.org/W3203200317","https://openalex.org/W2995877501","https://openalex.org/W2991384275","https://openalex.org/W2954806866","https://openalex.org/W2981709525","https://openalex.org/W4393095426","https://openalex.org/W4415618205","https://openalex.org/W3003578668","https://openalex.org/W4317388031"],"abstract_inverted_index":{"Osimertinib,":[0],"a":[1,39,44],"third-generation":[2],"epidermal":[3],"growth":[4,241],"factor":[5,158,242],"receptor":[6],"tyrosine":[7],"kinase":[8,133],"inhibitor":[9],"(EGFR-TKI),":[10],"has":[11,51],"overcome":[12,257],"the":[13,23,64,70,88,112,143,173,187,190,195,201,222,232,236,244,268,272],"acquired":[14,34,81,262,284],"resistance":[15,35,165,263],"of":[16,73,90,104,114,138,148,167,178,189,198,204,212,225,238,247,275],"first-":[17],"and":[18,86,92,95,102,116,132,140,146,151,161,175,180,206,227,260],"second-generation":[19],"EGFR-TKIs":[20],"due":[21],"to":[22,36,256,264],"EGFR":[24],"T790M":[25],"mutation":[26],"in":[27,55,75,96,280],"non-small":[28],"cell":[29,83],"lung":[30],"cancer":[31],"(NSCLC).":[32],"However,":[33],"osimertinib":[37,74,93,117,141,207,255,265,279],"remains":[38],"significant":[40],"clinical":[41,273],"challenge.":[42],"Luteolin,":[43],"natural":[45,65],"flavonoid":[46,66],"from":[47],"traditional":[48],"Chinese":[49],"medicine,":[50],"exerted":[52],"antitumor":[53,71],"effects":[54,72,89,120,197],"various":[56],"tumors.":[57],"In":[58,249],"this":[59],"study,":[60],"we":[61],"investigated":[62,122],"whether":[63],"luteolin":[67,91,115,139,205,251,277],"can":[68,252],"enhance":[69],"NSCLC":[76,281],"cells.":[77,106,169],"We":[78,154],"established":[79],"an":[80],"osimertinib-resistant":[82],"line,":[84],"H1975/OR,":[85],"evaluated":[87],"alone":[94],"combination":[97,113,137,171,233],"on":[98,200],"proliferation,":[99,144],"migration,":[100,145],"invasion,":[101],"apoptosis":[103],"H1975/OR":[105,149,168],"The":[107,136,170],"potential":[108,274],"mechanisms":[109,166],"by":[110,123,210,220,266],"which":[111],"exert":[118],"their":[119],"were":[121,208],"PCR,":[124],"western":[125],"blot,":[126],"gene":[127,174],"silencing,":[128],"molecular":[129],"docking,":[130],"SPR":[131],"activity":[134],"analysis.":[135],"inhibited":[142,181],"invasion":[147],"cells":[150],"promoted":[152],"apoptosis.":[153],"identified":[155],"mesenchymal-epithelial":[156],"transition":[157],"(MET)":[159],"amplification":[160,259],"overactivation":[162],"as":[163],"important":[164],"downregulated":[172,235],"protein":[176,183],"expression":[177,237],"MET":[179,199,219,226,258],"its":[182,229],"phosphorylation,":[184],"thereby":[185],"blocking":[186],"activation":[188],"downstream":[191],"Akt":[192],"pathway.":[193],"Additionally,":[194],"mediated":[196],"synergistic":[202],"effect":[203],"confirmed":[209],"silencing":[211],"MET.":[213,248],"Luteolin":[214],"strongly":[215],"bound":[216],"with":[217,254,278,283],"nonphosphorylated":[218],"occupying":[221],"active":[223],"pocket":[224],"inhibiting":[228],"activation.":[230],"Notably,":[231],"also":[234],"autocrine":[239],"hepatocyte":[240],"(HGF),":[243],"sole":[245],"ligand":[246],"conclusion,":[250],"synergize":[253],"overactivation-induced":[261],"suppressing":[267],"HGF-MET-Akt":[269],"pathway,":[270],"suggesting":[271],"combining":[276],"patients":[282],"resistance.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-12T00:00:00"}
