{"id":"https://openalex.org/W4387516253","doi":null,"title":"Construction and experimental validation of a necroptosis-related lncRNA signature as a prognostic model and immune-landscape predictor for lung adenocarcinoma.","display_name":"Construction and experimental validation of a necroptosis-related lncRNA signature as a prognostic model and immune-landscape predictor for lung adenocarcinoma.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387516253","pmid":"https://pubmed.ncbi.nlm.nih.gov/37818057","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560937"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560937","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560937/pdf/ajcr0013-4418.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560937/pdf/ajcr0013-4418.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100785382","display_name":"Tongtong Zhang","orcid":"https://orcid.org/0000-0002-1121-021X","observed_orcids":["https://orcid.org/0000-0002-1121-021X"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongtong Zhang","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052597405","display_name":"Ruoxuan Hei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoxuan Hei","raw_affiliation_strings":["Department of Clinical Diagnose, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Diagnose, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102566028","display_name":"Yue Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Huang","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jingjin Shao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjin Shao","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402917","display_name":"Min Zhang","orcid":"https://orcid.org/0000-0002-4863-9431","observed_orcids":["https://orcid.org/0000-0002-4863-9431"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043753512","display_name":"Kai Feng","orcid":"https://orcid.org/0000-0002-2348-1551","observed_orcids":["https://orcid.org/0000-0002-2348-1551"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Feng","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100310326","display_name":"Weishen Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weishen Qian","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Simin Li","raw_affiliation_strings":["Department of Clinical Diagnose, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Diagnose, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045169479","display_name":"Faguang Jin","orcid":"https://orcid.org/0000-0002-2466-3306","observed_orcids":["https://orcid.org/0000-0002-2466-3306"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Faguang Jin","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101563072","display_name":"Yanwei Chen","orcid":"https://orcid.org/0000-0002-7879-9567","observed_orcids":["https://orcid.org/0000-0002-7879-9567"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwei Chen","raw_affiliation_strings":["Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China","Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The 1st Affiliated Hospital of Shenzhen University Shenzhen 518035, Guangdong, PR China","institution_ids":["https://openalex.org/I180726961"]},{"raw_affiliation_string":"Department of Pulmonary Critical Care Medicine, The Second Affiliated Hospital of The Air Force Military Medical University Xinsi Road 569, Xi'an 710038, Shaanxi, PR China","institution_ids":["https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0937,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30856647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"13","issue":"9","first_page":"4418","last_page":"4433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lncrna-signature","display_name":"lncRNA signature","score":0.9330000281333923},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9089999794960022},{"id":"https://openalex.org/keywords/immune-landscape","display_name":"immune landscape","score":0.5170000195503235},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.8686217665672302},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6313781142234802},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5634743571281433},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5056970119476318},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4732528328895569},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4519398808479309},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.44780433177948},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4388730227947235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4282628297805786},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.412270188331604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40092480182647705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37791210412979126},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.338525652885437},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29964929819107056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28751611709594727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2840786576271057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2226976454257965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0703732967376709}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10560937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560937","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560937/pdf/ajcr0013-4418.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37818057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37818057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560937","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560937","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560937/pdf/ajcr0013-4418.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G485655840","display_name":"\u91cd\u53e0\u7efc\u5408\u75c7\u6a21\u5f0f\u4f4e\u6c27\u901a\u8fc7S1P/HDAC\u4fe1\u53f7\u8c03\u63a7\u80ba\u90e8\u708e\u75c7\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"82070096","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387516253.pdf","grobid_xml":"https://content.openalex.org/works/W4387516253.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1604468403","https://openalex.org/W1991235944","https://openalex.org/W2067337865","https://openalex.org/W2068762252","https://openalex.org/W2480295405","https://openalex.org/W2743021819","https://openalex.org/W2784371446","https://openalex.org/W2799741346","https://openalex.org/W2884358841","https://openalex.org/W2884660762","https://openalex.org/W2885079199","https://openalex.org/W2913505546","https://openalex.org/W2926636056","https://openalex.org/W2933413627","https://openalex.org/W2947880033","https://openalex.org/W2948362628","https://openalex.org/W2971126595","https://openalex.org/W2981309703","https://openalex.org/W2994939246","https://openalex.org/W3025785934","https://openalex.org/W3090765459","https://openalex.org/W3119303442","https://openalex.org/W3129625873","https://openalex.org/W3134538437","https://openalex.org/W3135074908","https://openalex.org/W3135265714","https://openalex.org/W3172850928","https://openalex.org/W3189051007","https://openalex.org/W3189912075","https://openalex.org/W3192493086","https://openalex.org/W3199917967","https://openalex.org/W3203014445","https://openalex.org/W3210249046","https://openalex.org/W3215965581","https://openalex.org/W4200492378","https://openalex.org/W4206488741","https://openalex.org/W4206841660","https://openalex.org/W4206897947"],"related_works":["https://openalex.org/W4403879033","https://openalex.org/W4296095886","https://openalex.org/W4221043859","https://openalex.org/W4225156100","https://openalex.org/W4307380436","https://openalex.org/W4213358210","https://openalex.org/W4294941559","https://openalex.org/W4286698769","https://openalex.org/W4296112820","https://openalex.org/W3195013504"],"abstract_inverted_index":{")":[0],"can":[1],"predict":[2],"the":[3,11,20],"prognosis":[4],"of":[5,24],"LUAD":[6],"and":[7,22],"are":[8],"associated":[9],"with":[10],"immune":[12],"response.":[13],"This":[14],"will":[15],"provide":[16],"new":[17],"insights":[18],"into":[19],"pathogenesis":[21],"development":[23],"therapies":[25],"for":[26],"LUAD.":[27]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-12T00:00:00"}