{"id":"https://openalex.org/W4387516048","doi":null,"title":"Normoblastemia in COVID-19 patients is associated with more severe disease and adverse outcome.","display_name":"Normoblastemia in COVID-19 patients is associated with more severe disease and adverse outcome.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387516048","pmid":"https://pubmed.ncbi.nlm.nih.gov/37818385","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560885"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560885","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560885/pdf/ijcep0016-0235.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560885/pdf/ijcep0016-0235.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010930697","display_name":"Kenneth Ofori","orcid":"https://orcid.org/0000-0002-4422-2882","observed_orcids":["https://orcid.org/0000-0002-4422-2882"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Ofori","raw_affiliation_strings":["Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051642696","display_name":"Diane Chen","orcid":"https://orcid.org/0000-0002-7302-9248","observed_orcids":["https://orcid.org/0000-0002-7302-9248"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Chen","raw_affiliation_strings":["Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009268016","display_name":"Jorge L. Sepulveda","orcid":"https://orcid.org/0000-0002-5577-9766","observed_orcids":["https://orcid.org/0000-0002-5577-9766"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Sepulveda","raw_affiliation_strings":["Department of Pathology, George Washington University Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, George Washington University Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014966517","display_name":"Govind Bhagat","orcid":"https://orcid.org/0000-0001-6250-048X","observed_orcids":["https://orcid.org/0000-0001-6250-048X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Govind Bhagat","raw_affiliation_strings":["Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040458965","display_name":"Bachir Alobeid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bachir Alobeid","raw_affiliation_strings":["Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18308694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"9","first_page":"235","last_page":"242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12796","display_name":"Dermatological and COVID-19 studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.781000018119812},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6060000061988831},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.5600000023841858},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7910000085830688},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/red-blood-cell-indices","display_name":"red blood cell indices","score":0.7039999961853027},{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.8379999995231628},{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.6299999952316284},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4129999876022339},{"id":"https://openalex.org/keywords/neutrophilia","display_name":"neutrophilia","score":0.5270000100135803},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hypoxemia","display_name":"hypoxemia","score":0.453000009059906},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7577497363090515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6772891283035278},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6309105753898621},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6204747557640076},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.6098584532737732},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.5306963324546814},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4388105571269989},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3393549621105194},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28839099407196045},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.22332942485809326},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.17525821924209595},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.07491600513458252},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10560885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560885","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560885/pdf/ijcep0016-0235.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:37818385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37818385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560885","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560885/pdf/ijcep0016-0235.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387516048.pdf","grobid_xml":"https://content.openalex.org/works/W4387516048.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1980584303","https://openalex.org/W2110541175","https://openalex.org/W3008827533","https://openalex.org/W3010625438","https://openalex.org/W3012566693","https://openalex.org/W3013959692","https://openalex.org/W3035856107","https://openalex.org/W3037185429","https://openalex.org/W3041142586","https://openalex.org/W3043040397","https://openalex.org/W3046496943","https://openalex.org/W3048520527","https://openalex.org/W3070884292","https://openalex.org/W3084050822","https://openalex.org/W3085260439","https://openalex.org/W3093590774","https://openalex.org/W3174033189","https://openalex.org/W4220847144"],"related_works":["https://openalex.org/W3198790476","https://openalex.org/W6968392264","https://openalex.org/W3141145306","https://openalex.org/W3085317665","https://openalex.org/W3097808366","https://openalex.org/W3171097358","https://openalex.org/W4220847144","https://openalex.org/W4283761566","https://openalex.org/W3151265317","https://openalex.org/W4285740677"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,225],"clinical,":[2],"pathological,":[3],"and":[4,73,92,188,200,212,229,237,279],"laboratory":[5],"correlates":[6],"of":[7,23,32,71,77,107,111,227,261,274],"normoblastemia":[8,24,254],"in":[9,25,65,247,264,268],"COVID-19":[10,42,89,112,269],"patients":[11,43],"have":[12],"not":[13],"been":[14],"adequately":[15],"explored.":[16],"We":[17,102],"sought":[18],"to":[19,60,255],"assess":[20],"the":[21,78,87,96,108],"frequency":[22],"COVID-19,":[26],"its":[27],"association":[28],"with":[29,48,272],"other":[30,37],"markers":[31,76,273],"disease,":[33,276],"as":[34,36],"well":[35],"clinical":[38,281],"outcomes.":[39],"METHODS:":[40],"All":[41],"seen":[44],"at":[45,49],"our":[46],"institution":[47],"least":[50],"one":[51],"automated":[52],"complete":[53],"blood":[54],"count":[55,128,215],"(aCBC)":[56],"evaluation":[57],"from":[58],"March":[59],"May":[61],"2020":[62],"were":[63,100,245],"included":[64],"this":[66],"retrospective":[67],"cohort":[68],"analysis.":[69],"Results":[70],"aCBC":[72],"tests":[74],"for":[75],"acute":[79],"phase":[80],"response":[81],"performed":[82],"within":[83],"5":[84],"days":[85,94],"before":[86],"first":[88],"positive":[90,98],"test":[91,99],"14":[93],"after":[95],"last":[97],"reviewed.":[101],"also":[103],"evaluated":[104],"histologic":[105],"features":[106],"reticuloendothelial":[109],"system":[110],"decedents.":[113],"RESULTS:":[114],"quartile)":[115],"WBC":[116],"(15.7":[117],"(11.2,":[118],"23.1)":[119],"u/L":[120,132,219],"vs.":[121,133,144,153,163,172,182,194,207,220,234,242],"8.3":[122],"(6.2,":[123],"11.5)":[124],"u/L),":[125,137],"absolute":[126,213],"neutrophil":[127],"(7.0":[129],"(5.1,":[130],"10.1)":[131],"5.1":[134],"(3.7,":[135],"7.3)":[136],"immature":[138],"granulocyte":[139],"percentage":[140],"(0.8":[141],"(0.5,":[142],"1.3)%":[143],"0.5":[145],"(0.3,":[146],"0.8)%),":[147],"ESR":[148],"(76.0":[149],"(60.5,":[150],"100.0)":[151],"mm/hr":[152],"66.0":[154],"(45.0,":[155],"87.0)":[156],"mm/hr),":[157],"ferritin":[158],"(1404.5":[159],"(645.0,":[160],"2871.0)":[161],"ng/mL":[162],"672.7":[164],"(313.4,":[165],"1348.0)":[166],"ng/mL),":[167],"INR":[168],"(1.4":[169],"(1.2,":[170],"1.7)":[171],"1.2":[173],"(1.1,":[174],"1.3)),":[175],"D-dimer":[176],"(8.2":[177],"(2.8,":[178],"20.0)":[179],"ug/mL":[180],"FEU":[181],"1.5":[183],"(0.8,":[184,222],"3.7)":[185],"\u00b5g/mL":[186],"FEU),":[187],"IL-6":[189],"(216.6":[190],"(77.7,":[191],"315.0)":[192],"pg/mL":[193],"54.3":[195],"(23.2,":[196],"127.8)":[197],"pg/mL)":[198],"levels,":[199],"lower":[201],"hemoglobin":[202],"(12.5":[203],"(10.7,":[204],"14.2)":[205],"g/dL":[206],"13.2":[208],"(11.8,":[209],"14.6)":[210],"g/dL)":[211],"lymphocyte":[214],"(1.0":[216],"(0.7,":[217],"1.3)":[218],"1.1":[221],"1.5)":[223],"u/L).":[224],"incidence":[226],"intubation":[228],"ventilation":[230],"support":[231],"(61.3%":[232],"(65/106)":[233],"10.5%":[235],"(31/263))":[236],"mortality":[238,263],"rates":[239],"(37.9%,":[240],"271/715":[241],"11.8%,":[243],"210/1786),":[244],"higher":[246],"normoblastemic":[248],"patients.":[249],"Multivariable":[250],"logistic":[251],"regression":[252],"revealed":[253],"be":[256],"an":[257],"independent":[258],"predictive":[259],"biomarker":[260],"short-term":[262],"COVID-19.":[265],"CONCLUSION:":[266],"Normoblastemia":[267],"is":[270],"associated":[271],"severe":[275],"extramedullary":[277],"erythropoiesis,":[278],"adverse":[280],"outcome.":[282]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-12T00:00:00"}