{"id":"https://openalex.org/W4387515951","doi":null,"title":"BMP signaling inhibition overcomes chemoresistance of prostate cancer.","display_name":"BMP signaling inhibition overcomes chemoresistance of prostate cancer.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387515951","pmid":"https://pubmed.ncbi.nlm.nih.gov/37818054","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560954"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560954","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560954","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560954/pdf/ajcr0013-4073.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560954/pdf/ajcr0013-4073.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090959358","display_name":"Chen Xie","orcid":"https://orcid.org/0000-0002-9337-9763","observed_orcids":["https://orcid.org/0000-0002-9337-9763"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Xie","raw_affiliation_strings":["College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437346","display_name":"Zhijun Wang","orcid":"https://orcid.org/0000-0002-1857-4366","observed_orcids":["https://orcid.org/0000-0002-1857-4366"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhijun Wang","raw_affiliation_strings":["Department of Clinical Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, CA 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, University of California Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011509212","display_name":"Yong Ba","orcid":"https://orcid.org/0000-0003-1079-4708","observed_orcids":["https://orcid.org/0000-0003-1079-4708"]},"institutions":[{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Ba","raw_affiliation_strings":["Department of Chemistry and Biochemistry, California State University Los Angeles, CA 90032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, California State University Los Angeles, CA 90032, USA","institution_ids":["https://openalex.org/I27825529"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jose Aguilar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Aguilar","raw_affiliation_strings":["College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083798845","display_name":"Austin Kyan","orcid":"https://orcid.org/0009-0006-2334-3171","observed_orcids":["https://orcid.org/0009-0006-2334-3171"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Kyan","raw_affiliation_strings":["College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049751624","display_name":"Li Zhong","orcid":"https://orcid.org/0000-0001-9522-854X","observed_orcids":["https://orcid.org/0000-0001-9522-854X"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Zhong","raw_affiliation_strings":["College of Osteopathic Medicine of the Pacific, Western University of Health Sciences Pomona, CA 91766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046138088","display_name":"Jijun Hao","orcid":"https://orcid.org/0000-0002-6769-9069","observed_orcids":["https://orcid.org/0000-0002-6769-9069"]},"institutions":[{"id":"https://openalex.org/I93393672","display_name":"Western University of Health Sciences","ror":"https://ror.org/05167c961","country_code":"US","type":"education","lineage":["https://openalex.org/I93393672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jijun Hao","raw_affiliation_strings":["College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA","institution_ids":["https://openalex.org/I93393672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7337,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71802483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"13","issue":"9","first_page":"4073","last_page":"4086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.15029999613761902,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sphere-formation","display_name":"sphere formation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8686174154281616},{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.7955490946769714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7081516981124878},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5597944259643555},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.556998074054718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5174261331558228},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5161224603652954},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5046631097793579},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4651661217212677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34837234020233154},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.22689884901046753}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10560954","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560954","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560954/pdf/ajcr0013-4073.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37818054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37818054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10560954","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560954","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560954/pdf/ajcr0013-4073.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306470","display_name":"Elsa U. Pardee Foundation","ror":"https://ror.org/05sjnvv07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387515951.pdf","grobid_xml":"https://content.openalex.org/works/W4387515951.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W104197529","https://openalex.org/W1616252333","https://openalex.org/W1654102341","https://openalex.org/W1966844804","https://openalex.org/W1998148693","https://openalex.org/W2007421939","https://openalex.org/W2020579083","https://openalex.org/W2025565204","https://openalex.org/W2025851584","https://openalex.org/W2028051779","https://openalex.org/W2046092556","https://openalex.org/W2047307361","https://openalex.org/W2050228244","https://openalex.org/W2051410494","https://openalex.org/W2061794702","https://openalex.org/W2064431569","https://openalex.org/W2071261047","https://openalex.org/W2072929879","https://openalex.org/W2086856480","https://openalex.org/W2097348057","https://openalex.org/W2099853576","https://openalex.org/W2100639629","https://openalex.org/W2102828824","https://openalex.org/W2104877542","https://openalex.org/W2108955823","https://openalex.org/W2112201043","https://openalex.org/W2112451226","https://openalex.org/W2120292596","https://openalex.org/W2121986702","https://openalex.org/W2123868836","https://openalex.org/W2124162994","https://openalex.org/W2128603782","https://openalex.org/W2138795809","https://openalex.org/W2139256061","https://openalex.org/W2148058489","https://openalex.org/W2149972129","https://openalex.org/W2155452177","https://openalex.org/W2165854506","https://openalex.org/W2282947991","https://openalex.org/W2467383595","https://openalex.org/W2522813048","https://openalex.org/W2554565213","https://openalex.org/W2613775504","https://openalex.org/W2626202714","https://openalex.org/W2766694910","https://openalex.org/W2884752855","https://openalex.org/W2885584965","https://openalex.org/W2889336950","https://openalex.org/W2923618138","https://openalex.org/W2982687902","https://openalex.org/W3092237949","https://openalex.org/W3128646645","https://openalex.org/W3203165279","https://openalex.org/W4220711487"],"related_works":["https://openalex.org/W4362596116","https://openalex.org/W4407421722","https://openalex.org/W2102828824","https://openalex.org/W2995202643","https://openalex.org/W2007454530","https://openalex.org/W2106738771","https://openalex.org/W2051528610","https://openalex.org/W2030197665","https://openalex.org/W2564571065","https://openalex.org/W2055831122"],"abstract_inverted_index":{".":[0],"In":[1,29],"addition,":[2],"we":[3],"showed":[4],"that":[5,34],"DMH1":[6],"disrupted":[7],"the":[8,18,24,49,54],"sphere":[9],"formation":[10],"in":[11],"DU145-TxR":[12],"and":[13,16,43],"PC3-TxR":[14],"cells,":[15],"suppressed":[17],"expression":[19],"of":[20,23,56],"marker":[21],"genes":[22],"cancer":[25,41,50],"stem":[26],"cells":[27],"(CSCs).":[28],"conclusion,":[30],"our":[31],"study":[32],"demonstrates":[33],"BMP":[35,44],"signaling":[36,45],"is":[37],"associated":[38],"with":[39],"prostate":[40],"chemoresistance":[42,51],"inhibition":[46],"effectively":[47],"overcomes":[48],"potentially":[52],"through":[53],"disruption":[55],"CSCs'":[57],"stemness.":[58]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-10-12T00:00:00"}