{"id":"https://openalex.org/W4387504591","doi":"https://doi.org/10.1016/j.bcp.2023.115845","title":"CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease","display_name":"CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease","publication_year":2023,"publication_date":"2023-10-10","ids":{"openalex":"https://openalex.org/W4387504591","doi":"https://doi.org/10.1016/j.bcp.2023.115845","pmid":"https://pubmed.ncbi.nlm.nih.gov/37827341"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2023.115845","doi":"https://doi.org/10.1016/j.bcp.2023.115845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bcp.2023.115845","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bcp.2023.115845","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033301683","display_name":"Lingnan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingnan Guo","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039141475","display_name":"Qiang Chen","orcid":"https://orcid.org/0000-0003-0207-484X","observed_orcids":["https://orcid.org/0000-0003-0207-484X"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210095527","display_name":"Zhejiang Provincial Hospital of TCM","ror":"https://ror.org/00mzdyq43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095527"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Chen","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China","Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China","institution_ids":["https://openalex.org/I114539943","https://openalex.org/I4210095527"]},{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025428814","display_name":"Yiyuan Gao","orcid":"https://orcid.org/0000-0002-3090-8912","observed_orcids":["https://orcid.org/0000-0002-3090-8912"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyuan Gao","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015736004","display_name":"Hao Jiang","orcid":"https://orcid.org/0000-0002-7590-953X","observed_orcids":["https://orcid.org/0000-0002-7590-953X"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Jiang","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019171181","display_name":"Feini Zhou","orcid":"https://orcid.org/0000-0002-4336-1880","observed_orcids":["https://orcid.org/0000-0002-4336-1880"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feini Zhou","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082263153","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0002-7178-8320","observed_orcids":["https://orcid.org/0000-0002-7178-8320"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. Electronic address: 417866562@qq.com","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. Electronic address: 417866562@qq.com","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003415305","display_name":"Maosheng Xu","orcid":"https://orcid.org/0000-0002-2396-1600","observed_orcids":["https://orcid.org/0000-0002-2396-1600"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Maosheng Xu","raw_affiliation_strings":["The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. Electronic address: xums166@zcmu.edu.cn","Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China"],"raw_orcid":"https://orcid.org/0000-0002-2396-1600","affiliations":[{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China; Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China. Electronic address: xums166@zcmu.edu.cn","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Key Laboratory of Digestive Pathophysiology of Zhejiang Province, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003415305","https://openalex.org/A5082263153"],"corresponding_institution_ids":["https://openalex.org/I114539943"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":6.3399,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.9748727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"217","issue":null,"first_page":"115845","last_page":"115845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdp-choline","display_name":"CDP-choline","score":0.9670000076293945},{"id":"https://openalex.org/keywords/citicoline","display_name":"citicoline","score":0.968999981880188},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cholinergic-anti-inflammatory-pathway","display_name":"cholinergic anti-inflammatory pathway","score":0.8740000128746033},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.6679999828338623},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/choline-transporter-1","display_name":"choline transporter 1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alpha7-nicotinic-acetylcholine-receptor","display_name":"alpha7 nicotinic acetylcholine receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7870000004768372},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hexanoic-acid","display_name":"hexanoic acid","score":0.949999988079071},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8759999871253967},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.8035999536514282},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6276209354400635},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5430145263671875},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5368018746376038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5215875506401062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5155518054962158},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5027167797088623},{"id":"https://openalex.org/C198399640","wikidata":"https://www.wikidata.org/wiki/Q14863671","display_name":"Choline acetyltransferase","level":3,"score":0.4567803144454956},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4473360478878021},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43729352951049805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.377011239528656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3038586974143982},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.301357239484787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2751580476760864},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.20512527227401733},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1006607711315155},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003566","descriptor_name":"Cytidine Diphosphate Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003566","descriptor_name":"Cytidine Diphosphate Choline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcp.2023.115845","doi":"https://doi.org/10.1016/j.bcp.2023.115845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bcp.2023.115845","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:37827341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37827341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bcp.2023.115845","doi":"https://doi.org/10.1016/j.bcp.2023.115845","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bcp.2023.115845","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6408540846","display_name":null,"funder_award_id":"81971600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1413208252","https://openalex.org/W1969507309","https://openalex.org/W1986386190","https://openalex.org/W2001361614","https://openalex.org/W2024346860","https://openalex.org/W2051256772","https://openalex.org/W2073295417","https://openalex.org/W2090201519","https://openalex.org/W2164457162","https://openalex.org/W2166757392","https://openalex.org/W2168682720","https://openalex.org/W2609398719","https://openalex.org/W2767674328","https://openalex.org/W2781999873","https://openalex.org/W2896011713","https://openalex.org/W2924306602","https://openalex.org/W2956799311","https://openalex.org/W2988471964","https://openalex.org/W3006796998","https://openalex.org/W3026140883","https://openalex.org/W3049074705","https://openalex.org/W3092414921","https://openalex.org/W3109043421","https://openalex.org/W3125542745","https://openalex.org/W3133511501","https://openalex.org/W3136109505","https://openalex.org/W3137815362","https://openalex.org/W3156648528","https://openalex.org/W3156847384","https://openalex.org/W3172837896","https://openalex.org/W3178558685","https://openalex.org/W3186603396","https://openalex.org/W3190932060","https://openalex.org/W3201482214","https://openalex.org/W3204521983","https://openalex.org/W3206352177","https://openalex.org/W4220900172","https://openalex.org/W4220950819","https://openalex.org/W4220980261","https://openalex.org/W4221007122","https://openalex.org/W4229447188","https://openalex.org/W4280529994","https://openalex.org/W4281797937","https://openalex.org/W4283391702","https://openalex.org/W4288514112","https://openalex.org/W4293574543","https://openalex.org/W4310038927","https://openalex.org/W4313245713"],"related_works":["https://openalex.org/W4308943724","https://openalex.org/W3049074705","https://openalex.org/W4225397308","https://openalex.org/W2576359618","https://openalex.org/W2040557082","https://openalex.org/W4200169556","https://openalex.org/W4320918862","https://openalex.org/W4220980261","https://openalex.org/W7208465366","https://openalex.org/W3133511501"],"abstract_inverted_index":{"Inflammatory":[0],"bowel":[1],"diseases":[2],"(IBD)":[3],"represent":[4],"chronic":[5],"gastrointestinal":[6],"inflammatory":[7],"disorders":[8],"characterized":[9],"by":[10,86,108,123,214],"a":[11,26,43,80,236],"complex":[12],"and":[13,30,36,50,65,101,106,132,151,164,177,186,217,224,232,239],"underexplored":[14],"pathogenic":[15],"mechanism.":[16],"Previous":[17],"research":[18],"has":[19],"revealed":[20],"that":[21,95,116],"IBD":[22,55,84,169],"patients":[23],"often":[24],"have":[25],"deficiency":[27],"of":[28,68,76,83,127,144,175,190,207,228],"choline":[29,77,129,216],"its":[31,218],"metabolites,":[32],"including":[33],"acetylcholine":[34,147],"(ACh)":[35],"phosphatidylcholine":[37],"(PC),":[38],"within":[39],"the":[40,63,110,120,125,142,153,173,188,205,222,226,229],"colon.":[41,138],"However,":[42],"comprehensive":[44],"study":[45,59,203],"linking":[46],"these":[47],"three":[48],"substances":[49],"their":[51],"mechanistic":[52],"implications":[53],"in":[54,79,103,135,168,193,198],"remains":[56],"lacking.":[57],"This":[58],"aimed":[60],"to":[61,159,209],"investigate":[62],"efficacy":[64],"underlying":[66],"mechanism":[67],"cytidine":[69],"diphosphate":[70],"(CDP)-choline":[71],"(citicoline),":[72],"an":[73],"intermediate":[74],"product":[75],"metabolism,":[78],"mouse":[81],"model":[82],"induced":[85],"dextran":[87],"sulfate":[88],"sodium":[89],"salt":[90],"(DSS).":[91],"The":[92],"results":[93],"demonstrated":[94],"CDP-choline":[96,117,140,181,208],"effectively":[97],"alleviated":[98],"colonic":[99],"inflammation":[100,213],"deficiencies":[102],"choline,":[104],"ACh,":[105],"PC":[107],"increasing":[109],"raw":[111],"material.":[112],"Further":[113],"detection":[114],"showed":[115],"also":[118],"increased":[119,141,187],"ACh":[121],"content":[122,189],"altering":[124],"expression":[126,143],"high-affinity":[128],"transporter":[130],"(ChT1)":[131],"acetylcholinesterase":[133],"(AChE)":[134],"DSS-induced":[136,211],"mice":[137],"Moreover,":[139],"alpha7":[145],"nicotinic":[146],"receptor":[148],"(\u03b17":[149],"nAChR)":[150],"activated":[152],"cholinergic":[154],"anti-inflammatory":[155],"pathway":[156],"(CAP),":[157],"leading":[158],"reduced":[160,182],"colon":[161,212],"macrophage":[162],"activation":[163],"proinflammatory":[165],"M1":[166],"polarization":[167],"mice,":[170],"thus":[171],"reducing":[172],"levels":[174],"TNF-\u03b1":[176],"IL-6.":[178],"In":[179,200],"addition,":[180],"intestinal":[183,230],"ecological":[184],"imbalance":[185],"hexanoic":[191],"acid":[192],"short-chain":[194],"fatty":[195],"acids":[196],"(SCFAs)":[197],"mice.":[199],"conclusion,":[201],"this":[202],"elucidates":[204],"ability":[206],"mitigate":[210],"addressing":[215],"metabolites":[219],"deficiencies,":[220],"activating":[221],"CAP,":[223],"regulating":[225],"composition":[227],"microbiome":[231],"SCFAs":[233],"content,":[234],"providing":[235],"potential":[237],"prophylactic":[238],"therapeutic":[240],"approach":[241],"for":[242],"IBD.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-11T00:00:00"}
