{"id":"https://openalex.org/W4387492000","doi":"https://doi.org/10.21203/rs.3.rs-3372637/v1","title":"Unraveling the Controversy: Transarterial Chemoembolization versus Radiofrequency Ablation in Early Hepatocellular Carcinoma - A Systematic Review and Meta-Analysis","display_name":"Unraveling the Controversy: Transarterial Chemoembolization versus Radiofrequency Ablation in Early Hepatocellular Carcinoma - A Systematic Review and Meta-Analysis","publication_year":2023,"publication_date":"2023-10-10","ids":{"openalex":"https://openalex.org/W4387492000","doi":"https://doi.org/10.21203/rs.3.rs-3372637/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3372637/v1","doi":"https://doi.org/10.21203/rs.3.rs-3372637/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3372637/v1","pdf_url":"https://www.researchsquare.com/article/rs-3372637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3372637/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080226958","display_name":"Mahmoud Shaaban Abdelgalil","orcid":"https://orcid.org/0000-0002-7325-0129","observed_orcids":["https://orcid.org/0000-0002-7325-0129"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":true,"raw_author_name":"Mahmoud Shaban Abdelgalil","raw_affiliation_strings":["Ain-shams University","Cairo University","Fayoum University","Jerash University","Medical Agency for Research and Statistics","Mutah University","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008368454","display_name":"Bahaa Elfakharany","orcid":"https://orcid.org/0009-0004-3046-847X","observed_orcids":["https://orcid.org/0009-0004-3046-847X"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Bahaa Elfakharany","raw_affiliation_strings":["Pharos University","Ain-shams University","Cairo University","Fayoum University","Jerash University","Medical Agency for Research and Statistics","Mutah University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000835170","display_name":"Mohamed El\u2010Samahy","orcid":"https://orcid.org/0000-0002-3517-0822","observed_orcids":["https://orcid.org/0000-0002-3517-0822","https://orcid.org/0000-0003-3822-6788"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Mohamed El-Samahy","raw_affiliation_strings":["Zagazig University","Ain-shams University","Cairo University","Fayoum University","Jerash University","Medical Agency for Research and Statistics","Mutah University","Pharos University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093034944","display_name":"Ibraheem M. lkhawaldeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Ibraheem M. lkhawaldeh","raw_affiliation_strings":["Mutah University","Ain-shams University","Cairo University","Fayoum University","Jerash University","Medical Agency for Research and Statistics","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033460481","display_name":"Neveen Refaey","orcid":"https://orcid.org/0000-0002-4255-5122","observed_orcids":["https://orcid.org/0000-0002-4255-5122"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Neveen Refaey","raw_affiliation_strings":["Cairo University","Ain-shams University","Fayoum University","Jerash University","Medical Agency for Research and Statistics","Mutah University","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113019819","display_name":"Saad Ashraf ALsaad","orcid":"https://orcid.org/0000-0002-2507-1628","observed_orcids":["https://orcid.org/0000-0002-2507-1628"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Saad Ashraf ALsaad","raw_affiliation_strings":["Jerash University","Ain-shams University","Cairo University","Fayoum University","Medical Agency for Research and Statistics","Mutah University","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093034945","display_name":"Dina Alaraby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Dina Alaraby","raw_affiliation_strings":["Medical Agency for Research and Statistics","Ain-shams University","Cairo University","Fayoum University","Jerash University","Mutah University","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050603845","display_name":"Mohamed Abd\u2010ElGawad","orcid":"https://orcid.org/0000-0003-4120-9161","observed_orcids":["https://orcid.org/0000-0003-4120-9161"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I146977602","display_name":"Pharos University in Alexandria","ror":"https://ror.org/04cgmbd24","country_code":"EG","type":"education","lineage":["https://openalex.org/I146977602"]},{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]},{"id":"https://openalex.org/I21173400","display_name":"Mutah University","ror":"https://ror.org/008g9ns82","country_code":"JO","type":"education","lineage":["https://openalex.org/I21173400"]},{"id":"https://openalex.org/I48714440","display_name":"Jerash University","ror":"https://ror.org/047mw5m74","country_code":"JO","type":"education","lineage":["https://openalex.org/I48714440"]},{"id":"https://openalex.org/I66513531","display_name":"Fayoum University","ror":"https://ror.org/023gzwx10","country_code":"EG","type":"education","lineage":["https://openalex.org/I66513531"]}],"countries":["EG","JO"],"is_corresponding":false,"raw_author_name":"Mohamed Abd-ElGawad","raw_affiliation_strings":["Fayoum University","Ain-shams University","Cairo University","Jerash University","Medical Agency for Research and Statistics","Mutah University","Pharos University","Zagazig University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fayoum University","institution_ids":["https://openalex.org/I66513531"]},{"raw_affiliation_string":"Ain-shams University","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Jerash University","institution_ids":["https://openalex.org/I48714440"]},{"raw_affiliation_string":"Medical Agency for Research and Statistics","institution_ids":[]},{"raw_affiliation_string":"Mutah University","institution_ids":["https://openalex.org/I21173400"]},{"raw_affiliation_string":"Pharos University","institution_ids":["https://openalex.org/I146977602"]},{"raw_affiliation_string":"Zagazig University","institution_ids":["https://openalex.org/I192398990"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5080226958"],"corresponding_institution_ids":["https://openalex.org/I107720978","https://openalex.org/I145487455","https://openalex.org/I146977602","https://openalex.org/I192398990","https://openalex.org/I21173400","https://openalex.org/I48714440","https://openalex.org/I66513531"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9440000057220459},{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"radiofrequency ablation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/early-stage-liver-cancer","display_name":"early-stage liver cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9039999842643738},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.972000002861023},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.8629999756813049},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8930000066757202},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.5440000295639038},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.861791729927063},{"id":"https://openalex.org/C2777377203","wikidata":"https://www.wikidata.org/wiki/Q1809554","display_name":"Radiofrequency ablation","level":3,"score":0.8444085121154785},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7891354560852051},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5914633274078369},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5832244157791138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5737829208374023},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5497902631759644},{"id":"https://openalex.org/C2776282453","wikidata":"https://www.wikidata.org/wiki/Q1352293","display_name":"Milan criteria","level":4,"score":0.5222238302230835},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5090162754058838},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.47225919365882874},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4603962302207947},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.440871000289917},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.34084463119506836},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3030870258808136},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2461620569229126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3372637/v1","doi":"https://doi.org/10.21203/rs.3.rs-3372637/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3372637/v1","pdf_url":"https://www.researchsquare.com/article/rs-3372637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3372637/v1","doi":"https://doi.org/10.21203/rs.3.rs-3372637/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3372637/v1","pdf_url":"https://www.researchsquare.com/article/rs-3372637/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387492000.pdf","grobid_xml":"https://content.openalex.org/works/W4387492000.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1472398560","https://openalex.org/W1598602811","https://openalex.org/W1883333379","https://openalex.org/W1901073739","https://openalex.org/W1968812902","https://openalex.org/W1984471249","https://openalex.org/W1986687895","https://openalex.org/W1997131915","https://openalex.org/W2011519790","https://openalex.org/W2035419626","https://openalex.org/W2050859850","https://openalex.org/W2058282345","https://openalex.org/W2075349352","https://openalex.org/W2126087064","https://openalex.org/W2127313936","https://openalex.org/W2133953792","https://openalex.org/W2138536356","https://openalex.org/W2153700824","https://openalex.org/W2170652972","https://openalex.org/W2171673899","https://openalex.org/W2277004004","https://openalex.org/W2315948693","https://openalex.org/W2322165260","https://openalex.org/W2406438510","https://openalex.org/W2514876526","https://openalex.org/W2582878252","https://openalex.org/W2761321759","https://openalex.org/W2761644862","https://openalex.org/W2774659630","https://openalex.org/W2793875195","https://openalex.org/W2801538075","https://openalex.org/W2926131009","https://openalex.org/W2932478128","https://openalex.org/W2944280089","https://openalex.org/W2999073510","https://openalex.org/W3020845468","https://openalex.org/W3092689258","https://openalex.org/W3146142859","https://openalex.org/W3203999475","https://openalex.org/W4220791770","https://openalex.org/W4296992767","https://openalex.org/W4302022990"],"related_works":["https://openalex.org/W3025194658","https://openalex.org/W3083762969","https://openalex.org/W3152589665","https://openalex.org/W4296992767","https://openalex.org/W7116973320","https://openalex.org/W4413196572","https://openalex.org/W4285014362","https://openalex.org/W2999073510","https://openalex.org/W2169838580","https://openalex.org/W3138261282"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Patients":[2],"with":[3,93],"hepatocellular":[4],"carcinoma":[5],"(HCC)":[6],"may":[7],"face":[8],"challenges":[9],"when":[10],"undergoing":[11],"radiofrequency":[12],"ablation":[13],"(RFA)":[14],"if":[15],"their":[16],"tumors":[17],"are":[18],"located":[19],"near":[20],"critical":[21],"liver":[22,39],"regions,":[23],"bile":[24],"ducts,":[25],"bowel":[26],"lumen,":[27],"or":[28,41,101,107,116,209],"diaphragm":[29],"due":[30],"to":[31,62,109,164],"increased":[32],"risk":[33],"of":[34,68,86],"complications.":[35],"In":[36],"these":[37],"cases,":[38],"resection":[40],"transplantation":[42],"is":[43],"not":[44],"possible;":[45],"therefore,":[46],"transarterial":[47],"chemoembolization":[48],"(TACE)":[49],"can":[50],"be":[51],"an":[52],"alternative":[53],"treatment":[54],"for":[55,188,238],"early":[56],"HCC":[57],"patients.":[58],"Our":[59,88],"study":[60],"aims":[61],"compare":[63],"the":[64],"efficacy":[65],"and":[66,84,138,159,234],"safety":[67],"TACE":[69,165],"versus":[70],"RFA.":[71],"Methods":[72],"We":[73],"collected":[74],"data":[75],"from":[76],"different":[77],"sources,":[78],"including":[79],"Cochrane":[80],"Library,":[81],"PubMed,":[82],"Scopus,":[83],"Web":[85],"Science.":[87],"inclusion":[89],"criteria":[90],"were":[91,149],"patients":[92,148],"a":[94],"single":[95],"tumor":[96,135],"less":[97,105],"than":[98,106],"5":[99],"cm":[100,111],"three":[102],"tumors,":[103],"each":[104],"equal":[108],"3":[110],"in":[112,197],"size,":[113],"without":[114],"spread":[115],"invasion.":[117],"The":[118],"review":[119],"examined":[120],"various":[121],"factors":[122],"such":[123],"as":[124],"overall":[125],"survival":[126,129,133],"(OS),":[127],"recurrence-free":[128],"rate":[130,141],"(RFS),":[131],"progression-free":[132],"(PFS),":[134],"response":[136],"(TR),":[137],"adverse":[139],"event":[140],"(AER).":[142],"Results":[143],"Eighteen":[144],"studies,":[145],"involving":[146],"4,537":[147],"reviewed.":[150],"Pooled":[151],"analysis":[152],"revealed":[153],"that":[154],"RFA":[155,213,239],"had":[156],"better":[157,215,232],"three-year":[158,233],"five-year":[160,235],"OS":[161,236],"rates":[162,237],"compared":[163],"(RR":[166,217,240],"=":[167,177,218,225,241,248,251],"0.85,":[168,252],"95%":[169,179,220,243,253],"CI":[170,180,221,244,254],"[0.78,":[171],"0.92],":[172,256],"p":[173,183,224,247,257],"<":[174,184,258],"0.00001;":[175],"RR":[176,250],"0.80,":[178],"[0.73,":[181],"0.89],":[182],"0.0001,":[185],"respectively).":[186,260],"However,":[187],"one-year":[189],"OS,":[190],"no":[191],"significant":[192],"difference":[193],"was":[194],"observed,":[195],"except":[196],"specific":[198],"subgroups":[199],"(patients":[200],"aged":[201],"\u2265":[202,206],"60":[203],"years,":[204],"AFP":[205],"100":[207],"ng/ml,":[208],"received":[210],"Adriamycin),":[211],"where":[212],"showed":[214],"outcomes":[216],"1.02,":[219],"[0.99,":[222],"1.05],":[223],"0.29).":[226],"Propensity":[227],"score-matching":[228],"analyses":[229],"also":[230],"demonstrated":[231],"0.91,":[242],"[0.85,":[245],"0.96],":[246],"0.001;":[249],"[0.79,":[255],"0.001,":[259]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-11T00:00:00"}