{"id":"https://openalex.org/W4387475541","doi":"https://doi.org/10.1101/2023.10.09.561524","title":"G protein subunit G\u03b313-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs","display_name":"G protein subunit G\u03b313-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs","publication_year":2023,"publication_date":"2023-10-10","ids":{"openalex":"https://openalex.org/W4387475541","doi":"https://doi.org/10.1101/2023.10.09.561524"},"language":"en","primary_location":{"id":"doi:10.1101/2023.10.09.561524","doi":"https://doi.org/10.1101/2023.10.09.561524","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2023.10.09.561524","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100709211","display_name":"Yihong Li","orcid":"https://orcid.org/0000-0002-5476-1943","observed_orcids":["https://orcid.org/0000-0002-5476-1943"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Hong Li","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100752152","display_name":"Yi-Sen Yang","orcid":"https://orcid.org/0000-0002-8341-7199","observed_orcids":["https://orcid.org/0000-0002-8341-7199"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Sen Yang","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101254090","display_name":"Yan-Bo Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Bo Xue","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112974294","display_name":"Lei Hao","orcid":"https://orcid.org/0000-0001-8162-4277","observed_orcids":["https://orcid.org/0000-0001-8162-4277"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Lei","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065807955","display_name":"Saisai Zhang","orcid":"https://orcid.org/0000-0002-0603-8873","observed_orcids":["https://orcid.org/0000-0002-0603-8873","https://orcid.org/0000-0003-4391-2619"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sai-Sai Zhang","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027494362","display_name":"Junbin Qian","orcid":"https://orcid.org/0000-0003-1483-1836","observed_orcids":["https://orcid.org/0000-0003-1483-1836"]},"institutions":[{"id":"https://openalex.org/I4210137217","display_name":"Women's Hospital, School of Medicine, Zhejiang University","ror":"https://ror.org/042t7yh44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137217"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junbin Qian","raw_affiliation_strings":["Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China","Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China","Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China","Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 10058, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China","institution_ids":["https://openalex.org/I4210137217","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 10058, P.R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086195538","display_name":"Yushi Yao","orcid":"https://orcid.org/0000-0003-1715-6805","observed_orcids":["https://orcid.org/0000-0003-1715-6805"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yushi Yao","raw_affiliation_strings":["Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University school of Medicine, Hangzhou, Zhejiang 310058, P.R. China","Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University school of Medicine, Hangzhou, Zhejiang 31008, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University school of Medicine, Hangzhou, Zhejiang 310058, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University school of Medicine, Hangzhou, Zhejiang 31008, P.R. China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078014032","display_name":"Ruhong Zhou","orcid":"https://orcid.org/0000-0001-8624-5591","observed_orcids":["https://orcid.org/0000-0001-8624-5591"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruhong Zhou","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","Zhejiang University Shanghai Institute for Advanced Study, Shanghai, Shanghai 201203, P.R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-8624-5591","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Zhejiang University Shanghai Institute for Advanced Study, Shanghai, Shanghai 201203, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015194475","display_name":"Liquan Huang","orcid":"https://orcid.org/0000-0003-3400-0685","observed_orcids":["https://orcid.org/0000-0003-3400-0685"]},"institutions":[{"id":"https://openalex.org/I2801261045","display_name":"Monell Chemical Senses Center","ror":"https://ror.org/01mdfdm06","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801261045"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Liquan Huang","raw_affiliation_strings":["College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","Monell Chemical Senses Center, c, PA 19104, United States","Zhejiang University Shanghai Institute for Advanced Study, Shanghai, Shanghai 201203, P.R. China","College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-3400-0685","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Monell Chemical Senses Center, c, PA 19104, United States","institution_ids":["https://openalex.org/I2801261045"]},{"raw_affiliation_string":"Zhejiang University Shanghai Institute for Advanced Study, Shanghai, Shanghai 201203, P.R. China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 30058, P. R. China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015194475","https://openalex.org/A5078014032"],"corresponding_institution_ids":["https://openalex.org/I2801261045","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuft-cells","display_name":"tuft cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.5709999799728394},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.7160000205039978},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9319999814033508},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7095583081245422},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6961225271224976},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5404809713363647},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4779351055622101},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3818615972995758},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3537329435348511},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33488932251930237},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3224547505378723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3078534007072449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23544692993164062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09153571724891663}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.10.09.561524","doi":"https://doi.org/10.1101/2023.10.09.561524","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2023.10.09.561524","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1496676716","https://openalex.org/W1592727056","https://openalex.org/W1965859904","https://openalex.org/W1976133370","https://openalex.org/W1980544777","https://openalex.org/W1983108533","https://openalex.org/W1983881012","https://openalex.org/W2002949601","https://openalex.org/W2010629543","https://openalex.org/W2014488464","https://openalex.org/W2023939486","https://openalex.org/W2036927671","https://openalex.org/W2037447122","https://openalex.org/W2039583380","https://openalex.org/W2049038291","https://openalex.org/W2049300468","https://openalex.org/W2050308681","https://openalex.org/W2080972001","https://openalex.org/W2086339199","https://openalex.org/W2089885047","https://openalex.org/W2090279335","https://openalex.org/W2092599690","https://openalex.org/W2115156649","https://openalex.org/W2138562836","https://openalex.org/W2139350288","https://openalex.org/W2157649826","https://openalex.org/W2168671905","https://openalex.org/W2169702025","https://openalex.org/W2191813810","https://openalex.org/W2233158352","https://openalex.org/W2278768857","https://openalex.org/W2398160652","https://openalex.org/W2606662408","https://openalex.org/W2767423581","https://openalex.org/W2773304849","https://openalex.org/W2799094919","https://openalex.org/W2802010205","https://openalex.org/W2802153632","https://openalex.org/W2807333794","https://openalex.org/W2884767481","https://openalex.org/W2887886950","https://openalex.org/W2889327866","https://openalex.org/W2893413429","https://openalex.org/W2895548037","https://openalex.org/W2898095365","https://openalex.org/W2898786204","https://openalex.org/W2917132599","https://openalex.org/W2923551021","https://openalex.org/W2955807511","https://openalex.org/W2970228891","https://openalex.org/W2989690151","https://openalex.org/W2999110625","https://openalex.org/W3002202609","https://openalex.org/W3003501994","https://openalex.org/W3005551106","https://openalex.org/W3011692913","https://openalex.org/W3014003872","https://openalex.org/W3082216319","https://openalex.org/W3097328475","https://openalex.org/W3107439198","https://openalex.org/W3158162632","https://openalex.org/W3159762970","https://openalex.org/W3184012559","https://openalex.org/W4214642236","https://openalex.org/W4221000305","https://openalex.org/W4221070479","https://openalex.org/W4224221954","https://openalex.org/W4225398111","https://openalex.org/W4225884586","https://openalex.org/W4233255696","https://openalex.org/W4253646161","https://openalex.org/W4280500609","https://openalex.org/W4281382047","https://openalex.org/W4293161942","https://openalex.org/W4294991033","https://openalex.org/W4296583677","https://openalex.org/W4306804088","https://openalex.org/W4309878957","https://openalex.org/W4313528133","https://openalex.org/W4313892012","https://openalex.org/W4362506319","https://openalex.org/W4378782056","https://openalex.org/W4385488846"],"related_works":["https://openalex.org/W7213652035","https://openalex.org/W4294991033","https://openalex.org/W4416666904","https://openalex.org/W7160898967","https://openalex.org/W7168106030","https://openalex.org/W7161542927","https://openalex.org/W2138642009","https://openalex.org/W4387937477","https://openalex.org/W2033979861","https://openalex.org/W2169717362"],"abstract_inverted_index":{"Abstract":[0],"Tuft":[1],"cells":[2,9,20,75,160],"are":[3],"a":[4],"group":[5],"of":[6,18,52,72,85,99,143,158],"rare":[7],"epithelial":[8,107],"that":[10,69,127],"can":[11],"detect":[12],"pathogenic":[13],"microbes":[14],"and":[15,67,111,121,140,164],"parasites.":[16],"Many":[17],"these":[19,36],"express":[21],"signaling":[22,38,62],"proteins":[23,39],"initially":[24],"found":[25,68],"in":[26,76],"taste":[27,37],"buds.":[28],"It":[29],"is,":[30],"however,":[31],"not":[32],"well":[33],"understood":[34],"how":[35],"contribute":[40],"to":[41,44,49,135,161],"the":[42,45,50,61,70,77,83,86,91,128,144,152,162],"response":[43],"invading":[46],"pathogens":[47],"or":[48],"recovery":[51],"injured":[53,78],"tissues.":[54],"In":[55],"this":[56],"study,":[57],"we":[58],"conditionally":[59],"nullified":[60],"G":[63],"protein":[64],"subunit":[65],"G\u03b313":[66],"number":[71],"ectopic":[73],"tuft":[74,136,159],"lung":[79,100],"was":[80],"reduced":[81],"following":[82],"infection":[84],"influenza":[87],"virus":[88],"H1N1.":[89],"Furthermore,":[90],"infected":[92],"mutant":[93],"mice":[94],"exhibited":[95],"significantly":[96],"larger":[97],"areas":[98],"injury,":[101],"increased":[102,122],"macrophage":[103],"infiltration,":[104],"severer":[105],"pulmonary":[106],"leakage,":[108],"augmented":[109],"pyroptosis":[110],"cell":[112],"death,":[113],"greater":[114],"bodyweight":[115],"loss,":[116],"slower":[117],"recovery,":[118],"worsened":[119],"fibrosis":[120],"fatality.":[123],"Our":[124],"data":[125],"demonstrate":[126],"G\u03b313-mediated":[129],"signal":[130],"transduction":[131],"pathway":[132],"is":[133,151],"critical":[134],"cells-mediated":[137],"inflammation":[138],"resolution":[139,163],"functional":[141],"repair":[142],"damaged":[145],"lungs.To":[146],"our":[147],"best":[148],"knowledge,":[149],"it":[150],"first":[153],"report":[154],"indicating":[155],"subtype-specific":[156],"contributions":[157],"recovery.":[165]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-11T00:00:00"}