{"id":"https://openalex.org/W4387455142","doi":"https://doi.org/10.2147/ndt.s426091","title":"Inhibition of SK Channels in VTA Affects Dopaminergic Neurons to Improve the Depression-Like Behaviors of Post-Stroke Depression Rats","display_name":"Inhibition of SK Channels in VTA Affects Dopaminergic Neurons to Improve the Depression-Like Behaviors of Post-Stroke Depression Rats","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387455142","doi":"https://doi.org/10.2147/ndt.s426091","pmid":"https://pubmed.ncbi.nlm.nih.gov/37840624","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10572402"},"language":"en","primary_location":{"id":"doi:10.2147/ndt.s426091","doi":"https://doi.org/10.2147/ndt.s426091","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s426091","pdf_url":"https://www.dovepress.com/getfile.php?fileID=93335","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=93335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040827252","display_name":"Anqi Wang","orcid":"https://orcid.org/0009-0002-1568-214X","observed_orcids":["https://orcid.org/0009-0002-1568-214X"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Wang","raw_affiliation_strings":["First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0002-1568-214X","affiliations":[{"raw_affiliation_string":"First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yujia Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujia Zhou","raw_affiliation_strings":["Second Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103182365","display_name":"Huangying Chen","orcid":"https://orcid.org/0000-0003-3622-6258","observed_orcids":["https://orcid.org/0000-0003-3622-6258"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huangying Chen","raw_affiliation_strings":["First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-3622-6258","affiliations":[{"raw_affiliation_string":"First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017778147","display_name":"Jiawei Jin","orcid":"https://orcid.org/0009-0006-0442-9914","observed_orcids":["https://orcid.org/0009-0006-0442-9914"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Jin","raw_affiliation_strings":["First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0006-0442-9914","affiliations":[{"raw_affiliation_string":"First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002376525","display_name":"Yingqi Mao","orcid":"https://orcid.org/0000-0002-9748-3031","observed_orcids":["https://orcid.org/0000-0002-9748-3031"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Yingqi Mao","raw_affiliation_strings":["Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9748-3031","affiliations":[{"raw_affiliation_string":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072200582","display_name":"Shuiliang Tao","orcid":"https://orcid.org/0000-0002-4184-4221","observed_orcids":["https://orcid.org/0000-0002-4184-4221"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuiliang Tao","raw_affiliation_strings":["Basic Medicine College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-4184-4221","affiliations":[{"raw_affiliation_string":"Basic Medicine College, Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007388157","display_name":"Tao Qiu","orcid":"https://orcid.org/0000-0002-1410-7795","observed_orcids":["https://orcid.org/0000-0002-1410-7795"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Qiu","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007388157","https://openalex.org/A5072200582"],"corresponding_institution_ids":["https://openalex.org/I114539943"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.7757,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.68751315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"Volume 19","issue":null,"first_page":"2127","last_page":"2139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.23080000281333923,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-conductance-calcium-activated-potassium-channels","display_name":"small conductance calcium-activated potassium channels","score":0.9449999928474426},{"id":"https://openalex.org/keywords/post-stroke-depression","display_name":"post-stroke depression","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apamin","display_name":"apamin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/kcnn3","display_name":"KCNN3","score":1.0},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9440000057220459},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.8330000042915344},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.7851245403289795},{"id":"https://openalex.org/C2776919887","wikidata":"https://www.wikidata.org/wiki/Q417260","display_name":"Apamin","level":3,"score":0.7694504261016846},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6871461272239685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.684112548828125},{"id":"https://openalex.org/C2776707286","wikidata":"https://www.wikidata.org/wiki/Q7233752","display_name":"Post-stroke depression","level":3,"score":0.49202725291252136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4572529196739197},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4458480775356293},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.4258239269256592},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3671705722808838},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.32828545570373535},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.13184460997581482},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12886890769004822}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ndt.s426091","doi":"https://doi.org/10.2147/ndt.s426091","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s426091","pdf_url":"https://www.dovepress.com/getfile.php?fileID=93335","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10572402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10572402","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10572402/pdf/ndt-19-2127.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},{"id":"pmid:37840624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37840624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric disease and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/87226","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/inhibition-of-sk-channels-in-vta-affects-dopaminergic-neurons-to-impro-peer-reviewed-fulltext-article-NDT","pdf_url":"https://www.dovepress.com/article/download/87226","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f8d28312573a4b0e95d0def3fdba21a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f8d28312573a4b0e95d0def3fdba21a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuropsychiatric Disease and Treatment, Vol Volume 19, Pp 2127-2139 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/ndt.s426091","doi":"https://doi.org/10.2147/ndt.s426091","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ndt.s426091","pdf_url":"https://www.dovepress.com/getfile.php?fileID=93335","source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G301891405","display_name":null,"funder_award_id":"81774230","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387455142.pdf","grobid_xml":"https://content.openalex.org/works/W4387455142.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1599756738","https://openalex.org/W1981654563","https://openalex.org/W1993369233","https://openalex.org/W2012070790","https://openalex.org/W2020405692","https://openalex.org/W2042670053","https://openalex.org/W2050677124","https://openalex.org/W2113544881","https://openalex.org/W2114130324","https://openalex.org/W2122289819","https://openalex.org/W2157952220","https://openalex.org/W2168420558","https://openalex.org/W2332243784","https://openalex.org/W2411013142","https://openalex.org/W2587088030","https://openalex.org/W2808339677","https://openalex.org/W2865698779","https://openalex.org/W2921918107","https://openalex.org/W2933452447","https://openalex.org/W2937907669","https://openalex.org/W2946066695","https://openalex.org/W2949707304","https://openalex.org/W2962791178","https://openalex.org/W2972287915","https://openalex.org/W2981585873","https://openalex.org/W2984883300","https://openalex.org/W2996266132","https://openalex.org/W2999249700","https://openalex.org/W3011333179","https://openalex.org/W3011811283","https://openalex.org/W3037934445","https://openalex.org/W3133877026","https://openalex.org/W3134516690","https://openalex.org/W3137177448","https://openalex.org/W3139874924","https://openalex.org/W3191902365","https://openalex.org/W3201511894","https://openalex.org/W3210932179","https://openalex.org/W4205728298","https://openalex.org/W4206452382","https://openalex.org/W4210307893","https://openalex.org/W4212971939","https://openalex.org/W4220915138","https://openalex.org/W4292687316","https://openalex.org/W4301394873","https://openalex.org/W4308440551","https://openalex.org/W4311092728","https://openalex.org/W4315478062","https://openalex.org/W4319870003","https://openalex.org/W4323664862"],"related_works":["https://openalex.org/W4205728298","https://openalex.org/W2546820741","https://openalex.org/W1553597166","https://openalex.org/W2161155137","https://openalex.org/W2012070790","https://openalex.org/W2005987427","https://openalex.org/W6925050722","https://openalex.org/W2797640728","https://openalex.org/W2011890916","https://openalex.org/W4404187293"],"abstract_inverted_index":{"Purpose:":[0],"This":[1,188],"study":[2,189,230],"aimed":[3],"to":[4,92,102,116,135,138,198,245],"investigate":[5],"the":[6,16,22,28,36,42,79,104,110,118,139,143,150,156,168,174,177,211,223,239],"effect":[7],"of":[8,30,38,50,106,120,149,155,170,176,207,228,235,241],"small-conductance":[9],"calcium-activated":[10],"potassium":[11],"channels":[12,158],"(SK":[13],"channels)":[14],"on":[15],"dopaminergic":[17],"(DA)":[18],"neuron":[19],"pathways":[20],"in":[21,94,109,159,167,173,201,210,218],"ventral":[23],"tegmental":[24],"area":[25],"(VTA)":[26],"during":[27],"pathogenesis":[29,237],"post-stroke":[31],"depression":[32,93,136],"(PSD)":[33],"and":[34,46,62,71,152,238],"explore":[35],"improvement":[37],"PSD":[39,140,178,202,219,236,247],"by":[40,221,248],"inhibiting":[41,222],"SK":[43,58,63,121,157,192,224,250],"channels.":[44,225,251],"Patients":[45],"Methods:":[47],"Four":[48],"groups":[49,96],"Sprague-Dawley":[51],"rats":[52,203,220],"were":[53,86,97],"randomly":[54],"divided:":[55],"Control,":[56],"PSD,":[57],"channel":[59,64,122,193],"inhibitor":[60],"(apamin)":[61],"activator":[65],"(CyPPA)":[66],"groups.":[67],"In":[68,78],"both":[69],"control":[70],"CyPPA":[72],"groups,":[73,82],"sham":[74],"surgery":[75],"was":[76,100,114,181],"performed.":[77],"other":[80],"two":[81],"middle":[83],"cerebral":[84],"arteries":[85],"occluded.":[87],"The":[88,125,226],"behavioral":[89,132],"indicators":[90,133],"related":[91,134],"different":[95],"compared.":[98],"Immunofluorescence":[99,162],"used":[101,115],"measure":[103],"activity":[105],"DA":[107,171,208],"neurons":[108,172,209],"VTA,":[111],"while":[112],"qRT-PCR":[113,144],"assess":[117],"expression":[119,148,169,206],"genes.":[123],"Results:":[124],"results":[126,227],"showed":[127],"that":[128,191],"apamin":[129,185],"treatment":[130],"improved":[131,217],"compared":[137],"group.":[141,161],"Furthermore,":[142],"analysis":[145,163],"revealed":[146,164],"differential":[147],"KCNN1":[151],"KCNN3":[153],"subgenes":[154],"each":[160],"an":[165],"increase":[166],"VTA":[175],"group,":[179],"which":[180],"subsequently":[182],"reduced":[183],"upon":[184],"intervention.":[186],"Conclusion:":[187],"suggests":[190],"activation":[194],"following":[195],"stroke":[196],"contributes":[197],"depression-related":[199,214],"behaviors":[200],"through":[204],"increased":[205],"VTA.":[212],"And":[213],"behavior":[215],"is":[216],"this":[229],"provide":[231],"a":[232],"new":[233,243],"understanding":[234],"possibility":[240],"developing":[242],"strategies":[244],"prevent":[246],"targeting":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-10T00:00:00"}