{"id":"https://openalex.org/W4387455035","doi":"https://doi.org/10.25259/jnrp_356_2023","title":"Guidelines for pharmacotherapy in Alzheimer\u2019s disease \u2013 A primer on FDA-approved drugs","display_name":"Guidelines for pharmacotherapy in Alzheimer\u2019s disease \u2013 A primer on FDA-approved drugs","publication_year":2023,"publication_date":"2023-10-07","ids":{"openalex":"https://openalex.org/W4387455035","doi":"https://doi.org/10.25259/jnrp_356_2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/38059250","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10696336"},"language":"en","primary_location":{"id":"doi:10.25259/jnrp_356_2023","doi":"https://doi.org/10.25259/jnrp_356_2023","is_oa":true,"landing_page_url":"https://doi.org/10.25259/jnrp_356_2023","pdf_url":null,"source":{"id":"https://openalex.org/S20361388","display_name":"Journal of Neurosciences in Rural Practice","issn_l":"0976-3147","issn":["0976-3147","0976-3155"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosciences in Rural Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.25259/jnrp_356_2023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010542974","display_name":"Ashvin Varadharajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashvin Varadharajan","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544665","display_name":"Aarjith Damian Davis","orcid":"https://orcid.org/0000-0001-9270-3798","observed_orcids":["https://orcid.org/0000-0001-9270-3798"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aarjith Damian Davis","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000211083","display_name":"Aishwarya Ghosh","orcid":"https://orcid.org/0009-0009-6204-1039","observed_orcids":["https://orcid.org/0009-0009-6204-1039"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aishwarya Ghosh","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054535747","display_name":"Tejaswini Jagtap","orcid":"https://orcid.org/0009-0009-7234-6928","observed_orcids":["https://orcid.org/0009-0009-7234-6928"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tejaswini Jagtap","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109645199","display_name":"Anjo Xavier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjo Xavier","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113009718","display_name":"Anjana Jayakumar Menon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anjana Jayakumar Menon","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104180421","display_name":"Dwaiti Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dwaiti Roy","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073638406","display_name":"Sandhya Gandhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandhya Gandhi","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":null,"display_name":"Thomas Gregor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Thomas Gregor","raw_affiliation_strings":["Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India,","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":6000,"currency":"INR","value_usd":125},"apc_paid":{"value":6000,"currency":"INR","value_usd":125},"fwci":3.8194,"has_fulltext":true,"cited_by_count":135,"citation_normalized_percentile":{"value":0.96308915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"14","issue":"4","first_page":"566","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fda-approved-drugs","display_name":"FDA-approved drugs","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.8090000152587891},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rivastigmine","display_name":"rivastigmine","score":0.996999979019165},{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":1.0},{"id":"https://openalex.org/keywords/brexpiprazole","display_name":"brexpiprazole","score":0.8330000042915344},{"id":"https://openalex.org/keywords/suvorexant","display_name":"suvorexant","score":0.9959999918937683},{"id":"https://openalex.org/keywords/behavioral-and-psychological-symptoms-of-dementia","display_name":"behavioral and psychological symptoms of dementia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7450000047683716},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/disease-modifying-drugs","display_name":"disease-modifying drugs","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9489762187004089},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.6180823445320129},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37463608384132385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22246086597442627}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.25259/jnrp_356_2023","doi":"https://doi.org/10.25259/jnrp_356_2023","is_oa":true,"landing_page_url":"https://doi.org/10.25259/jnrp_356_2023","pdf_url":null,"source":{"id":"https://openalex.org/S20361388","display_name":"Journal of Neurosciences in Rural Practice","issn_l":"0976-3147","issn":["0976-3147","0976-3155"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosciences in Rural Practice","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10696336","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10696336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci Rural Pract","raw_type":"Text"},{"id":"pmid:38059250","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38059250","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosciences in rural practice","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.25259/jnrp_356_2023","doi":"https://doi.org/10.25259/jnrp_356_2023","is_oa":true,"landing_page_url":"https://doi.org/10.25259/jnrp_356_2023","pdf_url":null,"source":{"id":"https://openalex.org/S20361388","display_name":"Journal of Neurosciences in Rural Practice","issn_l":"0976-3147","issn":["0976-3147","0976-3155"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosciences in Rural Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W200409320","https://openalex.org/W1590230654","https://openalex.org/W1968338902","https://openalex.org/W1971057491","https://openalex.org/W1973366052","https://openalex.org/W1974390938","https://openalex.org/W1985528178","https://openalex.org/W1994067502","https://openalex.org/W2001206572","https://openalex.org/W2003439867","https://openalex.org/W2009297217","https://openalex.org/W2016149437","https://openalex.org/W2019924732","https://openalex.org/W2034596923","https://openalex.org/W2045562525","https://openalex.org/W2049771698","https://openalex.org/W2050556307","https://openalex.org/W2054106674","https://openalex.org/W2064721530","https://openalex.org/W2067656054","https://openalex.org/W2088417013","https://openalex.org/W2091425658","https://openalex.org/W2093345349","https://openalex.org/W2108216694","https://openalex.org/W2120296399","https://openalex.org/W2142797329","https://openalex.org/W2148080316","https://openalex.org/W2153790456","https://openalex.org/W2154259512","https://openalex.org/W2160552877","https://openalex.org/W2288040218","https://openalex.org/W2414565701","https://openalex.org/W2442715208","https://openalex.org/W2463733761","https://openalex.org/W2497303700","https://openalex.org/W2783328454","https://openalex.org/W2802724927","https://openalex.org/W2885800496","https://openalex.org/W2923992900","https://openalex.org/W2978677315","https://openalex.org/W2988702876","https://openalex.org/W2992893037","https://openalex.org/W2999676104","https://openalex.org/W3182215044","https://openalex.org/W3191999594","https://openalex.org/W3201901176","https://openalex.org/W3204222713","https://openalex.org/W3208101326","https://openalex.org/W4206055706","https://openalex.org/W4210702981","https://openalex.org/W4210987525","https://openalex.org/W4220730266","https://openalex.org/W4224862282","https://openalex.org/W4284970070","https://openalex.org/W4288428132","https://openalex.org/W4309479679","https://openalex.org/W4310461604","https://openalex.org/W4312087441","https://openalex.org/W4312128797","https://openalex.org/W4328023305"],"related_works":["https://openalex.org/W2601162258","https://openalex.org/W2130035294","https://openalex.org/W4407056373","https://openalex.org/W4231621442","https://openalex.org/W2007611673","https://openalex.org/W2074717668","https://openalex.org/W4297920714","https://openalex.org/W190810406","https://openalex.org/W1969793439","https://openalex.org/W3002887984"],"abstract_inverted_index":{"The":[0,426],"growing":[1],"prevalence":[2],"of":[3,22,24,39,47,54,60,90,106,132,154,161,166,171,268,282,311,317,326,367,391,402,431,441,444,478],"dementia":[4,41,155,190],"makes":[5],"it":[6,140],"important":[7],"for":[8,144,458],"us":[9],"to":[10,18,52,67,186,199,266,303,354,470],"better":[11],"understand":[12],"its":[13],"pathophysiology":[14],"and":[15,26,58,117,124,146,163,169,192,213,215,232,253,319,349,357,359,378,420,454],"treatment":[16,64,131,464,477],"modalities,":[17],"improve":[19],"the":[20,35,43,83,88,91,113,126,130,223,315,365,381,395,429,432,439,455,459,476],"quality":[21],"life":[23],"patients":[25],"caregivers.":[27],"Alzheimer's":[28],"disease":[29,92],"(AD),":[30],"a":[31,72,135,141,182,241,275,308,341,361,400,472],"neurodegenerative":[32],"disease,":[33],"is":[34,49,222,229,263,414],"most":[36,224],"common":[37],"form":[38,366],"amnestic":[40],"in":[42,71,82,104,129,134,189,301,307,352,364,394,408],"geriatric":[44],"population.":[45],"Pathophysiology":[46],"AD":[48,107,133],"widely":[50],"attributed":[51],"aggregation":[53],"amyloid-beta":[55],"(A\u03b2)":[56],"plaques":[57,393],"hyperphosphorylation":[59],"tau":[61],"proteins.":[62],"Initial":[63],"modalities":[65,465],"aimed":[66],"increase":[68],"brain":[69],"perfusion":[70],"non-specific":[73],"manner.":[74],"Subsequent":[75],"therapy":[76,105],"focused":[77],"on":[78,428],"rectifying":[79],"neurotransmitter":[80],"imbalance":[81],"brain.":[84,396],"Newer":[85],"drugs":[86,102,128,374,398],"modify":[87],"progression":[89],"by":[93,112,324,386],"acting":[94],"against":[95,256],"aggregated":[96],"A\u03b2":[97,257,382,392],"plaques.":[98],"However,":[99,259,331],"not":[100],"all":[101],"used":[103,198],"have":[108,297,399,471],"been":[109,298],"granted":[110],"approval":[111],"United":[114],"States":[115],"Food":[116],"Drug":[118],"Administration":[119],"(FDA).":[120],"This":[121],"review":[122],"categorizes":[123],"summarizes":[125],"FDA-approved":[127],"manner":[136],"that":[137,151],"would":[138],"make":[139],"convenient":[142],"reference":[143],"researchers":[145],"practicing":[147],"physicians":[148],"alike.":[149],"Drugs":[150],"mitigate":[152],"symptoms":[153,306],"may":[156,233],"be":[157,234,336,435,468],"categorized":[158],"into":[159],"mitigators":[160,170,175,205],"Behavioral":[162],"Psychological":[164],"Symptoms":[165],"Dementia":[167],"(BPSD),":[168],"cognitive":[172,305],"decline.":[173],"BPSD":[174],"include":[176,206],"brexpiprazole,":[177],"an":[178,194,346,350],"atypical":[179],"antipsychotic":[180],"with":[181,388,410],"once-daily":[183,280,362],"dosage":[184,278,363],"suited":[185],"treat":[187,200],"agitation":[188],"patients,":[191],"suvorexant,":[193],"orexin":[195],"receptor":[196],"antagonist":[197],"sleep":[201],"disturbances.":[202],"Cognitive":[203],"decline":[204],"cholinesterase":[207],"inhibitors":[208,217],"such":[209,218,375],"as":[210,219,240,345,376],"donepezil,":[211,292],"rivastigmine,":[212],"galantamine":[214],"glutamate":[216,342],"memantine.":[220],"Donepezil":[221],"commonly":[225],"prescribed":[226,235],"drug.":[227],"It":[228,246,285],"cheap,":[230],"well-tolerated,":[231],"orally":[236],"once":[237,244,416,422],"daily,":[238],"or":[239,279,369],"transdermal":[242,283],"patch":[243],"weekly.":[245],"increases":[247],"ACh":[248],"levels,":[249],"enhances":[250],"oligodendrocyte":[251],"differentiation":[252],"also":[254,313,467],"protects":[255],"toxicity.":[258],"regular":[260],"cardiac":[261,269,288,332],"monitoring":[262],"required":[264],"due":[265],"reports":[267],"conduction":[270,333],"side":[271,289],"effects.":[272],"Rivastigmine":[273],"requires":[274,360],"twice-daily":[276],"oral":[277,371],"replacement":[281],"patch.":[284],"has":[286,320],"fewer":[287],"effects":[290],"than":[291],"but":[293],"local":[294],"application-site":[295],"reactions":[296],"noted.":[299],"Galantamine,":[300],"addition":[302,353],"improving":[304,355],"short":[309],"span":[310],"time,":[312],"delays":[314],"development":[316],"BPSDs":[318],"minimal":[321],"drug-drug":[322],"interactions":[323],"virtue":[325],"having":[327],"multiple":[328,448],"metabolic":[329],"pathways.":[330],"disturbances":[334],"must":[335,434,466],"closely":[337],"monitored":[338],"for.":[339],"Memantine,":[340],"regulator,":[343],"acts":[344],"anti-Parkinsonian":[347],"agent":[348],"antidepressant,":[351],"cognition":[356],"neuroprotection,":[358],"immediate-release":[368],"sustained-release":[370],"tablets.":[372],"Disease-modifying":[373],"aducanumab":[377],"lecanemab":[379,421],"reduce":[380],"burden.":[383],"Both":[384],"act":[385],"binding":[387],"fibrillary":[389],"conformations":[390],"These":[397],"risk":[401],"causing":[403],"amyloid-related":[404],"imaging":[405],"abnormalities,":[406],"especially":[407],"persons":[409],"ApoE4":[411],"gene.":[412],"Aducanumab":[413],"administered":[415],"every":[417,423],"4":[418],"weeks":[419],"2":[424],"weeks.":[425],"decision":[427],"choice":[430],"drug":[433],"made":[436],"after":[437],"considering":[438],"availability":[440],"drug,":[442],"compliance":[443],"patient":[445],"(once-daily":[446],"vs.":[447],"doses":[449],"daily),":[450],"cost,":[451],"specific":[452],"comorbidities,":[453],"risk-benefit":[456],"ratio":[457],"particular":[460],"patient.":[461],"Other":[462],"non-pharmacological":[463],"adopted":[469],"holistic":[473],"approach":[474],"toward":[475],"AD.":[479]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":58},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-10-10T00:00:00"}
