{"id":"https://openalex.org/W4387435286","doi":"https://doi.org/10.3390/cancers15194887","title":"Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial Cancer","display_name":"Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial Cancer","publication_year":2023,"publication_date":"2023-10-08","ids":{"openalex":"https://openalex.org/W4387435286","doi":"https://doi.org/10.3390/cancers15194887","pmid":"https://pubmed.ncbi.nlm.nih.gov/37835582","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10571568"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15194887","doi":"https://doi.org/10.3390/cancers15194887","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15194887","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers15194887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064980204","display_name":"Yeong Gyu Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeong Gyu Jeong","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117150","display_name":"Nar Bahadur Katuwal","orcid":"https://orcid.org/0000-0002-7648-8044","observed_orcids":["https://orcid.org/0000-0002-7648-8044"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nar Bahadur Katuwal","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-7648-8044","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088595783","display_name":"Min Sil Kang","orcid":"https://orcid.org/0000-0003-0062-1934","observed_orcids":["https://orcid.org/0000-0003-0062-1934"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Sil Kang","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-0062-1934","affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077431373","display_name":"Mithun Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mithun Ghosh","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037095893","display_name":"Sa Deok Hong","orcid":"https://orcid.org/0000-0001-6165-6773","observed_orcids":["https://orcid.org/0000-0001-6165-6773"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sa Deok Hong","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113018548","display_name":"Seong Min Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Min Park","raw_affiliation_strings":["Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, The Graduate School, CHA University, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084999063","display_name":"Seul\u2010Gi Kim","orcid":"https://orcid.org/0000-0003-1641-4059","observed_orcids":["https://orcid.org/0000-0003-1641-4059","https://orcid.org/0000-0001-8576-2714"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seul-Gi Kim","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005311229","display_name":"Tae Hoen Kim","orcid":"https://orcid.org/0000-0002-2241-6694","observed_orcids":["https://orcid.org/0000-0002-2241-6694"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae Hoen Kim","raw_affiliation_strings":["Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073849119","display_name":"Yong Wha Moon","orcid":"https://orcid.org/0000-0002-7943-974X","observed_orcids":["https://orcid.org/0000-0002-7943-974X"]},"institutions":[{"id":"https://openalex.org/I4210134376","display_name":"CHA University Bundang Medical Center","ror":"https://ror.org/04nbqb988","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210134376","https://openalex.org/I4210148737","https://openalex.org/I4405258985"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Wha Moon","raw_affiliation_strings":["Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-7943-974X","affiliations":[{"raw_affiliation_string":"Hematology and Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam-si 13496, Republic of Korea","institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073849119"],"corresponding_institution_ids":["https://openalex.org/I4210134376","https://openalex.org/I4210148737"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":1.7075,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.84556941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"19","first_page":"4887","last_page":"4887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alpelisib","display_name":"alpelisib","score":0.8700000047683716},{"id":"https://openalex.org/keywords/eribulin","display_name":"eribulin","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2776387010","wikidata":"https://www.wikidata.org/wiki/Q408717","display_name":"Eribulin","level":5,"score":0.9272748231887817},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8228529095649719},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6484469771385193},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6398155689239502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5108311176300049},{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.49184346199035645},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4174630641937256},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.41628116369247437},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.38944199681282043},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37742772698402405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3509101867675781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24901577830314636},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.20643186569213867},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.15805739164352417},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08097687363624573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05982217192649841}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers15194887","doi":"https://doi.org/10.3390/cancers15194887","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15194887","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10571568","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10571568","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10571568/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:37835582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37835582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15194887","doi":"https://doi.org/10.3390/cancers15194887","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15194887","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2646681599","display_name":null,"funder_award_id":"NRF-2021R1C1C1006882","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2876160263","display_name":null,"funder_award_id":"NRF-2021R1A6A3A01086364","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387435286.pdf","grobid_xml":"https://content.openalex.org/works/W4387435286.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1971924476","https://openalex.org/W2041440766","https://openalex.org/W2056422076","https://openalex.org/W2074638597","https://openalex.org/W2097348057","https://openalex.org/W2119607431","https://openalex.org/W2127152525","https://openalex.org/W2136376272","https://openalex.org/W2148678602","https://openalex.org/W2149517207","https://openalex.org/W2150026213","https://openalex.org/W2166405684","https://openalex.org/W2170352208","https://openalex.org/W2418650650","https://openalex.org/W2592120231","https://openalex.org/W2794839527","https://openalex.org/W2804300935","https://openalex.org/W2904352309","https://openalex.org/W2907139891","https://openalex.org/W2915587043","https://openalex.org/W2928051796","https://openalex.org/W2952074268","https://openalex.org/W2982324338","https://openalex.org/W2985502989","https://openalex.org/W2997205599","https://openalex.org/W3004744212","https://openalex.org/W3015444296","https://openalex.org/W3036204386","https://openalex.org/W3094374376","https://openalex.org/W3164077468","https://openalex.org/W3175030380","https://openalex.org/W3203537241","https://openalex.org/W4220780554","https://openalex.org/W4320893589","https://openalex.org/W4320918557","https://openalex.org/W4323356844","https://openalex.org/W4324149325"],"related_works":["https://openalex.org/W262637599","https://openalex.org/W2335585954","https://openalex.org/W4295226875","https://openalex.org/W2157079036","https://openalex.org/W4399327827","https://openalex.org/W4411643044","https://openalex.org/W4312139369","https://openalex.org/W2155295856","https://openalex.org/W3007491697","https://openalex.org/W2960589694"],"abstract_inverted_index":{"Endometrial":[0],"cancer":[1,82],"stands":[2],"as":[3],"the":[4,19,30,49,88,98,121,133,151,154,162,176,179,187],"predominant":[5],"gynecological":[6],"malignancy":[7],"in":[8,43,68,92,105,114,139,140,143,182],"developed":[9],"nations.":[10],"For":[11],"advanced":[12],"or":[13],"recurrent":[14],"disease,":[15],"paclitaxel-based":[16],"chemotherapy":[17],"is":[18,173],"standard":[20],"front-line":[21],"therapy.":[22],"However,":[23],"paclitaxel":[24,91,171],"resistance":[25,172],"eternally":[26],"develops.":[27],"Based":[28],"on":[29],"high":[31],"prevalence":[32],"of":[33,51,54,90,123,136,153,178,189],"phosphatidylinositol-4,5-bisphosphate":[34],"3-kinase":[35,57],"catalytic":[36],"subunit":[37],"alpha":[38],"(PIK3CA)":[39],"mutation,":[40],"reaching":[41],"50%,":[42],"endometrial":[44,72,81,184],"cancer,":[45,67,185],"we":[46,118,148,168],"preclinically":[47],"investigated":[48],"effectiveness":[50],"a":[52,55,62,190],"combination":[53,122,155,188],"phosphatidylinositol":[56],"(PI3K)":[58],"inhibitor":[59,192],"with":[60,112,175],"eribulin,":[61],"post-paclitaxel":[63],"therapy":[64],"for":[65],"breast":[66],"treating":[69],"paclitaxel-resistant,":[70],"PIK3CA-mutated":[71,80,183],"cancer.":[73],"We":[74,95],"generated":[75],"paclitaxel-resistant":[76,106,137],"cell":[77,83,93],"lines":[78,84],"from":[79],"by":[85,159],"gradually":[86],"increasing":[87],"concentration":[89],"cultures.":[94],"observed":[96],"that":[97,120,150,170],"PI3K/AKT":[99,163],"and":[100,128,142,164,186,193],"epithelial-mesenchymal":[101],"transition":[102],"(EMT)":[103],"pathways":[104],"cells":[107,138],"were":[108],"significantly":[109],"upregulated":[110],"compared":[111],"those":[113],"parental":[115],"cells.":[116],"Then,":[117],"demonstrated":[119,149],"alpelisib":[124],"(a":[125],"PI3K":[126,191],"inhibitor)":[127],"eribulin":[129,194],"more":[130],"effectively":[131],"suppressed":[132],"cellular":[134],"growth":[135],"vitro":[141],"vivo":[144],"xenograft":[145],"models.":[146],"Mechanistically,":[147],"effect":[152],"could":[156],"be":[157],"enhanced":[158],"inhibiting":[160],"both":[161],"EMT":[165],"pathways.":[166],"Therefore,":[167],"suggest":[169],"associated":[174],"activation":[177],"PIK3/AKT":[180],"pathway":[181],"merits":[195],"further":[196],"clinical":[197],"investigation.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-09T00:00:00"}