{"id":"https://openalex.org/W4387428457","doi":"https://doi.org/10.1016/j.yjpso.2023.100084","title":"Biologics and the timing of operative management of pediatric inflammatory bowel disease","display_name":"Biologics and the timing of operative management of pediatric inflammatory bowel disease","publication_year":2023,"publication_date":"2023-10-07","ids":{"openalex":"https://openalex.org/W4387428457","doi":"https://doi.org/10.1016/j.yjpso.2023.100084"},"language":"en","primary_location":{"id":"doi:10.1016/j.yjpso.2023.100084","doi":"https://doi.org/10.1016/j.yjpso.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yjpso.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4387286834","display_name":"Journal of Pediatric Surgery Open","issn_l":"2949-7116","issn":["2949-7116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.yjpso.2023.100084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007334621","display_name":"Tamara Sharf","orcid":"https://orcid.org/0000-0001-5014-844X","observed_orcids":["https://orcid.org/0000-0001-5014-844X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Sharf","raw_affiliation_strings":["Keck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, USA 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, USA 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039086055","display_name":"MaKayla L O'Guinn","orcid":"https://orcid.org/0000-0003-0865-0262","observed_orcids":["https://orcid.org/0000-0003-0865-0262"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MaKayla L. O'Guinn","raw_affiliation_strings":["Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027"],"raw_orcid":"https://orcid.org/0000-0003-0865-0262","affiliations":[{"raw_affiliation_string":"Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020155843","display_name":"Olivia A. Keane","orcid":"https://orcid.org/0000-0001-9464-1949","observed_orcids":["https://orcid.org/0000-0001-9464-1949"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia A. Keane","raw_affiliation_strings":["Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012727802","display_name":"Christopher P. Gayer","orcid":"https://orcid.org/0000-0002-5351-553X","observed_orcids":["https://orcid.org/0000-0002-5351-553X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher P. Gayer","raw_affiliation_strings":["Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027","Keck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, USA 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Los Angeles, Division of General Pediatric Surgery, 4650 Sunset Blvd, #100, Los Angeles, CA, USA 90027","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Keck School of Medicine of the University of Southern California, 1975 Zonal Ave, Los Angeles, CA, USA 90033","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012727802"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24277154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":"100084","last_page":"100084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-inflammatory-bowel-disease","display_name":"pediatric inflammatory bowel disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/operative-management","display_name":"operative management","score":0.7129999995231628},{"id":"https://openalex.org/keywords/timing-of-surgery","display_name":"timing of surgery","score":0.6970000267028809},{"id":"https://openalex.org/keywords/biologic-therapy-failure","display_name":"biologic failure","score":0.75},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.8190000057220459},{"id":"https://openalex.org/keywords/surgical-referral","display_name":"surgical referral","score":0.8539999723434448},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9667447805404663},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6995315551757812},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.6271353960037231},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5886967778205872},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5112190246582031},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4987506866455078},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.4805870056152344},{"id":"https://openalex.org/C2911221801","wikidata":"https://www.wikidata.org/wiki/Q2742406","display_name":"Biologic Agents","level":3,"score":0.4781580865383148},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.46664029359817505},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.41363951563835144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37065577507019043},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3424021005630493},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yjpso.2023.100084","doi":"https://doi.org/10.1016/j.yjpso.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yjpso.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4387286834","display_name":"Journal of Pediatric Surgery Open","issn_l":"2949-7116","issn":["2949-7116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery Open","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d63315aed5aa454b8f4863a69bfe6d34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d63315aed5aa454b8f4863a69bfe6d34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pediatric Surgery Open, Vol 4, Iss , Pp 100084- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.yjpso.2023.100084","doi":"https://doi.org/10.1016/j.yjpso.2023.100084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.yjpso.2023.100084","pdf_url":null,"source":{"id":"https://openalex.org/S4387286834","display_name":"Journal of Pediatric Surgery Open","issn_l":"2949-7116","issn":["2949-7116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Surgery Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1915598702","https://openalex.org/W1971802602","https://openalex.org/W1982508879","https://openalex.org/W2034410633","https://openalex.org/W2034892783","https://openalex.org/W2072738451","https://openalex.org/W2077151509","https://openalex.org/W2125799301","https://openalex.org/W2145184358","https://openalex.org/W2145860140","https://openalex.org/W2598386321","https://openalex.org/W2766310590","https://openalex.org/W2789693626","https://openalex.org/W2803076555","https://openalex.org/W2810227481","https://openalex.org/W2901356648","https://openalex.org/W2941353366","https://openalex.org/W2949937340","https://openalex.org/W2959639471","https://openalex.org/W2980618401","https://openalex.org/W2984395493","https://openalex.org/W2987478724","https://openalex.org/W2999873106","https://openalex.org/W3092207303","https://openalex.org/W3102892552","https://openalex.org/W3137851134","https://openalex.org/W3151875871","https://openalex.org/W3154676031","https://openalex.org/W4220738184","https://openalex.org/W4221004918","https://openalex.org/W4224296856"],"related_works":["https://openalex.org/W4395465005","https://openalex.org/W4316077549","https://openalex.org/W4282947190","https://openalex.org/W4414218746","https://openalex.org/W3154316074","https://openalex.org/W4243604023","https://openalex.org/W2893592052","https://openalex.org/W4321367074","https://openalex.org/W2587732213","https://openalex.org/W2921993653"],"abstract_inverted_index":{"Biologic":[0],"disease-modulating":[1],"antirheumatic":[2],"drugs":[3],"have":[4],"altered":[5],"the":[6,29,148,159,163,180],"management":[7,168],"of":[8,23,31,35,54,67,120,136,165,203],"inflammatory":[9,85],"bowel":[10],"disease,":[11],"reserving":[12],"surgery":[13,100],"for":[14,144,171],"patients":[15,68,128,140,149,189,210],"who":[16,94,150,190,211],"fail":[17,212],"pharmaceutical":[18],"therapies.":[19],"As":[20],"a":[21,176],"result":[22,58],"this,":[24],"it":[25,143],"may":[26],"lead":[27],"to":[28,102,199],"use":[30,47],"an":[32],"increasing":[33],"number":[34],"independent":[36,50],"biologic":[37,46,121,132,174,215],"medications":[38,51],"before":[39],"failure":[40,202],"is":[41],"declared.":[42],"We":[43,62,79,110],"hypothesize":[44],"that":[45],"beyond":[48],"two":[49,154,194,204],"without":[52],"signs":[53],"remission":[55],"will":[56],"ultimately":[57],"in":[59,216],"surgical":[60,207,229],"management.":[61],"conducted":[63],"retrospective":[64],"chart":[65],"review":[66],"with":[69,170],"IBD":[70,188],"treated":[71],"at":[72,87],"Children's":[73],"Hospital":[74],"Los":[75],"Angeles":[76],"between":[77],"2015-2018.":[78],"collected":[80],"demographics":[81],"and":[82,84,114,226],"nutritional":[83],"markers":[86],"diagnosis.":[88],"Treatment":[89],"regimens":[90],"were":[91,104,107,157],"recorded.":[92],"Patients":[93],"never":[95],"received":[96,99,151,178],"biologics":[97,103,155,195,205],"or":[98],"prior":[101],"excluded.":[105],"Cohorts":[106],"matched":[108],"one-to-two.":[109],"identified":[111],"43":[112],"operative":[113,127,160,167],"86":[115],"non-operative":[116,139],"patients.":[117],"The":[118],"duration":[119],"usage":[122],"varied":[123],"significantly.":[124],"On":[125],"average,":[126],"failed":[129],"their":[130,213],"first":[131,181,214],"within":[133],"10.8":[134],"months":[135,220],"use,":[137],"while":[138],"remained":[141],"on":[142,198],"20.4":[145],"months.":[146],"Of":[147],"more":[152,192,223],"than":[153,193,218],"70%":[156],"from":[158],"cohort.":[161],"Ultimately,":[162],"odds":[164],"requiring":[166],"doubled":[169],"each":[172],"additional":[173],"medication":[175],"patient":[177],"after":[179],"(OR":[182],"2.16;":[183],"95%":[184],"CI":[185],"(1.35-3.58)).":[186],"Pediatric":[187],"trial":[191],"frequently":[196],"proceed":[197],"surgery.":[200],"Therefore,":[201],"warrants":[206],"consideration.":[208],"Additionally,":[209],"less":[217],"12":[219],"should":[221],"be":[222],"closely":[224],"followed":[225],"receive":[227],"earlier":[228],"referral.":[230],"Level":[231],"III":[232]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2023-10-08T00:00:00"}