{"id":"https://openalex.org/W4387426401","doi":"https://doi.org/10.1186/s40634-023-00665-1","title":"Stem cells for the treatment of early to moderate osteoarthritis of the knee: a systematic review","display_name":"Stem cells for the treatment of early to moderate osteoarthritis of the knee: a systematic review","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387426401","doi":"https://doi.org/10.1186/s40634-023-00665-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37804354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560289"},"language":"en","primary_location":{"id":"doi:10.1186/s40634-023-00665-1","doi":"https://doi.org/10.1186/s40634-023-00665-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40634-023-00665-1","pdf_url":"https://jeo-esska.springeropen.com/counter/pdf/10.1186/s40634-023-00665-1","source":{"id":"https://openalex.org/S2738219336","display_name":"Journal of Experimental Orthopaedics","issn_l":"2197-1153","issn":["2197-1153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Orthopaedics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeo-esska.springeropen.com/counter/pdf/10.1186/s40634-023-00665-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083045734","display_name":"Theofylaktos Kyriakidis","orcid":"https://orcid.org/0000-0003-1466-5479","observed_orcids":["https://orcid.org/0000-0003-1466-5479"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2801260094","display_name":"Interbalkan Medical Center","ror":"https://ror.org/02hxrrn62","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801260094"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE","GR"],"is_corresponding":true,"raw_author_name":"Theofylaktos Kyriakidis","raw_affiliation_strings":["Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","Department of Orthopaedic Surgery and Traumatology Erasme University Hospital Universit\u00e9 Libre de Bruxelles Route de Lennik 808 1070 Brussels Belgium","Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece"],"raw_orcid":"https://orcid.org/0000-0003-1466-5479","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery and Traumatology Erasme University Hospital Universit\u00e9 Libre de Bruxelles Route de Lennik 808 1070 Brussels Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]},{"raw_affiliation_string":"Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece","institution_ids":["https://openalex.org/I2801260094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065217732","display_name":"Charalampos Pitsilos","orcid":"https://orcid.org/0000-0002-3091-866X","observed_orcids":["https://orcid.org/0000-0002-3091-866X"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Charalampos Pitsilos","raw_affiliation_strings":["Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029107116","display_name":"Myrto Aikaterini Iosifidou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myrto Iosifidou","raw_affiliation_strings":["Orthobiology Surgery Center, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthobiology Surgery Center, Thessaloniki, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012096193","display_name":"Alexandros P. Tzaveas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801260094","display_name":"Interbalkan Medical Center","ror":"https://ror.org/02hxrrn62","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801260094"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Tzaveas","raw_affiliation_strings":["Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece","3rd Orthopaedic Department, Interbalkan Medical Center, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece","institution_ids":["https://openalex.org/I2801260094"]},{"raw_affiliation_string":"3rd Orthopaedic Department, Interbalkan Medical Center, Thessaloniki, Greece","institution_ids":["https://openalex.org/I2801260094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049407051","display_name":"Ioannis Gigis","orcid":"https://orcid.org/0000-0002-4214-9036","observed_orcids":["https://orcid.org/0000-0002-4214-9036"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Gigis","raw_affiliation_strings":["Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072400776","display_name":"Konstantinos T. Ditsios","orcid":"https://orcid.org/0000-0003-4222-5745","observed_orcids":["https://orcid.org/0000-0003-4222-5745","https://orcid.org/0000-0002-0360-8842"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantinos Ditsios","raw_affiliation_strings":["Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery and Traumatology Aristotle University of Thessaloniki \u201cG. Gennimatas\u201d General Hospital Ethnikis Aminis 41 54635 Thessaloniki Hellas Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"2nd Department of Orthopaedic Surgery and Traumatology, Aristotle University of Thessaloniki, \"G. Gennimatas\" General Hospital, Ethnikis Aminis 41, 54635, Thessaloniki, Hellas, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037438534","display_name":"Michael I. Iosifidis","orcid":"https://orcid.org/0000-0002-8985-0057","observed_orcids":["https://orcid.org/0000-0002-8985-0057","https://orcid.org/0000-0001-7559-7161"]},"institutions":[{"id":"https://openalex.org/I2801260094","display_name":"Interbalkan Medical Center","ror":"https://ror.org/02hxrrn62","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2801260094"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michael Iosifidis","raw_affiliation_strings":["Orthobiology Surgery Center Thessaloniki Greece","Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece","3rd Orthopaedic Department, Interbalkan Medical Center, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthobiology Surgery Center Thessaloniki Greece","institution_ids":[]},{"raw_affiliation_string":"Orthopaedic Department Interbalkan Medical Center Thessaloniki Greece","institution_ids":["https://openalex.org/I2801260094"]},{"raw_affiliation_string":"3rd Orthopaedic Department, Interbalkan Medical Center, Thessaloniki, Greece","institution_ids":["https://openalex.org/I2801260094"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083045734"],"corresponding_institution_ids":["https://openalex.org/I132053463","https://openalex.org/I21370196","https://openalex.org/I2801260094","https://openalex.org/I2802054198"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.7665,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.62037962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"102","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kellgren-lawrence-grade","display_name":"Kellgren-Lawrence grade","score":0.7910000085830688},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.8510000109672546},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.8529999852180481},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9340000152587891},{"id":"https://openalex.org/keywords/stem-cell-therapy-safety-and-efficacy","display_name":"stem cell therapy safety and efficacy","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.9072284698486328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8412017822265625},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.768532395362854},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6861602067947388},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6246525049209595},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.6221975088119507},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.5785937309265137},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.5254879593849182},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5148783922195435},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.4833966791629791},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.47231101989746094},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.4159157872200012},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2651958465576172},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.24203798174858093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23102056980133057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13901197910308838},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s40634-023-00665-1","doi":"https://doi.org/10.1186/s40634-023-00665-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40634-023-00665-1","pdf_url":"https://jeo-esska.springeropen.com/counter/pdf/10.1186/s40634-023-00665-1","source":{"id":"https://openalex.org/S2738219336","display_name":"Journal of Experimental Orthopaedics","issn_l":"2197-1153","issn":["2197-1153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Orthopaedics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10560289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560289","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560289/pdf/40634_2023_Article_665.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Orthop","raw_type":"Text"},{"id":"pmid:37804354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37804354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental orthopaedics","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/372615","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/372615","pdf_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/372615/1/doi_356259.pdf","source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Orthopaedics, 10 (1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c1248e80a6af49e699db6355c58f3513","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c1248e80a6af49e699db6355c58f3513","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40634-023-00665-1","doi":"https://doi.org/10.1186/s40634-023-00665-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40634-023-00665-1","pdf_url":"https://jeo-esska.springeropen.com/counter/pdf/10.1186/s40634-023-00665-1","source":{"id":"https://openalex.org/S2738219336","display_name":"Journal of Experimental Orthopaedics","issn_l":"2197-1153","issn":["2197-1153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Orthopaedics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387426401.pdf","grobid_xml":"https://content.openalex.org/works/W4387426401.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1650284538","https://openalex.org/W2119744583","https://openalex.org/W2156098321","https://openalex.org/W2739995361","https://openalex.org/W2889382187","https://openalex.org/W2919999424","https://openalex.org/W2971625680","https://openalex.org/W2972113129","https://openalex.org/W2991792334","https://openalex.org/W3009013307","https://openalex.org/W3020650885","https://openalex.org/W3033760177","https://openalex.org/W3037245682","https://openalex.org/W3038928249","https://openalex.org/W3089038297","https://openalex.org/W3117086713","https://openalex.org/W3129994923","https://openalex.org/W3135059695","https://openalex.org/W3164706680","https://openalex.org/W4210410511","https://openalex.org/W4220666391","https://openalex.org/W4220844301","https://openalex.org/W4220878359","https://openalex.org/W4221098830","https://openalex.org/W4223423256","https://openalex.org/W4229039010","https://openalex.org/W4229332354","https://openalex.org/W4282920413","https://openalex.org/W4283661121","https://openalex.org/W4285495090","https://openalex.org/W4285528326","https://openalex.org/W4365816065"],"related_works":["https://openalex.org/W4408169718","https://openalex.org/W2895213878","https://openalex.org/W3020650885","https://openalex.org/W2119744583","https://openalex.org/W4229332354","https://openalex.org/W2341122477","https://openalex.org/W2531482076","https://openalex.org/W4410734690","https://openalex.org/W7084144029","https://openalex.org/W3124377809"],"abstract_inverted_index":{"PURPOSE:":[0],"Mesenchymal":[1],"stem":[2,33,84],"cells":[3],"(MSCs)":[4],"present":[5,20],"a":[6,112,161],"valuable":[7],"treatment":[8,166],"option":[9,167],"for":[10,54,87,118,168],"knee":[11,41,91,119,140,172],"osteoarthritis":[12,92,120],"with":[13,81,111],"promising":[14],"results.":[15],"The":[16],"purpose":[17],"of":[18,64,116,146,158,177],"the":[19,26,50,124,131,175,180,184],"study":[21],"was":[22,47],"to":[23,39],"systematically":[24],"review":[25],"clinical":[27,95],"and":[28,57,66,75,96,107,144,164,183,189],"functional":[29,97],"outcomes":[30,98,133,138],"following":[31],"mesenchymal":[32,83],"cell":[34,85],"application":[35],"focusing":[36],"on":[37,78,94,151],"early":[38],"moderate":[40],"osteoarthritis.":[42,173],"METHODS:":[43],"A":[44],"systematic":[45,126],"search":[46],"done":[48],"using":[49],"Preferred":[51],"Reporting":[52],"Items":[53],"Systematic":[55],"Reviews":[56],"Meta-Analyses":[58],"guidelines":[59],"in":[60,123,179,186],"Pubmed,":[61],"Scopus,":[62],"Web":[63],"Science,":[65],"Cochrane":[67],"Library":[68],"databases.":[69],"All":[70],"Studies":[71],"published":[72],"between":[73],"2017":[74],"March":[76],"2023":[77],"patients":[79,106],"treated":[80,110],"single":[82,113,155],"injection":[86,115,157],"Kellgren-Lawrence":[88,169],"grade":[89,170],"I-III":[90,171],"reported":[93,132],"were":[99,121,134],"included.":[100],"RESULTS:":[101],"Twelve":[102],"articles":[103],"comprising":[104],"539":[105],"576":[108],"knees":[109],"intraarticular":[114,156],"MSCs":[117,159,187],"included":[122,181],"current":[125],"review.":[127],"In":[128],"eligible":[129],"studies,":[130,154],"improved":[135],"concerning":[136],"patient-reported":[137],"measures,":[139],"function,":[141],"pain":[142],"relief,":[143],"quality":[145],"patient's":[147],"life.":[148],"CONCLUSION:":[149],"Based":[150],"high-level":[152],"evidence":[153],"is":[160],"safe,":[162],"reliable,":[163],"effective":[165],"However,":[174],"lack":[176],"homogeneity":[178],"studies":[182],"variance":[185],"sources":[188],"preparations":[190],"should":[191],"be":[192],"noted.":[193],"LEVEL":[194],"OF":[195],"EVIDENCE:":[196],"III.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-08T00:00:00"}
