{"id":"https://openalex.org/W4387407488","doi":"https://doi.org/10.1186/s12974-023-02915-6","title":"Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer\u2019s disease-like neuroinflammation triggered by periodontal disease","display_name":"Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer\u2019s disease-like neuroinflammation triggered by periodontal disease","publication_year":2023,"publication_date":"2023-10-06","ids":{"openalex":"https://openalex.org/W4387407488","doi":"https://doi.org/10.1186/s12974-023-02915-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/37803465","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10557354"},"language":"en","primary_location":{"id":"doi:10.1186/s12974-023-02915-6","doi":"https://doi.org/10.1186/s12974-023-02915-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-023-02915-6","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-023-02915-6","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-023-02915-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101884564","display_name":"Chuanjiang Zhao","orcid":"https://orcid.org/0000-0002-1359-0252","observed_orcids":["https://orcid.org/0000-0002-1359-0252"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Chuanjiang Zhao","raw_affiliation_strings":["Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","Department of Periodontology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Periodontology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050907847","display_name":"Ryutaro Kuraji","orcid":"https://orcid.org/0000-0002-7900-3604","observed_orcids":["https://orcid.org/0000-0002-7900-3604"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I35552710","display_name":"Nippon Dental University","ror":"https://ror.org/01s1hm369","country_code":"JP","type":"education","lineage":["https://openalex.org/I35552710"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ryutaro Kuraji","raw_affiliation_strings":["Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, 102-8159, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7900-3604","affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, 102-8159, Japan","institution_ids":["https://openalex.org/I35552710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003972827","display_name":"Changchang Ye","orcid":"https://orcid.org/0000-0003-4713-0809","observed_orcids":["https://orcid.org/0000-0003-4713-0809"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Changchang Ye","raw_affiliation_strings":["Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","Department of Periodontology, West China School of Stomatology, National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Periodontology, West China School of Stomatology, National Clinical Research Center for Oral Diseases, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610093, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4387155047","display_name":"Hospital of Stomatology, Sun Yat-sen University","ror":"https://ror.org/04bswr545","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387155047"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Li Gao","raw_affiliation_strings":["Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","Department of Periodontology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Periodontology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4387155047"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, 510050, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017881221","display_name":"Allan Radaic","orcid":"https://orcid.org/0000-0002-0899-9061","observed_orcids":["https://orcid.org/0000-0002-0899-9061"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan Radaic","raw_affiliation_strings":["Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA"],"raw_orcid":"https://orcid.org/0000-0002-0899-9061","affiliations":[{"raw_affiliation_string":"Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021638099","display_name":"Pachiyappan Kamarajan","orcid":"https://orcid.org/0009-0007-8413-5082","observed_orcids":["https://orcid.org/0009-0007-8413-5082"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pachiyappan Kamarajan","raw_affiliation_strings":["Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111052498","display_name":"Yoshimasa Taketani","orcid":"https://orcid.org/0009-0002-8632-8471","observed_orcids":["https://orcid.org/0009-0002-8632-8471"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I19283125","display_name":"Meikai University","ror":"https://ror.org/03thzz813","country_code":"JP","type":"education","lineage":["https://openalex.org/I19283125"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshimasa Taketani","raw_affiliation_strings":["Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, 350-0283, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, 350-0283, Japan","institution_ids":["https://openalex.org/I19283125"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022418072","display_name":"Yvonne Lorraine Kapila","orcid":"https://orcid.org/0000-0003-1330-0654","observed_orcids":["https://orcid.org/0000-0003-1330-0654"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yvonne L. Kapila","raw_affiliation_strings":["Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA. ykapila@dentistry.ucla.edu","Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA. ykapila@dentistry.ucla.edu","Section of Biosystems and Function, Section of Periodontology, UCLA School of Dentistry, 10833 Le Conte Ave, Box 951668, Los Angeles, CA, 90095-1668, USA. ykapila@dentistry.ucla.edu","Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA. ykapila@dentistry.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA. ykapila@dentistry.ucla.edu","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Section of Biosystems and Function, Section of Periodontology, UCLA School of Dentistry, 10833 Le Conte Ave, Box 951668, Los Angeles, CA, 90095-1668, USA. ykapila@dentistry.ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5022418072"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I180670191"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":8.6807,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.98853562,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"228","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.04340000078082085,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nisin","display_name":"nisin","score":1.0},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/lantibiotics","display_name":"lantibiotics","score":0.9070000052452087},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oral-dysbiosis","display_name":"oral dysbiosis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9290000200271606},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8899096250534058},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7958756685256958},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6633287072181702},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.5595074892044067},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5469012260437012},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.504379153251648},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.47896817326545715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47867947816848755},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4176931381225586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34692731499671936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29427123069763184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2743490934371948},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2080613672733307},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1440868377685547},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11140602827072144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08117687702178955},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009561","descriptor_name":"Nisin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12974-023-02915-6","doi":"https://doi.org/10.1186/s12974-023-02915-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-023-02915-6","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-023-02915-6","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10557354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10557354","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10557354/pdf/12974_2023_Article_2915.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:37803465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37803465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3gq0w8qq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3gq0w8qq","pdf_url":"https://escholarship.org/content/qt3gq0w8qq/qt3gq0w8qq.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, vol 20, iss 1","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1b5acb6d17bb461cb4c23495f5cd10d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b5acb6d17bb461cb4c23495f5cd10d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12974-023-02915-6","doi":"https://doi.org/10.1186/s12974-023-02915-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-023-02915-6","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-023-02915-6","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7407975613","display_name":"\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u306b\u7740\u76ee\u3057\u305f\u5916\u50b7\u6027\u54ac\u5408\u3092\u4f34\u3046\u6b6f\u5468\u708e\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u57fa\u790e\u7684\u7814\u7a76","funder_award_id":"23K16006","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000861997","display_name":"Treponema - Host Cell and Tissue Interactions","funder_award_id":"R01DE025225","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387407488.pdf","grobid_xml":"https://content.openalex.org/works/W4387407488.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1508289240","https://openalex.org/W1532610717","https://openalex.org/W1677668605","https://openalex.org/W1699912176","https://openalex.org/W1807251344","https://openalex.org/W1895216035","https://openalex.org/W1897291768","https://openalex.org/W1952330423","https://openalex.org/W1964117773","https://openalex.org/W1968125869","https://openalex.org/W1992031722","https://openalex.org/W1999545345","https://openalex.org/W2008006633","https://openalex.org/W2013392940","https://openalex.org/W2014492932","https://openalex.org/W2019094601","https://openalex.org/W2024307950","https://openalex.org/W2024735551","https://openalex.org/W2032340782","https://openalex.org/W2034383732","https://openalex.org/W2035588826","https://openalex.org/W2041546150","https://openalex.org/W2049057420","https://openalex.org/W2065139121","https://openalex.org/W2087243986","https://openalex.org/W2088565112","https://openalex.org/W2091988669","https://openalex.org/W2109984042","https://openalex.org/W2113944963","https://openalex.org/W2114790063","https://openalex.org/W2116784956","https://openalex.org/W2117586459","https://openalex.org/W2118470591","https://openalex.org/W2125282506","https://openalex.org/W2125312485","https://openalex.org/W2130450098","https://openalex.org/W2137951841","https://openalex.org/W2137984899","https://openalex.org/W2143824866","https://openalex.org/W2148851922","https://openalex.org/W2159326694","https://openalex.org/W2160899124","https://openalex.org/W2163663214","https://openalex.org/W2233236537","https://openalex.org/W2294532941","https://openalex.org/W2418037721","https://openalex.org/W2491787181","https://openalex.org/W2498452211","https://openalex.org/W2509934370","https://openalex.org/W2584820063","https://openalex.org/W2590046232","https://openalex.org/W2604892497","https://openalex.org/W2621695716","https://openalex.org/W2765303421","https://openalex.org/W2769997020","https://openalex.org/W2775236392","https://openalex.org/W2802436906","https://openalex.org/W2805321653","https://openalex.org/W2895374072","https://openalex.org/W2899018025","https://openalex.org/W2912555658","https://openalex.org/W2937346106","https://openalex.org/W3010985052","https://openalex.org/W3011318048","https://openalex.org/W3040245690","https://openalex.org/W3080159587","https://openalex.org/W3091269252","https://openalex.org/W3162700156","https://openalex.org/W3167836493","https://openalex.org/W3171974798","https://openalex.org/W3178906930","https://openalex.org/W3198761043","https://openalex.org/W4211050998","https://openalex.org/W4281703160","https://openalex.org/W4390946843"],"related_works":["https://openalex.org/W6958492352","https://openalex.org/W6920905313","https://openalex.org/W3173124741","https://openalex.org/W4281703160","https://openalex.org/W4401521971","https://openalex.org/W7167204793","https://openalex.org/W4390946843","https://openalex.org/W7035888471","https://openalex.org/W3208480296","https://openalex.org/W4402466489"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Periodontitis-related":[1],"oral":[2],"microbial":[3],"dysbiosis":[4,215],"is":[5],"thought":[6],"to":[7,9,50,167],"contribute":[8],"Alzheimer's":[10],"disease":[11,47,56],"(AD)":[12],"neuroinflammation":[13],"and":[14,64,74,91,94,123,147,195,223,225],"brain":[15,35,58,87,104,130,204,213],"amyloid":[16],"production.":[17],"Since":[18],"probiotics":[19],"can":[20],"modulate":[21],"periodontitis/oral":[22],"dysbiosis,":[23,60],"this":[24,55,69],"study":[25],"examined":[26],"the":[27,52,83,86,96,103,113,129,139,163,168,185,203,206],"effects":[28,53,218],"of":[29,45,54,98,116,141,205,212],"a":[30,230],"probiotic/lantibiotic,":[31],"nisin,":[32],"in":[33,68,85,102,128,162,202],"modulating":[34],"pathology":[36],"triggered":[37],"by":[38,106,134],"periodontitis.":[39],"METHODS:":[40],"A":[41],"polymicrobial":[42],"mouse":[43],"model":[44],"periodontal":[46,99,107,135],"was":[48],"used":[49],"evaluate":[51],"on":[57,219],"microbiome":[59,88,214],"neuroinflammation,":[61,224],"Alzheimer's-related":[62],"changes,":[63],"nisin's":[65],"therapeutic":[66,232],"potential":[67,231],"context.":[70],"RESULTS:":[71],"16S":[72],"sequencing":[73],"real-time":[75],"PCR":[76],"data":[77],"revealed":[78],"that":[79,131],"Nisin":[80,109,181,210],"treatment":[81,110,182],"mitigated":[82],"changes":[84,222],"composition,":[89],"diversity,":[90],"community":[92],"structure,":[93],"reduced":[95,184],"levels":[97],"pathogen":[100],"DNA":[101],"induced":[105],"disease.":[108],"significantly":[111,160],"decreased":[112],"mRNA":[114],"expression":[115],"pro-inflammatory":[117],"cytokines":[118],"(Interleukin-1\u03b2/IL-1":[119],"\u03b2,":[120],"Interleukin":[121],"6/IL-6,":[122],"Tumor":[124],"Necrosis":[125],"Factor":[126],"\u03b1/TNF-\u03b1)":[127],"were":[132,159],"elevated":[133],"infection.":[136],"In":[137],"addition,":[138],"concentrations":[140],"amyloid-\u03b2":[142],"42":[143],"(A\u03b242),":[144],"total":[145,190],"Tau,":[146],"Tau":[148,191,197],"(pS199)":[149],"(445.69":[150],"\u00b1":[151,154,157,172,175,178,188,193,199],"120.03,":[152],"1420.85":[153],"331.40,":[155],"137.20":[156],"36.01)":[158],"higher":[161],"infection":[164,207],"group":[165,170],"compared":[166],"control":[169],"(193.01":[171],"31.82,":[173],"384.27":[174],"363.93,":[176],"6.09":[177],"10.85),":[179],"respectively.":[180],"markedly":[183],"A\u03b242":[186],"(261.80":[187],"52.50),":[189],"(865.37":[192],"304.93),":[194],"phosphorylated":[196],"(82.53":[198],"15.77)":[200],"deposition":[201],"group.":[208],"DISCUSSION:":[209],"abrogation":[211],"induces":[216],"beneficial":[217],"AD-like":[220],"pathogenic":[221],"thereby":[226],"may":[227],"serve":[228],"as":[229],"for":[233],"periodontal-dysbiosis-related":[234],"AD.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":13}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-07T00:00:00"}
