{"id":"https://openalex.org/W4387380388","doi":"https://doi.org/10.1210/jendso/bvad114.835","title":"FRI613 Sex Differences In Human Islet Transcriptional Responses To Inflammation","display_name":"FRI613 Sex Differences In Human Islet Transcriptional Responses To Inflammation","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387380388","doi":"https://doi.org/10.1210/jendso/bvad114.835"},"language":"en","primary_location":{"id":"doi:10.1210/jendso/bvad114.835","doi":"https://doi.org/10.1210/jendso/bvad114.835","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1210/jendso/bvad114.835","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1210/jendso/bvad114.835","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044314852","display_name":"Kierstin L. Webster","orcid":"https://orcid.org/0000-0003-1316-9430","observed_orcids":["https://orcid.org/0000-0003-1316-9430"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kierstin L Webster","raw_affiliation_strings":["University of Chicago , Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL , USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084811923","display_name":"Wenting Wu","orcid":"https://orcid.org/0000-0003-0982-771X","observed_orcids":["https://orcid.org/0000-0003-0982-771X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenting Wu","raw_affiliation_strings":["Indiana University , Indianapolis, IN , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University , Indianapolis, IN , USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020443342","display_name":"Bobbie\u2010Jo Webb\u2010Robertson","orcid":"https://orcid.org/0000-0002-4744-2397","observed_orcids":["https://orcid.org/0000-0002-4744-2397"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bobbie-Jo Webb-Robertson","raw_affiliation_strings":["Pacific Northwest National Laboratory , Richland, WA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory , Richland, WA , USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037253743","display_name":"Ernesto Satoshi Nakayasu","orcid":"https://orcid.org/0000-0002-4056-2695","observed_orcids":["https://orcid.org/0000-0002-4056-2695"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto Nakayasu","raw_affiliation_strings":["Pacific Northwest National Laboratory , Richland, WA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory , Richland, WA , USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029196238","display_name":"Soumyadeep Sarkar","orcid":"https://orcid.org/0000-0002-1928-1848","observed_orcids":["https://orcid.org/0000-0002-1928-1848"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soumyadeep Sarkar","raw_affiliation_strings":["Pacific Northwest National Laboratory , Richland, WA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory , Richland, WA , USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063131669","display_name":"Carmella Evans\u2010Molina","orcid":"https://orcid.org/0000-0001-7764-8663","observed_orcids":["https://orcid.org/0000-0001-7764-8663"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmella Evans-Molina","raw_affiliation_strings":["Indiana University , Indianapolis, IN , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University , Indianapolis, IN , USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102940395","display_name":"Sarah A. Tersey","orcid":"https://orcid.org/0000-0003-0667-2361","observed_orcids":["https://orcid.org/0000-0003-0667-2361"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A Tersey","raw_affiliation_strings":["University of Chicago , Chicago, FL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, FL , USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055107260","display_name":"Jacob R. Enriquez","orcid":"https://orcid.org/0000-0002-5858-6759","observed_orcids":["https://orcid.org/0000-0002-5858-6759"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Enriquez","raw_affiliation_strings":["University of Chicago , Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL , USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039728337","display_name":"Stephen R. Hammes","orcid":"https://orcid.org/0000-0002-7367-276X","observed_orcids":["https://orcid.org/0000-0002-7367-276X"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R Hammes","raw_affiliation_strings":["University of Rochester , Rochester, NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester , Rochester, NY , USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031560696","display_name":"Raghavendra G. Mirmira","orcid":"https://orcid.org/0000-0002-5013-6075","observed_orcids":["https://orcid.org/0000-0002-5013-6075","https://orcid.org/0000-0003-3638-8409"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghavendra G Mirmira","raw_affiliation_strings":["University of Chicago , Chicago, IL , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago , Chicago, IL , USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":{"value":3100,"currency":"USD","value_usd":3100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14211362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9620000123977661},{"id":"https://openalex.org/keywords/human-pancreatic-islets","display_name":"human pancreatic islets","score":0.7670000195503235},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.5929999947547913},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9850000143051147},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/islet-transcriptome","display_name":"islet transcriptome","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sex-specific-gene-expression","display_name":"sex-specific gene expression","score":0.6729999780654907},{"id":"https://openalex.org/keywords/mda5","display_name":"MDA5","score":0.8330000042915344},{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":0.597000002861023},{"id":"https://openalex.org/keywords/interferon-lambda-receptor-1","display_name":"interferon lambda receptor 1","score":0.4869999885559082},{"id":"https://openalex.org/keywords/interferon-lambda-2","display_name":"interferon lambda 2","score":0.49799999594688416},{"id":"https://openalex.org/keywords/il28b","display_name":"IL28B","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ifnl4","display_name":"interferon lambda 4","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6818087100982666},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6441072821617126},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6272339224815369},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5684815645217896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.546191930770874},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5342520475387573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4846111238002777},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.46340155601501465},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4601799249649048},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42513272166252136},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4187832772731781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3769664466381073},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3631337285041809},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35107529163360596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23516571521759033}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1210/jendso/bvad114.835","doi":"https://doi.org/10.1210/jendso/bvad114.835","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1210/jendso/bvad114.835","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10554788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10554788","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10554788/pdf/bvad114.835.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Endocr Soc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1210/jendso/bvad114.835","doi":"https://doi.org/10.1210/jendso/bvad114.835","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1210/jendso/bvad114.835","pdf_url":null,"source":{"id":"https://openalex.org/S2735747656","display_name":"Journal of the Endocrine Society","issn_l":"2472-1972","issn":["2472-1972"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315851","host_organization_name":"Endocrine Society","host_organization_lineage":["https://openalex.org/P4310315851"],"host_organization_lineage_names":["Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Endocrine Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387380388.pdf","grobid_xml":"https://content.openalex.org/works/W4387380388.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414903724","https://openalex.org/W6939274074","https://openalex.org/W4317867047","https://openalex.org/W4399688155","https://openalex.org/W7163816112","https://openalex.org/W6923468717","https://openalex.org/W4403151699","https://openalex.org/W3212985109","https://openalex.org/W2939049448","https://openalex.org/W1806303658"],"abstract_inverted_index":{"Abstract":[0],"Disclosure:":[1],"K.L.":[2],"Webster:":[3],"None.":[4,7,10,13,16,19,22,25,28,31],"W.":[5],"Wu:":[6],"B.":[8],"Webb-Robertson:":[9],"E.":[11],"Nakayasu:":[12],"S.":[14],"Sarkar:":[15],"C.":[17],"Evans-Molina:":[18],"S.A.":[20],"Tersey:":[21],"J.":[23],"Enriquez:":[24],"S.R.":[26],"Hammes:":[27],"R.G.":[29],"Mirmira:":[30],"Higher":[32],"female":[33,68,209,317,393],"incidence":[34],"of":[35,76,88,97,192,341,352,412,417,467],"autoimmune":[36,399],"disease":[37],"is":[38,79],"often":[39,61],"attributed":[40],"to":[41,106,117,150,177,222,233,242,249,256,263,292,363,398,463],"sex":[42,69,112,174,342,404],"hormone-immune":[43],"cell":[44,72,99,115,445],"interactions":[45],"or":[46,143],"X":[47],"chromosome":[48],"immune":[49,89,226],"genes":[50,170,182,214],"escaping":[51],"inactivation.":[52],"Type":[53],"1":[54],"diabetes":[55],"(T1D),":[56],"however,":[57],"occurs":[58],"slightly":[59],"more":[60,469],"in":[62,91,175,197,208,239,260,301,306,321,331,345,358,361,387,391,429,449,460,473],"males,":[63,136],"and":[64,93,101,186,219,225,235,247,268,288,315,323,334,376,383,440],"studies":[65],"show":[66],"that":[67,82,94,111,435],"protects":[70],"beta":[71,83,98,114,444],"health":[73,102],"under":[74],"conditions":[75],"stress.":[77],"It":[78],"now":[80],"thought":[81],"cells":[84],"themselves":[85],"trigger":[86],"loss":[87],"tolerance":[90],"T1D":[92,120,152],"the":[95,272,339],"state":[96],"differentiation":[100,322],"dictates":[103],"their":[104],"susceptibility":[105],"autoimmunity.":[107],"Here,":[108],"we":[109,179,349],"hypothesized":[110],"influences":[113],"response":[116,176,362,426,462,472],"inflammation":[118],"during":[119],"development.":[121],"We":[122],"utilized":[123],"prior":[124],"bulk":[125],"RNA":[126,276],"sequencing":[127],"data":[128,433,455],"on":[129],"human":[130],"islets":[131,199,318,328,360,372,401,408],"from":[132,373,402,409],"10":[133],"donors":[134],"(6":[135],"4":[137],"females)":[138],"treated":[139],"for":[140,172,181,443],"18h":[141],"with":[142,183,200,299,380,465],"without":[144],"proinflammatory":[145],"cytokines":[146],"(PIC:":[147],"IL-1b,":[148,366],"IFNy)":[149],"mimic":[151],"inflammation.":[153],"Hierarchical":[154],"clustering":[155],"grouped":[156],"samples":[157],"largely":[158],"by":[159,164],"PIC":[160,201,300,364,381,423],"treatment":[161],"but":[162,447],"also":[163,427],"sex.":[165],"To":[166,337],"identify":[167],"differentially":[168],"expressed":[169],"(DEGs)":[171],"each":[173],"PIC,":[178],"filtered":[180],"fold":[184],"change>1.5":[185],"false":[187],"discovery":[188],"rate<0.05.":[189],"A":[190],"total":[191],"3754":[193],"DEGs":[194,230,254],"were":[195,206,215,231,237,258,319,329],"detected":[196,207],"male":[198,327],"treatment,":[202,424],"while":[203,326],"just":[204],"1117":[205],"islets.":[210],"Of":[211],"these,":[212],"1016":[213],"shared":[216],"between":[217],"sexes,":[218],"many":[220],"related":[221,241,262],"cytokine":[223],"signaling":[224,344],"responses.":[227],"Only":[228],"101":[229],"unique":[232,255],"females,":[234,307],"these":[236,454],"enriched":[238,259,320,330],"terms":[240,261],"leukocyte":[243],"aggregation,":[244],"glutamate":[245],"signaling,":[246,266],"responses":[248,287],"steroid":[250,335,343],"hormone":[251],"stimuli.":[252],"2738":[253],"males":[257,302,375],"inflammation,":[264,464],"NOTCH":[265],"differentiation,":[267],"estrogen":[269],"biosynthesis.":[270],"Notably,":[271],"gene":[273,310],"encoding":[274],"double-stranded":[275],"sensor":[277],"MDA5":[278],"(Ifih1),":[279],"whose":[280],"activity":[281],"induces":[282],"antiviral":[283],"type":[284],"I":[285],"IFN":[286],"has":[289],"been":[290],"linked":[291],"T1D,":[293],"showed":[294],"a":[295,425,450,457,468],"greater":[296],"average":[297],"increase":[298],"(9.99-fold":[303],"vs.":[304],"6.64-fold":[305],"p<0.05).":[308,385],"By":[309],"set":[311],"enrichment":[312],"analysis,":[313],"control":[314],"PIC-treated":[316],"development":[324],"pathways,":[325],"protein":[332],"translation":[333],"metabolism.":[336],"probe":[338],"role":[340],"islet":[346,461],"inflammatory":[347,471],"response,":[348],"measured":[350],"expression":[351,416],"Esr1":[353,379,436],"(encoding":[354,419],"ERa)":[355],"via":[356],"qRT-PCR":[357],"mouse":[359],"(IFNy,":[365],"TNFa).":[367],"In":[368],"non-diabetic":[369],"C57BL6/J":[370,410],"mice,":[371,390],"both":[374,413],"females":[377],"increased":[378,405],"(3.63-":[382],"4.39-fold,":[384],"However,":[386],"pre-diabetic":[388],"NOD":[389,430],"which":[392],"mice":[394,411],"are":[395],"highly":[396],"susceptible":[397],"diabetes,":[400],"neither":[403],"Esr1.":[406],"Interestingly,":[407],"sexes":[414],"decreased":[415],"Ar":[418,441],"androgen":[420],"receptor)":[421],"upon":[422],"absent":[428],"mice.":[431],"These":[432],"suggested":[434],"might":[437],"be":[438],"protective-":[439],"detrimental-":[442],"function,":[446],"not":[448],"sex-dependent":[451],"manner.":[452],"Collectively,":[453],"demonstrate":[456],"sexual":[458],"dimorphism":[459],"evidence":[466],"aggressive":[470],"males.":[474],"Presentation:":[475],"Friday,":[476],"June":[477],"16,":[478],"2023":[479]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-06T00:00:00"}
