{"id":"https://openalex.org/W4387375672","doi":"https://doi.org/10.3389/fmicb.2023.1244325","title":"Antimicrobial activity, membrane interaction and structural features of short arginine-rich antimicrobial peptides","display_name":"Antimicrobial activity, membrane interaction and structural features of short arginine-rich antimicrobial peptides","publication_year":2023,"publication_date":"2023-10-05","ids":{"openalex":"https://openalex.org/W4387375672","doi":"https://doi.org/10.3389/fmicb.2023.1244325","pmid":"https://pubmed.ncbi.nlm.nih.gov/37869668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10585156"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2023.1244325","doi":"https://doi.org/10.3389/fmicb.2023.1244325","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2023.1244325","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244325/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244325/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040702657","display_name":"Bruna Agrillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruna Agrillo","raw_affiliation_strings":["Ampure S.R.L., Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ampure S.R.L., Napoli, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051030651","display_name":"Alessandra Porritiello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108634","display_name":"Institute of Biosciences and Bioresources","ror":"https://ror.org/01gtsa866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Porritiello","raw_affiliation_strings":["National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy","institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084637309","display_name":"Lorena Gratino","orcid":"https://orcid.org/0000-0003-4699-9545","observed_orcids":["https://orcid.org/0000-0003-4699-9545"]},"institutions":[{"id":"https://openalex.org/I4210108634","display_name":"Institute of Biosciences and Bioresources","ror":"https://ror.org/01gtsa866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorena Gratino","raw_affiliation_strings":["National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy","institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001210415","display_name":"Marco Balestrieri","orcid":"https://orcid.org/0000-0003-4343-2148","observed_orcids":["https://orcid.org/0000-0003-4343-2148"]},"institutions":[{"id":"https://openalex.org/I4210108634","display_name":"Institute of Biosciences and Bioresources","ror":"https://ror.org/01gtsa866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Balestrieri","raw_affiliation_strings":["National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy","institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086934292","display_name":"Yolande Th\u00e9r\u00e8se Rose Proroga","orcid":"https://orcid.org/0000-0002-2748-9286","observed_orcids":["https://orcid.org/0000-0002-2748-9286"]},"institutions":[{"id":"https://openalex.org/I4210161349","display_name":"Istituto Zooprofilattico Sperimentale del Mezzogiorno","ror":"https://ror.org/05r7f8853","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210161349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Yolande Therese Proroga","raw_affiliation_strings":["Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy","institution_ids":["https://openalex.org/I4210161349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065582777","display_name":"Andrea Mancusi","orcid":"https://orcid.org/0000-0002-7069-3274","observed_orcids":["https://orcid.org/0000-0002-7069-3274"]},"institutions":[{"id":"https://openalex.org/I4210161349","display_name":"Istituto Zooprofilattico Sperimentale del Mezzogiorno","ror":"https://ror.org/05r7f8853","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210161349"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Mancusi","raw_affiliation_strings":["Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy","institution_ids":["https://openalex.org/I4210161349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091711562","display_name":"Loredana Cozzi","orcid":"https://orcid.org/0000-0002-8593-7550","observed_orcids":["https://orcid.org/0000-0002-8593-7550"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loredana Cozzi","raw_affiliation_strings":["Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072398843","display_name":"Teresa Vicenza","orcid":"https://orcid.org/0000-0002-9524-8476","observed_orcids":["https://orcid.org/0000-0002-9524-8476"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teresa Vicenza","raw_affiliation_strings":["Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0, Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035229728","display_name":"Principia Dardano","orcid":"https://orcid.org/0000-0002-0616-3914","observed_orcids":["https://orcid.org/0000-0002-0616-3914"]},"institutions":[{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Principia Dardano","raw_affiliation_strings":["National Research Council (ISASI-CNR), Institute of Applied Sciences and Intelligent Systems, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (ISASI-CNR), Institute of Applied Sciences and Intelligent Systems, Napoli, Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024079895","display_name":"Bruno Miranda","orcid":"https://orcid.org/0000-0002-8746-833X","observed_orcids":["https://orcid.org/0000-0002-8746-833X"]},"institutions":[{"id":"https://openalex.org/I4210091512","display_name":"Institute of Applied Science and Intelligent Systems","ror":"https://ror.org/00be3zh53","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bruno Miranda","raw_affiliation_strings":["National Research Council (ISASI-CNR), Institute of Applied Sciences and Intelligent Systems, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (ISASI-CNR), Institute of Applied Sciences and Intelligent Systems, Napoli, Italy","institution_ids":["https://openalex.org/I4210091512","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019545057","display_name":"Pablo V. Escrib\u00e1","orcid":"https://orcid.org/0000-0001-9795-182X","observed_orcids":["https://orcid.org/0000-0001-9795-182X"]},"institutions":[{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo V. Escrib\u00e1","raw_affiliation_strings":["Laboratory of Molecular Cell Biomedicine, University of the Balearic Islands, Palma, Spain","Laminar Pharmaceuticals, Palma, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cell Biomedicine, University of the Balearic Islands, Palma, Spain","institution_ids":["https://openalex.org/I50441567"]},{"raw_affiliation_string":"Laminar Pharmaceuticals, Palma, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050194246","display_name":"Marta Gogliettino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108634","display_name":"Institute of Biosciences and Bioresources","ror":"https://ror.org/01gtsa866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Gogliettino","raw_affiliation_strings":["National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy","institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042872767","display_name":"Gianna Palmieri","orcid":"https://orcid.org/0000-0002-9007-4075","observed_orcids":["https://orcid.org/0000-0002-9007-4075"]},"institutions":[{"id":"https://openalex.org/I4210108634","display_name":"Institute of Biosciences and Bioresources","ror":"https://ror.org/01gtsa866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianna Palmieri","raw_affiliation_strings":["Materias S.R.L., Naples, Italy","National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materias S.R.L., Naples, Italy","institution_ids":[]},{"raw_affiliation_string":"National Research Council (IBBR-CNR), Institute of Biosciences and Bioresources, Napoli, Italy","institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042872767"],"corresponding_institution_ids":["https://openalex.org/I4210108634","https://openalex.org/I4210155236"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":6.1777,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.97939379,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1244325","last_page":"1244325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9879999756813049},{"id":"https://openalex.org/keywords/arginine-rich-peptides","display_name":"arginine-rich peptides","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lysine-to-arginine-substitution","display_name":"lysine-to-arginine substitution","score":0.9850000143051147},{"id":"https://openalex.org/keywords/amphiphilic-peptides","display_name":"peptide amphiphiles","score":0.8230000138282776},{"id":"https://openalex.org/keywords/membrane-interactions","display_name":"membrane interactions","score":0.49300000071525574},{"id":"https://openalex.org/keywords/guanidinium","display_name":"guanidinium","score":0.7310000061988831},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.7080000042915344},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/virucidal-activity","display_name":"virucidal activity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/fungicidal-activity","display_name":"fungicidal activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hepatitis-a-virus","display_name":"hepatitis A virus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tryptophan-fluorescence","display_name":"tryptophan fluorescence","score":0.871999979019165},{"id":"https://openalex.org/keywords/peptide-self-assembly","display_name":"peptide self-assembly","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cationic-peptides","display_name":"cationic peptides","score":0.6620000004768372},{"id":"https://openalex.org/keywords/antimicrobial-peptide-design","display_name":"antimicrobial peptide design","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7997731566429138},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.6990411877632141},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.6858084797859192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6222858428955078},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6208077073097229},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5708942413330078},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5514333844184875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5451516509056091},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.40782618522644043},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08831426501274109}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2023.1244325","doi":"https://doi.org/10.3389/fmicb.2023.1244325","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2023.1244325","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244325/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10585156","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10585156","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10585156/pdf/fmicb-14-1244325.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:37869668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37869668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e7d3a152f50545ab900ce6884d367461","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e7d3a152f50545ab900ce6884d367461","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2023.1244325","doi":"https://doi.org/10.3389/fmicb.2023.1244325","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2023.1244325","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmicb.2023.1244325/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387375672.pdf","grobid_xml":"https://content.openalex.org/works/W4387375672.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W149428333","https://openalex.org/W310562816","https://openalex.org/W954092099","https://openalex.org/W1591545670","https://openalex.org/W1875710910","https://openalex.org/W1970709801","https://openalex.org/W1978592925","https://openalex.org/W1990291110","https://openalex.org/W1991081822","https://openalex.org/W1992265395","https://openalex.org/W2017032430","https://openalex.org/W2026727321","https://openalex.org/W2030460323","https://openalex.org/W2042694922","https://openalex.org/W2045743453","https://openalex.org/W2054602599","https://openalex.org/W2079886778","https://openalex.org/W2092599865","https://openalex.org/W2096451092","https://openalex.org/W2120335030","https://openalex.org/W2123231250","https://openalex.org/W2140260269","https://openalex.org/W2140611219","https://openalex.org/W2141682747","https://openalex.org/W2159861471","https://openalex.org/W2160780417","https://openalex.org/W2161267502","https://openalex.org/W2163316049","https://openalex.org/W2164432723","https://openalex.org/W2175270296","https://openalex.org/W2256756668","https://openalex.org/W2320700139","https://openalex.org/W2342937250","https://openalex.org/W2347137046","https://openalex.org/W2484966226","https://openalex.org/W2530145611","https://openalex.org/W2552080741","https://openalex.org/W2579003427","https://openalex.org/W2800043306","https://openalex.org/W2807596407","https://openalex.org/W2898250100","https://openalex.org/W2900988263","https://openalex.org/W2906960763","https://openalex.org/W2914899868","https://openalex.org/W2942754201","https://openalex.org/W2966888197","https://openalex.org/W3088251439","https://openalex.org/W3092909579","https://openalex.org/W3111531342","https://openalex.org/W3161940697","https://openalex.org/W3171783466","https://openalex.org/W3199775598","https://openalex.org/W3204048502","https://openalex.org/W4280610651","https://openalex.org/W4306385743"],"related_works":["https://openalex.org/W2898106666","https://openalex.org/W2066212204","https://openalex.org/W4404011642","https://openalex.org/W3199775598","https://openalex.org/W2275227768","https://openalex.org/W2134355193","https://openalex.org/W2801208649","https://openalex.org/W2318092718","https://openalex.org/W2069561948","https://openalex.org/W2608835695"],"abstract_inverted_index":{"Antimicrobial":[0],"activity":[1,76,107,182],"of":[2,17,33,65,88,98,153,157,180,191,216,228,252,276,286],"many":[3],"AMPs":[4,288],"can":[5],"be":[6],"improved":[7],"by":[8,243],"lysine-to-arginine":[9,100,140],"substitution":[10,251],"due":[11],"to":[12,205,250],"a":[13,25,62,99,111,177,270],"more":[14],"favourable":[15],"interaction":[16],"arginine":[18,43,124],"guanidinium":[19],"moiety":[20],"with":[21,85,122,132,210,254,289],"bacterial":[22],"membranes.":[23],"In":[24,263],"previous":[26],"work,":[27],"the":[28,45,96,118,150,170,188,223,274,281,284],"structural":[29,224],"and":[30,42,70,73,79,82,108,128,160,225,239,246,261],"functional":[31],"characterization":[32],"an":[34,123,147,211],"amphipathic":[35],"antimicrobial":[36,106,151,181,237,277],"peptide":[37,278],"named":[38,114],"RiLK1,":[39,217],"including":[40],"lysine":[41,119,253],"as":[44,257],"positively":[46],"charged":[47,207],"amino":[48],"acids":[49],"in":[50,116,130,149,155],"its":[51,58,133],"sequence,":[52],"was":[53,126,166],"reported.":[54],"Specifically,":[55],"RiLK1":[56,103,154,175],"retained":[57],"\u03b2-sheet":[59],"structure":[60],"under":[61],"wide":[63,178],"range":[64,179],"environmental":[66],"conditions":[67],"(temperature,":[68],"pH,":[69],"ionic":[71],"strength),":[72],"exhibited":[74,176],"bactericidal":[75],"against":[77,169],"Gram-positive":[78],"Gram-negative":[80],"bacteria":[81],"fungal":[83],"pathogens":[84],"no":[86,219],"evidence":[87],"toxicity":[89],"on":[90,102],"mammalian":[91],"cells.":[92],"To":[93],"further":[94],"elucidate":[95],"influence":[97],"replacement":[101],"conformational":[104],"properties,":[105],"peptide-liposome":[109],"interaction,":[110],"new":[112],"RiLK1-derivative,":[113],"RiLK3,":[115],"which":[117],"is":[120],"replaced":[121],"residue,":[125],"projected":[127],"characterised":[129],"comparison":[131],"parental":[134],"compound.":[135],"The":[136],"results":[137],"evidenced":[138],"that":[139,202,215,236],"mutation":[141],"not":[142,145,194],"only":[143],"did":[144],"assure":[146],"improvement":[148],"potency":[152],"terms":[156],"bactericidal,":[158],"virucidal":[159],"fungicidal":[161],"activities,":[162],"but":[163],"rather":[164],"it":[165],"completely":[167,195],"abolished":[168],"hepatitis":[171],"A":[172],"virus.":[173],"Therefore,":[174,232],"like":[183],"other":[184],"cationic":[185],"peptides,":[186],"although":[187,218],"exact":[189],"mechanisms":[190],"action":[192],"are":[193,241],"understood.":[196],"Moreover,":[197],"tryptophan":[198],"fluorescence":[199],"measurements":[200],"confirmed":[201],"RiLK3":[203],"bound":[204],"negatively":[206],"lipid":[208],"vesicles":[209],"affinity":[212],"lower":[213],"than":[214],"substantial":[220],"differences":[221],"from":[222],"self-assembled":[226],"point":[227],"view":[229],"were":[230],"evidenced.":[231],"our":[233],"findings":[234],"imply":[235],"efficacy":[238],"selectivity":[240],"affected":[242],"several":[244],"complex":[245],"interrelated":[247],"factors":[248],"related":[249],"arginine,":[255],"such":[256],"their":[258],"relative":[259],"proportion":[260],"position.":[262],"this":[264,266],"context,":[265],"study":[267],"could":[268],"provide":[269],"better":[271],"rationalisation":[272],"for":[273,283],"optimization":[275],"sequences,":[279],"paving":[280],"way":[282],"development":[285],"novel":[287],"broad":[290],"applications.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-06T00:00:00"}
