{"id":"https://openalex.org/W4387364607","doi":"https://doi.org/10.18008/1816-5095-2023-3-542-548","title":"New Possibilities for Hyposecretory Dry Eye Treatment","display_name":"New Possibilities for Hyposecretory Dry Eye Treatment","publication_year":2023,"publication_date":"2023-10-02","ids":{"openalex":"https://openalex.org/W4387364607","doi":"https://doi.org/10.18008/1816-5095-2023-3-542-548"},"language":"en","primary_location":{"id":"doi:10.18008/1816-5095-2023-3-542-548","doi":"https://doi.org/10.18008/1816-5095-2023-3-542-548","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2023-3-542-548","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18008/1816-5095-2023-3-542-548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039763470","display_name":"S. V. Yanchenko","orcid":"https://orcid.org/0000-0002-7371-689X","observed_orcids":["https://orcid.org/0000-0002-7371-689X"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. V. Yanchenko","raw_affiliation_strings":["Kuban State Medical University; Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuban State Medical University; Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084181773","display_name":"Alexey V. Malyshev","orcid":"https://orcid.org/0000-0002-1448-9690","observed_orcids":["https://orcid.org/0000-0002-1448-9690"]},"institutions":[{"id":"https://openalex.org/I168528297","display_name":"Kuban State Medical University","ror":"https://ror.org/04wa91k02","country_code":"RU","type":"education","lineage":["https://openalex.org/I168528297"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Malyshev","raw_affiliation_strings":["Kuban State Medical University; Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuban State Medical University; Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1","institution_ids":["https://openalex.org/I168528297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071633669","display_name":"Odilova Guljamol Rustamovna","orcid":"https://orcid.org/0000-0001-8825-8134","observed_orcids":["https://orcid.org/0000-0001-8825-8134"]},"institutions":[{"id":"https://openalex.org/I4210098011","display_name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","ror":"https://ror.org/00swkht58","country_code":"UZ","type":"healthcare","lineage":["https://openalex.org/I4210098011"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"G. R. Odilova","raw_affiliation_strings":["Bukhara State Medical Institute named after Abu Ali ibn Sino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bukhara State Medical Institute named after Abu Ali ibn Sino","institution_ids":["https://openalex.org/I4210098011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008195557","display_name":"L. M. Petrosyan","orcid":"https://orcid.org/0000-0002-3473-1157","observed_orcids":["https://orcid.org/0000-0002-3473-1157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. M. Petrosyan","raw_affiliation_strings":["Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Institution \u2014 S.V. Ochapovsky Regional Clinic Hospital No. 1","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093007794","display_name":"M. Yu. Odilov","orcid":"https://orcid.org/0009-0000-5071-3760","observed_orcids":["https://orcid.org/0009-0000-5071-3760"]},"institutions":[{"id":"https://openalex.org/I4210098011","display_name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","ror":"https://ror.org/00swkht58","country_code":"UZ","type":"healthcare","lineage":["https://openalex.org/I4210098011"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"M. Yu. Odilov","raw_affiliation_strings":["Bukhara State Medical Institute named after Abu Ali ibn Sino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bukhara State Medical Institute named after Abu Ali ibn Sino","institution_ids":["https://openalex.org/I4210098011"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6779,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62200666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"20","issue":"3","first_page":"542","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meibomian-gland-dysfunction","display_name":"meibomian gland dysfunction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/medium-chain-triglycerides","display_name":"medium-chain triglycerides","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.722000002861023},{"id":"https://openalex.org/keywords/tear-meniscus-height","display_name":"tear meniscus height","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ocular-surface-disease-index","display_name":"Ocular Surface Disease Index","score":0.7160000205039978},{"id":"https://openalex.org/keywords/ocular-surface","display_name":"ocular surface","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2777917749","wikidata":"https://www.wikidata.org/wiki/Q3143635","display_name":"Sodium hyaluronate","level":2,"score":0.7232562303543091},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.6505240201950073},{"id":"https://openalex.org/C2777165675","wikidata":"https://www.wikidata.org/wiki/Q1425513","display_name":"Meibomian gland","level":3,"score":0.6048617362976074},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5912856459617615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5614160299301147},{"id":"https://openalex.org/C206041023","wikidata":"https://www.wikidata.org/wiki/Q1751970","display_name":"Wilcoxon signed-rank test","level":3,"score":0.5280619263648987},{"id":"https://openalex.org/C2781302119","wikidata":"https://www.wikidata.org/wiki/Q48228","display_name":"Eyelid","level":2,"score":0.430881530046463},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31129294633865356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22300422191619873},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18008/1816-5095-2023-3-542-548","doi":"https://doi.org/10.18008/1816-5095-2023-3-542-548","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2023-3-542-548","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},{"id":"pmh:oai:oai.ophthalmology.elpub.ru:article/2186","doi":null,"is_oa":true,"landing_page_url":"https://www.ophthalmojournal.com/opht/article/view/2186","pdf_url":"https://www.ophthalmojournal.com/opht/article/download/2186/1144","source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ophthalmology in Russia; \u0422\u043e\u043c 20, \u2116 3 (2023); 542-548","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:856f382890b248538d4a6ed2f7626ae7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/856f382890b248538d4a6ed2f7626ae7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oftal\u02b9mologi\u00e2, Vol 20, Iss 3, Pp 542-548 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18008/1816-5095-2023-3-542-548","doi":"https://doi.org/10.18008/1816-5095-2023-3-542-548","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2023-3-542-548","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328539","display_name":"Bausch Health","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387364607.pdf","grobid_xml":"https://content.openalex.org/works/W4387364607.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1970613833","https://openalex.org/W2080839328","https://openalex.org/W2098986513","https://openalex.org/W2114172570","https://openalex.org/W2318800627","https://openalex.org/W2329888037","https://openalex.org/W2333235068","https://openalex.org/W2468865563","https://openalex.org/W2557770498","https://openalex.org/W2621361010","https://openalex.org/W2739359388","https://openalex.org/W2743670010","https://openalex.org/W2749811049","https://openalex.org/W2757726197","https://openalex.org/W2792859014","https://openalex.org/W2883214502","https://openalex.org/W2904867640","https://openalex.org/W2918005780","https://openalex.org/W3037893510","https://openalex.org/W3133992920","https://openalex.org/W3174968955","https://openalex.org/W3179821249","https://openalex.org/W4229064091","https://openalex.org/W4327662631"],"related_works":["https://openalex.org/W1976281846","https://openalex.org/W4389547383","https://openalex.org/W2331370299","https://openalex.org/W3029311287","https://openalex.org/W2749811049","https://openalex.org/W3181644408","https://openalex.org/W4388569268","https://openalex.org/W3018427008","https://openalex.org/W3217804321","https://openalex.org/W4254221244"],"abstract_inverted_index":{"Purpose:":[0],"to":[1,324],"evaluate":[2],"the":[3,21,52,66,78,97,102,114,117,151,164,175,182,185,205,213,229,236,242,279,285,296,304,328],"effectiveness":[4,98,214],"of":[5,9,40,56,60,68,80,99,116,159,163,174,177,184,215,231,244,287,306,312,330,336],"a":[6,17,57,74,89,198,225,246,249,260,266,273,290,320,343,353],"fixed":[7,58,310],"combination":[8,59,311],"0.24":[10,61,313],"%":[11,62,314],"hyaluronic":[12,63,315],"acid,":[13,316],"carbomer,":[14,71,317],"glycerol":[15,72,318],"and":[16,27,43,73,156,166,189,207,265,289,298,319,348,357],"lipid":[18,75,321],"component":[19,76,322],"in":[20,38,51,150,179,202,220,228,251,263,268,276,284,293,303,327,334,346,355],"hyposecretory":[22,32,331],"dry":[23,34],"eye":[24,35],"treatment.":[25],"Patients":[26],"methods.":[28],"We":[29],"examined":[30],"35":[31],"moderate":[33,332],"(DE)":[36],"patients":[37,49,196],"conditions":[39,335],"lipidaquas-mucin":[41],"deficiency":[42],"meibomian":[44],"gland":[45],"dysfunction":[46],"(MGD).":[47],"All":[48],"included":[50],"study":[53],"received":[54],"instillations":[55],"acid":[64],"(in":[65,77],"form":[67,79],"sodium":[69],"hyaluronate),":[70],"medium":[81],"chain":[82],"triglycerides)":[83],"\u2014":[84],"Artelak":[85],"Night":[86],"(3":[87],"times":[88],"day,":[90],"2":[91,157],"months).":[92],"The":[93,195,218],"main":[94],"criterion":[95],"for":[96],"therapy":[100,191],"was":[101,222,253,256,340],"tear":[103,131],"film":[104],"brake":[105],"up":[106],"time":[107],"(TBUT,":[108],"Norn\u2019s":[109],"test,":[110],"s).":[111],"In":[112],"addition,":[113],"dynamics":[115],"following":[118],"indicators":[119,180],"were":[120,270],"taken":[121],"into":[122],"account:":[123],"OSDI":[124,269,356],"(scores),":[125],"\u201clid-wiper\u2019":[126],"symptom":[127],"(LWS,":[128],"scores),":[129],"lower":[130],"meniscus":[132],"height":[133],"(LTMH,":[134],"\u03bcm;":[135],"OCT,":[136],"OptoVue),":[137],"Bijsterveld`s":[138],"xerosis":[139],"index":[140],"(XI,":[141],"scores;":[142],"lyssamine":[143],"green":[144],"stained).":[145],"Control":[146],"points:":[147],"at":[148,204,235,278,295],"inclusion":[149],"study;":[152],"examination":[153],"after":[154,190],"1":[155],"months":[158],"therapy.":[160,217],"Statistics:":[161],"calculation":[162],"mean":[165],"its":[167],"standard":[168],"deviation":[169],"(M":[170],"\u00b1":[171],"s);":[172],"assessment":[173],"reliability":[176],"differences":[178],"characterizing":[181],"state":[183],"ocular":[186],"surface":[187],"before":[188],"(Wilcoxon":[192],"t-test).":[193],"Results.":[194],"showed":[197],"statistically":[199,257],"significant":[200,226,261,274,291,344],"increase":[201,219,262,275,345],"TBUT":[203,221,264,347],"second":[206,297],"third":[208,280,299],"control":[209,238,281,300],"points,":[210],"which":[211,255,339],"indicated":[212],"DE":[216,232,333],"accompanied":[223,341],"by":[224,342],"decrease":[227,250,267,292,354],"severity":[230,286,305],"subjective":[233],"symptoms":[234],"same":[237],"points":[239,301],"(OSDI).":[240],"On":[241],"background":[243],"therapy,":[245],"trend":[247],"towards":[248],"LWS":[252],"recorded,":[254],"insignificant.":[258],"Apparently,":[259],"associated":[271],"with":[272],"LTMH":[277],"point":[282],"(decrease":[283,302],"aqua-deficiency)":[288],"XI":[294],"mucose-deficiency).":[307],"Conclusion.":[308],"A":[309],"proved":[323],"be":[325],"effective":[326],"treatment":[329],"lipid-water-mucin":[337],"deficiency,":[338],"LTMH,":[349],"as":[350,352],"well":[351],"XI.":[358]},"counts_by_year":[{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-06T00:00:00"}