{"id":"https://openalex.org/W4387344737","doi":"https://doi.org/10.1021/acssynbio.3c00372","title":"Molecular Imaging with Aquaporin-Based Reporter Genes: Quantitative Considerations from Monte Carlo Diffusion Simulations","display_name":"Molecular Imaging with Aquaporin-Based Reporter Genes: Quantitative Considerations from Monte Carlo Diffusion Simulations","publication_year":2023,"publication_date":"2023-10-04","ids":{"openalex":"https://openalex.org/W4387344737","doi":"https://doi.org/10.1021/acssynbio.3c00372","pmid":"https://pubmed.ncbi.nlm.nih.gov/37333205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10274877"},"language":"en","primary_location":{"id":"doi:10.1021/acssynbio.3c00372","doi":"https://doi.org/10.1021/acssynbio.3c00372","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssynbio.3c00372","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/11/2023.06.09.544324.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041475088","display_name":"Rochishnu Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rochishnu Chowdhury","raw_affiliation_strings":["Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, United States","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112934475","display_name":"Jinyang Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinyang Wan","raw_affiliation_strings":["Department of Chemistry, University of California, Santa Barbara, California 93106, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Santa Barbara, California 93106, United States","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066178695","display_name":"R\u00e9my Marc M. Gardier","orcid":"https://orcid.org/0000-0001-6073-0812","observed_orcids":["https://orcid.org/0000-0001-6073-0812"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Remy Gardier","raw_affiliation_strings":["Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029798036","display_name":"Jonathan Rafael\u2010Pati\u00f1o","orcid":"https://orcid.org/0000-0002-8960-5465","observed_orcids":["https://orcid.org/0000-0002-8960-5465"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jonathan Rafael-Patino","raw_affiliation_strings":["Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1005 Lausanne, Switzerland","Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1005 Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067782007","display_name":"Jean\u2010Philippe Thiran","orcid":"https://orcid.org/0000-0003-2938-9657","observed_orcids":["https://orcid.org/0000-0003-2938-9657"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Thiran","raw_affiliation_strings":["Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1005 Lausanne, Switzerland","Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1005 Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Signal Processing Laboratory (LTS5), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081112761","display_name":"Fr\u00e9d\u00e9ric Gibou","orcid":"https://orcid.org/0000-0001-7022-5262","observed_orcids":["https://orcid.org/0000-0001-7022-5262"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederic Gibou","raw_affiliation_strings":["Department of Mechanical Engineering \u00a0and\u00a0 Department of Computer Science, University of California, Santa Barbara, California 93106, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering \u00a0and\u00a0 Department of Computer Science, University of California, Santa Barbara, California 93106, United States","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063875629","display_name":"Arnab Mukherjee","orcid":"https://orcid.org/0000-0003-3571-8015","observed_orcids":["https://orcid.org/0000-0003-3571-8015"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arnab Mukherjee","raw_affiliation_strings":["Department of Chemistry,\u00a0 Department of Chemical Engineering,\u00a0 Biomolecular Science and Engineering,\u00a0 Biological Engineering \u00a0and\u00a0 Neuroscience Research Institute, University of California, Santa Barbara, California 93106, United States"],"raw_orcid":"https://orcid.org/0000-0003-3571-8015","affiliations":[{"raw_affiliation_string":"Department of Chemistry,\u00a0 Department of Chemical Engineering,\u00a0 Biomolecular Science and Engineering,\u00a0 Biological Engineering \u00a0and\u00a0 Neuroscience Research Institute, University of California, Santa Barbara, California 93106, United States","institution_ids":["https://openalex.org/I154570441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063875629"],"corresponding_institution_ids":["https://openalex.org/I154570441"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.541,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46685269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"12","issue":"10","first_page":"3041","last_page":"3049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.1437000036239624,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aquaporins","display_name":"aquaporins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/reporter-genes","display_name":"reporter genes","score":0.8669999837875366},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.7979999780654907},{"id":"https://openalex.org/keywords/water-diffusion","display_name":"water diffusion","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cell-packing-density","display_name":"cell packing density","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cell-radius","display_name":"cell radius","score":0.800000011920929},{"id":"https://openalex.org/keywords/intracellular-volume-fraction","display_name":"intracellular volume fraction","score":0.9459999799728394},{"id":"https://openalex.org/keywords/differential-imaging","display_name":"differential imaging","score":0.7049999833106995},{"id":"https://openalex.org/keywords/deep-tissue-imaging","display_name":"deep tissue imaging","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C154280991","wikidata":"https://www.wikidata.org/wiki/Q623090","display_name":"Aquaporin","level":2,"score":0.808205246925354},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.7267232537269592},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.49792909622192383},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4319077730178833},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3881375789642334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34925028681755066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3425264358520508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2916571795940399},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22096103429794312},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1179535984992981},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07346707582473755},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.1021/acssynbio.3c00372","doi":"https://doi.org/10.1021/acssynbio.3c00372","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acssynbio.3c00372","pdf_url":null,"source":{"id":"https://openalex.org/S54167817","display_name":"ACS Synthetic Biology","issn_l":"2161-5063","issn":["2161-5063"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Synthetic Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.06.09.544324","doi":"https://doi.org/10.1101/2023.06.09.544324","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.09.544324","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/11/2023.06.09.544324.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37333205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37333205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37793076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37793076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS synthetic biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11604347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11604347","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11604347/pdf/nihms-2033390.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ACS Synth Biol","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt5p1775jr","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5p1775jr","pdf_url":"https://escholarship.org/content/qt5p1775jr/qt5p1775jr.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Synthetic Biology, vol 12, iss 10","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10274877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10274877","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10274877/pdf/nihpp-2023.06.09.544324v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:infoscience.epfl.ch:307760","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/203715","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"},{"id":"pmh:oai:iris.unil.ch:iris/144114","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/144114","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_6E1FF59417D8","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_6E1FF59417D8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS synthetic biology, vol. 12, no. 10, pp. 3041-3049","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/2023.06.09.544324","doi":"https://doi.org/10.1101/2023.06.09.544324","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.06.09.544324","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/11/2023.06.09.544324.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2045646697","display_name":null,"funder_award_id":"DMR 1720256","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G321649331","display_name":null,"funder_award_id":"W911NF-19-D-0001-0009","funder_id":"https://openalex.org/F4320338502","funder_display_name":"Institute for Collaborative Biotechnologies"},{"id":"https://openalex.org/G3221264126","display_name":"MRI: Acquisition of a Fast-scanning Confocal Microscope to Advance Biophysics, Neuroscience and Bioengineering Research and Training","funder_award_id":"1625770","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G325663671","display_name":null,"funder_award_id":"DMR  1720256","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G4096929283","display_name":"A genetically encoded MRI reporter for noninvasive imaging of activity-dependent gene expression in neurons","funder_award_id":"R03DA050971","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4250104368","display_name":null,"funder_award_id":"1720256","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5681652957","display_name":null,"funder_award_id":"W911NF-19-D-0001-0009","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G608057831","display_name":null,"funder_award_id":"W911NF-19","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6512159266","display_name":null,"funder_award_id":"1720256","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G65411870","display_name":null,"funder_award_id":"W911NF-19-D-0001","funder_id":"https://openalex.org/F4320338502","funder_display_name":"Institute for Collaborative Biotechnologies"},{"id":"https://openalex.org/G6912258823","display_name":"Materials Research Science and Engineering Center at UCSB","funder_award_id":"1720256","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7400121136","display_name":null,"funder_award_id":"W911NF\u201019\u2010D\u20100001","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G7437795455","display_name":null,"funder_award_id":"1720256","funder_id":"https://openalex.org/F4320332500","funder_display_name":"University of California, Santa Barbara"},{"id":"https://openalex.org/G7452299184","display_name":null,"funder_award_id":"W911NF","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G7511209169","display_name":null,"funder_award_id":"1625770","funder_id":"https://openalex.org/F4320332500","funder_display_name":"University of California, Santa Barbara"},{"id":"https://openalex.org/G8415477955","display_name":null,"funder_award_id":"W911NF-19","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8729722292","display_name":"Engineering fluorescence and magnetic resonance reporter genes for imaging biological function in hypoxic cells and in vivo","funder_award_id":"R35GM133530","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8989612170","display_name":"Engineering a calcium reporter gene for magnetic resonance imaging of neural activity","funder_award_id":"R21EB033989","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000869092","display_name":"Metal-free, genetically encoded reporters for calcium recording with MRI","funder_award_id":"R01NS128278","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320306192","display_name":"Silicon Valley Community Foundation","ror":"https://ror.org/001ader08"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"},{"id":"https://openalex.org/F4320333422","display_name":"Materials Research Science and Engineering Center, Harvard University","ror":"https://ror.org/01qa5ep47"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"},{"id":"https://openalex.org/F4320338502","display_name":"Institute for Collaborative Biotechnologies","ror":"https://ror.org/04kz4p343"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387344737.pdf","grobid_xml":"https://content.openalex.org/works/W4387344737.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1489748138","https://openalex.org/W1506280935","https://openalex.org/W1601929875","https://openalex.org/W1963839205","https://openalex.org/W1968840983","https://openalex.org/W1976376022","https://openalex.org/W1994409241","https://openalex.org/W1998187150","https://openalex.org/W2017933173","https://openalex.org/W2019815347","https://openalex.org/W2021939133","https://openalex.org/W2043151182","https://openalex.org/W2045726965","https://openalex.org/W2050028923","https://openalex.org/W2051019611","https://openalex.org/W2070540496","https://openalex.org/W2073265682","https://openalex.org/W2074507470","https://openalex.org/W2077203280","https://openalex.org/W2078936885","https://openalex.org/W2081192009","https://openalex.org/W2098735497","https://openalex.org/W2102520467","https://openalex.org/W2116941191","https://openalex.org/W2118111623","https://openalex.org/W2123176564","https://openalex.org/W2128759493","https://openalex.org/W2133902464","https://openalex.org/W2135256295","https://openalex.org/W2135993898","https://openalex.org/W2145611758","https://openalex.org/W2147607085","https://openalex.org/W2154009044","https://openalex.org/W2156348429","https://openalex.org/W2161447192","https://openalex.org/W2340876277","https://openalex.org/W2394738358","https://openalex.org/W2399186596","https://openalex.org/W2415727024","https://openalex.org/W2561217468","https://openalex.org/W2588463317","https://openalex.org/W2621155715","https://openalex.org/W2754671366","https://openalex.org/W2801551831","https://openalex.org/W2894333093","https://openalex.org/W2907956656","https://openalex.org/W2971116154","https://openalex.org/W2998792856","https://openalex.org/W3024058493","https://openalex.org/W3090064140","https://openalex.org/W3111489650","https://openalex.org/W3135454107","https://openalex.org/W3205458099","https://openalex.org/W3212190986","https://openalex.org/W4206655776","https://openalex.org/W4213139558","https://openalex.org/W4225016307","https://openalex.org/W4283078993","https://openalex.org/W4283159240","https://openalex.org/W4297491184","https://openalex.org/W4353041361","https://openalex.org/W4366140923","https://openalex.org/W4379508363","https://openalex.org/W4407987811"],"related_works":["https://openalex.org/W2561217468","https://openalex.org/W4400768531","https://openalex.org/W4391172199","https://openalex.org/W2904898365","https://openalex.org/W7146196814","https://openalex.org/W2094695853","https://openalex.org/W4226064534","https://openalex.org/W6996026698","https://openalex.org/W7084177696","https://openalex.org/W4401569276"],"abstract_inverted_index":{"Aquaporins":[0],"provide":[1],"a":[2,22,54,74,121,144],"unique":[3],"approach":[4,77],"for":[5],"imaging":[6,76],"genetic":[7],"activity":[8],"in":[9,132,139,149,169],"deep":[10],"tissues":[11],"by":[12,41,89],"increasing":[13],"the":[14,31,95,106,111,126,154,161],"rate":[15],"of":[16,113,129,147,156,165],"cellular":[17],"water":[18,37],"diffusion,":[19],"which":[20],"generates":[21],"magnetic":[23],"resonance":[24],"contrast.":[25],"However,":[26],"distinguishing":[27],"aquaporin":[28,69,92,118],"signals":[29,81,93],"from":[30,94],"tissue":[32,96],"background":[33],"is":[34,39],"challenging":[35],"because":[36],"diffusion":[38,84],"influenced":[40],"structural":[42],"factors,":[43],"such":[44],"as":[45],"cell":[46,61],"size":[47],"and":[48,63,110,119,163],"packing":[49],"density.":[50],"Here,":[51],"we":[52],"developed":[53,138],"Monte":[55,101],"Carlo":[56,102],"model":[57],"to":[58,104,116,158],"analyze":[59,105],"how":[60],"radius":[62],"intracellular":[64],"volume":[65,127],"fraction":[66,128],"quantitatively":[67],"affect":[68],"signals.":[70],"We":[71,98],"demonstrated":[72],"that":[73,123],"differential":[75],"based":[78],"on":[79],"subtracting":[80],"at":[82],"two":[83],"times":[85],"can":[86],"improve":[87],"specificity":[88],"unambiguously":[90],"isolating":[91],"background.":[97],"further":[99],"used":[100],"simulations":[103],"connection":[107],"between":[108],"diffusivity":[109],"percentage":[112],"cells":[114,131],"engineered":[115,167],"express":[117],"established":[120],"mapping":[122],"accurately":[124],"determined":[125],"aquaporin-expressing":[130],"mixed":[133],"populations.":[134],"The":[135],"quantitative":[136],"framework":[137],"this":[140],"study":[141],"will":[142],"enable":[143],"broad":[145],"range":[146],"applications":[148],"biomedical":[150],"synthetic":[151],"biology,":[152],"requiring":[153],"use":[155],"aquaporins":[157],"noninvasively":[159],"monitor":[160],"location":[162],"function":[164],"genetically":[166],"devices":[168],"live":[170],"animals.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-10-05T00:00:00"}