{"id":"https://openalex.org/W4387344359","doi":"https://doi.org/10.3390/genes14101906","title":"Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges","display_name":"Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges","publication_year":2023,"publication_date":"2023-10-04","ids":{"openalex":"https://openalex.org/W4387344359","doi":"https://doi.org/10.3390/genes14101906","pmid":"https://pubmed.ncbi.nlm.nih.gov/37895255","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10606762"},"language":"en","primary_location":{"id":"doi:10.3390/genes14101906","doi":"https://doi.org/10.3390/genes14101906","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes14101906","pdf_url":"https://www.mdpi.com/2073-4425/14/10/1906/pdf?version=1696426905","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4425/14/10/1906/pdf?version=1696426905","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033621761","display_name":"D\u00e9bora Dummer Meira","orcid":"https://orcid.org/0000-0002-6092-2459","observed_orcids":["https://orcid.org/0000-0002-6092-2459"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"D\u00e9bora Dummer Meira","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077499605","display_name":"Maria Clara de Castro e Caetano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Clara de Castro e Caetano","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054471201","display_name":"Matheus Correia Casotti","orcid":"https://orcid.org/0000-0002-9191-8858","observed_orcids":["https://orcid.org/0000-0002-9191-8858"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Matheus Correia Casotti","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9191-8858","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024853892","display_name":"Al\u00e9xia Stefani Siqueira Zetum","orcid":"https://orcid.org/0000-0002-5086-411X","observed_orcids":["https://orcid.org/0000-0002-5086-411X"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Al\u00e9xia Stefani Siqueira Zetum","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081090469","display_name":"Andr\u00e9 Felipe Monteiro Gon\u00e7alves","orcid":"https://orcid.org/0000-0003-4194-7922","observed_orcids":["https://orcid.org/0000-0003-4194-7922"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Felipe Monteiro Gon\u00e7alves","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4194-7922","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113296717","display_name":"Andr\u00e9 Rodrigues Moreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Rodrigues Moreira","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100577324","display_name":"Augusto Henrique de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Augusto Henrique de Oliveira","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078989074","display_name":"Fellipe Pesente","orcid":"https://orcid.org/0009-0004-8707-4762","observed_orcids":["https://orcid.org/0009-0004-8707-4762"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fellipe Pesente","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0009-0004-8707-4762","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074909070","display_name":"Gabriel Mendon\u00e7a Santana","orcid":"https://orcid.org/0009-0000-1650-8042","observed_orcids":["https://orcid.org/0009-0000-1650-8042"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel Mendon\u00e7a Santana","raw_affiliation_strings":["Centro de Ci\u00eancias da Sa\u00fade, Curso de Medicina, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29090-040, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Ci\u00eancias da Sa\u00fade, Curso de Medicina, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29090-040, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070093496","display_name":"Daniel de Almeida Duque","orcid":"https://orcid.org/0000-0002-5288-7059","observed_orcids":["https://orcid.org/0000-0002-5288-7059"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel de Almeida Duque","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005741689","display_name":"Gierleson Santos Cangussu Pereira","orcid":"https://orcid.org/0009-0006-2418-7721","observed_orcids":["https://orcid.org/0009-0006-2418-7721"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gierleson Santos Cangussu Pereira","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104178469","display_name":"Giulia de Souza Cupertino de Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giulia de Souza Cupertino de Castro","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084008191","display_name":"Isabele Pagani Pavan","orcid":"https://orcid.org/0000-0002-5796-6944","observed_orcids":["https://orcid.org/0000-0002-5796-6944"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabele Pagani Pavan","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102846567","display_name":"Jo\u00e3o Pedro Sarcinelli Chagas","orcid":"https://orcid.org/0009-0001-7865-4835","observed_orcids":["https://orcid.org/0009-0001-7865-4835"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Pedro Sarcinelli Chagas","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0009-0001-7865-4835","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109662118","display_name":"Jos\u00e9 Henrique Borges Bourguignon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Henrique Borges Bourguignon","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001387041","display_name":"Juliana Ribeiro de Oliveira","orcid":"https://orcid.org/0000-0002-3430-2088","observed_orcids":["https://orcid.org/0000-0002-3430-2088"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana Ribeiro de Oliveira","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053194941","display_name":"Karen Ruth Michio Barbosa","orcid":"https://orcid.org/0009-0005-1868-8821","observed_orcids":["https://orcid.org/0009-0005-1868-8821"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karen Ruth Michio Barbosa","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012296988","display_name":"Lorena Souza Castro Alto\u00e9","orcid":"https://orcid.org/0000-0001-6118-485X","observed_orcids":["https://orcid.org/0000-0001-6118-485X"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lorena Souza Castro Alto\u00e9","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6118-485X","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091417001","display_name":"Luana Santos Louro","orcid":"https://orcid.org/0009-0007-3436-9980","observed_orcids":["https://orcid.org/0009-0007-3436-9980"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luana Santos Louro","raw_affiliation_strings":["Centro de Ci\u00eancias da Sa\u00fade, Curso de Medicina, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29090-040, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Ci\u00eancias da Sa\u00fade, Curso de Medicina, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29090-040, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090519204","display_name":"Luiza Poppe Merigueti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiza Poppe Merigueti","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030517939","display_name":"Lyvia Neves Rebello Alves","orcid":"https://orcid.org/0000-0001-5107-3689","observed_orcids":["https://orcid.org/0000-0001-5107-3689"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lyvia Neves Rebello Alves","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-5107-3689","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025083597","display_name":"Marlon Ramos Rosado Machado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marlon Ramos Rosado Machado","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104178470","display_name":"Maria Lu\u00edsa Rodrigues Oliveira Roque","orcid":"https://orcid.org/0009-0004-1677-8615","observed_orcids":["https://orcid.org/0009-0004-1677-8615"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Lu\u00edsa Rodrigues Oliveira Roque","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109749808","display_name":"Pedro Santana Prates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Pedro Santana Prates","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093002930","display_name":"Sayuri Honorio de Paula Seg\u00e1ua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sayuri Honorio de Paula Seg\u00e1ua","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078094024","display_name":"Taissa dos Santos Uchiya","orcid":"https://orcid.org/0009-0002-8375-6075","observed_orcids":["https://orcid.org/0009-0002-8375-6075"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Taissa dos Santos Uchiya","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006830805","display_name":"Thomas Erik Santos Louro","orcid":"https://orcid.org/0000-0001-8986-5489","observed_orcids":["https://orcid.org/0000-0001-8986-5489"]},"institutions":[{"id":"https://openalex.org/I4210109824","display_name":"Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria","ror":"https://ror.org/01qcg0c38","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210109824"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thomas Erik Santos Louro","raw_affiliation_strings":["Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria (EMESCAM), Curso de Medicina, Vit\u00f3ria 29027-502, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escola Superior de Ci\u00eancias da Santa Casa de Miseric\u00f3rdia de Vit\u00f3ria (EMESCAM), Curso de Medicina, Vit\u00f3ria 29027-502, Brazil","institution_ids":["https://openalex.org/I4210109824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080082588","display_name":"Vinicius Eduardo Daleprane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vinicius Eduardo Daleprane","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082502736","display_name":"Yasmin Moreto Guaitolini","orcid":"https://orcid.org/0009-0007-6500-3092","observed_orcids":["https://orcid.org/0009-0007-6500-3092"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yasmin Moreto Guaitolini","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0009-0007-6500-3092","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018470675","display_name":"Creuza Rachel Vicente","orcid":"https://orcid.org/0000-0003-0182-7969","observed_orcids":["https://orcid.org/0000-0003-0182-7969"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Creuza Rachel Vicente","raw_affiliation_strings":["Departamento de Medicina Social, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29090-040, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0182-7969","affiliations":[{"raw_affiliation_string":"Departamento de Medicina Social, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29090-040, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051369168","display_name":"Raquel Silva dos Reis Trabach","orcid":"https://orcid.org/0000-0003-2496-9265","observed_orcids":["https://orcid.org/0000-0003-2496-9265"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raquel Silva dos Reis Trabach","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028691393","display_name":"Bruno Cancian de Ara\u00fajo","orcid":"https://orcid.org/0000-0002-0562-917X","observed_orcids":["https://orcid.org/0000-0002-0562-917X"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Cancian de Ara\u00fajo","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026421854","display_name":"Eldam\u00e1ria de Vargas Wolfgramm dos Santos","orcid":"https://orcid.org/0000-0003-3815-0760","observed_orcids":["https://orcid.org/0000-0003-3815-0760"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eldam\u00e1ria de Vargas Wolfgramm dos Santos","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050138668","display_name":"Flavia Paula","orcid":"https://orcid.org/0000-0001-8679-2982","observed_orcids":["https://orcid.org/0000-0001-8679-2982"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via de Paula","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109644025","display_name":"Tiago Jos\u00e9 S. Lopes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]},{"id":"https://openalex.org/I4405286413","display_name":"National Research Institute for Child Health and Development","ror":"https://ror.org/022h8bf50","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tiago Jos\u00e9 S. Lopes","raw_affiliation_strings":["Department of Reproductive Biology, National Center for Child Health and Development Research Institute, Tokyo 157-8535, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reproductive Biology, National Center for Child Health and Development Research Institute, Tokyo 157-8535, Japan","institution_ids":["https://openalex.org/I4210132193","https://openalex.org/I4405286413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021538382","display_name":"Elizeu Fagundes de Carvalho","orcid":"https://orcid.org/0000-0003-4620-7253","observed_orcids":["https://orcid.org/0000-0003-4620-7253"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elizeu Fagundes de Carvalho","raw_affiliation_strings":["Instituto de Biologia Roberto Alc\u00e2ntara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20551-030, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biologia Roberto Alc\u00e2ntara Gomes (IBRAG), Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro 20551-030, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075577337","display_name":"I\u00fari Drumond Louro","orcid":"https://orcid.org/0000-0001-5160-9615","observed_orcids":["https://orcid.org/0000-0001-5160-9615"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"I\u00fari Drumond Louro","raw_affiliation_strings":["N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-5160-9615","affiliations":[{"raw_affiliation_string":"N\u00facleo de Gen\u00e9tica Humana e Molecular, Centro de Ci\u00eancias Humanas e Naturais, Departamento de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Esp\u00edrito Santo (UFES), Vit\u00f3ria 29075-910, Brazil","institution_ids":["https://openalex.org/I51235708"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033621761"],"corresponding_institution_ids":["https://openalex.org/I51235708"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2669},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2669},"fwci":0.6602,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.55242267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"10","first_page":"1906","last_page":"1906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6729999780654907},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7519183158874512},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.566909670829773},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.541450023651123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5340036153793335},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4769924283027649},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47307926416397095},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42829740047454834},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4261648654937744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34163612127304077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2603141665458679},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15645712614059448},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14199024438858032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09170600771903992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07124507427215576}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/genes14101906","doi":"https://doi.org/10.3390/genes14101906","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes14101906","pdf_url":"https://www.mdpi.com/2073-4425/14/10/1906/pdf?version=1696426905","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10606762","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10606762","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10606762/pdf/genes-14-01906.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes (Basel)","raw_type":"Text"},{"id":"pmid:37895255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37895255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/genes14101906","doi":"https://doi.org/10.3390/genes14101906","is_oa":true,"landing_page_url":"https://doi.org/10.3390/genes14101906","pdf_url":"https://www.mdpi.com/2073-4425/14/10/1906/pdf?version=1696426905","source":{"id":"https://openalex.org/S194631498","display_name":"Genes","issn_l":"2073-4425","issn":["2073-4425"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387344359.pdf","grobid_xml":"https://content.openalex.org/works/W4387344359.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W95053512","https://openalex.org/W1505421350","https://openalex.org/W1580957736","https://openalex.org/W1936327534","https://openalex.org/W1983501949","https://openalex.org/W1996590048","https://openalex.org/W2027433423","https://openalex.org/W2038954195","https://openalex.org/W2065949767","https://openalex.org/W2096198395","https://openalex.org/W2099530756","https://openalex.org/W2102576865","https://openalex.org/W2104347254","https://openalex.org/W2110845635","https://openalex.org/W2111662961","https://openalex.org/W2114786335","https://openalex.org/W2133243388","https://openalex.org/W2136549983","https://openalex.org/W2137622697","https://openalex.org/W2138045897","https://openalex.org/W2139110945","https://openalex.org/W2140707518","https://openalex.org/W2142850084","https://openalex.org/W2145757533","https://openalex.org/W2150735425","https://openalex.org/W2166084034","https://openalex.org/W2171755671","https://openalex.org/W2182059603","https://openalex.org/W2198093519","https://openalex.org/W2217777817","https://openalex.org/W2252547313","https://openalex.org/W2270301593","https://openalex.org/W2342551435","https://openalex.org/W2409383155","https://openalex.org/W2467513671","https://openalex.org/W2500444800","https://openalex.org/W2518804156","https://openalex.org/W2538770802","https://openalex.org/W2552941561","https://openalex.org/W2560367415","https://openalex.org/W2567564314","https://openalex.org/W2572174216","https://openalex.org/W2584142822","https://openalex.org/W2609723037","https://openalex.org/W2623725180","https://openalex.org/W2624310346","https://openalex.org/W2735084022","https://openalex.org/W2736996422","https://openalex.org/W2737306670","https://openalex.org/W2738947042","https://openalex.org/W2747965175","https://openalex.org/W2760639821","https://openalex.org/W2762186461","https://openalex.org/W2773938961","https://openalex.org/W2790649727","https://openalex.org/W2793215860","https://openalex.org/W2795258695","https://openalex.org/W2796616654","https://openalex.org/W2803699386","https://openalex.org/W2803802743","https://openalex.org/W2806325305","https://openalex.org/W2809501033","https://openalex.org/W2884070870","https://openalex.org/W2886790097","https://openalex.org/W2889866282","https://openalex.org/W2889904868","https://openalex.org/W2890413077","https://openalex.org/W2894476389","https://openalex.org/W2897084175","https://openalex.org/W2899668190","https://openalex.org/W2900470825","https://openalex.org/W2911496892","https://openalex.org/W2920175805","https://openalex.org/W2936661866","https://openalex.org/W2937830908","https://openalex.org/W2938245541","https://openalex.org/W2942744719","https://openalex.org/W2945279909","https://openalex.org/W2946017308","https://openalex.org/W2947161881","https://openalex.org/W2947477797","https://openalex.org/W2954723566","https://openalex.org/W2964471257","https://openalex.org/W2964617822","https://openalex.org/W2969577346","https://openalex.org/W2976334328","https://openalex.org/W2979707956","https://openalex.org/W2982602983","https://openalex.org/W2987053327","https://openalex.org/W2987975377","https://openalex.org/W2989637766","https://openalex.org/W2990041408","https://openalex.org/W2995372308","https://openalex.org/W2995846969","https://openalex.org/W3000668520","https://openalex.org/W3006593042","https://openalex.org/W3007337815","https://openalex.org/W3008903497","https://openalex.org/W3009605856","https://openalex.org/W3009637078","https://openalex.org/W3013347515","https://openalex.org/W3016393959","https://openalex.org/W3016783954","https://openalex.org/W3027428490","https://openalex.org/W3031018272","https://openalex.org/W3032578076","https://openalex.org/W3036524434","https://openalex.org/W3037014259","https://openalex.org/W3082015854","https://openalex.org/W3087288726","https://openalex.org/W3087591535","https://openalex.org/W3088349285","https://openalex.org/W3093535367","https://openalex.org/W3107445852","https://openalex.org/W3112993115","https://openalex.org/W3113212578","https://openalex.org/W3114411436","https://openalex.org/W3133958186","https://openalex.org/W3136207749","https://openalex.org/W3153403308","https://openalex.org/W3165134528","https://openalex.org/W3172081492","https://openalex.org/W3184611276","https://openalex.org/W3185217833","https://openalex.org/W3191219220","https://openalex.org/W3197088712","https://openalex.org/W3199359439","https://openalex.org/W3199531046","https://openalex.org/W3199752582","https://openalex.org/W3201087911","https://openalex.org/W3201219318","https://openalex.org/W3203821399","https://openalex.org/W3206796634","https://openalex.org/W3207284521","https://openalex.org/W3207592456","https://openalex.org/W4200082955","https://openalex.org/W4200220270","https://openalex.org/W4220856988","https://openalex.org/W4223935840","https://openalex.org/W4224281491","https://openalex.org/W4225143067","https://openalex.org/W4226065969","https://openalex.org/W4226075561","https://openalex.org/W4281964110","https://openalex.org/W4285020427","https://openalex.org/W4285030657","https://openalex.org/W4285087928","https://openalex.org/W4285784529","https://openalex.org/W4290960388","https://openalex.org/W4294739470","https://openalex.org/W4306737628","https://openalex.org/W4307945544","https://openalex.org/W4308513902","https://openalex.org/W4309288061","https://openalex.org/W4309519156","https://openalex.org/W4309647301","https://openalex.org/W4310266277","https://openalex.org/W4313381237","https://openalex.org/W4317433555","https://openalex.org/W4320494313","https://openalex.org/W4321459102","https://openalex.org/W4327599673","https://openalex.org/W4361004561","https://openalex.org/W4361007113","https://openalex.org/W4365515486","https://openalex.org/W4366760362","https://openalex.org/W4378229158","https://openalex.org/W4378627846","https://openalex.org/W4378980382","https://openalex.org/W4381800499","https://openalex.org/W4382369717","https://openalex.org/W4384557739","https://openalex.org/W4385658197","https://openalex.org/W4385763968","https://openalex.org/W6634609803","https://openalex.org/W6680490454","https://openalex.org/W6685516044","https://openalex.org/W6726143842"],"related_works":["https://openalex.org/W2411979118","https://openalex.org/W3192493086","https://openalex.org/W2033352472","https://openalex.org/W2124433696","https://openalex.org/W4403814171","https://openalex.org/W2069532233","https://openalex.org/W2053740948","https://openalex.org/W2211283429","https://openalex.org/W2047004048","https://openalex.org/W3031033607"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,32],"is":[2],"a":[3,133,137,167],"highly":[4],"aggressive":[5],"neoplasm":[6],"and,":[7],"despite":[8],"the":[9,19,45,57,92,102,113,119,160],"development":[10],"of":[11,48,95,105,121,140,147,162],"recent":[12],"therapies,":[13],"tumor":[14],"progression":[15],"and":[16,52,86,100,132,145],"recurrence":[17],"following":[18],"initial":[20],"response":[21,49],"remains":[22],"unsolved.":[23],"Several":[24],"questions":[25],"remain":[26],"unanswered":[27],"about":[28],"non-small":[29],"cell":[30],"lung":[31,96],"(NSCLC):":[33],"(1)":[34],"Which":[35],"patients":[36],"will":[37,90],"actually":[38],"benefit":[39],"from":[40],"therapy?":[41],"(2)":[42],"What":[43,55],"are":[44,56],"predictive":[46],"factors":[47],"to":[50],"MAbs":[51],"TKIs?":[53],"(3)":[54],"best":[58],"combination":[59,170],"strategies":[60],"with":[61,171],"conventional":[62],"treatments":[63],"or":[64],"new":[65,126,141],"antineoplastic":[66],"drugs?":[67],"To":[68],"answer":[69],"these":[70],"questions,":[71],"an":[72],"integrative":[73],"literature":[74],"review":[75],"was":[76],"carried":[77],"out,":[78],"searching":[79],"articles":[80],"in":[81],"PUBMED,":[82],"NCBI-PMC,":[83],"Google":[84],"Academic,":[85],"others.":[87],"Here,":[88],"we":[89],"examine":[91],"molecular":[93,110],"genetics":[94],"cancer,":[97],"emphasizing":[98],"NSCLC,":[99],"delineate":[101],"primary":[103],"categories":[104],"inhibitors":[106],"based":[107,128],"on":[108,118,129,159],"their":[109],"targets,":[111],"alongside":[112],"main":[114],"treatment":[115],"alternatives":[116],"depending":[117],"type":[120],"acquired":[122],"resistance.":[123],"We":[124],"highlighted":[125],"therapies":[127],"epigenetic":[130],"information":[131],"single-cell":[134],"approach":[135],"as":[136,156,158],"potential":[138],"source":[139],"biomarkers.":[142],"The":[143],"current":[144],"future":[146],"NSCLC":[148],"management":[149],"hinges":[150],"upon":[151],"genotyping":[152],"correct":[153],"prognostic":[154],"markers,":[155],"well":[157],"evolution":[161],"precision":[163],"medicine,":[164],"which":[165],"guarantees":[166],"tailored":[168],"drug":[169],"precise":[172],"targeting.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-05T00:00:00"}