{"id":"https://openalex.org/W4387327187","doi":"https://doi.org/10.1111/cns.14483","title":"Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury","display_name":"Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury","publication_year":2023,"publication_date":"2023-10-03","ids":{"openalex":"https://openalex.org/W4387327187","doi":"https://doi.org/10.1111/cns.14483","pmid":"https://pubmed.ncbi.nlm.nih.gov/37789643","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11017417"},"language":"en","primary_location":{"id":"doi:10.1111/cns.14483","doi":"https://doi.org/10.1111/cns.14483","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14483","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052607928","display_name":"Yabin Ji","orcid":"https://orcid.org/0000-0003-0094-4143","observed_orcids":["https://orcid.org/0000-0003-0094-4143"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yabin Ji","raw_affiliation_strings":["Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011387754","display_name":"Yiman Chen","orcid":"https://orcid.org/0000-0001-6809-4291","observed_orcids":["https://orcid.org/0000-0001-6809-4291"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiman Chen","raw_affiliation_strings":["Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013054017","display_name":"Xixi Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xixi Tan","raw_affiliation_strings":["Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","Department of Neurology, Yangjiang People's Hospital, Yangjiang, China","Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Neurology, Yangjiang People's Hospital, Yangjiang, China","institution_ids":[]},{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004423572","display_name":"Xiaowen Huang","orcid":"https://orcid.org/0000-0001-5179-0370","observed_orcids":["https://orcid.org/0000-0001-5179-0370"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Huang","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004277321","display_name":"Qiang Gao","orcid":"https://orcid.org/0000-0001-7262-3942","observed_orcids":["https://orcid.org/0000-0001-7262-3942"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Gao","raw_affiliation_strings":["Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101102520","display_name":"Yinzhong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinzhong Ma","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023325380","display_name":"Shilun Yang","orcid":"https://orcid.org/0000-0003-2734-3698","observed_orcids":["https://orcid.org/0000-0003-2734-3698"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shilun Yang","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0003-2734-3698","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meifang Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meifang Yin","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104106914","display_name":"Min Yu","orcid":"https://orcid.org/0000-0002-4885-8829","observed_orcids":["https://orcid.org/0000-0002-4885-8829"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Fang","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107306837","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0001-8697-2940","observed_orcids":["https://orcid.org/0000-0001-8697-2940","https://orcid.org/0000-0001-7894-6523","https://orcid.org/0000-0002-1968-2588","https://orcid.org/0000-0001-8826-7911"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology and Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101712371","display_name":"Zhu Shi","orcid":"https://orcid.org/0000-0002-6677-3271","observed_orcids":["https://orcid.org/0000-0002-6677-3271"]},"institutions":[{"id":"https://openalex.org/I4210122949","display_name":"Dongguan People\u2019s Hospital","ror":"https://ror.org/022s5gm85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122949"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhu Shi","raw_affiliation_strings":["Department of Neurology, 10th Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China"],"raw_orcid":"https://orcid.org/0000-0002-6677-3271","affiliations":[{"raw_affiliation_string":"Department of Neurology, 10th Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China","institution_ids":["https://openalex.org/I4210122949","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026922421","display_name":"Junlei Chang","orcid":"https://orcid.org/0000-0002-0319-9022","observed_orcids":["https://orcid.org/0000-0002-0319-9022"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junlei Chang","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-0319-9022","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5026922421","https://openalex.org/A5101712371"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210122949","https://openalex.org/I4210145761","https://openalex.org/I58200834"],"apc_list":{"value":3410,"currency":"USD","value_usd":3410},"apc_paid":{"value":3410,"currency":"USD","value_usd":3410},"fwci":1.5095,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81503254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"30","issue":"4","first_page":"e14483","last_page":"e14483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.10809999704360962,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9229999780654907},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.7720000147819519},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oxygen-glucose-deprivation","display_name":"oxygen-glucose deprivation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/thrombospondin-1","display_name":"thrombospondin-1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":0.8539999723434448},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.878000020980835},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6121960282325745},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5619285702705383},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48349693417549133},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.44670000672340393},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4350042939186096},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37892672419548035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.316083699464798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.272943377494812},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.252294659614563},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.18943935632705688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16434702277183533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13383609056472778},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1187334954738617},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.10070443153381348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09701463580131531},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015424","descriptor_name":"Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cns.14483","doi":"https://doi.org/10.1111/cns.14483","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14483","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2216319/v1","doi":"https://doi.org/10.21203/rs.3.rs-2216319/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2216319/v1","pdf_url":"https://www.researchsquare.com/article/rs-2216319/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11017417","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11017417","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11017417/pdf/CNS-30-e14483.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:37789643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37789643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cns.14483","doi":"https://doi.org/10.1111/cns.14483","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cns.14483","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14483","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7096351678","display_name":null,"funder_award_id":"2021B1515120089","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7942778278","display_name":null,"funder_award_id":"32170985","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387327187.pdf","grobid_xml":"https://content.openalex.org/works/W4387327187.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W145549817","https://openalex.org/W1540025214","https://openalex.org/W1968295892","https://openalex.org/W1972304129","https://openalex.org/W2001552996","https://openalex.org/W2005332632","https://openalex.org/W2017408459","https://openalex.org/W2022149149","https://openalex.org/W2024070670","https://openalex.org/W2030485098","https://openalex.org/W2045445343","https://openalex.org/W2056710301","https://openalex.org/W2066189463","https://openalex.org/W2066283275","https://openalex.org/W2067935721","https://openalex.org/W2071868069","https://openalex.org/W2073109785","https://openalex.org/W2084813257","https://openalex.org/W2090806477","https://openalex.org/W2091356216","https://openalex.org/W2095298843","https://openalex.org/W2128551987","https://openalex.org/W2139621750","https://openalex.org/W2146336916","https://openalex.org/W2190558971","https://openalex.org/W2262564012","https://openalex.org/W2585634100","https://openalex.org/W2587695410","https://openalex.org/W2741362367","https://openalex.org/W2755692938","https://openalex.org/W2792146494","https://openalex.org/W2803900332","https://openalex.org/W2805933942","https://openalex.org/W2946487204","https://openalex.org/W2951344798","https://openalex.org/W2986328061","https://openalex.org/W3004140856","https://openalex.org/W4239184618","https://openalex.org/W4300773097","https://openalex.org/W4313424209","https://openalex.org/W4323353027","https://openalex.org/W4323809130"],"related_works":["https://openalex.org/W2406096784","https://openalex.org/W2805609101","https://openalex.org/W4365483412","https://openalex.org/W4408235302","https://openalex.org/W4323036875","https://openalex.org/W2004998610","https://openalex.org/W4405763433","https://openalex.org/W3034916027","https://openalex.org/W2252938521","https://openalex.org/W4386593496"],"abstract_inverted_index":{"BACKGROUND:":[0],"Reperfusion":[1],"therapy":[2,231],"after":[3,229],"ischemic":[4,233],"stroke":[5],"often":[6],"causes":[7],"brain":[8,160,176,192,213,226],"microvascular":[9,27,227],"injury.":[10],"However,":[11],"the":[12,72,89,148,181,196,208,223],"underlying":[13],"mechanisms":[14],"are":[15],"unclear.":[16],"METHODS:":[17],"Transcriptomic":[18,63],"and":[19,42,60,74,103,123,130,140,150,158,168,195,217],"proteomic":[20],"analyses":[21],"were":[22,50,83,116,142],"performed":[23],"on":[24],"human":[25],"cerebral":[26,58,156,202],"endothelial":[28,127,177,193,214],"cells":[29,194],"following":[30],"oxygen-glucose":[31],"deprivation":[32],"(OGD)":[33],"or":[34],"OGD":[35,75],"plus":[36],"recovery":[37],"(OGD/R)":[38],"to":[39],"identify":[40],"molecules":[41],"signaling":[43,91,94,101,105,162],"pathways":[44],"dysregulated":[45],"by":[46,144,166],"reperfusion.":[47,61],"Major":[48],"findings":[49],"further":[51],"validated":[52],"in":[53,191,199,232],"a":[54],"mouse":[55],"model":[56],"of":[57,126,184,212,225],"ischemia":[59,157],"RESULTS:":[62],"analysis":[64,78,108],"identified":[65,109],"390":[66],"differentially":[67,111],"expressed":[68,112],"genes":[69,82,134],"(DEGs)":[70],"between":[71],"OGD/R":[73,145],"group.":[76],"Pathway":[77],"indicated":[79],"that":[80],"these":[81],"mostly":[84],"associated":[85,118],"with":[86,119,155,171],"inflammation,":[87],"including":[88],"TNF":[90,161],"pathway,":[92,95,102],"TGF-\u03b2":[93],"cytokine-cytokine":[96],"receptor":[97,100],"interaction,":[98],"NOD-like":[99],"NF-\u03baB":[104],"pathway.":[106],"Proteomic":[107],"201":[110],"proteins":[113],"(DEPs),":[114],"which":[115],"primarily":[117],"extracellular":[120],"matrix":[121],"destruction":[122],"remodeling,":[124],"impairment":[125],"transport":[128],"function,":[129],"inflammatory":[131],"responses.":[132],"Six":[133],"(DUSP1,":[135],"JUNB,":[136],"NFKBIA,":[137],"NR4A1,":[138],"SERPINE1,":[139],"THBS1)":[141],"upregulated":[143,188],"at":[146],"both":[147],"mRNA":[149],"protein":[151,182],"levels.":[152],"In":[153,179],"mice":[154,200],"reperfusion,":[159,167],"pathway":[163],"was":[164,186],"activated":[165],"inhibiting":[169],"TNF-\u03b1":[170],"adalimumab":[172],"significantly":[173],"attenuated":[174],"reperfusion-induced":[175],"inflammation.":[178],"addition,":[180],"level":[183],"THBS1":[185],"substantially":[187],"upon":[189],"reperfusion":[190,215,230],"peri-endothelial":[197],"area":[198],"receiving":[201],"ischemia.":[203],"CONCLUSION:":[204],"Our":[205],"study":[206],"reveals":[207],"key":[209],"molecular":[210],"signatures":[211],"injury":[216,228],"provides":[218],"potential":[219],"therapeutic":[220],"targets":[221],"for":[222],"treatment":[224],"stroke.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-10-05T00:00:00"}
