{"id":"https://openalex.org/W4387326421","doi":"https://doi.org/10.1007/s11357-023-00955-7","title":"Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases","display_name":"Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases","publication_year":2023,"publication_date":"2023-10-04","ids":{"openalex":"https://openalex.org/W4387326421","doi":"https://doi.org/10.1007/s11357-023-00955-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37792157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10643444"},"language":"en","primary_location":{"id":"doi:10.1007/s11357-023-00955-7","doi":"https://doi.org/10.1007/s11357-023-00955-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-023-00955-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-023-00955-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11357-023-00955-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053298832","display_name":"Ramasamy Selvarani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramasamy Selvarani","raw_affiliation_strings":["Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073081674","display_name":"Hoang Van M. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoang Van Michelle Nguyen","raw_affiliation_strings":["Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004364771","display_name":"Nidheesh Thadathil","orcid":"https://orcid.org/0000-0003-2168-8337","observed_orcids":["https://orcid.org/0000-0003-2168-8337"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidheesh Thadathil","raw_affiliation_strings":["Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109710826","display_name":"Roman F. Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099251","display_name":"Oklahoma City VA Medical Center","ror":"https://ror.org/010md9d18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099251","https://openalex.org/I4210113540","https://openalex.org/I4210133336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman F. Wolf","raw_affiliation_strings":["Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I4210099251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542431","display_name":"Willard M. Freeman","orcid":"https://orcid.org/0000-0001-7027-999X","observed_orcids":["https://orcid.org/0000-0001-7027-999X"]},"institutions":[{"id":"https://openalex.org/I4210099251","display_name":"Oklahoma City VA Medical Center","ror":"https://ror.org/010md9d18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099251","https://openalex.org/I4210113540","https://openalex.org/I4210133336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willard M. Freeman","raw_affiliation_strings":["Okalahoma Medical Research Foundation, Oklahoma City, OK, USA","Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Okalahoma Medical Research Foundation, Oklahoma City, OK, USA","institution_ids":[]},{"raw_affiliation_string":"Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I4210099251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074520942","display_name":"Christopher D. Wiley","orcid":"https://orcid.org/0000-0002-7699-6866","observed_orcids":["https://orcid.org/0000-0002-7699-6866"]},"institutions":[{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Wiley","raw_affiliation_strings":["Jean Mayer USDA Human Nutrition Center On Aging, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jean Mayer USDA Human Nutrition Center On Aging, Boston, MA, USA","institution_ids":["https://openalex.org/I4210111395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021130584","display_name":"Sathyaseelan S. Deepa","orcid":"https://orcid.org/0000-0002-3669-4820","observed_orcids":["https://orcid.org/0000-0002-3669-4820"]},"institutions":[{"id":"https://openalex.org/I4390039380","display_name":"OU Health Stephenson Cancer Center","ror":"https://ror.org/02bmcqd02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039271","https://openalex.org/I4390039380"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathyaseelan S. Deepa","raw_affiliation_strings":["Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","Stephenson Cancer Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Stephenson Cancer Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I4390039380"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061020688","display_name":"Arlan G Richardson","orcid":"https://orcid.org/0000-0001-9622-7311","observed_orcids":["https://orcid.org/0000-0001-9622-7311"]},"institutions":[{"id":"https://openalex.org/I4210099251","display_name":"Oklahoma City VA Medical Center","ror":"https://ror.org/010md9d18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099251","https://openalex.org/I4210113540","https://openalex.org/I4210133336"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arlan Richardson","raw_affiliation_strings":["Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. arlan-richardson@ouhsc.edu","Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA. arlan-richardson@ouhsc.edu","Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. arlan-richardson@ouhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA. arlan-richardson@ouhsc.edu","institution_ids":["https://openalex.org/I4210099251"]},{"raw_affiliation_string":"Okalahoma Veteran Affairs Medical Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I4210099251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061020688"],"corresponding_institution_ids":["https://openalex.org/I4210099251","https://openalex.org/I49332381"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":1.3303,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.79573532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"45","issue":"6","first_page":"3241","last_page":"3256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":1.0},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mlkl","display_name":"MLKL","score":0.9860000014305115},{"id":"https://openalex.org/keywords/knockin-mouse-model","display_name":"knockin mouse model","score":0.8399999737739563},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.8420000076293945},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.7799999713897705},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9940000176429749},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6909999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.9561440944671631},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6930348873138428},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5979059934616089},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5141173005104065},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4627407193183899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3658285140991211},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3565024733543396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34278208017349243},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2773131728172302},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27434930205345154},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23345455527305603},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20537075400352478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.203060120344162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10201671719551086}],"mesh":[{"descriptor_ui":"D000079302","descriptor_name":"Necroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11357-023-00955-7","doi":"https://doi.org/10.1007/s11357-023-00955-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-023-00955-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-023-00955-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10643444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10643444","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10643444/pdf/11357_2023_Article_955.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Text"},{"id":"pmid:37792157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37792157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11357-023-00955-7","doi":"https://doi.org/10.1007/s11357-023-00955-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11357-023-00955-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11357-023-00955-7.pdf","source":{"id":"https://openalex.org/S4210237251","display_name":"GeroScience","issn_l":"2152-4041","issn":["2152-4041","2331-3773","2509-2715","2509-2723"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GeroScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2315640595","display_name":"Role of necroptosis in inflammation and NAFLD to HCC progression","funder_award_id":"R03CA262044","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2619364971","display_name":null,"funder_award_id":"IK6 BX005238","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3495715663","display_name":null,"funder_award_id":"I01BX004538","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G692538568","display_name":null,"funder_award_id":"IK6 BX006033","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000890460","display_name":"Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging","funder_award_id":"P30AG050911","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906619","display_name":"The role of hepatocyte necroptosis and inflammation in liver-brain crosstalk in aging","funder_award_id":"R01AG059718","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320310851","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387326421.pdf","grobid_xml":"https://content.openalex.org/works/W4387326421.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1035050697","https://openalex.org/W1736633110","https://openalex.org/W1906972812","https://openalex.org/W1988848002","https://openalex.org/W1989969354","https://openalex.org/W2014830013","https://openalex.org/W2023122823","https://openalex.org/W2034106656","https://openalex.org/W2042637324","https://openalex.org/W2082870439","https://openalex.org/W2091263717","https://openalex.org/W2104028914","https://openalex.org/W2110796758","https://openalex.org/W2129155846","https://openalex.org/W2144919352","https://openalex.org/W2146358940","https://openalex.org/W2594120765","https://openalex.org/W2739182934","https://openalex.org/W2744074503","https://openalex.org/W2801853437","https://openalex.org/W2887043640","https://openalex.org/W2888323682","https://openalex.org/W2891123677","https://openalex.org/W2904356101","https://openalex.org/W2921610009","https://openalex.org/W2989291073","https://openalex.org/W2993908729","https://openalex.org/W3000585291","https://openalex.org/W3013616343","https://openalex.org/W3092584602","https://openalex.org/W3117349407","https://openalex.org/W3118331092","https://openalex.org/W3200313493","https://openalex.org/W3213621514","https://openalex.org/W4286742005","https://openalex.org/W4295222758","https://openalex.org/W4377093194"],"related_works":["https://openalex.org/W4407319303","https://openalex.org/W4404164174","https://openalex.org/W3213621514","https://openalex.org/W4319597772","https://openalex.org/W4416579015","https://openalex.org/W4410053359","https://openalex.org/W3118331092","https://openalex.org/W2750390778","https://openalex.org/W2801853437","https://openalex.org/W3176958235"],"abstract_inverted_index":{"Abstract":[0],"To":[1],"study":[2,230],"the":[3,57,62,75,78,108,185,188,209,212,219,231],"impact":[4,232],"of":[5,77,97,187,202,211,233],"necroptosis-induced":[6],"chronic":[7,240],"inflammation":[8,106,241],"on":[9,239],"age-related":[10,245],"diseases":[11],"and":[12,19,65,71,105,125,135,154,162,170,175,215,244],"aging,":[13],"two":[14,25,58],"knockin":[15],"mouse":[16,221],"models":[17,222],"(Ripk3-KI":[18],"Mlkl-KI)":[20,136],"were":[21,68,181,205],"generated":[22],"that":[23,177,226],"overexpress":[24],"genes":[26],"involved":[27],"in":[28,61,74,101,107,121,140,147,184,208,236,242],"necroptosis":[29,103,141,235],"(Ripk3":[30],"or":[31,41,52,80,87,191],"Mlkl)":[32],"when":[33],"crossed":[34],"to":[35,44,111,129,195,229],"Cre":[36],"transgenic":[37,46],"mice.":[38,82,137,198,217],"Crossing":[39],"Ripk3-KI":[40,134],"Mlkl-KI":[42],"mice":[43,47,89,113,127,193],"albumin-Cre":[45],"produced":[48],"hepatocyte":[49],"specific":[50,237],"hRipk3-KI":[51,79,86,124,190,214],"hMlkl-KI":[53,81,88,126,192,216],"mice,":[54],"which":[55],"express":[56],"transgenes":[59],"only":[60],"liver.":[63],"Ripk3":[64],"Mlkl":[66],"proteins":[67],"overexpressed":[69],"10-":[70],"fourfold,":[72],"respectively,":[73],"livers":[76,186,210],"Treating":[83],"young":[84],"(2-month)":[85],"with":[90,144,179],"carbon":[91],"tetrachloride":[92],"(CCl4),":[93],"a":[94],"chemical":[95],"inducer":[96],"oxidative":[98],"stress,":[99],"resulted":[100],"increased":[102,120,207],"(Mlkl-oligomers)":[104],"liver":[109],"compared":[110,128,194],"control":[112,131,197],"receiving":[114],"CCl4.":[115],"Mlkl-oligomerization":[116],"also":[117],"was":[118,142],"significantly":[119,182,206],"old":[122,130,189,196,213],"(18-month)":[123],"(Cre":[132],"negative,":[133],"The":[138],"increase":[139,146,178],"associated":[143],"an":[145],"inflammation,":[148],"e.g.,":[149],"inflammatory":[150],"cytokines":[151],"(TNF\u03b1,":[152],"IL-6)":[153],"macrophage":[155],"markers":[156,201],"(F4/80,":[157],"CD68).":[158],"Importantly,":[159],"steatosis":[160],"(triglycerides)":[161],"fibrosis":[163],"(e.g.,":[164],"picrosirius":[165],"red":[166],"staining,":[167],"hydroxyproline":[168],"levels,":[169],"transcripts":[171],"for":[172],"TGF\u03b2,":[173],"Col1\u03b11,":[174],"Col3\u03b11)":[176],"age":[180],"higher":[183],"In":[199],"addition,":[200],"cellular":[203],"senescence":[204],"Thus,":[218],"first":[220],"have":[223],"been":[224],"developed":[225],"allow":[227],"researchers":[228],"inducing":[234],"cells/tissues":[238],"aging":[243],"diseases.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-05T00:00:00"}