{"id":"https://openalex.org/W4387312286","doi":"https://doi.org/10.1038/s41598-023-36733-w","title":"Whole genome sequencing of increased number of azithromycin-resistant Shigella flexneri 1b isolates in Ontario","display_name":"Whole genome sequencing of increased number of azithromycin-resistant Shigella flexneri 1b isolates in Ontario","publication_year":2023,"publication_date":"2023-10-03","ids":{"openalex":"https://openalex.org/W4387312286","doi":"https://doi.org/10.1038/s41598-023-36733-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37789081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10547750"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-36733-w","doi":"https://doi.org/10.1038/s41598-023-36733-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-36733-w","pdf_url":"https://www.nature.com/articles/s41598-023-36733-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-36733-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011120287","display_name":"Alefiya Neemuchwala","orcid":"https://orcid.org/0000-0003-3103-5823","observed_orcids":["https://orcid.org/0000-0003-3103-5823"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alefiya Neemuchwala","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069100857","display_name":"Sandra I. Zittermann","orcid":"https://orcid.org/0000-0002-9574-113X","observed_orcids":["https://orcid.org/0000-0002-9574-113X"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandra Zittermann","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019409766","display_name":"Karen O. Johnson","orcid":"https://orcid.org/0000-0001-5198-0502","observed_orcids":["https://orcid.org/0000-0001-5198-0502"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen Johnson","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070101235","display_name":"Dean Middleton","orcid":"https://orcid.org/0000-0001-7586-1698","observed_orcids":["https://orcid.org/0000-0001-7586-1698"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dean Middleton","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065318386","display_name":"Patrick J. Stapleton","orcid":"https://orcid.org/0000-0003-4724-9121","observed_orcids":["https://orcid.org/0000-0003-4724-9121"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick J. Stapleton","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054434026","display_name":"Vithusha Ravirajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vithusha Ravirajan","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004604994","display_name":"Kirby I. Cronin","orcid":"https://orcid.org/0000-0002-5124-3446","observed_orcids":["https://orcid.org/0000-0002-5124-3446"]},"institutions":[{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kirby Cronin","raw_affiliation_strings":["Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101546789","display_name":"Vanessa G Allen","orcid":"https://orcid.org/0000-0001-9802-9730","observed_orcids":["https://orcid.org/0000-0001-9802-9730"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vanessa G. Allen","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","Sinai Health, Mount Sinai Hospital, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada","institution_ids":["https://openalex.org/I4210125326"]},{"raw_affiliation_string":"Sinai Health, Mount Sinai Hospital, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101763935","display_name":"Samir N. Patel","orcid":"https://orcid.org/0000-0001-9824-7623","observed_orcids":["https://orcid.org/0000-0001-9824-7623"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210125326","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210125326"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Samir.N. Patel","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Samir.Patel@oahpp.ca","Microbiology and Laboratory Science, Public Health Ontario, 661 University Ave, Suite 1701, Toronto, ON, M5G 1M1, Canada. Samir.Patel@oahpp.ca","Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada. Samir.Patel@oahpp.ca","Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Samir.Patel@oahpp.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Microbiology and Laboratory Science, Public Health Ontario, 661 University Ave, Suite 1701, Toronto, ON, M5G 1M1, Canada. Samir.Patel@oahpp.ca","institution_ids":["https://openalex.org/I4210125326"]},{"raw_affiliation_string":"Ontario Agency for Health Protection and Promotion (Public Health Ontario), Toronto, ON, Canada. Samir.Patel@oahpp.ca","institution_ids":["https://openalex.org/I4210125326"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101763935"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4210125326"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.8501,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63474086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"16582","last_page":"16582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azithromycin-resistance","display_name":"azithromycin resistance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/incfii-plasmid","display_name":"IncFII plasmid","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ciprofloxacin-resistance","display_name":"ciprofloxacin resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/clonal-populations","display_name":"clonal populations","score":0.49900001287460327},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/international-travel","display_name":"international travel","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ontario","display_name":"Ontario","score":0.5550000071525574},{"id":"https://openalex.org/keywords/ceftriaxone-resistance","display_name":"ceftriaxone resistance","score":0.7519999742507935},{"id":"https://openalex.org/keywords/plasmid-mediated-resistance","display_name":"plasmid-mediated resistance","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2778907293","wikidata":"https://www.wikidata.org/wiki/Q165399","display_name":"Azithromycin","level":3,"score":0.7341340780258179},{"id":"https://openalex.org/C2781217973","wikidata":"https://www.wikidata.org/wiki/Q1644417","display_name":"Shigella flexneri","level":4,"score":0.7143813371658325},{"id":"https://openalex.org/C2776986154","wikidata":"https://www.wikidata.org/wiki/Q131029","display_name":"Shigella","level":4,"score":0.6675719022750854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5213293433189392},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5138290524482727},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5096940994262695},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.4697205126285553},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.4528648257255554},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4238026738166809},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.4119473993778229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3901708126068115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3705921471118927},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2962135076522827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21506628394126892},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.20689889788627625},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.15126261115074158},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09717637300491333},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09274005889892578},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000073336","descriptor_name":"Whole Genome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004405","descriptor_name":"Dysentery, Bacillary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004405","descriptor_name":"Dysentery, Bacillary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009864","descriptor_name":"Ontario","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012763","descriptor_name":"Shigella flexneri","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017963","descriptor_name":"Azithromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-36733-w","doi":"https://doi.org/10.1038/s41598-023-36733-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-36733-w","pdf_url":"https://www.nature.com/articles/s41598-023-36733-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10547750","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10547750","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10547750/pdf/41598_2023_Article_36733.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37789081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37789081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:108a51a57e194fe09ebce96ddb50237f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/108a51a57e194fe09ebce96ddb50237f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-36733-w","doi":"https://doi.org/10.1038/s41598-023-36733-w","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41598-023-36733-w","pdf_url":"https://www.nature.com/articles/s41598-023-36733-w.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4426235973","display_name":"Public Health Ontario","ror":"https://ror.org/025z8ah66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387312286.pdf","grobid_xml":"https://content.openalex.org/works/W4387312286.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W26641785","https://openalex.org/W94352609","https://openalex.org/W970043262","https://openalex.org/W1972145956","https://openalex.org/W1998217335","https://openalex.org/W2013465444","https://openalex.org/W2021724381","https://openalex.org/W2027831845","https://openalex.org/W2041257508","https://openalex.org/W2048100005","https://openalex.org/W2055043387","https://openalex.org/W2091030812","https://openalex.org/W2096093282","https://openalex.org/W2098916578","https://openalex.org/W2111647009","https://openalex.org/W2117834417","https://openalex.org/W2120902911","https://openalex.org/W2134852597","https://openalex.org/W2148291724","https://openalex.org/W2162494851","https://openalex.org/W2427128367","https://openalex.org/W2430736883","https://openalex.org/W2440472260","https://openalex.org/W2486541549","https://openalex.org/W2509014851","https://openalex.org/W2610656577","https://openalex.org/W2747104183","https://openalex.org/W2758894305","https://openalex.org/W2797381074","https://openalex.org/W2799524357","https://openalex.org/W2803222720","https://openalex.org/W2883838322","https://openalex.org/W2885680427","https://openalex.org/W2909721632","https://openalex.org/W2940090207","https://openalex.org/W2941864079","https://openalex.org/W2949182334","https://openalex.org/W2951278111","https://openalex.org/W2952167528","https://openalex.org/W2982531601","https://openalex.org/W2987365002","https://openalex.org/W3001782343","https://openalex.org/W3045082280","https://openalex.org/W3125998537","https://openalex.org/W4211093840","https://openalex.org/W4220961986"],"related_works":["https://openalex.org/W4402364343","https://openalex.org/W3037224970","https://openalex.org/W2148291724","https://openalex.org/W4413104707","https://openalex.org/W4393114531","https://openalex.org/W2981101173","https://openalex.org/W2787740262","https://openalex.org/W2590559939","https://openalex.org/W3207546099","https://openalex.org/W2743624175"],"abstract_inverted_index":{"Abstract":[0],"Azithromycin":[1],"(AZM)":[2],"resistance":[3,158],"among":[4,51,106,180],"Shigella":[5,18],"is":[6],"a":[7,70,101,171],"major":[8,62],"public":[9],"health":[10],"concern.":[11],"Here,":[12],"we":[13],"investigated":[14],"the":[15,29,143],"epidemiology":[16],"of":[17,33,41,46,66,90,114,145],"flexneri":[19],"serotype":[20],"1b":[21],"recovered":[22],"during":[23],"2016\u20132018":[24],"in":[25,127,170],"Ontario,":[26],"to":[27,120,124,138,142,155,162],"describe":[28],"prevalence":[30],"and":[31,64,86,94,132,166,182,191],"spread":[32],"AZM":[34,130,139],"resistance.":[35],"We":[36,174],"found":[37,183],"that":[38,184],"72.3%":[39],"(47/65)":[40],"cases":[42],"were":[43,50,129],"AZM\u2013resistant":[44],"(AZMR),":[45],"which":[47],"95.7%":[48],"(45/47)":[49],"males":[52,108,181],"(P":[53],"<":[54],"0.001).":[55],"Whole-genome":[56],"based":[57],"phylogenetic":[58],"analysis":[59,186],"showed":[60],"three":[61],"clusters,":[63],"56.9%":[65],"isolates":[67,115,177],"grouped":[68],"within":[69],"single":[71,77,172],"closely-related":[72],"cluster":[73,104],"(0\u201310":[74],"\u2206SNP).":[75],"A":[76,112],"AZMR":[78,103,176],"clonal":[79],"population":[80],"was":[81,140,168],"persistent":[82],"over":[83],"3":[84],"years":[85],"involved":[87],"67.9%":[88],"(36/53)":[89],"all":[91],"male":[92],"cases,":[93],"none":[95],"reported":[96,134],"international":[97,135],"travel.":[98,111,136],"In":[99],"2018,":[100],"different":[102],"appeared":[105],"adult":[107],"not":[109],"reporting":[110],"proportion":[113],"(10.7%)":[116],"with":[117],"reduced":[118],"susceptibility":[119],"ciprofloxacin":[121],"(CIP)":[122],"due":[123,141],"S83L":[125],"mutation":[126],"gyrA":[128],"susceptible,":[131],"71.4%":[133],"Resistance":[137],"acquisition":[144],"mph":[146],"gene-bearing":[147],"incFII":[148],"plasmids":[149],"having":[150],">":[151],"95%":[152],"nucleotide":[153],"similarity":[154],"pKSR100.":[156],"Plasmid-borne":[157],"limiting":[159],"treatment":[160],"options":[161],"AZM,":[163],"ceftriaxone":[164],"(CRO)":[165],"CIP":[167],"noted":[169],"isolate.":[173],"characterized":[175],"circulating":[178],"locally":[179],"genomic":[185],"can":[187],"support":[188],"targeted":[189],"prevention":[190],"mitigation":[192],"strategies":[193],"against":[194],"antimicrobial-resistance.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-04T00:00:00"}