{"id":"https://openalex.org/W4387299253","doi":"https://doi.org/10.1101/2023.10.02.560423","title":"A weak coupling mechanism mediates the recovery stroke of myosin VI: a free energy simulation and string method analysis","display_name":"A weak coupling mechanism mediates the recovery stroke of myosin VI: a free energy simulation and string method analysis","publication_year":2023,"publication_date":"2023-10-03","ids":{"openalex":"https://openalex.org/W4387299253","doi":"https://doi.org/10.1101/2023.10.02.560423"},"language":"en","primary_location":{"id":"doi:10.1101/2023.10.02.560423","doi":"https://doi.org/10.1101/2023.10.02.560423","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.02.560423","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/10/05/2023.10.02.560423.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/10/05/2023.10.02.560423.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068021762","display_name":"Florian E.C. Blanc","orcid":"https://orcid.org/0000-0002-0762-0478","observed_orcids":["https://orcid.org/0000-0002-0762-0478"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210096046","display_name":"Institut de Chimie de Strasbourg","ror":"https://ror.org/00se7bf12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Florian E.C. Blanc","raw_affiliation_strings":["Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","Structural Motility, Institut Curie, CNRS, UMR 144, PSL Research University, F-75005 Paris, France","Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 777 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France"],"raw_orcid":"https://orcid.org/0000-0002-0762-0478","affiliations":[{"raw_affiliation_string":"Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Structural Motility, Institut Curie, CNRS, UMR 144, PSL Research University, F-75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"raw_affiliation_string":"Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 777 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022975047","display_name":"Anne Houdusse","orcid":"https://orcid.org/0000-0002-8566-0336","observed_orcids":["https://orcid.org/0000-0002-8566-0336"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Houdusse","raw_affiliation_strings":["Structural Motility, Institut Curie, CNRS, UMR 144, PSL Research University, F-75005 Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-8566-0336","affiliations":[{"raw_affiliation_string":"Structural Motility, Institut Curie, CNRS, UMR 144, PSL Research University, F-75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210161403","https://openalex.org/I80043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054527529","display_name":"Marco Cecchini","orcid":"https://orcid.org/0000-0003-2671-1583","observed_orcids":["https://orcid.org/0000-0003-2671-1583"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210096046","display_name":"Institut de Chimie de Strasbourg","ror":"https://ror.org/00se7bf12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Marco Cecchini","raw_affiliation_strings":["Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 777 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France"],"raw_orcid":"https://orcid.org/0000-0003-2671-1583","affiliations":[{"raw_affiliation_string":"Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 7177 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Molecular Function Engineering, Institut de Chimie de Strasbourg, UMR 777 CNRS, Universit\u00e9 de Strasbourg, F-67083 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210096046","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5054527529","https://openalex.org/A5068021762"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I4210096046","https://openalex.org/I4210161403","https://openalex.org/I68947357","https://openalex.org/I80043"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.09510000050067902,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-vi","display_name":"myosin VI","score":0.996999979019165},{"id":"https://openalex.org/keywords/recovery-stroke","display_name":"recovery stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/converter-domain","display_name":"converter domain","score":0.703000009059906},{"id":"https://openalex.org/keywords/free-energy-landscape","display_name":"free energy landscape","score":0.6940000057220459},{"id":"https://openalex.org/keywords/transition-pathways","display_name":"transition pathways","score":0.5600000023841858},{"id":"https://openalex.org/keywords/weak-coupling","display_name":"weak coupling","score":0.4320000112056732},{"id":"https://openalex.org/keywords/thermal-fluctuations","display_name":"thermal fluctuations","score":0.777999997138977},{"id":"https://openalex.org/keywords/ratchet-mechanism","display_name":"ratchet mechanism","score":0.8339999914169312},{"id":"https://openalex.org/keywords/actin-motor-proteins","display_name":"actin motor proteins","score":0.5059999823570251},{"id":"https://openalex.org/keywords/free-energy-simulation","display_name":"free energy simulation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/string-method","display_name":"string method","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6907451152801514},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.6125278472900391},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.565910279750824},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4553561210632324},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.4538286328315735},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.44973862171173096},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.4323156774044037},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4151081442832947},{"id":"https://openalex.org/C15954220","wikidata":"https://www.wikidata.org/wiki/Q24780076","display_name":"Myosin head","level":4,"score":0.4149995744228363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37718507647514343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2541816234588623},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.20676448941230774},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17916715145111084},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.1367795467376709},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1104801595211029},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.10.02.560423","doi":"https://doi.org/10.1101/2023.10.02.560423","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.02.560423","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/10/05/2023.10.02.560423.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.10.02.560423","doi":"https://doi.org/10.1101/2023.10.02.560423","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.02.560423","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/10/05/2023.10.02.560423.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.9200000166893005,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321047","display_name":"Partnership for Advanced Computing in Europe AISBL","ror":"https://ror.org/038j4hz26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387299253.pdf","grobid_xml":"https://content.openalex.org/works/W4387299253.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W185137928","https://openalex.org/W1031578623","https://openalex.org/W1821679912","https://openalex.org/W1965645117","https://openalex.org/W1970849882","https://openalex.org/W1976998887","https://openalex.org/W1978943385","https://openalex.org/W1983372570","https://openalex.org/W1984787419","https://openalex.org/W1986614779","https://openalex.org/W1989096170","https://openalex.org/W1990529462","https://openalex.org/W1993177346","https://openalex.org/W1994158181","https://openalex.org/W1996684376","https://openalex.org/W1998775587","https://openalex.org/W2010347742","https://openalex.org/W2024400312","https://openalex.org/W2024762727","https://openalex.org/W2029913540","https://openalex.org/W2030800594","https://openalex.org/W2034256284","https://openalex.org/W2049074426","https://openalex.org/W2049738344","https://openalex.org/W2051813735","https://openalex.org/W2052933248","https://openalex.org/W2053081979","https://openalex.org/W2055725168","https://openalex.org/W2057557940","https://openalex.org/W2058971275","https://openalex.org/W2061579713","https://openalex.org/W2071974851","https://openalex.org/W2078629389","https://openalex.org/W2101234009","https://openalex.org/W2136106382","https://openalex.org/W2143171629","https://openalex.org/W2149146343","https://openalex.org/W2149655632","https://openalex.org/W2150981663","https://openalex.org/W2151430724","https://openalex.org/W2154535641","https://openalex.org/W2315713833","https://openalex.org/W2473398903","https://openalex.org/W2548349631","https://openalex.org/W2559781202","https://openalex.org/W2563321337","https://openalex.org/W2589483645","https://openalex.org/W2612790657","https://openalex.org/W2806983822","https://openalex.org/W2949233567","https://openalex.org/W2985959859","https://openalex.org/W3003257820","https://openalex.org/W3030442361","https://openalex.org/W3030773691","https://openalex.org/W3094792618","https://openalex.org/W3136708306","https://openalex.org/W3171739214","https://openalex.org/W4310472920","https://openalex.org/W4318220624","https://openalex.org/W4377047665","https://openalex.org/W6610211995"],"related_works":["https://openalex.org/W4395447891","https://openalex.org/W2806983822","https://openalex.org/W2949564101","https://openalex.org/W6959787290","https://openalex.org/W1965645117","https://openalex.org/W1970849882","https://openalex.org/W1984787419","https://openalex.org/W2051813735","https://openalex.org/W3132049124","https://openalex.org/W1996684376"],"abstract_inverted_index":{"Abstract":[0],"Myosin":[1,303],"motors":[2],"use":[3],"the":[4,20,27,49,53,65,76,81,88,96,100,121,124,140,147,171,175,178,189,197,204,208,211,214,221,226,230,234,241,250,261,282,321,349,362,365,368,379,384,387,406,409,414,450],"energy":[5,137,163,331],"of":[6,19,38,52,68,75,91,99,177,196,210,225,253,260,323,351,364,381,386,390,397,408,413],"ATP":[7,23,57,274,333,357,426],"to":[8,46,103,129,180,220,361,438],"produce":[9],"force":[10],"and":[11,56,115,139,151,207,273,292,320,383,423],"directed":[12],"movement":[13,195],"on":[14],"actin":[15],"by":[16,41,73,244,289,294,420,425,446],"a":[17,104,160,193,256,298,339,402],"swing":[18,51],"lever":[21,54],"arm.":[22],"is":[24,44,71,155,192,237,286,304,310,338,359,416],"hydrolysed":[25],"during":[26,367],"off-actin":[28],"re-priming":[29,98,272,363,407],"transition":[30,122,164,182],"termed":[31],"recovery":[32,66,89,262,284,369,388],"stroke.":[33],"To":[34],"provide":[35],"an":[36,305,394,442],"understanding":[37],"chemo-mechanical":[39],"transduction":[40],"myosin,":[42,356],"it":[43,154],"critical":[45],"determine":[47],"how":[48,327],"reverse":[50],"arm":[55],"hydrolysis":[58,275,334,358],"are":[59,276],"coupled.":[60],"Previous":[61],"studies":[62],"concluded":[63],"that":[64,87,110,153,200,233,240,270,281,309,432],"stroke":[67,90,263,285,370,389],"myosin":[69,92,132,265,283,328,391,433],"II":[70,78,113,246],"initiated":[72,243],"closure":[74],"Switch":[77,112,245],"loop":[79],"in":[80,131,203,213,264,343,404,441],"nucleotide-binding":[82],"site.":[83,223],"Recently,":[84],"we":[85,119,377],"proposed":[86],"VI":[93,133,392],"starts":[94],"with":[95,183,217,393],"spontaneous":[97],"converter":[101],"domain":[102],"putative":[105],"pre-transition":[106],"state":[107,128,149],"(PTS)":[108],"intermediate":[109,259],"precedes":[111],"closing":[114],"ATPase":[116],"activation.":[117],"Here,":[118],"investigate":[120],"from":[123,157,332],"pre-recovery,":[125],"post-rigor":[126],"(PR)":[127],"PTS":[130,148,181,254],"using":[134,170],"geometric":[135],"free":[136,162],"simulations":[138],"string":[141,172],"method.":[142],"First,":[143],"our":[144],"calculations":[145,169],"rediscover":[146],"agnostically":[150],"show":[152],"accessible":[156],"PR":[158,179],"via":[159,297],"low":[161],"path.":[165],"Second,":[166],"separate":[167],"path":[168,231],"method":[173],"illuminate":[174],"mechanism":[176,236,403,430],"atomic":[184],"resolution.":[185],"In":[186,355],"this":[187],"mechanism,":[188],"initiating":[190],"event":[191],"large":[194],"converter/lever-arm":[198],"region":[199,206,412],"triggers":[201],"rearrangements":[202],"Relay-SH1":[205],"formation":[209],"kink":[212],"Relay":[215],"helix":[216],"no":[218],"coupling":[219],"active":[222],"Analysis":[224],"free-energy":[227],"barriers":[228],"along":[229],"suggests":[232,269,431],"converter-initiated":[235],"much":[238],"faster":[239],"one":[242],"closure,":[247],"which":[248,346,405],"supports":[249],"biological":[251],"relevance":[252],"as":[255],"major":[257],"on-pathway":[258],"VI.":[266],"Our":[267],"analysis":[268],"lever-arm":[271,366],"only":[277],"weakly":[278],"coupled,":[279],"so":[280],"mostly":[287],"driven":[288,419],"thermal":[290,421,436],"fluctuations":[291,422,437,448],"stabilised":[293],"nucleotide":[295],"consumption":[296],"ratchet-like":[299],"mechanism.":[300],"Author":[301],"summary":[302],"ATP-powered":[306],"motor":[307],"protein":[308,415],"crucial":[311],"for":[312],"cellular":[313],"functions":[314],"like":[315,449],"muscle":[316],"contraction,":[317],"cell":[318],"division,":[319],"transport":[322],"molecular":[324,374],"cargos.":[325],"Understanding":[326],"transforms":[329],"chemical":[330],"into":[335],"mechanical":[336,410],"work":[337,439],"central":[340],"open":[341],"question":[342],"structural":[344],"bioenergetics,":[345],"could":[347],"guide":[348],"design":[350],"next-generation":[352],"synthetic":[353],"nanomachines.":[354],"coupled":[360],"transition.":[371],"Using":[372],"advanced":[373],"dynamics":[375],"simulations,":[376],"described":[378],"sequence":[380],"events":[382],"energetics":[385],"unprecedented":[395],"level":[396],"detail.":[398],"The":[399],"results":[400],"support":[401],"amplifier":[411],"almost":[417],"entirely":[418],"stabilized":[424],"hydrolysis.":[427],"This":[428],"weakly-coupled":[429],"can":[434],"\u201crectify\u201d":[435],"efficiently":[440],"isothermal":[443],"environment":[444],"dominated":[445],"stochastic":[447],"cell.":[451]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-10-04T00:00:00"}