{"id":"https://openalex.org/W4387264256","doi":"https://doi.org/10.1158/1055-9965.c.6861316","title":"Data from The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk","display_name":"Data from The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk","publication_year":2023,"publication_date":"2023-10-02","ids":{"openalex":"https://openalex.org/W4387264256","doi":"https://doi.org/10.1158/1055-9965.c.6861316"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6861316","doi":"https://doi.org/10.1158/1055-9965.c.6861316","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6861316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6861316","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067426136","display_name":"Cassandra A. Hathaway","orcid":"https://orcid.org/0000-0002-2919-0499","observed_orcids":["https://orcid.org/0000-0002-2919-0499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cassandra A. Hathaway","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2919-0499","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068795567","display_name":"Mary K. Townsend","orcid":"https://orcid.org/0000-0003-2452-4477","observed_orcids":["https://orcid.org/0000-0003-2452-4477","https://orcid.org/0000-0002-9954-4846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary K. Townsend","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2452-4477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077134273","display_name":"Elliot M. Sklar","orcid":"https://orcid.org/0009-0007-5246-7883","observed_orcids":["https://orcid.org/0009-0007-5246-7883"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elliot M. Sklar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-5246-7883","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089317077","display_name":"Kamilah B. Thomas-Purcell","orcid":"https://orcid.org/0000-0002-7523-128X","observed_orcids":["https://orcid.org/0000-0002-7523-128X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamilah B. Thomas-Purcell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7523-128X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051731200","display_name":"Kathryn L. Terry","orcid":"https://orcid.org/0009-0002-5848-4661","observed_orcids":["https://orcid.org/0009-0002-5848-4661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn L. Terry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5848-4661","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050104828","display_name":"Britton L. Trabert","orcid":"https://orcid.org/0000-0002-1539-6090","observed_orcids":["https://orcid.org/0000-0002-1539-6090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Britton Trabert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1539-6090","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054091966","display_name":"Shelley S. Tworoger","orcid":"https://orcid.org/0000-0002-6986-7046","observed_orcids":["https://orcid.org/0000-0002-6986-7046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shelley S. Tworoger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6986-7046","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer-risk","display_name":"ovarian cancer risk","score":0.8970000147819519},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9739999771118164},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.8539999723434448},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.8379999995231628},{"id":"https://openalex.org/keywords/serum-potassium","display_name":"serum potassium","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endometrioid-ovarian-carcinoma","display_name":"endometrioid ovarian cancer","score":0.7730000019073486},{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation-and-tumorigenesis","display_name":"inflammation and tumorigenesis","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7115117311477661},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.701941967010498},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6887279152870178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6316506266593933},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5373740196228027},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.46316254138946533},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.45883578062057495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4538475573062897},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.446668416261673},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.4305066764354706},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.41821280121803284},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4015344977378845},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3763177990913391},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3641892969608307},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.27165114879608154}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6861316","doi":"https://doi.org/10.1158/1055-9965.c.6861316","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6861316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6861316","doi":"https://doi.org/10.1158/1055-9965.c.6861316","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6861316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385564277","https://openalex.org/W4392685546","https://openalex.org/W2971233813","https://openalex.org/W4386437909","https://openalex.org/W4403335931","https://openalex.org/W4362524700","https://openalex.org/W4361942607","https://openalex.org/W2106290913","https://openalex.org/W2419477524","https://openalex.org/W2887906662"],"abstract_inverted_index":{"AbstractBackground:":[0],"One":[1],"of":[2,5,36,62,223,233,235],"the":[3,34,49,195,230],"mechanisms":[4],"ovarian":[6,24,45,68,89,105,143,181,200,241],"tumorigenesis":[7],"is":[8,13,214],"through":[9],"inflammation.":[10],"Kidney":[11,174],"dysfunction":[12],"associated":[14,119,137,179],"with":[15,23,44,67,120,138,148,180,205,219],"increased":[16,199],"inflammation;":[17],"thus,":[18],"we":[19,32,95],"assessed":[20,76],"its":[21],"relationship":[22],"cancer":[25,46,69,90,106,144,182,201,242],"risk.":[26,183,243],"Methods:":[27],"In":[28],"prospectively":[29],"collected":[30],"samples,":[31],"evaluated":[33],"association":[35,98],"kidney":[37,134,207,236],"function":[38,135,175,208,237],"markers":[39,66,234],"and":[40,64,72,104,127,209],"C-reactive":[41],"protein":[42],"(CRP)":[43],"risk":[47,70,107,145,202],"in":[48,142,203,217,238],"UK":[50],"Biobank.":[51],"We":[52,75],"used":[53],"multivariable-adjusted":[54],"Cox":[55],"proportional":[56],"hazards":[57],"models":[58],"to":[59,188,240],"evaluate":[60,189],"quartiles":[61],"serum":[63],"urine":[65],"overall":[71],"by":[73,79],"histology.":[74],"effect":[77],"modification":[78],"CRP":[80,171],"(\u22643.0,":[81],">3.0":[82],"mg/L).":[83],"Results:":[84],"Among":[85],"232,908":[86],"women":[87,147,204],"(1,110":[88],"cases":[91],"diagnosed":[92],"from":[93],"2006\u20132020),":[94],"observed":[96],"no":[97],"between":[99],"estimated":[100],"glomerular":[101],"filtration":[102],"rate":[103],"(Q4":[108,122],"vs.":[109,123,155],"Q1:":[110,124],"HR,":[111],"1.00;":[112],"95%":[113],"confidence":[114],"intervals,":[115],"0.83\u20131.22).":[116],"Potassium":[117],"was":[118,136,176],"endometrioid":[121],"0.33,":[125],"0.11\u20130.98)":[126],"clear":[128],"cell":[129],"(4.74,":[130],"1.39\u201316.16)":[131],"tumors.":[132],"Poor":[133],"a":[139,220],"nonsignificant":[140],"increase":[141],"among":[146],"CRP>3.0":[149],"mg/L":[150,162],"(e.g.,":[151],"uric":[152],"acid":[153],"Q4":[154],"Q1;":[156],"1.23,":[157],"0.81\u20131.86),":[158],"but":[159],"not":[160,168,177],"CRP\u22643.0":[161],"(0.83,":[163],"0.66\u20131.05).":[164],"Other":[165],"associations":[166],"did":[167],"vary":[169],"across":[170],"categories.":[172],"Conclusions:":[173],"clearly":[178],"Larger":[184],"studies":[185],"are":[186],"needed":[187],"possible":[190],"histology":[191],"specific":[192],"associations.":[193],"Given":[194],"suggestive":[196],"trend":[197],"for":[198],"poor":[206],"high":[210,221],"CRP,":[211],"future":[212],"work":[213],"needed,":[215],"particularly":[216],"populations":[218],"prevalence":[222],"inflammatory":[224],"conditions.":[225],"Impact:":[226],"This":[227],"study":[228],"provided":[229],"first":[231],"evaluation":[232],"relation":[239]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-10-03T00:00:00"}