{"id":"https://openalex.org/W4387253285","doi":"https://doi.org/10.1161/atvb.43.suppl_1.273","title":"Abstract 273: Smooth Muscle Cell Specific Beclin-1 Deficiency Accelerates Aortic Aneurysms In Male And Female Normolipidemic And Hypercholesterolemic Mice","display_name":"Abstract 273: Smooth Muscle Cell Specific Beclin-1 Deficiency Accelerates Aortic Aneurysms In Male And Female Normolipidemic And Hypercholesterolemic Mice","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4387253285","doi":"https://doi.org/10.1161/atvb.43.suppl_1.273"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.43.suppl_1.273","doi":"https://doi.org/10.1161/atvb.43.suppl_1.273","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.43.suppl_1.273","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058234994","display_name":"Ana Clara Frony","orcid":"https://orcid.org/0000-0002-0040-3788","observed_orcids":["https://orcid.org/0000-0002-0040-3788"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Clara Frony","raw_affiliation_strings":["UNIVERSITY OF MISSOURI, COLUMBIA, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSOURI, COLUMBIA, MO","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047640192","display_name":"Aida Javidan","orcid":"https://orcid.org/0009-0006-2455-8270","observed_orcids":["https://orcid.org/0009-0006-2455-8270"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aida Javidan","raw_affiliation_strings":["UNIVERSITY OF KENTUCKY, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF KENTUCKY, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033714582","display_name":"Weihua Jiang","orcid":"https://orcid.org/0000-0001-6529-7843","observed_orcids":["https://orcid.org/0000-0001-6529-7843"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihua Jiang","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086015666","display_name":"Lihua Yang","orcid":"https://orcid.org/0000-0002-6293-4816","observed_orcids":["https://orcid.org/0000-0002-6293-4816"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua Yang","raw_affiliation_strings":["Univ of Kentucky, Lexington, KY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Kentucky, Lexington, KY","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103283466","display_name":"Venkateswaran Subramanian","orcid":"https://orcid.org/0000-0002-1183-7717","observed_orcids":["https://orcid.org/0000-0002-1183-7717"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkateswaran Subramanian","raw_affiliation_strings":["UNIVERSITY OF MISSOURI, COLUMBIA, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF MISSOURI, COLUMBIA, MO","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-aneurysm","display_name":"aortic aneurysm","score":0.9639999866485596},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.871999979019165},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ldlr-knockout-mice","display_name":"Ldlr knockout mice","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aortic-dilation","display_name":"aortic dilatation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6029999852180481},{"id":"https://openalex.org/keywords/aortic-media","display_name":"aortic media","score":0.36000001430511475},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7570000290870667},{"id":"https://openalex.org/keywords/aortic-rupture","display_name":"aortic rupture","score":0.33899998664855957},{"id":"https://openalex.org/keywords/aortic-dissection","display_name":"aortic dissection","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6237735152244568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6231372356414795},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5338002443313599},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4997437000274658},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4885214567184448},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4876641035079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4061574637889862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3960006535053253},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3582151532173157},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2979275584220886},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15466079115867615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1376277506351471},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.43.suppl_1.273","doi":"https://doi.org/10.1161/atvb.43.suppl_1.273","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.43.suppl_1.273","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5699999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312720709","https://openalex.org/W4400952285","https://openalex.org/W2781350053","https://openalex.org/W2259082608","https://openalex.org/W6903723658","https://openalex.org/W2619581924","https://openalex.org/W2931473293","https://openalex.org/W7171496996","https://openalex.org/W2801234188","https://openalex.org/W4415371340"],"abstract_inverted_index":{"Background":[0],"and":[1,4,85,89,114,128,176,271,307],"Objective:":[2],"Ascending":[3],"abdominal":[5,272],"aortic":[6,25,156,285,296,304,336],"aneurysms":[7],"(AAs)":[8],"are":[9],"permanent":[10],"dilations":[11],"of":[12,70,77,95,121,151,169,199,210,318],"the":[13,74,155,167],"aorta":[14],"with":[15,92,135,205,315],"80%":[16],"mortality":[17],"after":[18],"rupture.":[19],"Vascular":[20],"smooth":[21],"muscle":[22],"cell":[23,37],"(SMC)-rich":[24],"media":[26,157],"is":[27,32,57],"disrupted":[28],"in":[29,59,83,97,112,154,222,334,339],"AAs.":[30],"Autophagy":[31],"a":[33,331],"process":[34],"by":[35,101,214],"which":[36],"recycles":[38],"their":[39],"cytoplasmic":[40],"materials":[41],"for":[42,140,193,217],"energy":[43],"purposes":[44],"under":[45],"stress.":[46],"Recent":[47],"clinical":[48],"studies":[49],"highlighted":[50],"that":[51,328],"Beclin-1,":[52],"an":[53],"autophagy":[54],"induction":[55],"gene,":[56],"upregulated":[58],"AA":[60,81],"tissues":[61],"from":[62,158],"patients.":[63],"Using":[64],"Angiotensin":[65],"II":[66],"(AngII)":[67],"infusion":[68],"model":[69],"AAs,":[71],"we":[72],"examined":[73],"functional":[75],"role":[76,168,333],"SMC-derived":[78],"Beclin-1":[79,96,109,123,152],"during":[80],"development":[82],"normolipidemic":[84,113,171,224],"hypercholesterolemic":[86,115,173,226],"mice.":[87,340],"Methods":[88],"Results:":[90],"Mice":[91],"inducible":[93],"deletion":[94],"SMCs":[98],"were":[99,133,182,203],"produced":[100],"breeding":[102],"male":[103,174],"Acta2-Cre":[104,125],"ERT2":[105,126],"hemizygous":[106],"mice":[107,111,132,160,181,202,227],"female":[108],"floxed":[110],"(LDLR-/-)":[116],"background.":[117],"At":[118],"8":[119],"weeks":[120],"age,":[122],"x":[124],"(Cre+)":[127],"non-Cre":[129],"littermates":[130],"(Cre-)":[131],"injected":[134],"tamoxifen":[136],"(75":[137],"mg/kg,":[138],"i.p.)":[139],"5":[141,194],"days.":[142],"After":[143,196],"2":[144],"weeks,":[145],"Western":[146],"blot":[147],"analyses":[148],"showed":[149],"depletion":[150],"protein":[153],"Cre+":[159,175],"compared":[161],"to":[162],"Cre-":[163,177,311],"littermates.":[164],"To":[165],"study":[166],"SMC-Beclin-1,":[170],"or":[172,186,207,225],"(N=7":[178],"per":[179],"group)":[180],"fed":[183],"either":[184,223],"chow":[185],"fat-enriched":[187],"diet":[188,200],"(21%":[189],"fat;":[190],"0.15%":[191],"cholesterol)":[192],"weeks.":[195,219],"1":[197],"week":[198],"feeding,":[201],"infused":[204],"saline":[206],"low":[208],"dose":[209],"AngII":[211],"(500":[212],"ng/kg/min)":[213],"osmotic":[215],"mini-pumps":[216],"4":[218],"SMC-Beclin-1":[220,293,300,329],"deficiency":[221,294,301],"spontaneously":[228],"but":[229],"significantly":[230,302],"accelerated":[231,295],"ascending":[232],"(Cre-:":[233,246,259,273],"1.2":[234],"\u00b1":[235,240,248,253,261,266,275,280],"0.07":[236],"vs":[237,250,263,277,312],"Cre+:":[238,251,264,278],"1.8":[239,252],"0.04":[241,249,262,267],"mm;":[242,255,268,282],"P":[243,256,269,283],"<0.001),":[244,257,270],"arch":[245],"1.1":[247,260],"0.03":[254],"descending":[258],"1.5":[265,279],"1.0":[274],"0.02":[276],"0.14":[281],"<0.001)":[284],"expansion.":[286,297],"AngII-infusion":[287],"had":[288],"no":[289],"additional":[290],"influence":[291],"on":[292],"In":[298],"addition,":[299],"increased":[303],"medial":[305,319],"hypertrophy":[306],"elastin":[308],"breaks":[309],"(P<0.001":[310],"Cre+)":[313],"associated":[314],"complete":[316],"loss":[317],"alpha-SMC":[320],"actin":[321],"positive":[322],"area.":[323],"Conclusion:":[324],"These":[325],"findings":[326],"demonstrate":[327],"plays":[330],"critical":[332],"suppressing":[335],"aneurysmal":[337],"formation":[338]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2023-10-03T00:00:00"}