{"id":"https://openalex.org/W4387253148","doi":"https://doi.org/10.1161/atvb.43.suppl_1.132","title":"Abstract 132: Mechanism By Which Coagulation Factor XI Regulates Endothelial Cell Permeability And Barrier Function In Vitro And In Vivo","display_name":"Abstract 132: Mechanism By Which Coagulation Factor XI Regulates Endothelial Cell Permeability And Barrier Function In Vitro And In Vivo","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4387253148","doi":"https://doi.org/10.1161/atvb.43.suppl_1.132"},"language":"en","primary_location":{"id":"doi:10.1161/atvb.43.suppl_1.132","doi":"https://doi.org/10.1161/atvb.43.suppl_1.132","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.43.suppl_1.132","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074003801","display_name":"Cristina Puy","orcid":"https://orcid.org/0000-0002-5911-8156","observed_orcids":["https://orcid.org/0000-0002-5911-8156"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Puy","raw_affiliation_strings":["Oregon Health & Science Univ, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science Univ, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017113502","display_name":"Christina U. Lorentz","orcid":"https://orcid.org/0000-0002-6885-2352","observed_orcids":["https://orcid.org/0000-0002-6885-2352"]},"institutions":[{"id":"https://openalex.org/I4210094792","display_name":"Aronora (United States)","ror":"https://ror.org/00vrz7m04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina U Lorentz","raw_affiliation_strings":["Aronora Inc, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aronora Inc, Portland, OR","institution_ids":["https://openalex.org/I4210094792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011450008","display_name":"Erik I. Tucker","orcid":"https://orcid.org/0000-0003-0532-113X","observed_orcids":["https://orcid.org/0000-0003-0532-113X"]},"institutions":[{"id":"https://openalex.org/I4210094792","display_name":"Aronora (United States)","ror":"https://ror.org/00vrz7m04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210094792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Tucker","raw_affiliation_strings":["Aronora, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aronora, Portland, OR","institution_ids":["https://openalex.org/I4210094792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056174184","display_name":"Florea Lupu","orcid":"https://orcid.org/0000-0003-1249-9278","observed_orcids":["https://orcid.org/0000-0003-1249-9278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florea Lupu","raw_affiliation_strings":["Oklahoma Med Rsch FND, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med Rsch FND, Oklahoma City, OK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021496734","display_name":"David Gailani","orcid":"https://orcid.org/0000-0001-8142-8014","observed_orcids":["https://orcid.org/0000-0001-8142-8014"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gailani","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050978437","display_name":"Owen J. T. McCarty","orcid":"https://orcid.org/0000-0001-9481-0124","observed_orcids":["https://orcid.org/0000-0001-9481-0124"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Owen J McCarty","raw_affiliation_strings":["Oregon Health & Science Univ, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science Univ, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-xi","display_name":"factor XI","score":0.8930000066757202},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.7129999995231628},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.8870000243186951},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vldlr","display_name":"VLDLR","score":0.8050000071525574},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vegfr2-signaling","display_name":"VEGFR2 signaling","score":0.7599999904632568},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/src-kinase-phosphorylation","display_name":"Src kinase phosphorylation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6737056970596313},{"id":"https://openalex.org/C2781380885","wikidata":"https://www.wikidata.org/wiki/Q17859848","display_name":"VE-cadherin","level":4,"score":0.6044983267784119},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5815063714981079},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5173527598381042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4866819977760315},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47490108013153076},{"id":"https://openalex.org/C2777834122","wikidata":"https://www.wikidata.org/wiki/Q5939177","display_name":"Human umbilical vein endothelial cell","level":4,"score":0.461404025554657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40587639808654785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36801522970199585},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.35630494356155396},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.3063929080963135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2841428518295288},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16229572892189026},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10983473062515259},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07580342888832092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/atvb.43.suppl_1.132","doi":"https://doi.org/10.1161/atvb.43.suppl_1.132","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/atvb.43.suppl_1.132","pdf_url":null,"source":{"id":"https://openalex.org/S3485792","display_name":"Arteriosclerosis Thrombosis and Vascular Biology","issn_l":"1079-5642","issn":["1079-5642","1524-4636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arteriosclerosis, Thrombosis, and Vascular Biology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312644651","https://openalex.org/W4388597471","https://openalex.org/W4388597544","https://openalex.org/W4401686052","https://openalex.org/W3032703650","https://openalex.org/W4408280577","https://openalex.org/W2888930783","https://openalex.org/W2944829321","https://openalex.org/W2979258374","https://openalex.org/W2069313943"],"abstract_inverted_index":{"Introduction:":[0],"Proteolysis":[1],"of":[2,11,20,144,153,220,240,247,253,259,280,290],"vascular":[3],"endothelial":[4,12],"(VE)-cadherin":[5],"is":[6,58,60],"a":[7,33,40,129,226,244,295],"biomarker":[8],"for":[9,82],"disruption":[10],"cell":[13,110],"(EC)":[14],"barrier":[15,301],"function,":[16],"with":[17,25,76,117,170,210,261],"elevated":[18],"levels":[19,48,252],"soluble":[21],"VE":[22],"(sVE)-cadherin":[23],"associated":[24],"atherosclerosis":[26],"and":[27,38,45,79,95,109,132,141,172,180,194,263],"sepsis.":[28],"Factor":[29],"XI":[30],"(FXI)":[31],"plays":[32],"regulatory":[34],"role":[35],"in":[36,114,224,243,303],"inflammation,":[37],"while":[39],"relationship":[41],"between":[42],"FXI":[43,64,241,292],"activity":[44],"VE-cadherin":[46,67,92,130,164,201,221,235],"expression":[47,152],"has":[49],"been":[50],"observed,":[51],"the":[52,136,151,186,195,218,238,251,272,278,284,288],"mechanism":[53],"by":[54,122,166,203,222],"which":[55,276],"this":[56],"process":[57],"mediated":[59],"unknown.":[61],"Hypothesis:":[62],"Activated":[63],"(FXIa)":[65],"induces":[66],"proteolysis.":[68],"Methods:":[69],"Human":[70],"umbilical":[71],"vein":[72],"ECs":[73,134],"were":[74],"stimulated":[75],"FXIa":[77,125,149,168,184,260],"(30":[78],"5":[80],"nM)":[81,127],"six":[83],"hours.":[84],"Western":[85],"blot":[86],"analysis":[87],"was":[88,120,207],"used":[89],"to":[90,283,298],"study":[91],"proteolysis,":[93],"disintegrin":[94],"metalloproteinase":[96],"10":[97],"(ADAM10)":[98],"expression,":[99],"FXIa-PAI-1":[100],"or":[101],"-very":[102],"low":[103],"density":[104],"lipoprotein":[105],"receptor":[106],"(VLDLR)":[107],"interactions,":[108],"signaling":[111,188,274],"events.":[112],"SVE-cadherin":[113],"baboons":[115],"challenged":[116],"Staphylococcus":[118],"aureus":[119],"detected":[121],"ELISA.":[123],"Results:":[124],"(5":[126],"generated":[128],"fragment":[131],"increased":[133],"permeability;":[135],"serine":[137],"protease":[138],"inhibitor,":[139,192,198,215],"PPACK,":[140],"an":[142],"inhibitor":[143],"ADAM10":[145,155,282],"reversed":[146],"these":[147],"processes.":[148],"induced":[150,178,277],"active":[154,281],"on":[156,174,233],"ECs.":[157,175],"The":[158,190,212,256],"receptor-associated":[159],"protein":[160],"(RAP)":[161],"blocked":[162],"FXIa-induced":[163,234],"proteolysis":[165,202],"preventing":[167],"interaction":[169,177],"PAI-1":[171,262],"VLDLR":[173,264],"FXIa-VLDLR":[176],"Dab1":[179],"Src":[181,196,266,269],"kinases":[182,197],"phosphorylation.":[183,268],"activated":[185],"VEGFR2-PLCgamma1-ERK1/2":[187,273],"pathway.":[189],"ERK1/2":[191],"LY3214996,":[193],"PP2,":[199],"inhibited":[200],"FXIa.":[204],"PLCgamma1":[205],"phosphorylation":[206],"also":[208],"prevented":[209,217],"PP2.":[211],"VEGFR2":[213],"kinase":[214,267],"SU1498,":[216],"cleavage":[219,289],"FXIa;":[223],"contrast,":[225],"VEGF":[227],"blocking":[228],"antibody":[229],"had":[230],"no":[231],"effect":[232],"cleavage.":[236],"Finally,":[237],"inhibition":[239],"activation":[242,270],"baboon":[245],"model":[246],"sepsis":[248],"significantly":[249],"decreased":[250],"sVE-cadherin.":[254],"Conclusion:":[255],"complex":[257],"formation":[258],"promoted":[265],"triggered":[271],"pathway,":[275],"trafficking":[279],"EC":[285,300],"surfaces":[286],"inducing":[287],"VE-cadherin.":[291],"may":[293],"be":[294],"druggable":[296],"target":[297],"protect":[299],"function":[302],"inflammatory":[304],"diseases.":[305]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-10-03T00:00:00"}