{"id":"https://openalex.org/W4387218247","doi":"https://doi.org/10.1002/jbm.a.37623","title":"Necrostatin\u20101 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes","display_name":"Necrostatin\u20101 releasing nanoparticles: In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes","publication_year":2023,"publication_date":"2023-09-30","ids":{"openalex":"https://openalex.org/W4387218247","doi":"https://doi.org/10.1002/jbm.a.37623","pmid":"https://pubmed.ncbi.nlm.nih.gov/37776226"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.37623","doi":"https://doi.org/10.1002/jbm.a.37623","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/jbm.a.37623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.a.37623","source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.a.37623","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002218358","display_name":"Alexandra M. Smink","orcid":"https://orcid.org/0000-0002-9714-1779","observed_orcids":["https://orcid.org/0000-0002-9714-1779"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Alexandra M. Smink","raw_affiliation_strings":["Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9714-1779","affiliations":[{"raw_affiliation_string":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087987188","display_name":"Juan D. Medina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan D. Medina","raw_affiliation_strings":["Petit Institute for Bioengineering and Bioscience, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Petit Institute for Bioengineering and Bioscience, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I2802612298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064387290","display_name":"Bart J. de Haan","orcid":"https://orcid.org/0000-0003-3466-0448","observed_orcids":["https://orcid.org/0000-0003-3466-0448"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart J. de Haan","raw_affiliation_strings":["Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011208920","display_name":"Andr\u00e9s J. Garc\u0131\u0301a","orcid":"https://orcid.org/0000-0001-6602-2518","observed_orcids":["https://orcid.org/0000-0001-6602-2518"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s J. Garc\u00eda","raw_affiliation_strings":["Petit Institute for Bioengineering and Bioscience, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA"],"raw_orcid":"https://orcid.org/0000-0001-6602-2518","affiliations":[{"raw_affiliation_string":"Petit Institute for Bioengineering and Bioscience, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053142611","display_name":"Paul de Vos","orcid":"https://orcid.org/0000-0001-9618-2408","observed_orcids":["https://orcid.org/0000-0001-9618-2408"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul de Vos","raw_affiliation_strings":["Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9618-2408","affiliations":[{"raw_affiliation_string":"Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002218358"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":1.0674,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76765914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"112","issue":"2","first_page":"288","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrostatin-1","display_name":"necrostatin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.7749999761581421},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8640000224113464},{"id":"https://openalex.org/keywords/immunoisolation","display_name":"immunoisolation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/alginate-microcapsules","display_name":"alginate microcapsules","score":0.9929999709129333},{"id":"https://openalex.org/keywords/islet-graft-survival","display_name":"islet graft survival","score":0.781000018119812},{"id":"https://openalex.org/keywords/beta-cell-death","display_name":"beta-cell death","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hypoxia-induced-cell-death","display_name":"hypoxia-induced cell death","score":0.9620000123977661},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/biomaterial-biocompatibility","display_name":"biomaterial biocompatibility","score":0.7129999995231628},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8270952701568604},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8073892593383789},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7537262439727783},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6446953415870667},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.5811043977737427},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.4896874725818634},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.48883169889450073},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48590269684791565},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.46379098296165466},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4534974992275238},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.39093172550201416},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3701756000518799},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2945735454559326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24717572331428528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21506357192993164},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.17473089694976807},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17183056473731995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14576929807662964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11103054881095886},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jbm.a.37623","doi":"https://doi.org/10.1002/jbm.a.37623","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/jbm.a.37623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.a.37623","source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:37776226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37776226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/e4356552-b9de-4814-8bc2-eeede8e55492","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/e4356552-b9de-4814-8bc2-eeede8e55492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Smink, A M, Medina, J D, de Haan, B J, Garc\u00eda, A J & de Vos, P 2024, 'Necrostatin-1 releasing nanoparticles : In vitro and in vivo efficacy for supporting immunoisolated islet transplantation outcomes', Journal of Biomedical Materials Research. Part A, vol. 112, no. 2, pp. 288-295. https://doi.org/10.1002/jbm.a.37623","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/jbm.a.37623","doi":"https://doi.org/10.1002/jbm.a.37623","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/jbm.a.37623","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.a.37623","source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2297191681","display_name":null,"funder_award_id":"2\u2010SRA\u20102018\u2010523\u2010S\u2010B","funder_id":"https://openalex.org/F687319775","funder_display_name":"JDRF"},{"id":"https://openalex.org/G990801566","display_name":null,"funder_award_id":"2\u2010SRA\u20102018\u2010523\u2010S\u2010B","funder_id":"https://openalex.org/F4320310820","funder_display_name":"Juvenile Diabetes Research Foundation United States of America"}],"funders":[{"id":"https://openalex.org/F4320310820","display_name":"Juvenile Diabetes Research Foundation United States of America","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"},{"id":"https://openalex.org/F687319775","display_name":"JDRF","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387218247.pdf","grobid_xml":"https://content.openalex.org/works/W4387218247.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1966977448","https://openalex.org/W1991380853","https://openalex.org/W1998944797","https://openalex.org/W2022282748","https://openalex.org/W2098899709","https://openalex.org/W2107989359","https://openalex.org/W2108371710","https://openalex.org/W2109820649","https://openalex.org/W2110796758","https://openalex.org/W2126546123","https://openalex.org/W2131357993","https://openalex.org/W2154945223","https://openalex.org/W2163175336","https://openalex.org/W2171678230","https://openalex.org/W2171843438","https://openalex.org/W2334288083","https://openalex.org/W2412906118","https://openalex.org/W2790308759","https://openalex.org/W2802427215","https://openalex.org/W2807187539","https://openalex.org/W2948652216","https://openalex.org/W2973588353","https://openalex.org/W3094281164","https://openalex.org/W3103916466","https://openalex.org/W3174574231","https://openalex.org/W3187424681","https://openalex.org/W4200198734","https://openalex.org/W4205738925","https://openalex.org/W4225136216","https://openalex.org/W4313596781","https://openalex.org/W4382601792"],"related_works":["https://openalex.org/W4411227238","https://openalex.org/W7155410999","https://openalex.org/W4225136216","https://openalex.org/W7106029843","https://openalex.org/W3082073790","https://openalex.org/W4395038658","https://openalex.org/W2973588353","https://openalex.org/W2043780207","https://openalex.org/W4415345971","https://openalex.org/W3187424681"],"abstract_inverted_index":{"Immunoisolation":[0],"of":[1,13,31,43,60,82,110,163,180,188,191,202],"pancreatic":[2],"islets":[3],"in":[4,10,47,87,90,112,132,142,157,171,175],"alginate":[5,204],"microcapsules":[6],"allows":[7],"for":[8,129],"transplantation":[9,52,156],"the":[11,35,48,80,108,161,176,199,203,217],"absence":[12,162,177],"immunosuppression":[14],"but":[15],"graft":[16,24,167,189],"survival":[17,25,168,190],"time":[18],"is":[19,26,54,114],"still":[20],"limited.":[21],"This":[22],"limited":[23,115],"caused":[27,55],"by":[28,56,116,198],"a":[29,57,75,97,209],"combination":[30],"tissue":[32,212],"responses":[33],"to":[34,63,223],"encapsulating":[36],"biomaterial":[37],"and":[38,53,89,119,134,153,178,234],"islets.":[39],"A":[40],"significant":[41],"loss":[42,81],"islet":[44,61,83,173],"cells":[45,62,84,137],"occurs":[46],"immediate":[49],"period":[50],"after":[51],"high":[58,200],"susceptibility":[59],"inflammatory":[64,229],"stress":[65,86],"during":[66],"this":[67,93],"period.":[68],"Here":[69],"we":[70,95,183],"investigated":[71],"whether":[72],"necrostatin-1":[73],"(Nec-1),":[74],"necroptosis":[76],"inhibitor,":[77],"can":[78],"reduce":[79],"under":[85],"vitro":[88,133],"vivo.":[91],"To":[92],"end,":[94],"developed":[96],"Nec-1":[98,111,128,147],"controlled-release":[99],"system":[100,206],"using":[101],"poly":[102],"(D,L-lactide-co-glycolide)":[103],"(PLGA)":[104],"nanoparticles":[105],"(NPs)":[106],"as":[107,166,232],"application":[109,222],"vivo":[113],"low":[117],"stability":[118],"possible":[120],"side":[121,164],"effects.":[122],"The":[123],"PLGA":[124],"NPs":[125,148,219],"stably":[126],"released":[127],"6":[130],"days":[131,150],"protected":[135],"beta":[136],"against":[138],"hypoxia-induced":[139],"cell":[140],"death":[141],"vitro.":[143],"Treatment":[144],"with":[145],"these":[146],"at":[149],"0,":[151],"6,":[152],"12":[154],"post-islet":[155],"streptozotocin-diabetic":[158],"mice":[159],"confirmed":[160],"effects":[165],"was":[169],"similar":[170],"encapsulated":[172,192],"grafts":[174,193],"presence":[179],"Nec-1.":[181],"However,":[182],"found":[184],"no":[185],"further":[186],"prolongation":[187],"which":[194],"might":[195],"be":[196],"explained":[197],"biocompatibility":[201],"encapsulation":[205],"that":[207,216,226],"provoked":[208],"very":[210],"mild":[211],"response.":[213],"We":[214],"expect":[215],"Nec-1-releasing":[218],"could":[220],"find":[221],"immunoisolation":[224],"systems":[225],"elicit":[227],"stronger":[228],"responses,":[230],"such":[231],"macrodevices":[233],"vasculogenic":[235],"biomaterials.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-01T00:00:00"}
