{"id":"https://openalex.org/W4387209973","doi":"https://doi.org/10.1016/j.jconrel.2023.09.021","title":"Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration","display_name":"Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration","publication_year":2023,"publication_date":"2023-10-04","ids":{"openalex":"https://openalex.org/W4387209973","doi":"https://doi.org/10.1016/j.jconrel.2023.09.021","pmid":"https://pubmed.ncbi.nlm.nih.gov/37774953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10842193"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2023.09.021","doi":"https://doi.org/10.1016/j.jconrel.2023.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2023.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jconrel.2023.09.021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111048312","display_name":"Eduardo A. Chacin Ruiz","orcid":"https://orcid.org/0009-0005-2553-5647","observed_orcids":["https://orcid.org/0009-0005-2553-5647"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo A. Chacin Ruiz","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028358016","display_name":"Katelyn E. Swindle\u2010Reilly","orcid":"https://orcid.org/0000-0003-1739-0263","observed_orcids":["https://orcid.org/0000-0003-1739-0263"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn E. Swindle-Reilly","raw_affiliation_strings":["William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA; Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, USA","Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA","Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, USA","William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA; Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024222019","display_name":"Ashlee N. Ford Versypt","orcid":"https://orcid.org/0000-0001-9059-5703","observed_orcids":["https://orcid.org/0000-0001-9059-5703"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashlee N. Ford Versypt","raw_affiliation_strings":["Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA; Institute for Artificial Intelligence and Data Science, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address: ashleefv@buffalo.edu","Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA","Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA","Institute for Artificial Intelligence and Data Science, University at Buffalo, The State University of New York, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA; Institute for Artificial Intelligence and Data Science, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address: ashleefv@buffalo.edu","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Institute for Artificial Intelligence and Data Science, University at Buffalo, The State University of New York, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024222019"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":4540,"currency":"USD","value_usd":4540},"apc_paid":{"value":4540,"currency":"USD","value_usd":4540},"fwci":0.5788,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.47349823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"363","issue":null,"first_page":"464","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intravitreal-drug-delivery","display_name":"intravitreal drug delivery","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-inhibition","display_name":"vascular endothelial growth factor inhibition","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.734000027179718},{"id":"https://openalex.org/keywords/ocular-implants","display_name":"ocular implants","score":0.890999972820282},{"id":"https://openalex.org/keywords/particulate-drug-delivery","display_name":"particulate drug delivery","score":0.5740000009536743},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ocular-pharmacokinetics","display_name":"ocular pharmacokinetics","score":0.8019999861717224},{"id":"https://openalex.org/keywords/compartmental-model","display_name":"compartmental model","score":0.7210000157356262},{"id":"https://openalex.org/keywords/physiologically-based-model","display_name":"physiologically based model","score":0.878000020980835},{"id":"https://openalex.org/keywords/mathematical-modeling-of-drug-release","display_name":"mathematical modeling of drug release","score":0.7229999899864197},{"id":"https://openalex.org/keywords/posterior-segment-of-the-eye","display_name":"posterior segment of the eye","score":0.7089999914169312},{"id":"https://openalex.org/keywords/vision-loss","display_name":"vision loss","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8780391216278076},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7515991926193237},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.615046501159668},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5923557281494141},{"id":"https://openalex.org/C113520495","wikidata":"https://www.wikidata.org/wiki/Q2359854","display_name":"Posterior segment of eyeball","level":2,"score":0.5575771331787109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5139791369438171},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5076299905776978},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.417403906583786},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3937565088272095},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.37433114647865295},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19014957547187805},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18161731958389282}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jconrel.2023.09.021","doi":"https://doi.org/10.1016/j.jconrel.2023.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2023.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:37774953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37774953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10842193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10842193","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10842193/pdf/nihms-1941105.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Control Release","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jconrel.2023.09.021","doi":"https://doi.org/10.1016/j.jconrel.2023.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2023.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000065555","display_name":"Quantitative Systems Biomedicine and Pharmacology for Multiscale Tissue Damage","funder_award_id":"R35GM133763","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000193160","display_name":"Predictive Drug Release from a Tunable Injectable Capsule","funder_award_id":"R01EB032870","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":198,"referenced_works":["https://openalex.org/W46341933","https://openalex.org/W139580965","https://openalex.org/W181662657","https://openalex.org/W321881051","https://openalex.org/W335964859","https://openalex.org/W617270794","https://openalex.org/W1193708566","https://openalex.org/W1492861575","https://openalex.org/W1539664785","https://openalex.org/W1563561582","https://openalex.org/W1888897387","https://openalex.org/W1966045434","https://openalex.org/W1966070581","https://openalex.org/W1967521101","https://openalex.org/W1969453607","https://openalex.org/W1970501937","https://openalex.org/W1977285837","https://openalex.org/W1977643250","https://openalex.org/W1981215463","https://openalex.org/W1982969749","https://openalex.org/W1989601471","https://openalex.org/W1995424714","https://openalex.org/W1997408710","https://openalex.org/W1997410081","https://openalex.org/W1999240903","https://openalex.org/W1999501080","https://openalex.org/W2000623566","https://openalex.org/W2002807067","https://openalex.org/W2004123015","https://openalex.org/W2005966406","https://openalex.org/W2006898897","https://openalex.org/W2009720233","https://openalex.org/W2010507474","https://openalex.org/W2012260669","https://openalex.org/W2013156861","https://openalex.org/W2017632637","https://openalex.org/W2018516156","https://openalex.org/W2019621166","https://openalex.org/W2024929982","https://openalex.org/W2029761910","https://openalex.org/W2030409545","https://openalex.org/W2032032896","https://openalex.org/W2032621293","https://openalex.org/W2036999791","https://openalex.org/W2041919596","https://openalex.org/W2047657288","https://openalex.org/W2049883735","https://openalex.org/W2050656614","https://openalex.org/W2053862338","https://openalex.org/W2054505016","https://openalex.org/W2056304970","https://openalex.org/W2056834871","https://openalex.org/W2057614987","https://openalex.org/W2060584135","https://openalex.org/W2061690224","https://openalex.org/W2061954970","https://openalex.org/W2062187054","https://openalex.org/W2062785231","https://openalex.org/W2062885086","https://openalex.org/W2063543655","https://openalex.org/W2064338219","https://openalex.org/W2064638666","https://openalex.org/W2068204079","https://openalex.org/W2069838435","https://openalex.org/W2071521950","https://openalex.org/W2072005992","https://openalex.org/W2072544476","https://openalex.org/W2074402397","https://openalex.org/W2076895069","https://openalex.org/W2078916806","https://openalex.org/W2079546021","https://openalex.org/W2087669977","https://openalex.org/W2090153504","https://openalex.org/W2091457816","https://openalex.org/W2092748432","https://openalex.org/W2093535511","https://openalex.org/W2096547439","https://openalex.org/W2115277332","https://openalex.org/W2125010860","https://openalex.org/W2126886911","https://openalex.org/W2130244147","https://openalex.org/W2134175990","https://openalex.org/W2134954483","https://openalex.org/W2138787512","https://openalex.org/W2140848006","https://openalex.org/W2142350493","https://openalex.org/W2144523453","https://openalex.org/W2147842670","https://openalex.org/W2148583530","https://openalex.org/W2154157438","https://openalex.org/W2158455128","https://openalex.org/W2235873751","https://openalex.org/W2258736649","https://openalex.org/W2282416438","https://openalex.org/W2326565381","https://openalex.org/W2369816396","https://openalex.org/W2414283300","https://openalex.org/W2416448449","https://openalex.org/W2466571810","https://openalex.org/W2506659406","https://openalex.org/W2516197405","https://openalex.org/W2535970209","https://openalex.org/W2539812081","https://openalex.org/W2540082048","https://openalex.org/W2546564717","https://openalex.org/W2547311226","https://openalex.org/W2560124981","https://openalex.org/W2565136318","https://openalex.org/W2566969332","https://openalex.org/W2567416294","https://openalex.org/W2578733585","https://openalex.org/W2584383093","https://openalex.org/W2587005936","https://openalex.org/W2624379932","https://openalex.org/W2625391125","https://openalex.org/W2701452818","https://openalex.org/W2738996050","https://openalex.org/W2765562693","https://openalex.org/W2777339059","https://openalex.org/W2778828335","https://openalex.org/W2779899519","https://openalex.org/W2783913866","https://openalex.org/W2790871616","https://openalex.org/W2794269820","https://openalex.org/W2795652076","https://openalex.org/W2797779923","https://openalex.org/W2798185170","https://openalex.org/W2799370215","https://openalex.org/W2801785887","https://openalex.org/W2806851300","https://openalex.org/W2807398685","https://openalex.org/W2890882648","https://openalex.org/W2893654625","https://openalex.org/W2899460974","https://openalex.org/W2901537735","https://openalex.org/W2905414395","https://openalex.org/W2908317738","https://openalex.org/W2916438057","https://openalex.org/W2944704306","https://openalex.org/W2946477419","https://openalex.org/W2948929745","https://openalex.org/W2948956708","https://openalex.org/W2948978473","https://openalex.org/W2959656067","https://openalex.org/W2966579001","https://openalex.org/W2968044429","https://openalex.org/W2981897718","https://openalex.org/W2987049800","https://openalex.org/W3002623593","https://openalex.org/W3005116564","https://openalex.org/W3005169765","https://openalex.org/W3011522762","https://openalex.org/W3015148462","https://openalex.org/W3031210748","https://openalex.org/W3033428304","https://openalex.org/W3040811945","https://openalex.org/W3045987141","https://openalex.org/W3086057753","https://openalex.org/W3090543494","https://openalex.org/W3093878325","https://openalex.org/W3097959146","https://openalex.org/W3100510055","https://openalex.org/W3104078781","https://openalex.org/W3114476027","https://openalex.org/W3120646953","https://openalex.org/W3131039269","https://openalex.org/W3134273682","https://openalex.org/W3158359366","https://openalex.org/W3171624526","https://openalex.org/W3173949228","https://openalex.org/W3179371112","https://openalex.org/W3188055023","https://openalex.org/W3199949243","https://openalex.org/W3206914415","https://openalex.org/W3208654732","https://openalex.org/W4200187629","https://openalex.org/W4200257452","https://openalex.org/W4210961494","https://openalex.org/W4211236610","https://openalex.org/W4213156772","https://openalex.org/W4221084260","https://openalex.org/W4224218448","https://openalex.org/W4236172464","https://openalex.org/W4245258144","https://openalex.org/W4247214019","https://openalex.org/W4255365998","https://openalex.org/W4280533393","https://openalex.org/W4300883298","https://openalex.org/W4303943707","https://openalex.org/W4308334510","https://openalex.org/W4309279745","https://openalex.org/W4310703799","https://openalex.org/W4312139080","https://openalex.org/W4313909320","https://openalex.org/W4315648737","https://openalex.org/W6680034198","https://openalex.org/W6979089391","https://openalex.org/W7002168065"],"related_works":["https://openalex.org/W7215210510","https://openalex.org/W2402454829","https://openalex.org/W4416613250","https://openalex.org/W4412653782","https://openalex.org/W3175553403","https://openalex.org/W2981897718","https://openalex.org/W4285733205","https://openalex.org/W7131260572","https://openalex.org/W33236977","https://openalex.org/W1551415020"],"abstract_inverted_index":{"Several":[0,143],"chronic":[1],"eye":[2],"diseases":[3,214],"affect":[4],"the":[5,9,27,34,46,56,101,107,206,216,220],"posterior":[6,217],"segment":[7,218],"of":[8,26,30,48,86,109,136,189,208,215,219],"eye.":[10,221],"Among":[11],"them":[12],"age-related":[13,209],"macular":[14,210],"degeneration":[15,211],"can":[16,123,129,197],"cause":[17],"vision":[18],"loss":[19],"if":[20],"left":[21],"untreated":[22],"and":[23,93,113,119,140,150,160,168,212],"is":[24,63],"one":[25],"leading":[28],"causes":[29],"visual":[31],"impairment":[32],"in":[33,100],"world.":[35],"Most":[36],"treatments":[37],"are":[38,157,184],"based":[39,162],"on":[40,106],"intravitreally":[41],"injected":[42],"therapeutics":[43],"that":[44,96,170],"inhibit":[45],"action":[47],"vascular":[49],"endothelial":[50],"growth":[51],"factor.":[52],"However,":[53],"due":[54],"to":[55,199],"need":[57],"for":[58,147,164,205],"monthly":[59],"injections,":[60],"this":[61,71],"method":[62],"associated":[64],"with":[65,193],"poor":[66],"patient":[67],"compliance.":[68],"To":[69],"address":[70],"problem,":[72],"numerous":[73],"drug":[74,120,138,152,166,173,190],"delivery":[75,153,178],"systems":[76,95,156],"(DDSs)":[77],"have":[78,97,171],"been":[79,98],"developed.":[80],"This":[81],"review":[82],"covers":[83],"a":[84,182],"selection":[85],"particulate":[87],"systems,":[88],"non-stimuli":[89],"responsive":[90],"hydrogels,":[91],"implants,":[92],"composite":[94],"developed":[99],"last":[102],"few":[103],"decades.":[104],"Depending":[105],"type":[108],"DDS,":[110],"polymer":[111],"material,":[112],"preparation":[114],"method,":[115],"different":[116],"mechanical":[117],"properties":[118],"release":[121,139,180,191],"profiles":[122,175],"be":[124,130],"achieved.":[125],"Furthermore,":[126],"DDS":[127,183],"development":[128],"optimized":[131],"by":[132],"implementing":[133],"mathematical":[134,145],"modeling":[135],"both":[137],"pharmacokinetic":[141,195],"aspects.":[142],"existing":[144],"models":[146,163,192,196],"diffusion-controlled,":[148],"swelling-controlled,":[149],"erosion-controlled":[151],"from":[154,181],"polymeric":[155],"summarized.":[158],"Compartmental":[159],"physiologically":[161],"ocular":[165,194],"transport":[167],"pharmacokinetics":[169],"studied":[172],"concentration":[174],"after":[176],"intravitreal":[177],"or":[179],"also":[185],"reviewed.":[186],"The":[187],"coupling":[188],"lead":[198],"obtaining":[200],"much":[201],"more":[202],"efficient":[203],"DDSs":[204],"treatment":[207],"other":[213]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-01T00:00:00"}