{"id":"https://openalex.org/W4387207983","doi":"https://doi.org/10.1016/j.ijrobp.2023.06.317","title":"In Silico Discovery and Investigation of Novel Small Molecules Targeting PSMA7 for the Treatment of GBM","display_name":"In Silico Discovery and Investigation of Novel Small Molecules Targeting PSMA7 for the Treatment of GBM","publication_year":2023,"publication_date":"2023-09-29","ids":{"openalex":"https://openalex.org/W4387207983","doi":"https://doi.org/10.1016/j.ijrobp.2023.06.317"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2023.06.317","doi":"https://doi.org/10.1016/j.ijrobp.2023.06.317","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2023.06.317","pdf_url":"http://www.redjournal.org/article/S036030162304751X/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.redjournal.org/article/S036030162304751X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078626117","display_name":"Christian A. Showalter","orcid":"https://orcid.org/0000-0002-8187-7773","observed_orcids":["https://orcid.org/0000-0002-8187-7773"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C.A. Showalter","raw_affiliation_strings":["Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054018754","display_name":"Priyani V. Rajasekera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Rajasekera","raw_affiliation_strings":["Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030287810","display_name":"Sarah E. Biehn","orcid":"https://orcid.org/0000-0001-9712-4621","observed_orcids":["https://orcid.org/0000-0001-9712-4621"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Biehn","raw_affiliation_strings":["Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092972650","display_name":"B. P\u00e9rez-Soto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. P\u00e9rez-Soto","raw_affiliation_strings":["Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044975181","display_name":"Steffen Lindert","orcid":"https://orcid.org/0000-0002-3976-3473","observed_orcids":["https://orcid.org/0000-0002-3976-3473"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Lindert","raw_affiliation_strings":["Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109426473","display_name":"Chad E. Bennett","orcid":"https://orcid.org/0009-0009-3514-3195","observed_orcids":["https://orcid.org/0009-0009-3514-3195"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bennett","raw_affiliation_strings":["Drug Development Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development Institute, Comprehensive Cancer Center, The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109415462","display_name":"J. McElroy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. McElroy","raw_affiliation_strings":["The Ohio State University, Center for Biostatistics, Department of Biomedical Informatics, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Center for Biostatistics, Department of Biomedical Informatics, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052906180","display_name":"H. Manring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Manring","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088186001","display_name":"Saikh Jaharul Haque","orcid":"https://orcid.org/0000-0003-1223-5598","observed_orcids":["https://orcid.org/0000-0003-1223-5598"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.J. Haque","raw_affiliation_strings":["Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018381770","display_name":"Arnab Chakravarti","orcid":"https://orcid.org/0000-0002-5392-8721","observed_orcids":["https://orcid.org/0000-0002-5392-8721"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Chakravarti","raw_affiliation_strings":["Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078626117"],"corresponding_institution_ids":["https://openalex.org/I2799885155"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12379556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"117","issue":"2","first_page":"S43","last_page":"S43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/psma7","display_name":"PSMA7","score":0.9729999899864197},{"id":"https://openalex.org/keywords/20s-proteasome","display_name":"20S proteasome","score":0.9079999923706055},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.921999990940094},{"id":"https://openalex.org/keywords/temozolomide-resistance","display_name":"temozolomide resistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6990000009536743},{"id":"https://openalex.org/keywords/proteasome-activity","display_name":"proteasome activity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/glioblastoma-xenografts","display_name":"glioblastoma xenografts","score":0.6079999804496765},{"id":"https://openalex.org/keywords/small-molecule-drug-discovery","display_name":"small molecule drug discovery","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7029243111610413},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6740550994873047},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5975661277770996},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.5373820662498474},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5046261548995972},{"id":"https://openalex.org/C65556437","wikidata":"https://www.wikidata.org/wiki/Q766195","display_name":"Protein Data Bank (RCSB PDB)","level":2,"score":0.497243195772171},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49144208431243896},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4718824625015259},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.4471122920513153},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4103958010673523},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3539876341819763},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33851373195648193},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.23070421814918518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19389274716377258},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1743369698524475},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijrobp.2023.06.317","doi":"https://doi.org/10.1016/j.ijrobp.2023.06.317","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2023.06.317","pdf_url":"http://www.redjournal.org/article/S036030162304751X/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2023.06.317","doi":"https://doi.org/10.1016/j.ijrobp.2023.06.317","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2023.06.317","pdf_url":"http://www.redjournal.org/article/S036030162304751X/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387207983.pdf","grobid_xml":"https://content.openalex.org/works/W4387207983.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4307063381","https://openalex.org/W4409635953","https://openalex.org/W4402908322","https://openalex.org/W4394817188","https://openalex.org/W2589079590","https://openalex.org/W3014370182","https://openalex.org/W7161295015","https://openalex.org/W3208887836","https://openalex.org/W4396829244","https://openalex.org/W2973921744"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-09-30T00:00:00"}