{"id":"https://openalex.org/W438720182","doi":null,"title":"Approche clonale de la sp\u00e9cificit\u00e9 antig\u00e8nique et du ph\u00e9notype fonctionnel de la r\u00e9ponse T auxiliaire humaine anti-schistosome : possibles relations \u00e0 la r\u00e9sistance","display_name":"Approche clonale de la sp\u00e9cificit\u00e9 antig\u00e8nique et du ph\u00e9notype fonctionnel de la r\u00e9ponse T auxiliaire humaine anti-schistosome : possibles relations \u00e0 la r\u00e9sistance","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W438720182","mag":"438720182"},"language":"fr","primary_location":{"id":"mag:438720182","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1992AIX22079","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041577761","display_name":"Patricia Couissinier\u2010Paris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patricia Couissinier\u2010Paris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041577761"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9980000257492065},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/th-cell-response","display_name":"Th cell response","score":0.6349999904632568},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/parasite-antigens","display_name":"parasite antigens","score":0.6700000166893005},{"id":"https://openalex.org/keywords/immune-resistance","display_name":"immune resistance","score":0.3240000009536743},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.671999990940094},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.902999997138977},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.609000027179718},{"id":"https://openalex.org/keywords/parasite-exposure","display_name":"parasite exposure","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6219199299812317},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.40155625343322754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3115806579589844}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:438720182","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1992AIX22079","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080392475","https://openalex.org/W596365594","https://openalex.org/W125604972","https://openalex.org/W2156651092","https://openalex.org/W566396112","https://openalex.org/W570154046","https://openalex.org/W760070237","https://openalex.org/W2131043396","https://openalex.org/W2889096680","https://openalex.org/W2731983858"],"abstract_inverted_index":{"Au":[0],"cours":[1],"du":[2],"present":[3],"travail,":[4],"nous":[5,6,26,109],"sommes":[7],"proposes":[8],"deux":[9],"aspects":[10],"de":[11,66,97,115,121,129,136,170,185,196,201],"la":[12,38,85,98,162,194,197],"reponse":[13,39,198],"t":[14,40],"auxiliaire":[15,41],"humaine":[16,42,164],"contre":[17],"le":[18,112,211],"parasite":[19,215],"schistosoma":[20],"mansoni:":[21],"dans":[22],"une":[23,30,50,71,78,106],"premiere":[24],"etude":[25],"avons":[27,110],"entrepris":[28],"par":[29,173,210],"approche":[31,46],"clonale,":[32],"d'identifier":[33,49],"des":[34,60,80,178,182],"antigenes":[35],"parasitaires":[36],"stimulant":[37],"anti-s.":[43,118,143],"Mansoni.":[44],"Cette":[45],"a":[47,88,100,124,165],"permis":[48],"fraction":[51],"antigenique":[52],"dont":[53],"les":[54,140],"proprietes":[55],"ont":[56],"ete":[57],"evaluees":[58],"chez":[59,102,204],"individus":[61],"vivant":[62],"en":[63],"zone":[64],"endemique":[65],"schistosome,":[67],"montrant":[68],"qu'elle":[69],"contenait":[70],"(ou":[72],"plusieurs)":[73],"molecule(s)":[74],"tres":[75],"immunogenique(s)":[76],"pour":[77],"majorite":[79],"sujets":[81,122],"testes,":[82],"et":[83,153,180,184,190],"que":[84,139,161,193],"reactivite":[86],"immunologique":[87],"cette":[89],"fraction,":[90],"augmentait":[91],"avec":[92],"l'age,":[93],"parallelement":[94],"au":[95,214],"developpement":[96],"resistance":[99,163],"l'infection":[101],"ces":[103,126],"individus.":[104],"Dans":[105],"seconde":[107],"etude,":[108],"caracterise":[111],"phenotype":[113],"fonctionnel":[114],"clones":[116,127,141],"th":[117,142,199],"Mansoni":[119,144,167,203],"derives":[120,145],"resistant":[123],"l'infection:":[125],"produisent":[128,134,150],"grandes":[130],"quantites":[131],"d'il4":[132],"mais":[133],"egalement":[135],"l'ifn-gamma":[137,186],"tandis":[138],"d'un":[146],"sujet":[147],"accidentellement":[148],"infecte":[149],"beaucoup":[151],"d'ifn-gamma":[152],"peu":[154],"d'il4.":[155],"Ces":[156],"resultats":[157],"suggerent":[158],"d'une":[159],"part,":[160,192],"s.":[166,202],"pourrait":[168,207],"dependre":[169],"mecanismes":[171],"regules":[172],"l'il4":[174],"(cytotoxicite":[175,187],"cellulaire":[176,188],"dependante":[177],"anticorps,":[179],"notamment":[181],"ige)":[183],"directe),":[189],"d'autre":[191],"nature":[195],"specifique":[200],"l'etre":[205],"humain,":[206],"etre":[208],"influencee":[209],"nombre":[212],"d'expositions":[213]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
