{"id":"https://openalex.org/W4387170481","doi":"https://doi.org/10.3390/nu15194208","title":"Mendelian Randomization Analysis Reveals Causal Effects of Polyunsaturated Fatty Acids on Subtypes of Diabetic Retinopathy Risk","display_name":"Mendelian Randomization Analysis Reveals Causal Effects of Polyunsaturated Fatty Acids on Subtypes of Diabetic Retinopathy Risk","publication_year":2023,"publication_date":"2023-09-29","ids":{"openalex":"https://openalex.org/W4387170481","doi":"https://doi.org/10.3390/nu15194208","pmid":"https://pubmed.ncbi.nlm.nih.gov/37836492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10574403"},"language":"en","primary_location":{"id":"doi:10.3390/nu15194208","doi":"https://doi.org/10.3390/nu15194208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15194208","pdf_url":"https://www.mdpi.com/2072-6643/15/19/4208/pdf?version=1695977743","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/15/19/4208/pdf?version=1695977743","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shaojie Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145773","display_name":"Tianjin Medical University Eye Hospital","ror":"https://ror.org/04j2cfe69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145773"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaojie Ren","raw_affiliation_strings":["Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China","institution_ids":["https://openalex.org/I4210145773","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104317164","display_name":"Xue Chen","orcid":"https://orcid.org/0009-0002-9220-7991","observed_orcids":["https://orcid.org/0009-0002-9220-7991"]},"institutions":[{"id":"https://openalex.org/I4210145773","display_name":"Tianjin Medical University Eye Hospital","ror":"https://ror.org/04j2cfe69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145773"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Xue","raw_affiliation_strings":["Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China","institution_ids":["https://openalex.org/I4210145773","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022931388","display_name":"Manhong Xu","orcid":"https://orcid.org/0000-0003-0548-6305","observed_orcids":["https://orcid.org/0000-0003-0548-6305"]},"institutions":[{"id":"https://openalex.org/I4210145773","display_name":"Tianjin Medical University Eye Hospital","ror":"https://ror.org/04j2cfe69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145773"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Manhong Xu","raw_affiliation_strings":["Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China"],"raw_orcid":"https://orcid.org/0000-0003-0548-6305","affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China","institution_ids":["https://openalex.org/I4210145773","https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100409015","display_name":"Xiaorong Li","orcid":"https://orcid.org/0000-0003-0641-2797","observed_orcids":["https://orcid.org/0000-0003-0641-2797","https://orcid.org/0009-0007-2325-4512","https://orcid.org/0009-0006-8583-2341"]},"institutions":[{"id":"https://openalex.org/I4210145773","display_name":"Tianjin Medical University Eye Hospital","ror":"https://ror.org/04j2cfe69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145773"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaorong Li","raw_affiliation_strings":["Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China"],"raw_orcid":"https://orcid.org/0000-0003-0641-2797","affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China","institution_ids":["https://openalex.org/I4210145773","https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100409015"],"corresponding_institution_ids":["https://openalex.org/I4210145773","https://openalex.org/I5740404"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":2.2544,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86001666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"19","first_page":"4208","last_page":"4208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.4207000136375427,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9150000214576721},{"id":"https://openalex.org/keywords/omega-6-fatty-acids","display_name":"omega-6 fatty acids","score":1.0},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/proliferative-diabetic-retinopathy","display_name":"proliferative diabetic retinopathy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nonproliferative-diabetic-retinopathy","display_name":"non-proliferative diabetic retinopathy","score":0.972000002861023},{"id":"https://openalex.org/keywords/causal-effects","display_name":"causal effects","score":0.46399998664855957},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8759999871253967},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.3540000021457672},{"id":"https://openalex.org/keywords/fatty-acid-ratio","display_name":"fatty acid ratio","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9253882169723511},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.8110888004302979},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5028364062309265},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.462461918592453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4571073651313782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.443593829870224},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.42967846989631653},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35849541425704956},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33664488792419434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3317074179649353},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3316725492477417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3284270167350769},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.2414402961730957},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20464348793029785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19054922461509705},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1522669792175293},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1436842679977417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13936707377433777}],"mesh":[{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu15194208","doi":"https://doi.org/10.3390/nu15194208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15194208","pdf_url":"https://www.mdpi.com/2072-6643/15/19/4208/pdf?version=1695977743","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10574403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10574403","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10574403/pdf/nutrients-15-04208.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:37836492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37836492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/nu15194208","doi":"https://doi.org/10.3390/nu15194208","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15194208","pdf_url":"https://www.mdpi.com/2072-6643/15/19/4208/pdf?version=1695977743","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4816275781","display_name":null,"funder_award_id":"82171085","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326234","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89"},{"id":"https://openalex.org/F4320337072","display_name":"Tianjin Medical University Eye Hospital","ror":"https://ror.org/04j2cfe69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387170481.pdf","grobid_xml":"https://content.openalex.org/works/W4387170481.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1996742749","https://openalex.org/W2012107032","https://openalex.org/W2044687682","https://openalex.org/W2047003538","https://openalex.org/W2078456243","https://openalex.org/W2085485348","https://openalex.org/W2099020618","https://openalex.org/W2113699335","https://openalex.org/W2143431760","https://openalex.org/W2152513056","https://openalex.org/W2175704762","https://openalex.org/W2227154220","https://openalex.org/W2260107689","https://openalex.org/W2323650856","https://openalex.org/W2324862792","https://openalex.org/W2416504328","https://openalex.org/W2509396687","https://openalex.org/W2511136653","https://openalex.org/W2520048741","https://openalex.org/W2528302205","https://openalex.org/W2616356421","https://openalex.org/W2765391558","https://openalex.org/W2768855358","https://openalex.org/W2770598799","https://openalex.org/W2775574923","https://openalex.org/W2803072880","https://openalex.org/W2804346130","https://openalex.org/W2805983714","https://openalex.org/W2818417770","https://openalex.org/W2945858586","https://openalex.org/W2945864320","https://openalex.org/W2974570896","https://openalex.org/W3083934892","https://openalex.org/W3092532329","https://openalex.org/W3111078905","https://openalex.org/W3116017818","https://openalex.org/W3120633690","https://openalex.org/W3146028045","https://openalex.org/W3157851866","https://openalex.org/W3158522809","https://openalex.org/W3161871886","https://openalex.org/W3173645996","https://openalex.org/W3181573421","https://openalex.org/W3198590100","https://openalex.org/W3200094880","https://openalex.org/W3210406414","https://openalex.org/W3210570897","https://openalex.org/W4200507892","https://openalex.org/W4200613555","https://openalex.org/W4210591715","https://openalex.org/W4211031298","https://openalex.org/W4211103501","https://openalex.org/W4220668653","https://openalex.org/W4225278778","https://openalex.org/W4251267479","https://openalex.org/W4255815262","https://openalex.org/W4281714153","https://openalex.org/W4306967477","https://openalex.org/W4307106797","https://openalex.org/W4312056009","https://openalex.org/W4313827473","https://openalex.org/W4317390883","https://openalex.org/W4376638690","https://openalex.org/W4379537455"],"related_works":["https://openalex.org/W4401403982","https://openalex.org/W2175704762","https://openalex.org/W3092532329","https://openalex.org/W2106967013","https://openalex.org/W4407397298","https://openalex.org/W3161871886","https://openalex.org/W3030058643","https://openalex.org/W2758866518","https://openalex.org/W2988415973","https://openalex.org/W3193980348"],"abstract_inverted_index":{"Polyunsaturated":[0],"fatty":[1,44,64],"acids":[2,45,65],"(PUFAs)":[3],"affect":[4],"several":[5],"physiological":[6],"processes,":[7],"including":[8],"visual":[9],"acuity,":[10],"but":[11],"their":[12,47],"relationship":[13,171],"with":[14,128,140,151],"diabetic":[15],"retinopathy":[16],"(DR)":[17],"remains":[18],"elusive.":[19],"The":[20],"aim":[21],"of":[22,89,121,131,144,154,194],"this":[23],"study":[24,103],"was":[25,138],"to":[26,104,115,125],"determine":[27],"whether":[28],"PUFAs":[29,90,122,173],"have":[30,91],"a":[31,98,141,169],"causal":[32,170],"effect":[33],"on":[34,94,199],"DR.":[35,200],"PUFAs-":[36],"(total":[37],"and":[38,41,46,49,66,79,96,110,134,157,174,191,197],"omega-3":[39],"[FAw3]":[40],"omega-6":[42],"[FAw6]":[43],"ratio)":[48],"DR-associated":[50],"single":[51],"nucleotide":[52],"polymorphisms":[53],"derived":[54],"from":[55],"genome-wide":[56],"association":[57,150],"studies;":[58],"sample":[59],"sizes":[60],"were":[61,113,123],"114,999":[62],"for":[63,68,164,168],"216,666":[67],"any":[69],"DR":[70,73,77,81,95,176],"(ADR),":[71],"background":[72],"(BDR),":[74],"severe":[75],"non-proliferative":[76],"(SNPDR),":[78],"proliferative":[80],"(PDR).":[82],"We":[83],"hypothesized":[84],"that":[85],"the":[86,106,165,188],"intra-body":[87],"levels":[88,120],"an":[92,149],"impact":[93],"conducted":[97],"two-sample":[99],"Mendelian":[100],"randomization":[101],"(MR)":[102],"assess":[105],"causality.":[107],"Pleiotropy,":[108],"heterogeneity,":[109],"sensitivity":[111],"analyses":[112],"performed":[114],"verify":[116],"result":[117],"reliability.":[118],"High":[119],"found":[124],"be":[126],"associated":[127,139],"reduced":[129,175],"risk":[130,143],"both":[132,155],"ADR":[133],"PDR.":[135,158],"Moreover,":[136],"FAw3":[137],"decreased":[142],"PDR,":[145],"whereas":[146],"FAw6":[147,198],"demonstrated":[148],"lowered":[152],"risks":[153],"BDR":[156],"Our":[159],"findings":[160],"provide":[161],"genetic":[162],"evidence,":[163],"first":[166],"time,":[167],"between":[172],"risk.":[177],"Consequently,":[178],"our":[179],"comprehensive":[180],"MR":[181],"analysis":[182],"strongly":[183],"urges":[184],"further":[185],"investigation":[186],"into":[187],"precise":[189],"functions":[190],"long-term":[192],"effects":[193],"PUFAs,":[195],"FAw3,":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-09-30T00:00:00"}