{"id":"https://openalex.org/W4387064965","doi":"https://doi.org/10.1107/s2053273323099436","title":"Visualization of the human manganese superoxide dismutase product inhibition mechanism and protonation states","display_name":"Visualization of the human manganese superoxide dismutase product inhibition mechanism and protonation states","publication_year":2023,"publication_date":"2023-07-07","ids":{"openalex":"https://openalex.org/W4387064965","doi":"https://doi.org/10.1107/s2053273323099436"},"language":"en","primary_location":{"id":"doi:10.1107/s2053273323099436","doi":"https://doi.org/10.1107/s2053273323099436","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s2053273323099436","pdf_url":"https://journals.iucr.org/a/issues/2023/a1/00/a61936/a61936.pdf","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.iucr.org/a/issues/2023/a1/00/a61936/a61936.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009645180","display_name":"Jahaun Azadmanesh","orcid":"https://orcid.org/0000-0002-3615-7785","observed_orcids":["https://orcid.org/0000-0002-3615-7785"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahaun Azadmanesh","raw_affiliation_strings":["University of Nebraska Medical Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center ,","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katelyn Slobodnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Slobodnik","raw_affiliation_strings":["University of Nebraska Medical Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center ,","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003035333","display_name":"William E. Lutz","orcid":"https://orcid.org/0000-0002-7248-4994","observed_orcids":["https://orcid.org/0000-0002-7248-4994"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Lutz","raw_affiliation_strings":["University of Nebraska Medical Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center ,","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015921759","display_name":"Leighton Coates","orcid":"https://orcid.org/0000-0003-2342-049X","observed_orcids":["https://orcid.org/0000-0003-2342-049X"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leighton Coates","raw_affiliation_strings":["Oak Ridge National Laboratory ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory ,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011656540","display_name":"Kevin L. Weiss","orcid":"https://orcid.org/0000-0002-6486-8007","observed_orcids":["https://orcid.org/0000-0002-6486-8007"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin L. Weiss","raw_affiliation_strings":["Oak Ridge National Laboratory ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory ,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078892637","display_name":"Dean A. A. Myles","orcid":"https://orcid.org/0000-0002-7693-4964","observed_orcids":["https://orcid.org/0000-0002-7693-4964"]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean A. A. Myles","raw_affiliation_strings":["Oak Ridge National Laboratory ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oak Ridge National Laboratory ,","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038593209","display_name":"Thomas Kr\u00f6ll","orcid":"https://orcid.org/0000-0003-2176-6905","observed_orcids":["https://orcid.org/0000-0003-2176-6905"]},"institutions":[{"id":"https://openalex.org/I2801935854","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Kroll","raw_affiliation_strings":["SLAC National Accelerator Laboratory ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SLAC National Accelerator Laboratory ,","institution_ids":["https://openalex.org/I2801935854"]}]},{"author_position":"last","author":{"id":null,"display_name":"Gloria E. O. Borgstahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gloria E. O. Borgstahl","raw_affiliation_strings":["University of Nebraska Medical Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center ,","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10516213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"a1","first_page":"a56","last_page":"a56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/proton-coupled-electron-transfer","display_name":"proton-coupled electron transfer","score":0.800000011920929},{"id":"https://openalex.org/keywords/oxidoreductases","display_name":"oxidative enzymes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7519999742507935},{"id":"https://openalex.org/keywords/enzyme-inhibition-mechanism","display_name":"enzyme inhibition mechanism","score":0.699999988079071},{"id":"https://openalex.org/keywords/protonation-states","display_name":"protonation states","score":0.9539999961853027},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/protein-crystal-structure","display_name":"protein crystal structure","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.7031365633010864},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6767235994338989},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6717870831489563},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.6682921648025513},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5764476656913757},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.49480313062667847},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.4149317145347595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32028791308403015},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1501973271369934},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12794315814971924},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11680331826210022},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0889400839805603},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.07066529989242554},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.044999539852142334},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1107/s2053273323099436","doi":"https://doi.org/10.1107/s2053273323099436","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s2053273323099436","pdf_url":"https://journals.iucr.org/a/issues/2023/a1/00/a61936/a61936.pdf","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1107/s2053273323099436","doi":"https://doi.org/10.1107/s2053273323099436","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s2053273323099436","pdf_url":"https://journals.iucr.org/a/issues/2023/a1/00/a61936/a61936.pdf","source":{"id":"https://openalex.org/S4393918093","display_name":"Acta Crystallographica Section A Foundations and Advances","issn_l":"2053-2733","issn":["2053-2733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-200","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section A Foundations and Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387064965.pdf","grobid_xml":"https://content.openalex.org/works/W4387064965.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889962518","https://openalex.org/W3163876185","https://openalex.org/W4400689042","https://openalex.org/W7101411653","https://openalex.org/W4399188205","https://openalex.org/W4407851884","https://openalex.org/W6948258399","https://openalex.org/W4211265368","https://openalex.org/W3113370292","https://openalex.org/W1969423904"],"abstract_inverted_index":{"About":[0],"25%":[1],"of":[2,30,35,59,77,97],"known":[3],"enzymes":[4,47],"are":[5,71],"oxidoreductases":[6,26,72,98],"that":[7,12,73],"catalyze":[8],"the":[9,21,28,33,60,75],"electron":[10,42,66],"transfers":[11],"life":[13],"depends":[14],"on.To":[15],"chemically":[16],"accelerate":[17],"redox":[18,86],"reactions":[19],"to":[20,32,105],"rates":[22],"needed":[23],"for":[24,100],"life,":[25],"couple":[27],"transfer":[29,34,43,67],"electrons":[31],"protons":[36],"in":[37,63,82],"a":[38],"process":[39],"called":[40],"proton-coupled":[41],"(PCET).The":[44],"biochemistry":[45],"behind":[46],"utilizing":[48],"PCETs":[49],"is":[50],"not":[51],"well":[52],"understood":[53],"as":[54],"it":[55],"requires":[56],"precise":[57],"definition":[58],"proton":[61],"donors/acceptors":[62],"tandem":[64],"with":[65],"steps.Of":[68],"particular":[69],"note":[70],"regulate":[74],"concentration":[76],"reactive":[78],"oxygen":[79],"species":[80],"(ROS)":[81],"cells":[83],"through":[84],"PCET-mediated":[85],"reactions.ROS":[87],"levels":[88],"mediate":[89],"mitophagy":[90],"and":[91,95,110],"programmed":[92],"cell":[93],"death":[94],"dysfunction":[96],"responsible":[99],"limiting":[101],"ROS":[102],"concentrations":[103],"contribute":[104],"cardiovascular":[106],"disease,":[107,109],"neurological":[108],"cancer":[111],"progression.":[112]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-09-27T00:00:00"}
