{"id":"https://openalex.org/W4387052665","doi":"https://doi.org/10.1249/01.mss.0000989472.72909.f1","title":"Common Muscle Damage Markers Are Associated With Divergent Gene Expression Changes After Eccentric Exercise","display_name":"Common Muscle Damage Markers Are Associated With Divergent Gene Expression Changes After Eccentric Exercise","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4387052665","doi":"https://doi.org/10.1249/01.mss.0000989472.72909.f1"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000989472.72909.f1","doi":"https://doi.org/10.1249/01.mss.0000989472.72909.f1","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1249/01.mss.0000989472.72909.f1","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020771852","display_name":"Dakota Tiede","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dakota Tiede","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068225719","display_name":"Michael R. Deyhle","orcid":"https://orcid.org/0000-0001-8526-4758","observed_orcids":["https://orcid.org/0000-0001-8526-4758"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Deyhle","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Xin","raw_affiliation_strings":["The University of Mississippi, Oxford, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Mississippi, Oxford, MS","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033326925","display_name":"Robert D. Hyldahl","orcid":"https://orcid.org/0000-0003-4961-1868","observed_orcids":["https://orcid.org/0000-0003-4961-1868"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Hyldahl","raw_affiliation_strings":["Brigham Young University, Provo, UT. (Sponsor: Monica Hubal, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham Young University, Provo, UT. (Sponsor: Monica Hubal, FACSM)","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021612557","display_name":"Monica J. Hubal","orcid":"https://orcid.org/0000-0001-6579-6036","observed_orcids":["https://orcid.org/0000-0001-6579-6036"]},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica J. Hubal","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN","Brigham Young University, Provo, UT. (Sponsor: Monica Hubal, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Brigham Young University, Provo, UT. (Sponsor: Monica Hubal, FACSM)","institution_ids":["https://openalex.org/I100005738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"9S","first_page":"1035","last_page":"1035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise-induced-muscle-damage","display_name":"exercise-induced muscle damage","score":0.9769999980926514},{"id":"https://openalex.org/keywords/eccentric-exercise","display_name":"eccentric exercise","score":0.9980000257492065},{"id":"https://openalex.org/keywords/muscle-soreness","display_name":"muscle soreness","score":0.7879999876022339},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.7459999918937683},{"id":"https://openalex.org/keywords/muscle-strength-loss","display_name":"muscle strength decline","score":0.8159999847412109},{"id":"https://openalex.org/keywords/serotonin-receptor-signaling","display_name":"serotonin receptor signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skeletal-muscle-transcriptome","display_name":"skeletal muscle transcriptome","score":0.4729999899864197},{"id":"https://openalex.org/keywords/post-exercise-recovery","display_name":"post-exercise recovery","score":0.5099999904632568},{"id":"https://openalex.org/keywords/isometric-strength","display_name":"isometric strength","score":0.375}],"concepts":[{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.8359755277633667},{"id":"https://openalex.org/C2778470209","wikidata":"https://www.wikidata.org/wiki/Q5332180","display_name":"Eccentric exercise","level":3,"score":0.7021681666374207},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.66263747215271},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.6239944100379944},{"id":"https://openalex.org/C2780063275","wikidata":"https://www.wikidata.org/wiki/Q574415","display_name":"Delayed onset muscle soreness","level":3,"score":0.5138037800788879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4858219623565674},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48250341415405273},{"id":"https://openalex.org/C2993817360","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Muscle damage","level":2,"score":0.47204670310020447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4381718635559082},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41225147247314453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4061252772808075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31135571002960205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18138167262077332},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000989472.72909.f1","doi":"https://doi.org/10.1249/01.mss.0000989472.72909.f1","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1249/01.mss.0000989472.72909.f1","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391383790","https://openalex.org/W3181976268","https://openalex.org/W4294844282","https://openalex.org/W2136131808","https://openalex.org/W1564210324","https://openalex.org/W95838583","https://openalex.org/W2344392224","https://openalex.org/W1978722637","https://openalex.org/W2947082630","https://openalex.org/W2064501536"],"abstract_inverted_index":{"PURPOSE:":[0],"Unaccustomed":[1],"eccentric":[2],"(ECC)":[3],"exercise":[4,54,100],"results":[5,299],"in":[6,31,48,67,178,286,291,303],"exercise-induced":[7,279],"muscle":[8,147,280,296],"damage":[9],"(EIMD).":[10],"Soreness,":[11],"strength":[12,110,169,224,265,338],"loss":[13,170],"and":[14,69,123,136,171,226,332,345],"serum":[15,124],"creatine":[16,125],"kinase":[17,126],"(CK)":[18],"levels":[19],"are":[20,34,242,306],"often":[21],"used":[22,150,193],"to":[23,59,72,151,181,194,289],"evaluate":[24],"the":[25,39,63,76,196,206,233,307],"extent":[26],"of":[27,167,198,277,295,309],"EIMD,":[28],"however,":[29],"changes":[30,285,302],"these":[32,304],"markers":[33,294,305,324],"not":[35],"fully":[36],"understood":[37],"at":[38],"mechanistic":[40],"level.":[41],"In":[42,274],"this":[43],"study,":[44],"we":[45,282],"leveraged":[46],"variation":[47,290],"each":[49,68,73,83,201,251],"indirect":[50,293],"marker":[51,252],"following":[52,143,207],"standardized":[53],"using":[55,185],"correlated":[56,164,236,321],"gene":[57,154,176,287],"expression":[58,155,177,288],"gain":[60],"insight":[61],"into":[62],"different":[64],"processes":[65,312],"involved":[66],"their":[70],"relationship":[71],"other,":[74],"with":[75,175,217,222,229,237,313,322,336,349],"hypothesis":[77],"that":[78,301],"unique":[79],"molecular":[80],"pathways":[81,320],"drive":[82],"response.":[84],"METHODS:":[85],"Vastus":[86],"lateralis":[87],"biopsies":[88,148],"were":[89,127],"collected":[90],"(N":[91],"=":[92],"35)":[93],"from":[94,146],"young":[95],"men":[96],"3":[97],"hr":[98],"post-ECC":[99,173],"(non-exercised":[101],"contralateral":[102],"leg":[103],"(CON)":[104],"as":[105,342],"a":[106,113,275],"control).":[107],"Maximal":[108],"isometric":[109],"measured":[111],"on":[112,200],"Biodex":[114],"isokinetic":[115],"dynamometer,":[116],"soreness":[117],"measure":[118],"via":[119],"visual":[120],"analog":[121],"scale,":[122],"assessed":[128],"24":[129,138],"h":[130,134],"pre-":[131],"exercise,":[132],"0":[133],"post-exercise,":[135],"every":[137],"hours":[139],"for":[140,250,257,263,270],"5":[141],"days":[142],"exercise.":[144],"RNA":[145],"was":[149,192],"generate":[152],"global":[153],"profiles":[156],"(Agilent":[157],"Whole":[158],"Genome":[159],"Microarrays).":[160],"Partek":[161],"Genomics":[162],"Suite":[163],"peak":[165,218,223,230,258,264,271,337,350],"values":[166],"soreness,":[168,219,259],"CK":[172],"(0-5d)":[174],"ECC":[179],"relative":[180],"intra-subject":[182],"paired":[183],"CON":[184],"Pearson":[186],"linear":[187],"correlation.":[188],"One-way":[189],"RM":[190],"ANOVA":[191],"examine":[195],"effect":[197],"time":[199],"marker.":[202],"RESULTS:":[203],"We":[204],"detected":[205],"correlations":[208],"(all":[209],"p":[210],"<":[211],"0.05)":[212],"after":[213],"ECC:":[214],"2677":[215],"genes":[216,221,228,235,249,255,261,268],"3333":[220],"loss,":[225,266],"3077":[227],"CK.":[231,272],"Of":[232],"9087":[234],"ECC,":[238],"only":[239],"16":[240],"(0.17%)":[241],"shared":[243,315],"between":[244,317],"all":[245],"three":[246],"markers.":[247,318],"Unique":[248],"were:":[253],"2346":[254],"(88%)":[256],"3032":[260],"(91%)":[262],"2937":[267],"(95%)":[269],"CONCLUSION:":[273],"model":[276],"moderate":[278],"damage,":[281],"related":[283],"early":[284],"common":[292],"damage.":[297],"Our":[298],"suggest":[300],"result":[308],"distinct":[310],"biological":[311],"little":[314],"variance":[316],"Top":[319],"key":[323],"include":[325],"GABA":[326],"receptor":[327,330],"signaling,":[328,331],"serotonin":[329],"cAMP":[333],"mediated":[334],"signaling":[335,344],"loss.":[339],"As":[340],"well":[341],"NF-\u03ba\u03b2":[343],"actin":[346],"cytoskeleton":[347],"remodeling":[348],"soreness.":[351]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-09-27T00:00:00"}