{"id":"https://openalex.org/W4387048482","doi":"https://doi.org/10.3389/fimmu.2023.1265969","title":"Extracellular vesicles in hematological malignancies: EV-dence for reshaping the tumoral microenvironment","display_name":"Extracellular vesicles in hematological malignancies: EV-dence for reshaping the tumoral microenvironment","publication_year":2023,"publication_date":"2023-09-26","ids":{"openalex":"https://openalex.org/W4387048482","doi":"https://doi.org/10.3389/fimmu.2023.1265969","pmid":"https://pubmed.ncbi.nlm.nih.gov/37822925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10562589"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1265969","doi":"https://doi.org/10.3389/fimmu.2023.1265969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1265969","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265969/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265969/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092614020","display_name":"David Van Morckhoven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David Van Morckhoven","raw_affiliation_strings":["Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080195544","display_name":"Nathan Dubois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nathan Dubois","raw_affiliation_strings":["Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050300241","display_name":"D Bron","orcid":"https://orcid.org/0000-0002-1634-1104","observed_orcids":["https://orcid.org/0000-0002-1634-1104"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dominique Bron","raw_affiliation_strings":["Departement of Hematology, Jules Bordet Institute, Brussels, Belgium","Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement of Hematology, Jules Bordet Institute, Brussels, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038795221","display_name":"Nathalie Meuleman","orcid":"https://orcid.org/0000-0003-0479-2474","observed_orcids":["https://orcid.org/0000-0003-0479-2474"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nathalie Meuleman","raw_affiliation_strings":["Departement of Hematology, Jules Bordet Institute, Brussels, Belgium","Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement of Hematology, Jules Bordet Institute, Brussels, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074992319","display_name":"Laurence Lagneaux","orcid":"https://orcid.org/0000-0002-9190-0682","observed_orcids":["https://orcid.org/0000-0002-9190-0682"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laurence Lagneaux","raw_affiliation_strings":["Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038527413","display_name":"Basile Stamatopoulos","orcid":"https://orcid.org/0000-0002-0580-7394","observed_orcids":["https://orcid.org/0000-0002-0580-7394"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Basile Stamatopoulos","raw_affiliation_strings":["Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Cell Therapy, Jules Bordet Institute, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038527413"],"corresponding_institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2801838318"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.8328,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.67300658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":null,"first_page":"1265969","last_page":"1265969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9890000224113464},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/microparticles","display_name":"microparticles","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.871999979019165},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.9089999794960022},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/therapeutic-potential","display_name":"therapeutic potential","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.8756108283996582},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.8102352619171143},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7022583484649658},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.675597608089447},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6624385118484497},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5491306781768799},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5285831093788147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47297847270965576},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4259393811225891},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40324071049690247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.389671266078949},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35062721371650696},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2176515758037567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07609370350837708},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2023.1265969","doi":"https://doi.org/10.3389/fimmu.2023.1265969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1265969","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265969/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10562589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10562589","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10562589/pdf/fimmu-14-1265969.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37822925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37822925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/364798","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/364798","pdf_url":"https://dipot.ulb.ac.be/dspace/bitstream/2013/364798/1/doi_348442.pdf","source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in immunology, 14","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6dac9033c962489eadf1277711c46f72","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6dac9033c962489eadf1277711c46f72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1265969","doi":"https://doi.org/10.3389/fimmu.2023.1265969","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1265969","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265969/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320325019","display_name":"Amis de l'Institut Bordet","ror":"https://ror.org/0073n0s52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387048482.pdf","grobid_xml":"https://content.openalex.org/works/W4387048482.grobid-xml"},"referenced_works_count":206,"referenced_works":["https://openalex.org/W154103547","https://openalex.org/W746787659","https://openalex.org/W1492263161","https://openalex.org/W1507575667","https://openalex.org/W1531083786","https://openalex.org/W1558827591","https://openalex.org/W1569016295","https://openalex.org/W1601856726","https://openalex.org/W1638318949","https://openalex.org/W1965851569","https://openalex.org/W1972070926","https://openalex.org/W1985016870","https://openalex.org/W1998307755","https://openalex.org/W2001149149","https://openalex.org/W2005154332","https://openalex.org/W2009649000","https://openalex.org/W2027963168","https://openalex.org/W2028248159","https://openalex.org/W2059767791","https://openalex.org/W2090926836","https://openalex.org/W2095932809","https://openalex.org/W2098364791","https://openalex.org/W2105726520","https://openalex.org/W2115956819","https://openalex.org/W2116268000","https://openalex.org/W2117375925","https://openalex.org/W2126210405","https://openalex.org/W2128384671","https://openalex.org/W2135175417","https://openalex.org/W2138208694","https://openalex.org/W2145852879","https://openalex.org/W2151917704","https://openalex.org/W2155366992","https://openalex.org/W2160275670","https://openalex.org/W2165195065","https://openalex.org/W2168913562","https://openalex.org/W2259481044","https://openalex.org/W2271778158","https://openalex.org/W2280332147","https://openalex.org/W2307271768","https://openalex.org/W2372867259","https://openalex.org/W2487582526","https://openalex.org/W2511826048","https://openalex.org/W2533551028","https://openalex.org/W2557894794","https://openalex.org/W2567622668","https://openalex.org/W2568513163","https://openalex.org/W2588057136","https://openalex.org/W2599872580","https://openalex.org/W2613158616","https://openalex.org/W2616397673","https://openalex.org/W2623721888","https://openalex.org/W2739501186","https://openalex.org/W2747254185","https://openalex.org/W2747910946","https://openalex.org/W2754123122","https://openalex.org/W2768082276","https://openalex.org/W2770029409","https://openalex.org/W2783965560","https://openalex.org/W2786514708","https://openalex.org/W2794087648","https://openalex.org/W2799975463","https://openalex.org/W2810113794","https://openalex.org/W2887033855","https://openalex.org/W2889899236","https://openalex.org/W2891837607","https://openalex.org/W2896682958","https://openalex.org/W2898281775","https://openalex.org/W2900257133","https://openalex.org/W2900311227","https://openalex.org/W2900493338","https://openalex.org/W2900756811","https://openalex.org/W2901346015","https://openalex.org/W2910185016","https://openalex.org/W2910896051","https://openalex.org/W2911909663","https://openalex.org/W2913329172","https://openalex.org/W2914287288","https://openalex.org/W2914373241","https://openalex.org/W2914662982","https://openalex.org/W2925078732","https://openalex.org/W2942050688","https://openalex.org/W2945684633","https://openalex.org/W2946574691","https://openalex.org/W2952388834","https://openalex.org/W2955215268","https://openalex.org/W2964876593","https://openalex.org/W2966288630","https://openalex.org/W2969834274","https://openalex.org/W2977213662","https://openalex.org/W2977861561","https://openalex.org/W2979776183","https://openalex.org/W2982299434","https://openalex.org/W2990737966","https://openalex.org/W2996516547","https://openalex.org/W3000686436","https://openalex.org/W3000847957","https://openalex.org/W3003135273","https://openalex.org/W3005605138","https://openalex.org/W3009751715","https://openalex.org/W3011004873","https://openalex.org/W3011743573","https://openalex.org/W3014584966","https://openalex.org/W3016238224","https://openalex.org/W3025152065","https://openalex.org/W3028434757","https://openalex.org/W3029489073","https://openalex.org/W3030558382","https://openalex.org/W3032046506","https://openalex.org/W3037375356","https://openalex.org/W3038038649","https://openalex.org/W3038753161","https://openalex.org/W3041669837","https://openalex.org/W3042064298","https://openalex.org/W3043328885","https://openalex.org/W3047255275","https://openalex.org/W3054195156","https://openalex.org/W3082064887","https://openalex.org/W3088307847","https://openalex.org/W3092043345","https://openalex.org/W3097305002","https://openalex.org/W3097949988","https://openalex.org/W3102752513","https://openalex.org/W3104169955","https://openalex.org/W3107826411","https://openalex.org/W3111493221","https://openalex.org/W3112116221","https://openalex.org/W3113165341","https://openalex.org/W3116157210","https://openalex.org/W3119921402","https://openalex.org/W3120669295","https://openalex.org/W3126578536","https://openalex.org/W3127772482","https://openalex.org/W3128028151","https://openalex.org/W3131479340","https://openalex.org/W3139485054","https://openalex.org/W3142338040","https://openalex.org/W3142408614","https://openalex.org/W3153757762","https://openalex.org/W3154091431","https://openalex.org/W3154279061","https://openalex.org/W3155060851","https://openalex.org/W3157705546","https://openalex.org/W3158940958","https://openalex.org/W3160486839","https://openalex.org/W3161408545","https://openalex.org/W3162148080","https://openalex.org/W3163023470","https://openalex.org/W3165149594","https://openalex.org/W3175628958","https://openalex.org/W3179366589","https://openalex.org/W3183661141","https://openalex.org/W3187266776","https://openalex.org/W3188381474","https://openalex.org/W3194451181","https://openalex.org/W3196406220","https://openalex.org/W3197655188","https://openalex.org/W3201581875","https://openalex.org/W3201665227","https://openalex.org/W3204486370","https://openalex.org/W3213975580","https://openalex.org/W3214949482","https://openalex.org/W3215794102","https://openalex.org/W4200006438","https://openalex.org/W4200180589","https://openalex.org/W4200231149","https://openalex.org/W4200295861","https://openalex.org/W4200468735","https://openalex.org/W4205326779","https://openalex.org/W4206616525","https://openalex.org/W4206806017","https://openalex.org/W4210358440","https://openalex.org/W4210805264","https://openalex.org/W4211058750","https://openalex.org/W4211191410","https://openalex.org/W4212822472","https://openalex.org/W4214711818","https://openalex.org/W4220654217","https://openalex.org/W4220683329","https://openalex.org/W4220805142","https://openalex.org/W4220852537","https://openalex.org/W4223412840","https://openalex.org/W4225145238","https://openalex.org/W4225693002","https://openalex.org/W4225851499","https://openalex.org/W4235474157","https://openalex.org/W4237089740","https://openalex.org/W4238808378","https://openalex.org/W4242533571","https://openalex.org/W4249579699","https://openalex.org/W4250295293","https://openalex.org/W4281885127","https://openalex.org/W4283260949","https://openalex.org/W4284884233","https://openalex.org/W4284971996","https://openalex.org/W4285088469","https://openalex.org/W4285091190","https://openalex.org/W4285392934","https://openalex.org/W4293786848","https://openalex.org/W4295932262","https://openalex.org/W4308168284","https://openalex.org/W4308507501","https://openalex.org/W4312190599","https://openalex.org/W4318753982","https://openalex.org/W4321749356","https://openalex.org/W4362525471"],"related_works":["https://openalex.org/W4224230984","https://openalex.org/W2138929080","https://openalex.org/W2620659987","https://openalex.org/W7100470549","https://openalex.org/W3017726737","https://openalex.org/W3128712229","https://openalex.org/W3042739394","https://openalex.org/W7214731101","https://openalex.org/W2802826951","https://openalex.org/W4378528519"],"abstract_inverted_index":{"Following":[0],"their":[1,100],"discovery":[2],"at":[3],"the":[4,7,23,103,120,139,165,171,196,202,213],"end":[5],"of":[6,25,36,66,84,105,122,176,185,198,204,217],"20th":[8],"century,":[9],"extracellular":[10,95,177,186],"vesicles":[11,96,178,187,200],"(EVs)":[12],"ranging":[13],"from":[14],"50-1,000":[15],"nm":[16],"have":[17,52],"proven":[18],"to":[19,55,137,143,208,211],"be":[20],"paramount":[21],"in":[22,57,149,179,189,195,201],"progression":[24],"many":[26],"cancers,":[27],"including":[28],"hematological":[29,181,218],"malignancies.":[30,182,219],"EVs":[31,43,49,133],"are":[32,79,134],"a":[33,81,106],"heterogeneous":[34],"group":[35],"cell-derived":[37],"membranous":[38],"structures":[39],"that":[40,97],"include":[41],"small":[42],"(commonly":[44],"called":[45],"exosomes)":[46],"and":[47,60,74,109,111,125,142,158,168,173,215],"large":[48],"(microparticles).":[50],"They":[51,78],"been":[53],"demonstrated":[54],"participate":[56],"multiple":[58],"physiological":[59],"pathological":[61],"processes":[62],"by":[63,117],"allowing":[64],"exchange":[65],"biological":[67],"material":[68],"(including":[69],"among":[70],"others":[71],"proteins,":[72],"DNA":[73],"RNA)":[75],"between":[76],"cells.":[77],"therefore":[80],"crucial":[82],"way":[83],"intercellular":[85],"communication.":[86],"In":[87,131],"this":[88],"context,":[89],"malignant":[90],"cells":[91,124],"can":[92,98],"release":[93],"these":[94,199],"influence":[99],"microenvironment,":[101],"induce":[102],"formation":[104],"tumorigenic":[107],"niche,":[108],"prepare":[110],"establish":[112,144],"distant":[113],"niches":[114],"facilitating":[115],"metastasis":[116],"significantly":[118],"impacting":[119],"phenotypes":[121],"surrounding":[123],"turning":[126],"them":[127],"toward":[128],"supportive":[129],"roles.":[130],"addition,":[132],"also":[135],"able":[136],"manipulate":[138],"immune":[140],"response":[141],"an":[145],"immunosuppressive":[146],"microenvironment.":[147],"This":[148],"turn":[150],"allows":[151],"for":[152,155],"ideal":[153],"conditions":[154],"heightened":[156],"chemoresistance":[157],"increased":[159],"disease":[160,205],"burden.":[161],"Here,":[162],"we":[163],"review":[164],"latest":[166],"findings":[167],"reports":[169],"studying":[170],"effects":[172],"therapeutic":[174],"potential":[175],"various":[180],"The":[183],"study":[184],"remains":[188],"its":[190],"infancy;":[191],"however,":[192],"rapid":[193],"advances":[194],"analysis":[197],"context":[203],"allow":[206],"us":[207],"envision":[209],"prospects":[210],"improve":[212],"detection":[214],"treatment":[216]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-09-27T00:00:00"}