{"id":"https://openalex.org/W4387034074","doi":"https://doi.org/10.1002/pmic.202200424","title":"Application of sample displacement batch chromatography for fractionation of proteoforms","display_name":"Application of sample displacement batch chromatography for fractionation of proteoforms","publication_year":2023,"publication_date":"2023-09-26","ids":{"openalex":"https://openalex.org/W4387034074","doi":"https://doi.org/10.1002/pmic.202200424","pmid":"https://pubmed.ncbi.nlm.nih.gov/37750450"},"language":"en","primary_location":{"id":"doi:10.1002/pmic.202200424","doi":"https://doi.org/10.1002/pmic.202200424","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202200424","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202200424","source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202200424","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039577762","display_name":"Siti Nurul Hidayah","orcid":"https://orcid.org/0000-0002-7669-6548","observed_orcids":["https://orcid.org/0000-0002-7669-6548"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE","ID"],"is_corresponding":false,"raw_author_name":"Siti Nurul Hidayah","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sleman, Yogyakarta, Indonesia","Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sleman, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]},{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011952622","display_name":"Ali Biabani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ali Biabani","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108688191","display_name":"Manasi Gaikwad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manasi Gaikwad","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060430475","display_name":"Paula Nissen","orcid":"https://orcid.org/0009-0009-5044-0403","observed_orcids":["https://orcid.org/0009-0009-5044-0403"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paula Nissen","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881283","display_name":"Hannah Vo\u00df","orcid":"https://orcid.org/0000-0001-7236-6624","observed_orcids":["https://orcid.org/0000-0001-7236-6624"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannah Vo\u00df","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009790492","display_name":"Maria Riedner","orcid":"https://orcid.org/0000-0003-4421-998X","observed_orcids":["https://orcid.org/0000-0003-4421-998X"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Riedner","raw_affiliation_strings":["Technology Platform Mass Spectrometry, University of Hamburg, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Platform Mass Spectrometry, University of Hamburg, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037776901","display_name":"Hartmut Schl\u00fcter","orcid":"https://orcid.org/0000-0002-9358-7036","observed_orcids":["https://orcid.org/0000-0002-9358-7036"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hartmut Schl\u00fcter","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9358-7036","affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050571419","display_name":"Bente Siebels","orcid":"https://orcid.org/0000-0001-9183-0381","observed_orcids":["https://orcid.org/0000-0001-9183-0381"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bente Siebels","raw_affiliation_strings":["Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section Mass Spectrometric Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037776901","https://openalex.org/A5050571419"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":{"value":4220,"currency":"USD","value_usd":4220},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"3-4","first_page":"e2200424","last_page":"e2200424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteoforms","display_name":"proteoforms","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cation-exchange-chromatography","display_name":"cation exchange chromatography","score":0.921999990940094},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.7829999923706055},{"id":"https://openalex.org/keywords/protein-heterogeneity","display_name":"protein heterogeneity","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.694536030292511},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.6732772588729858},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5123785734176636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5004494190216064},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.45220494270324707},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4409680664539337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09116432070732117},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0726761519908905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002845","descriptor_name":"Chromatography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pmic.202200424","doi":"https://doi.org/10.1002/pmic.202200424","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202200424","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202200424","source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},{"id":"doi:10.22541/au.167845030.02114773/v1","doi":"https://doi.org/10.22541/au.167845030.02114773/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.167845030.02114773/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.167845030.02114773","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:37750450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37750450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pmic.202200424","doi":"https://doi.org/10.1002/pmic.202200424","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pmic.202200424","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pmic.202200424","source":{"id":"https://openalex.org/S182655450","display_name":"PROTEOMICS","issn_l":"1615-9853","issn":["1615-9853","1615-9861"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G103040316","display_name":null,"funder_award_id":"INST 337/16\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3426420526","display_name":null,"funder_award_id":"INST337/15-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7109857494","display_name":null,"funder_award_id":"INST 152/837\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G870017301","display_name":"Analytics for Biologics","funder_award_id":"765502","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387034074.pdf","grobid_xml":"https://content.openalex.org/works/W4387034074.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W63040013","https://openalex.org/W1487520311","https://openalex.org/W1534259153","https://openalex.org/W1568341953","https://openalex.org/W1595136005","https://openalex.org/W1869516088","https://openalex.org/W1970133737","https://openalex.org/W1977934682","https://openalex.org/W1988896387","https://openalex.org/W1989506111","https://openalex.org/W1999429063","https://openalex.org/W2008406923","https://openalex.org/W2009383936","https://openalex.org/W2012600566","https://openalex.org/W2048049691","https://openalex.org/W2061583540","https://openalex.org/W2071319825","https://openalex.org/W2083344986","https://openalex.org/W2114402868","https://openalex.org/W2121234677","https://openalex.org/W2126066786","https://openalex.org/W2169353837","https://openalex.org/W2175608963","https://openalex.org/W2334348545","https://openalex.org/W2408858902","https://openalex.org/W2421901735","https://openalex.org/W2754219023","https://openalex.org/W2779082428","https://openalex.org/W2786505886","https://openalex.org/W2805255143","https://openalex.org/W2883416581","https://openalex.org/W2889050507","https://openalex.org/W2902534081","https://openalex.org/W2915850944","https://openalex.org/W2963729327","https://openalex.org/W2971361489","https://openalex.org/W3033086268","https://openalex.org/W3081277885","https://openalex.org/W3118332210","https://openalex.org/W3152486012","https://openalex.org/W3208691473","https://openalex.org/W4237706925","https://openalex.org/W6628974867"],"related_works":["https://openalex.org/W4405215118","https://openalex.org/W7137449111","https://openalex.org/W2987849054","https://openalex.org/W2982480750","https://openalex.org/W7097660947","https://openalex.org/W6983617902","https://openalex.org/W2116924678","https://openalex.org/W4321598488","https://openalex.org/W2971361489","https://openalex.org/W4237706925"],"abstract_inverted_index":{"Fractionation":[0],"of":[1,12,21,41,51,54,69,88,160,169,185],"proteoforms":[2,22,53,70,171,187],"is":[3,26,80,90,117],"currently":[4],"the":[5,10,19,39,52,73,77,83,86,100,146,176],"most":[6,142],"challenging":[7,81],"topic":[8],"in":[9,23,30,34,38,85,97],"field":[11],"proteoform":[13,102],"analysis.":[14],"The":[15,65,141],"need":[16],"for":[17,124,145,156,174],"considering":[18],"existence":[20],"experimental":[24],"approaches":[25],"not":[27],"only":[28],"important":[29],"Life":[31],"Science":[32],"research":[33],"general":[35],"but":[36],"especially":[37],"manufacturing":[40],"therapeutic":[42,47],"proteins":[43],"(TPs)":[44],"like":[45],"recombinant":[46],"antibodies":[48],"(mAbs).":[49],"Some":[50],"TPs":[55],"have":[56],"significantly":[57],"decreased":[58],"actions":[59],"or":[60],"even":[61],"cause":[62],"side":[63],"effects.":[64],"identification":[66],"and":[67,94,121,154],"removal":[68],"differing":[71],"from":[72],"main":[74,101],"species,":[75],"having":[76],"desired":[78],"action,":[79],"because":[82],"difference":[84],"composition":[87],"atoms":[89],"often":[91],"very":[92],"small":[93],"their":[95],"concentration":[96],"comparison":[98],"to":[99],"can":[103],"be":[104],"low.":[105],"In":[106],"this":[107],"study,":[108],"we":[109],"demonstrate":[110],"that":[111],"sample":[112,130],"displacement":[113],"batch":[114],"chromatography":[115,165],"(SDBC)":[116],"an":[118],"easy-to-handle,":[119],"economical,":[120],"efficient":[122],"method":[123],"fractionating":[125],"proteoforms.":[126,140],"As":[127],"a":[128,131,151,157,182],"model":[129],"commercial":[132],"ovalbumin":[133,139,161],"fraction":[134],"was":[135,172,188],"used,":[136],"containing":[137],"many":[138],"promising":[143],"parameters":[144],"SDBC":[147,177],"were":[148],"determined":[149],"by":[150],"screening":[152],"approach":[153],"applied":[155],"10-segment":[158],"fractionation":[159,178],"with":[162],"cation":[163],"exchange":[164],"resins.":[166],"Mass":[167],"spectrometry":[168],"intact":[170],"used":[173],"characterizing":[175],"process.":[179],"By":[180],"SDBC,":[181],"significant":[183],"separation":[184],"different":[186],"obtained.":[189]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-09-27T00:00:00"}