{"id":"https://openalex.org/W4387033273","doi":"https://doi.org/10.1001/jama.2023.16875","title":"Clinical Care for People Who Survive Childhood Cancer","display_name":"Clinical Care for People Who Survive Childhood Cancer","publication_year":2023,"publication_date":"2023-09-26","ids":{"openalex":"https://openalex.org/W4387033273","doi":"https://doi.org/10.1001/jama.2023.16875","pmid":"https://pubmed.ncbi.nlm.nih.gov/37750876"},"language":"en","primary_location":{"id":"doi:10.1001/jama.2023.16875","doi":"https://doi.org/10.1001/jama.2023.16875","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2023.16875","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043738456","display_name":"Smita Bhatia","orcid":"https://orcid.org/0000-0002-7755-5683","observed_orcids":["https://orcid.org/0000-0002-7755-5683"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smita Bhatia","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology/Oncology, Heersink School of Medicine, University of Alabama at Birmingham","Institute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Heersink School of Medicine, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Institute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035581841","display_name":"Emily S. Tonorezos","orcid":"https://orcid.org/0000-0002-1185-5210","observed_orcids":["https://orcid.org/0000-0002-1185-5210"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily S. Tonorezos","raw_affiliation_strings":["Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067398740","display_name":"Wendy Landier","orcid":"https://orcid.org/0000-0003-3319-5652","observed_orcids":["https://orcid.org/0000-0003-3319-5652"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Landier","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology/Oncology, Heersink School of Medicine, University of Alabama at Birmingham","Institute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Heersink School of Medicine, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]},{"raw_affiliation_string":"Institute for Cancer Outcomes and Survivorship, Heersink School of Medicine, University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2013,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.9811828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"330","issue":"12","first_page":"1175","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-cancer-survivors","display_name":"childhood cancer survivors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/late-effects-of-cancer-therapy","display_name":"late effects of cancer treatment","score":0.8830000162124634},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/second-primary-neoplasms","display_name":"second primary neoplasms","score":0.7200000286102295},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6460000276565552},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cranial-irradiation","display_name":"cranial irradiation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.7070000171661377},{"id":"https://openalex.org/keywords/lifespan-shortening","display_name":"lifespan reduction","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9457396268844604},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6481567025184631},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6007811427116394},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5616771578788757},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5305583477020264},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5140718221664429},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4928191006183624},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4659242331981659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3752402067184448},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.37448281049728394}],"mesh":[{"descriptor_ui":"D000073116","descriptor_name":"Cancer Survivors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004700","descriptor_name":"Endocrine System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004700","descriptor_name":"Endocrine System Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.2023.16875","doi":"https://doi.org/10.1001/jama.2023.16875","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.2023.16875","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"pmid:37750876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37750876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1986820010","https://openalex.org/W2006491639","https://openalex.org/W2024751402","https://openalex.org/W2033912991","https://openalex.org/W2037066552","https://openalex.org/W2049537158","https://openalex.org/W2066617715","https://openalex.org/W2087023624","https://openalex.org/W2096572053","https://openalex.org/W2096762273","https://openalex.org/W2096913417","https://openalex.org/W2104546143","https://openalex.org/W2109626360","https://openalex.org/W2114738305","https://openalex.org/W2116819794","https://openalex.org/W2122704305","https://openalex.org/W2137336819","https://openalex.org/W2137895742","https://openalex.org/W2138105710","https://openalex.org/W2142732613","https://openalex.org/W2143608188","https://openalex.org/W2144209063","https://openalex.org/W2147606107","https://openalex.org/W2157134137","https://openalex.org/W2159012899","https://openalex.org/W2198590456","https://openalex.org/W2264971268","https://openalex.org/W2303955852","https://openalex.org/W2314446106","https://openalex.org/W2328599825","https://openalex.org/W2460724181","https://openalex.org/W2548949853","https://openalex.org/W2554464434","https://openalex.org/W2594318825","https://openalex.org/W2600402428","https://openalex.org/W2618647272","https://openalex.org/W2746300090","https://openalex.org/W2752414510","https://openalex.org/W2770100081","https://openalex.org/W2776066112","https://openalex.org/W2887490171","https://openalex.org/W2888939095","https://openalex.org/W2903555724","https://openalex.org/W2916317903","https://openalex.org/W2924746473","https://openalex.org/W2943918000","https://openalex.org/W2951953464","https://openalex.org/W2954161574","https://openalex.org/W2980780905","https://openalex.org/W2997702690","https://openalex.org/W3013910396","https://openalex.org/W3020066230","https://openalex.org/W3109674153","https://openalex.org/W3194046747","https://openalex.org/W3207063697","https://openalex.org/W4214825610","https://openalex.org/W4220993040","https://openalex.org/W4226085319","https://openalex.org/W4226094984","https://openalex.org/W4230262487","https://openalex.org/W4231276126","https://openalex.org/W4234608211","https://openalex.org/W4243111308","https://openalex.org/W4282922101","https://openalex.org/W4283073652","https://openalex.org/W4304990118","https://openalex.org/W4312018756","https://openalex.org/W4316040870","https://openalex.org/W4383874455"],"related_works":["https://openalex.org/W2417644950","https://openalex.org/W2319133654","https://openalex.org/W4256278478","https://openalex.org/W3191095796","https://openalex.org/W4249102402","https://openalex.org/W2090117055","https://openalex.org/W3046179605","https://openalex.org/W2462702034","https://openalex.org/W2770340827","https://openalex.org/W174813206"],"abstract_inverted_index":{"Importance:":[0],"An":[1],"estimated":[2],"15":[3],"000":[4,63,301],"children":[5,286],"and":[6,22,111,124,147,154,193,297,328,337],"adolescents":[7],"aged":[8],"0":[9],"to":[10,52,84,131,151,164,247,339],"19":[11],"years":[12,34,272],"are":[13,90,139,323],"diagnosed":[14,259,290],"with":[15,178,182,229,234,260,291],"cancer":[16,44,55,86,106,109,133,153,180,253,262,275,292,322],"each":[17],"year":[18],"in":[19,67,263,293,305,317],"the":[20,53,68,144,148,210,239,264,274,294,306],"US,":[21],"more":[23],"than":[24],"85%":[25],"survive":[26,42],"for":[27,171,213,237,268,335],"at":[28,157,168,209,269],"least":[29,270],"5":[30,271],"years.":[31],"By":[32],"45":[33],"of":[35,39,160,241,343],"age,":[36],"approximately":[37],"95%":[38],"people":[40,64,248],"who":[41,220,249,266,287,319],"childhood":[43,54,72,85,136,255,261,310,321],"will":[45],"develop":[46,156,187,202],"a":[47,132,278,333],"significant":[48],"health":[49,81,174,191,206,216,243],"problem":[50],"related":[51,83,130],"diagnosis":[56,134,276],"or":[57,78,87,96,107,117,137,189,204,233,256],"its":[58,88],"treatment.":[59],"Observations:":[60],"Approximately":[61,299],"500":[62,300],"currently":[65,303],"alive":[66,304],"US":[69,307],"have":[70,252,277,308,340],"survived":[71,221,267,309,320],"cancer.":[73,311],"The":[74,312],"most":[75,140,313],"common":[76,314],"severe":[77,188,203],"life-threatening":[79,190,205],"chronic":[80],"problems":[82,175,217,244],"treatment":[89],"endocrine":[91,324],"disorders":[92],"such":[93,103,114],"as":[94,104,115,225],"hypothyroidism":[95],"growth":[97],"hormone":[98],"deficiency":[99],"(44%),":[100],"subsequent":[101,242,326],"neoplasms":[102],"breast":[105],"thyroid":[108],"(7%),":[110],"cardiovascular":[112,329],"disease":[113,126],"cardiomyopathy":[116],"congestive":[118],"heart":[119],"failure,":[120],"coronary":[121],"artery":[122],"disease,":[123],"cerebrovascular":[125],"(5.3%).":[127],"Medical":[128],"conditions":[129],"during":[135,254],"adolescence":[138],"commonly":[141],"caused":[142],"by":[143],"radiation":[145],"therapy":[146],"chemotherapies":[149],"used":[150],"treat":[152],"may":[155],"varying":[158],"lengths":[159],"time":[161],"after":[162,273],"exposure":[163],"these":[165,344],"treatments.":[166],"Individuals":[167,208],"highest":[169],"risk":[170,212],"developing":[172,214],"treatment-related":[173,215],"include":[176,218],"patients":[177,338],"brain":[179],"treated":[181,228],"cranial":[183],"irradiation":[184],"(approximately":[185,200],"70%":[186],"problems)":[192],"allogeneic":[194],"hematopoietic":[195],"stem":[196],"cell":[197],"transplant":[198],"recipients":[199],"60%":[201],"problems).":[207],"lowest":[211],"those":[219],"solid":[222],"tumors":[223],"(such":[224],"Wilms":[226],"tumor)":[227],"surgical":[230],"resection":[231],"alone":[232],"minimal":[235],"chemotherapy,":[236],"whom":[238],"prevalence":[240],"is":[245,332],"similar":[246],"did":[250],"not":[251,289],"adolescence.":[257],"People":[258],"1990s":[265],"shorter":[279],"lifespan":[280],"(by":[281],"about":[282],"9":[283],"years)":[284],"vs":[285],"were":[288],"1990s.":[295],"Conclusions":[296],"Relevance:":[298],"individuals":[302,318],"adverse":[315],"effects":[316],"disorders,":[325],"neoplasms,":[327],"disease.":[330],"There":[331],"need":[334],"clinicians":[336],"heightened":[341],"awareness":[342],"complications.":[345]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-27T00:00:00"}