{"id":"https://openalex.org/W4387009928","doi":"https://doi.org/10.1021/acs.jafc.3c02733","title":"DPP-IV Inhibitory Peptides from Coix Seed Prolamins: Release, Identification, and Analysis of the Interaction between Key Residues and Enzyme Domains","display_name":"DPP-IV Inhibitory Peptides from Coix Seed Prolamins: Release, Identification, and Analysis of the Interaction between Key Residues and Enzyme Domains","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W4387009928","doi":"https://doi.org/10.1021/acs.jafc.3c02733","pmid":"https://pubmed.ncbi.nlm.nih.gov/37748081"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.3c02733","doi":"https://doi.org/10.1021/acs.jafc.3c02733","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.3c02733","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100452876","display_name":"Shu Zhang","orcid":"https://orcid.org/0000-0003-4179-118X","observed_orcids":["https://orcid.org/0000-0003-4179-118X"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Zhang","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":"https://orcid.org/0000-0003-4179-118X","affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100726299","display_name":"Zhiming Li","orcid":"https://orcid.org/0000-0001-5589-1136","observed_orcids":["https://orcid.org/0000-0001-5589-1136"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-ming Li","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101256044","display_name":"Yuchao Feng","orcid":"https://orcid.org/0000-0001-6097-3806","observed_orcids":["https://orcid.org/0000-0001-6097-3806"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuchao Feng","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042965321","display_name":"Shibo Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibo Yu","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061369238","display_name":"Zhijiang Li","orcid":"https://orcid.org/0000-0001-9712-2220","observed_orcids":["https://orcid.org/0000-0001-9712-2220"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijiang Li","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":"https://orcid.org/0000-0001-9712-2220","affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768210","display_name":"Dongjie Zhang","orcid":"https://orcid.org/0000-0003-3536-8422","observed_orcids":["https://orcid.org/0000-0003-3536-8422"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongjie Zhang","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","Key Laboratory of Agro-products Processing and Quality Safety of Heilongjiang Province, Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":"https://orcid.org/0000-0003-3536-8422","affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"Key Laboratory of Agro-products Processing and Quality Safety of Heilongjiang Province, Daqing 163319, PR China","institution_ids":[]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100622766","display_name":"Changyuan Wang","orcid":"https://orcid.org/0000-0001-7692-286X","observed_orcids":["https://orcid.org/0000-0001-7692-286X"]},"institutions":[{"id":"https://openalex.org/I4210124184","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210124184"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changyuan Wang","raw_affiliation_strings":["College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","Heilongjiang Food and Biotechnology Innovation and Research Center (International Cooperation), Daqing 163319, PR China","National Coarse Cereals Engineering Research Center, Daqing 163319, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food, Heilongjiang Bayi Agricultural University, Xinfeng Lu 5, Daqing 163319, PR China","institution_ids":["https://openalex.org/I4210124184"]},{"raw_affiliation_string":"Heilongjiang Food and Biotechnology Innovation and Research Center (International Cooperation), Daqing 163319, PR China","institution_ids":[]},{"raw_affiliation_string":"National Coarse Cereals Engineering Research Center, Daqing 163319, PR China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100622766","https://openalex.org/A5100768210"],"corresponding_institution_ids":["https://openalex.org/I4210124184"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.9841,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94138321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"71","issue":"40","first_page":"14575","last_page":"14592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coix-seed","display_name":"coix seed","score":0.4830000102519989},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.33799999952316284},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.5770000219345093},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pi-pi-stacking","display_name":"\u03c0-\u03c0 stacking","score":0.7699999809265137},{"id":"https://openalex.org/keywords/peptide-secondary-structure","display_name":"peptide secondary structure","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2781074434","wikidata":"https://www.wikidata.org/wiki/Q1186042","display_name":"Coix","level":4,"score":0.8070539236068726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.725395679473877},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6790155172348022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6439594626426697},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.4988672733306885},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4848714768886566},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.47150248289108276},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4350528120994568},{"id":"https://openalex.org/C2780165273","wikidata":"https://www.wikidata.org/wiki/Q424471","display_name":"Prolamin","level":4,"score":0.4153158664703369},{"id":"https://openalex.org/C97564808","wikidata":"https://www.wikidata.org/wiki/Q425526","display_name":"Storage protein","level":3,"score":0.16658782958984375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031742","descriptor_name":"Coix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D054873","descriptor_name":"Dipeptidyl-Peptidase IV Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055315","descriptor_name":"Prolamins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jafc.3c02733","doi":"https://doi.org/10.1021/acs.jafc.3c02733","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.3c02733","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:37748081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37748081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4587592354","display_name":null,"funder_award_id":"YJSCX2022-Z04","funder_id":"https://openalex.org/F4320325404","funder_display_name":"Heilongjiang Bayi Agricultural University"},{"id":"https://openalex.org/G8498588700","display_name":null,"funder_award_id":"TD2020C003","funder_id":"https://openalex.org/F4320323085","funder_display_name":"Natural Science Foundation of Heilongjiang Province"}],"funders":[{"id":"https://openalex.org/F4320323085","display_name":"Natural Science Foundation of Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320325404","display_name":"Heilongjiang Bayi Agricultural University","ror":"https://ror.org/030jxf285"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W636179936","https://openalex.org/W1971521691","https://openalex.org/W1972458261","https://openalex.org/W1985628945","https://openalex.org/W1987894698","https://openalex.org/W1998471404","https://openalex.org/W2032088540","https://openalex.org/W2050655362","https://openalex.org/W2054038699","https://openalex.org/W2062767224","https://openalex.org/W2132281337","https://openalex.org/W2463467188","https://openalex.org/W2463734469","https://openalex.org/W2560323685","https://openalex.org/W2595409088","https://openalex.org/W2744856126","https://openalex.org/W2757652611","https://openalex.org/W2762825110","https://openalex.org/W2767864990","https://openalex.org/W2791613077","https://openalex.org/W2886380361","https://openalex.org/W2903696194","https://openalex.org/W2909678677","https://openalex.org/W2920860772","https://openalex.org/W2950230349","https://openalex.org/W2969343523","https://openalex.org/W2979645943","https://openalex.org/W2995880934","https://openalex.org/W3002373631","https://openalex.org/W3004009929","https://openalex.org/W3011211676","https://openalex.org/W3011299805","https://openalex.org/W3031804782","https://openalex.org/W3048529469","https://openalex.org/W3106048907","https://openalex.org/W3138872756","https://openalex.org/W3168524149","https://openalex.org/W3172012213","https://openalex.org/W3214673218","https://openalex.org/W4205307072","https://openalex.org/W4210916893","https://openalex.org/W4280588491","https://openalex.org/W4283743336","https://openalex.org/W4286005694","https://openalex.org/W4291143978","https://openalex.org/W4295421029","https://openalex.org/W4307904224","https://openalex.org/W4317870997"],"related_works":["https://openalex.org/W4382585314","https://openalex.org/W4220724180","https://openalex.org/W4212860071","https://openalex.org/W4365478925","https://openalex.org/W1971504080","https://openalex.org/W2560323685","https://openalex.org/W4408260913","https://openalex.org/W4385602773","https://openalex.org/W4410030380","https://openalex.org/W4413148259"],"abstract_inverted_index":{"Dipeptidyl":[0],"peptidase":[1],"IV":[2],"(DPP-IV)":[3],"inhibitory":[4,26,86,145,152],"peptides":[5,27,57,75,90,134,172,211],"can":[6],"regulate":[7],"type":[8],"2":[9],"diabetes":[10],"by":[11],"inhibiting":[12],"the":[13,54,62,107,118,123,126,131,203,207,224,237,251],"cleavage":[14],"of":[15,24,36,56,64,88,100,122,133,253],"glucagon-like":[16],"peptide-1":[17],"and":[18,61,81,111,138,157,168,191,199],"prolonging":[19],"its":[20],"half-life.":[21],"The":[22,33,85,103,215],"development":[23,252],"DPP-IV":[25,92,144,151,177],"is":[28,51],"still":[29],"a":[30,140,219,229],"hot":[31],"topic.":[32],"primary":[34],"structure":[35,120],"coix":[37,59,72,101,208,254],"seed":[38,73,209],"prolamins":[39],"contains":[40],"peptide":[41,226,243],"sequence":[42],"fragments":[43],"that":[44,106],"potentially":[45],"inhibit":[46],"DPP-IV;":[47],"however,":[48],"limited":[49],"information":[50],"available":[52],"regarding":[53],"extraction":[55],"from":[58],"seeds":[60],"analysis":[63],"their":[65],"conformational":[66],"relationships.":[67],"In":[68],"this":[69],"study,":[70],"novel":[71],"prolamin-derived":[74],"were":[76,166,202],"obtained":[77],"through":[78],"single":[79,115],"hydrolysis":[80],"double-enzyme":[82],"stepwise":[83],"hydrolysis.":[84],"activity":[87,146],"these":[89],"against":[91],"was":[93,218],"evaluated":[94],"to":[95,114,206,213],"explore":[96],"new":[97],"functional":[98],"properties":[99],"seeds.":[102],"results":[104],"evidenced":[105],"step-by-step":[108],"enzymolysis":[109,116],"(papain":[110],"alcalase)":[112],"compared":[113],"promoted":[117],"secondary":[119],"disruption":[121],"hydrolysates,":[124],"enhanced":[125],"\u03b2-turn":[127],"structure,":[128],"significantly":[129],"increased":[130],"content":[132],"below":[135],"1":[136],"kDa,":[137],"exhibited":[139,173,186],"substantial":[141],"increase":[142],"in":[143,223,236],"(97%":[147],"inhibition).":[148],"Three":[149],"nontoxic":[150],"peptides,":[153],"namely,":[154],"LPFYPN,":[155],"TFFPQ,":[156],"ATFFPQ":[158,192],"(IC":[159],"50":[160],"=":[161],"70.24,":[162],"176.87,":[163],"268.31":[164],"\u03bcM),":[165],"isolated":[167],"identified.":[169],"All":[170],"three":[171],"strong":[174],"interactions":[175,201],"with":[176,234],"(all":[178],"K":[179],"A":[180],"values":[181],">10":[182],"3":[183],").":[184],"LPFYPN":[185],"competitive":[187],"inhibition,":[188],"while":[189],"TFFPQ":[190],"demonstrated":[193],"mixed":[194],"competitive\u2013noncompetitive":[195],"inhibition.":[196],"Hydrogen":[197],"bonding":[198],"hydrophobic":[200],"main":[204],"contributors":[205],"prolamin":[210],"binding":[212],"DPP-IV.":[214],"central":[216],"residue":[217],"key":[220],"amino":[221],"acid":[222],"parent":[225],"sequence,":[227],"forming":[228],"more":[230],"stable":[231],"\u03c0\u2013\u03c0":[232],"stacking":[233],"residues":[235],"active":[238],"pocket,":[239],"which":[240],"may":[241],"facilitate":[242],"activity.":[244],"This":[245],"study":[246],"provides":[247],"theoretical":[248],"support":[249],"for":[250],"seed-derived":[255],"hypoglycemic":[256],"peptides.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":7}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2023-09-26T00:00:00"}