{"id":"https://openalex.org/W4387004356","doi":"https://doi.org/10.3389/fnut.2023.1273328","title":"Orally administered low-molecular weight agaro-oligosaccharides are absorbed into the plasma of healthy humans","display_name":"Orally administered low-molecular weight agaro-oligosaccharides are absorbed into the plasma of healthy humans","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W4387004356","doi":"https://doi.org/10.3389/fnut.2023.1273328","pmid":"https://pubmed.ncbi.nlm.nih.gov/37818337","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560721"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2023.1273328","doi":"https://doi.org/10.3389/fnut.2023.1273328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1273328","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fnut.2023.1273328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028892000","display_name":"Ikuya Shirai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]},{"id":"https://openalex.org/I4405276503","display_name":"INA FOOD Industry Co., Ltd. (Japan)","ror":"https://ror.org/05k506q90","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuya Shirai","raw_affiliation_strings":["Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Japan","Ina Food Industry Co., Ltd., Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]},{"raw_affiliation_string":"Ina Food Industry Co., Ltd., Nagano, Japan","institution_ids":["https://openalex.org/I4405276503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110532401","display_name":"Yu Iwasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191055192","display_name":"Tokyo Kasei University","ror":"https://ror.org/05xbyzq55","country_code":"JP","type":"education","lineage":["https://openalex.org/I191055192"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Iwasaki","raw_affiliation_strings":["Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan","institution_ids":["https://openalex.org/I191055192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001956420","display_name":"Koji Karasawa","orcid":"https://orcid.org/0000-0001-9746-364X","observed_orcids":["https://orcid.org/0000-0001-9746-364X"]},"institutions":[{"id":"https://openalex.org/I4405276503","display_name":"INA FOOD Industry Co., Ltd. (Japan)","ror":"https://ror.org/05k506q90","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Karasawa","raw_affiliation_strings":["Ina Food Industry Co., Ltd., Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ina Food Industry Co., Ltd., Nagano, Japan","institution_ids":["https://openalex.org/I4405276503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038332068","display_name":"Yasutaka Shigemura","orcid":"https://orcid.org/0000-0001-7161-5545","observed_orcids":["https://orcid.org/0000-0001-7161-5545"]},"institutions":[{"id":"https://openalex.org/I191055192","display_name":"Tokyo Kasei University","ror":"https://ror.org/05xbyzq55","country_code":"JP","type":"education","lineage":["https://openalex.org/I191055192"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasutaka Shigemura","raw_affiliation_strings":["Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Domestic Science, Tokyo Kasei University, Tokyo, Japan","institution_ids":["https://openalex.org/I191055192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001559927","display_name":"Shigeru Katayama","orcid":"https://orcid.org/0000-0002-7692-0167","observed_orcids":["https://orcid.org/0000-0002-7692-0167"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeru Katayama","raw_affiliation_strings":["Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Nagano, Japan","Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]},{"raw_affiliation_string":"Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, Nagano, Japan","institution_ids":["https://openalex.org/I137975476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001559927","https://openalex.org/A5038332068"],"corresponding_institution_ids":["https://openalex.org/I137975476","https://openalex.org/I191055192"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.0884,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71991594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1273328","last_page":"1273328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agaro-oligosaccharides","display_name":"agaro-oligosaccharides","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oral-absorption","display_name":"oral absorption","score":0.7160000205039978},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.8389999866485596},{"id":"https://openalex.org/keywords/molecular-weight-dependence","display_name":"molecular weight dependence","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.578000009059906},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5169910192489624},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.4621821641921997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.455111563205719},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3950241208076477}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnut.2023.1273328","doi":"https://doi.org/10.3389/fnut.2023.1273328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1273328","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10560721","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10560721","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10560721/pdf/fnut-10-1273328.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Nutr","raw_type":"Text"},{"id":"pmid:37818337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37818337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8c85de36ee5d4dabb7840db67994356d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c85de36ee5d4dabb7840db67994356d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Nutrition, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2023.1273328","doi":"https://doi.org/10.3389/fnut.2023.1273328","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2023.1273328","pdf_url":null,"source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387004356.pdf","grobid_xml":"https://content.openalex.org/works/W4387004356.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W179115830","https://openalex.org/W1685618362","https://openalex.org/W1971517729","https://openalex.org/W1983295393","https://openalex.org/W2001750230","https://openalex.org/W2002910797","https://openalex.org/W2012767431","https://openalex.org/W2013819796","https://openalex.org/W2030270428","https://openalex.org/W2036547670","https://openalex.org/W2050019946","https://openalex.org/W2057086723","https://openalex.org/W2071534885","https://openalex.org/W2091218396","https://openalex.org/W2095645301","https://openalex.org/W2145123908","https://openalex.org/W2166136998","https://openalex.org/W2285253591","https://openalex.org/W2762282499","https://openalex.org/W2883277503","https://openalex.org/W2917852893","https://openalex.org/W4296047180"],"related_works":["https://openalex.org/W4296047180","https://openalex.org/W2376140441","https://openalex.org/W3159701177","https://openalex.org/W4280606696","https://openalex.org/W2465122138","https://openalex.org/W7167799021","https://openalex.org/W4409736248","https://openalex.org/W2897419654","https://openalex.org/W2587409935","https://openalex.org/W2079916200"],"abstract_inverted_index":{"Agaro-oligosaccharides":[0],"(AOSs)":[1],"are":[2],"known":[3],"to":[4,120,156],"have":[5],"biological":[6],"activities,":[7],"such":[8],"as":[9],"anti-inflammatory,":[10],"anti-tumor,":[11],"and":[12,68,71,116,135],"anti-obesity":[13],"effects.":[14],"Although":[15],"existing":[16],"evidence":[17],"suggests":[18],"the":[19,33,48,56,93,121,132,137,143,161],"presence":[20],"of":[21,59,96,103,114,140,150,160,163],"AOSs":[22,30,42,166],"in":[23,167],"peripheral":[24,168],"tissues":[25],"after":[26,74,83],"oral":[27],"administration,":[28],"whether":[29],"permeate":[31,47],"into":[32],"blood":[34],"circulation":[35],"remains":[36],"unknown.":[37],"Thus,":[38],"we":[39],"hypothesized":[40],"that":[41,92,102,126,136,149],"with":[43,85],"low-molecular":[44],"weight":[45,134],"can":[46],"human":[49],"gastrointestinal":[50,144],"tract.":[51],"To":[52],"test":[53],"this":[54],"hypothesis,":[55],"time":[57],"course":[58],"absorption":[60,139],"was":[61,77,99,108],"examined":[62],"by":[63],"analyzing":[64],"plasma":[65,94,112],"samples":[66],"before":[67],"1,":[69],"2,":[70],"4":[72],"h":[73],"ingestion.":[75],"Analysis":[76],"performed":[78],"using":[79],"liquid":[80],"chromatography/mass":[81],"spectrometry":[82],"labeling":[84],"p-aminobenzoic":[86],"ethyl":[87],"ester.":[88],"Our":[89],"results":[90,124],"showed":[91],"concentration":[95],"agarobiose":[97],"(Abi)":[98],"higher":[100],"than":[101,148],"agarotetraose":[104],"(Ate);":[105],"however,":[106],"agarohexaose":[107],"not":[109],"detected.":[110],"Additionally,":[111],"levels":[113],"Abi":[115,141],"Ate":[117],"were":[118],"proportional":[119],"dose.":[122],"These":[123,152],"suggest":[125],"permeation":[127],"efficiency":[128],"is":[129,146],"dependent":[130],"on":[131],"molecular":[133],"systemic":[138],"via":[142],"tract":[145],"better":[147,158],"Ate.":[151],"findings":[153],"will":[154],"contribute":[155],"a":[157],"understanding":[159],"bioactivity":[162],"orally":[164],"administered":[165],"tissues.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-09-26T00:00:00"}