{"id":"https://openalex.org/W4387002187","doi":"https://doi.org/10.1097/md.0000000000035267","title":"Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer","display_name":"Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4387002187","doi":"https://doi.org/10.1097/md.0000000000035267","pmid":"https://pubmed.ncbi.nlm.nih.gov/37747019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10519541"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000035267","doi":"https://doi.org/10.1097/md.0000000000035267","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000035267","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000035267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089068543","display_name":"Jin\u2010Hyuk Choi","orcid":"https://orcid.org/0000-0001-5625-0912","observed_orcids":["https://orcid.org/0000-0001-5625-0912"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]},{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hyuk Choi","raw_affiliation_strings":["Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","Kosin University College of Medicine, Busan, Korea","102:38(e35267)","All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]},{"raw_affiliation_string":"102:38(e35267)","institution_ids":[]},{"raw_affiliation_string":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","institution_ids":[]},{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103939557","display_name":"Jesang Yu","orcid":"https://orcid.org/0000-0002-0469-2660","observed_orcids":["https://orcid.org/0000-0002-0469-2660"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]},{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jesang Yu","raw_affiliation_strings":["Department of Radiation Oncology, Kosin University Gospel Hospital, Busan, Korea","Kosin University College of Medicine, Busan, Korea","102:38(e35267)","All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]},{"raw_affiliation_string":"102:38(e35267)","institution_ids":[]},{"raw_affiliation_string":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","institution_ids":[]},{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072912859","display_name":"Min-Jung Jung","orcid":"https://orcid.org/0000-0002-2831-9430","observed_orcids":["https://orcid.org/0000-0002-2831-9430"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]},{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minjung Jung","raw_affiliation_strings":["Department of Pathology, Kosin University Gospel Hospital, Busan, Korea","Kosin University College of Medicine, Busan, Korea","102:38(e35267)","All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]},{"raw_affiliation_string":"102:38(e35267)","institution_ids":[]},{"raw_affiliation_string":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","institution_ids":[]},{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092932483","display_name":"Junyong Jekal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Junyong Jekal","raw_affiliation_strings":["Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","102:38(e35267)","All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"102:38(e35267)","institution_ids":[]},{"raw_affiliation_string":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","institution_ids":[]},{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085039958","display_name":"Ku Sang Kim","orcid":"https://orcid.org/0000-0003-2710-112X","observed_orcids":["https://orcid.org/0000-0003-2710-112X"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ku Sang Kim","raw_affiliation_strings":["Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","102:38(e35267)","All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"102:38(e35267)","institution_ids":[]},{"raw_affiliation_string":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was waived for all subjects involved in the study","institution_ids":[]},{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Choi JH, Yu J, Jung M, Jekal J, Kim KS, Jung SU. Prognostic significance of TP53 and PIK3CA mutations analyzed by next-generation sequencing in breast cancer. Medicine 2023","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017048064","display_name":"Sung Ui Jung","orcid":"https://orcid.org/0000-0002-0131-8593","observed_orcids":["https://orcid.org/0000-0002-0131-8593"]},"institutions":[{"id":"https://openalex.org/I2801674040","display_name":"Kosin University Gospel Hospital","ror":"https://ror.org/02xkmx604","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801674040"]},{"id":"https://openalex.org/I90735388","display_name":"Kosin University","ror":"https://ror.org/024b57v39","country_code":"KR","type":"education","lineage":["https://openalex.org/I90735388"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sung Ui Jung","raw_affiliation_strings":["Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","Kosin University College of Medicine, Busan, Korea","Sung Ui Jung, Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, 262, Gamcheon-ro, Seo-gu, Busan, Republic of Korea (e-mail"],"raw_orcid":"https://orcid.org/0000-0002-0131-8593","affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, Busan, Korea","institution_ids":["https://openalex.org/I2801674040"]},{"raw_affiliation_string":"Kosin University College of Medicine, Busan, Korea","institution_ids":["https://openalex.org/I90735388"]},{"raw_affiliation_string":"Sung Ui Jung, Division of Breast Surgery, Department of Surgery, Kosin University Gospel Hospital, 262, Gamcheon-ro, Seo-gu, Busan, Republic of Korea (e-mail","institution_ids":["https://openalex.org/I2801674040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017048064"],"corresponding_institution_ids":["https://openalex.org/I2801674040","https://openalex.org/I90735388"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":1.0684,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73413747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"38","first_page":"e35267","last_page":"e35267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":1.0},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9470000267028809},{"id":"https://openalex.org/keywords/invasive-ductal-carcinoma","display_name":"invasive ductal carcinoma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/erbb2-mutations","display_name":"ERBB2 mutations","score":0.890999972820282},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.8859999775886536},{"id":"https://openalex.org/keywords/mastectomy","display_name":"mastectomy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.903256893157959},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.809038519859314},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6751459836959839},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5856263637542725},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.5713443756103516},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5099343061447144},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.46987396478652954},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45008012652397156},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.44472068548202515},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4423045516014099},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4191315174102783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22599396109580994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11066976189613342},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008408","descriptor_name":"Mastectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000035267","doi":"https://doi.org/10.1097/md.0000000000035267","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000035267","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10519541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10519541","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10519541/pdf/medi-102-e35267.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:37747019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37747019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000035267","doi":"https://doi.org/10.1097/md.0000000000035267","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000035267","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322350","display_name":"College of Medicine, Koisin University","ror":"https://ror.org/024b57v39"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387002187.pdf","grobid_xml":"https://content.openalex.org/works/W4387002187.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1530437552","https://openalex.org/W1981515448","https://openalex.org/W1983689010","https://openalex.org/W1988485005","https://openalex.org/W1991494214","https://openalex.org/W1991847152","https://openalex.org/W1999130958","https://openalex.org/W2045324973","https://openalex.org/W2072772580","https://openalex.org/W2074270635","https://openalex.org/W2095156669","https://openalex.org/W2096140370","https://openalex.org/W2101657563","https://openalex.org/W2117775530","https://openalex.org/W2127057139","https://openalex.org/W2157840751","https://openalex.org/W2168611571","https://openalex.org/W2375577403","https://openalex.org/W2569569779","https://openalex.org/W2759444489","https://openalex.org/W2894491737","https://openalex.org/W2945564879","https://openalex.org/W2982037499","https://openalex.org/W3080458669","https://openalex.org/W3092279597","https://openalex.org/W3096239350","https://openalex.org/W3134218627","https://openalex.org/W3152912537","https://openalex.org/W3154313504","https://openalex.org/W3203777534","https://openalex.org/W6669052872"],"related_works":["https://openalex.org/W3026599075","https://openalex.org/W2192099811","https://openalex.org/W4416379259","https://openalex.org/W3199936041","https://openalex.org/W4411287523","https://openalex.org/W2200358539","https://openalex.org/W4366705286","https://openalex.org/W4379328510","https://openalex.org/W4385767028","https://openalex.org/W7170855724"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,36,54,104],"is":[2,14],"one":[3],"of":[4,34,89,99,166,223,292,301,311,325,328],"the":[5,32,39,75,87,130,153,167,174,184,212,229,237,290,299,309,326],"most":[6,213,231,239],"prevalent":[7],"malignant":[8],"tumors":[9],"affecting":[10],"women":[11],"globally.":[12],"It":[13],"a":[15,43,97,141,202,322],"heterogeneous":[16],"disease":[17],"characterized":[18],"by":[19],"mutations":[20,79,148,206,227,235,242,254,274,285,303,330],"in":[21,53,80,149,209,275,334],"several":[22],"genes.":[23],"Several":[24],"gene":[25,142],"panels":[26],"have":[27,305],"been":[28,50],"applied":[29],"to":[30,57,73,320],"assess":[31],"risk":[33],"breast":[35,81,103,276,293,312],"and":[37,65,86,94,112,135,173,199,233,283,316,331],"determine":[38],"appropriate":[40],"treatment.":[41],"As":[42],"powerful":[44],"tool,":[45],"Next-generation":[46],"sequencing":[47],"(NGS)":[48],"has":[49],"widely":[51],"utilized":[52],"research":[55,315],"due":[56],"its":[58],"advantages,":[59],"including":[60],"high":[61,63,66],"speed,":[62],"throughput,":[64],"accuracy.":[67],"In":[68,125,267],"this":[69,126],"study,":[70,127,269],"we":[71,128,144,270,279],"aim":[72],"analyze":[74],"correlation":[76,137],"between":[77],"somatic":[78,147,205,273],"cancer,":[82],"analyzed":[83,129],"using":[84],"NGS,":[85,210],"prognosis":[88,291,310,335],"patients.":[90],"Between":[91],"May":[92,95],"2018":[93],"2019,":[96],"total":[98,110],"313":[100],"patients":[101,157,168],"with":[102,121,138,211,245,257,289],"underwent":[105,196,201],"surgical":[106],"treatment,":[107],"which":[108,219],"included":[109,156],"mastectomy":[111],"breast-conserving":[113,197],"surgery.":[114],"Among":[115,183],"these":[116,329],"patients,":[117,186],"265":[118,185],"were":[119,207,228,236,243,255],"diagnosed":[120],"invasive":[122],"ductal":[123],"carcinoma.":[124],"NGS":[131],"results,":[132],"clinicopathological":[133],"characteristics,":[134],"their":[136,332],"prognosis.":[139],"Using":[140],"panel,":[143],"examined":[145],"143":[146],"solid":[150],"cancers.":[151],"Notably,":[152],"study":[154],"population":[155],"who":[158],"had":[159,188],"received":[160,189],"neoadjuvant":[161],"chemotherapy.":[162],"The":[163],"mean":[164],"age":[165],"was":[169,178],"53.1":[170],"(\u00b110.28)":[171],"years,":[172],"median":[175],"follow-up":[176],"time":[177],"48":[179],"months":[180],"(range,":[181],"8-54).":[182],"68":[187],"prior":[190],"systemic":[191],"therapy.":[192],"Of":[193],"these,":[194],"203":[195],"surgery,":[198],"62":[200],"mastectomy.":[203],"Various":[204],"observed":[208],"frequent":[214],"mutation":[215],"being":[216],"PIK3CA":[217,253,265,284],"mutations,":[218],"accounted":[220],"for":[221,307],"44%":[222],"all":[224],"mutations.":[225],"TP53":[226,241,282],"second":[230],"frequent,":[232],"ERBB2":[234],"third":[238],"frequent.":[240],"associated":[244,256,288],"poor":[246],"disease-free":[247,259],"survival":[248,260],"(P":[249,261],"=":[250,262],".027),":[251],"while":[252],"better":[258],".035)":[263],"than":[264],"wild-type.":[266],"our":[268],"identified":[271],"various":[272],"cancer.":[277,294,313],"Particularly,":[278],"found":[280],"that":[281,298],"are":[286,318],"potentially":[287],"These":[295],"findings":[296],"suggest":[297],"presence":[300],"specific":[302],"may":[304],"implications":[306],"predicting":[308],"Further":[314],"validation":[317],"needed":[319],"gain":[321],"deeper":[323],"understanding":[324],"role":[327],"mechanisms":[333],"prediction.":[336]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-09-26T00:00:00"}
