{"id":"https://openalex.org/W4387002118","doi":"https://doi.org/10.1165/rcmb.2023-0312ed","title":"Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury","display_name":"Making Mountains out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-driven Lung Injury","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W4387002118","doi":"https://doi.org/10.1165/rcmb.2023-0312ed","pmid":"https://pubmed.ncbi.nlm.nih.gov/37747355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768831"},"language":"en","primary_location":{"id":"doi:10.1165/rcmb.2023-0312ed","doi":"https://doi.org/10.1165/rcmb.2023-0312ed","is_oa":true,"landing_page_url":"https://doi.org/10.1165/rcmb.2023-0312ed","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1165/rcmb.2023-0312ed","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053691848","display_name":"Michael J. Yaeger","orcid":"https://orcid.org/0000-0001-7039-6360","observed_orcids":["https://orcid.org/0000-0001-7039-6360"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Yaeger","raw_affiliation_strings":["Wexner Medical Center The Ohio State University Columbus, Ohio","The Ohio State University Wexner Medical Center, 12306, Columbus, Ohio, United States"],"raw_orcid":"https://orcid.org/0000-0001-7039-6360","affiliations":[{"raw_affiliation_string":"Wexner Medical Center The Ohio State University Columbus, Ohio","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, 12306, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024757186","display_name":"Saame Raza Shaikh","orcid":"https://orcid.org/0000-0003-1950-2521","observed_orcids":["https://orcid.org/0000-0003-1950-2521"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saame Raza Shaikh","raw_affiliation_strings":["Gillings School of Global Public Health","School of Medicine University of North Carolina at Chapel Hill Chapel Hill, North Carolina","The University of North Carolina at Chapel Hill Gillings School of Global Public Health, 41474, Chapel Hill, North Carolina, United States"],"raw_orcid":"https://orcid.org/0000-0003-1950-2521","affiliations":[{"raw_affiliation_string":"Gillings School of Global Public Health","institution_ids":[]},{"raw_affiliation_string":"School of Medicine University of North Carolina at Chapel Hill Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"The University of North Carolina at Chapel Hill Gillings School of Global Public Health, 41474, Chapel Hill, North Carolina, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006672267","display_name":"Kymberly M. Gowdy","orcid":"https://orcid.org/0000-0002-7227-0697","observed_orcids":["https://orcid.org/0000-0002-7227-0697"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kymberly M. Gowdy","raw_affiliation_strings":["Wexner Medical Center The Ohio State University Columbus, Ohio","The Ohio State University Wexner Medical Center, 12306, Columbus, Ohio, United States; kymberly.gowdy@osumc.edu"],"raw_orcid":"https://orcid.org/0000-0002-7227-0697","affiliations":[{"raw_affiliation_string":"Wexner Medical Center The Ohio State University Columbus, Ohio","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Wexner Medical Center, 12306, Columbus, Ohio, United States; kymberly.gowdy@osumc.edu","institution_ids":["https://openalex.org/I2802841970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"1","first_page":"3","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd36","display_name":"CD36","score":0.9269999861717224},{"id":"https://openalex.org/keywords/oxidized-phospholipids","display_name":"oxidized phospholipids","score":0.996999979019165},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.8100000023841858},{"id":"https://openalex.org/keywords/scavenger-receptors","display_name":"scavenger receptors","score":0.6480000019073486},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6000000238418579},{"id":"https://openalex.org/keywords/macrophage-inflammatory-response","display_name":"macrophage inflammation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6819999814033508},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.734000027179718},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.5180000066757202},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.597000002861023},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.6759999990463257},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7931552529335022},{"id":"https://openalex.org/C124815738","wikidata":"https://www.wikidata.org/wiki/Q41509","display_name":"Mole","level":2,"score":0.7397521138191223},{"id":"https://openalex.org/C2779828298","wikidata":"https://www.wikidata.org/wiki/Q4035577","display_name":"CD36","level":3,"score":0.6734075546264648},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5207262635231018},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3652580976486206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2979161739349365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27840715646743774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20906475186347961},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12312942743301392},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1165/rcmb.2023-0312ed","doi":"https://doi.org/10.1165/rcmb.2023-0312ed","is_oa":true,"landing_page_url":"https://doi.org/10.1165/rcmb.2023-0312ed","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10768831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768831","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10768831/pdf/rcmb.2023-0312ED.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},{"id":"pmid:37747355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37747355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1165/rcmb.2023-0312ed","doi":"https://doi.org/10.1165/rcmb.2023-0312ed","is_oa":true,"landing_page_url":"https://doi.org/10.1165/rcmb.2023-0312ed","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6150587355","display_name":null,"funder_award_id":"R01ES031378","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7757070283","display_name":"Dietary DHA mitigates ozone induced pulmonary inflammation","funder_award_id":"R01ES031378","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W150537216","https://openalex.org/W1979241245","https://openalex.org/W2033098486","https://openalex.org/W2040997863","https://openalex.org/W2067185786","https://openalex.org/W2099635702","https://openalex.org/W2182405985","https://openalex.org/W2465274972","https://openalex.org/W2808278657","https://openalex.org/W2901406070","https://openalex.org/W3217736332","https://openalex.org/W4224025633","https://openalex.org/W4241104748","https://openalex.org/W4317708528","https://openalex.org/W4386861202"],"related_works":["https://openalex.org/W2061080721","https://openalex.org/W1974135424","https://openalex.org/W3016917884","https://openalex.org/W4383741028","https://openalex.org/W4386861202","https://openalex.org/W2078255669","https://openalex.org/W2063116304","https://openalex.org/W2402477347","https://openalex.org/W2959982113","https://openalex.org/W2114520821"],"abstract_inverted_index":{"Phospholipid-driven":[0],"Lung":[1],"InjuryPhospholipids":[2],"are":[3,73,233,279],"a":[4,29,80,206,329],"core":[5],"unit":[6],"of":[7,32,60,65,110,119,125,130,223,250,337],"cell":[8,254],"biology,":[9],"making":[10],"up":[11],"membranes,":[12],"affecting":[13],"membrane":[14,17],"fluidity,":[15],"facilitating":[16],"transport,":[18],"participating":[19],"in":[20,40,79,165,191,210,228,341],"cellular":[21],"signaling":[22],"and":[23,35,46,101,127,138,146,160,181,226,256,268,274,316,344,351],"cell-cell":[24],"adhesion,":[25],"storing":[26],"energy,":[27],"constituting":[28],"large":[30],"component":[31],"lung":[33],"surfactant,":[34],"influencing":[36],"immune":[37],"responses":[38],"(1).However,":[39],"chronic":[41,47,306,349],"inflammatory":[42,307],"diseases":[43],"including":[44,141],"atherosclerosis":[45],"obstructive":[48],"pulmonary":[49],"disease,":[50],"oxidative":[51,169],"stress":[52,170],"is":[53,217,298,309,328],"induced,":[54],"which":[55,72,240,270],"leads":[56,121],"to":[57,122,162,186,198,212,219,230,247,305,312,332,348,371],"the":[58,108,123,128,166,221,248],"production":[59,258,276],"oxidized":[61,242,345],"phospholipids":[62,66,152],"(OxPLs).Mechanistically,":[63],"oxidation":[64],"occurs":[67],"either":[68],"enzymatically":[69],"by":[70,103,236],"lipoxygenases,":[71],"upregulated":[74],"during":[75,168],"inflammation,":[76,188,252],"or":[77,88,107,116,325],"nonenzymatically":[78],"lipid":[81],"peroxidation":[82],"reaction":[83],"from":[84,285],"reactive":[85],"oxygen":[86],"species":[87],"oxidizing":[89],"pollutants":[90],"such":[91,133,265],"as":[92,134,266,365],"ozone":[93],"(2,":[94],"3).OxPLs":[95],"activate":[96,187,320],"inflammation":[97,225,292,321,335,350],"primarily":[98],"through":[99,293,322],"recognition":[100,118],"internalization":[102],"scavenger":[104],"receptors":[105,112],"(SRs)":[106],"activation":[109,124,249],"Toll-like":[111],"(TLRs)":[113],"(4).Either":[114],"SR":[115],"TLR":[117],"OxPLs":[120,155,172,180,214,262,287,343],"NF-kB":[126,273],"upregulation":[129],"proinflammatory":[131,208],"cytokines":[132],"IL-6,":[135],"IL-1b,":[136],"TNF-a,":[137],"adhesion":[139,143],"molecules":[140],"intracellular":[142],"molecule-1":[144],"(ICAM-1)":[145],"VCAM-1":[147],"(5).More":[148],"recently,":[149],"oxidatively":[150],"fragmented":[151],"termed":[153],"truncated":[154],"(Tr-OxPLs)":[156],"have":[157,173,358],"been":[158,174],"identified":[159],"found":[161],"be":[163],"increased":[164],"circulation":[167],"(6).However,":[171],"more":[175,207],"thoroughly":[176],"characterized":[177,301],"than":[178],"Tr-OxPLs.Although":[179],"Tr-OxPLs":[182,195,278,315,319],"use":[183],"similar":[184],"mechanisms":[185,222],"they":[189,282,289],"differ":[190,283],"some":[192],"areas.For":[193],"example,":[194],"induce":[196,291],"macrophages":[197,204],"upregulate":[199,272],"an":[200],"antioxidant":[201],"response,":[202],"whereas":[203],"exhibit":[205],"profile":[209],"response":[211],"full-length":[213,231,261,286],"(7).Therefore,":[215],"it":[216,297],"important":[218,311],"study":[220,314],"Tr-OxPL-induced":[224,334],"injury":[227],"juxtaposition":[229],"OxPLs.OxPLs":[232],"classically":[234],"recognized":[235],"SRs,":[237,323],"particularly":[238],"CD36,":[239],"binds":[241],"low-density":[243],"lipoprotein":[244],"(LDL),":[245],"leading":[246,347],"macrophage":[251],"foam":[253],"formation,":[255],"cytokine":[257,275],"(8).In":[259],"addition,":[260,296],"bind":[263],"TLRs":[264],"TLR2":[267],"TLR4,":[269],"directly":[271],"(9).Although":[277],"structurally":[280],"similar,":[281],"enough":[284],"that":[288],"may":[290],"different":[294],"mechanisms.In":[295],"not":[299],"well":[300],"how":[302],"Tr-OxPL":[303],"contribute":[304],"diseases.It":[308],"therefore":[310],"further":[313],"consider":[317],"if":[318],"TLRs,":[324],"both.Inhibiting":[326],"CD36":[327],"prime":[330],"candidate":[331],"block":[333],"because":[336],"its":[338],"known":[339],"role":[340],"binding":[342],"LDL,":[346],"driving":[352],"cardiopulmonary":[353],"diseases.Synthetic":[354],"amphipathic":[355],"helical":[356],"peptides":[357,370],"gained":[359],"attention":[360],"for":[361],"targeting":[362],"CD36.Originally":[363],"designed":[364],"apoA-1":[366],"(apolipoprotein":[367],"A-1)":[368],"mimetic":[369]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-26T00:00:00"}
